D-PANTHENOL

D-PANTHENOL

CAS NUMBER: 81-13-0

D-PANTHENOL; D PANTHENOL; d-panthenol; d panten; d-panten; DL-Panthenol; panthenol; 16485-10-2; DL-Pantothenol; DL-Pantothenyl alcohol; 2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide; Panthenolum; Pantenol; Pantenolo; Penthenol; Varitan; Panthenol , DL-form; (+-)-Pantothenyl alcohol; Pantenolo [DCIT]; Urupan; Alcool DL-pantotenilico; C9H19NO4; Pantenol [INN-Spanish]; Panthenolum [INN-Latin]; Pantothenylol; Intrapan; Pantenyl; D-(+)-Panthenol; Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-; Provitamin B5; Alcool DL-pantotenilico [Italian]; Dextro pantothenyl alcohol; EINECS 240-540-6; MFCD00002944; Alcopan-250; D-(+)-Pantothenyl alcohol; Dexpantenol; Dexpanthenolum; 2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide; Pantothenol, D-; 62507-76-0; AK-60852; (+-)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide; Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (+)- (9CI); Dexpantenol [INN-Spanish]; Dexpanthenolum [INN-Latin]; Q-201031; CCRIS 3947; HSDB 296; EINECS 201-327-3; Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (+-)-; Butyramide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, DL-; component of Zentinic; Panthenol, (+)-; BRN 1724947; SMR000857333; N-Pantoyl-3-propanolamine; SR-05000001760; (R)-2,4-Dihydroxy-N-(3-hydroxy-propyl)-3,3-dimethylbutanamide; Dexpanthenol [USAN:INN:BAN]; NSC302962; D(+)-alpha,gamma-Dihydroxy-N-(3-hydroxypropyl)-beta,beta-dimethylbutyramide; d,l- panthenol; Fancol DL; alpha,gamma-Dihydroxy-N-(3-hydroxypropyl)-beta,beta-dimethylbutyramide, D-(+)-; Panthenol [USAN:BAN:INN:JAN]; Panthenol, racemic; NCGC00186658-01; AK113720; pantothenylol alcohol; ACMC-20ajzi; Dexpanthenol [USAN); DL-Panthenol 99%; Panthenol [USAN:USP:INN:BAN:JAN]; 2,3-dimethylbutyramide; DL-Panthenol, 99%; ACMC-209pkr; Panthenol (USP/INN); Dexpanthenol (Panthenol); ACMC-1AYN9; compnent of ilopan-Choline; EC 240-540-6; DSSTox_CID_24598; DSSTox_RID_80341; DSSTox_GSID_44598; SCHEMBL15567; MLS001336015; MLS001336016; (R)-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide; [DID-no:2618]; Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (theta)-; CHEMBL1371937; D-(+)-2,3-dimethylbutyramide; DTXSID3044598; HMS2093B14; HMS2234M16; HMS3371M11; Pharmakon1600-01505420; Pharmakon1600-01505656; HY-B1024; KS-00000G3O; Tox21_302660; ANW-22120; NSC759127; NSC759899; s4566; STL453540; DL-Pantothenol;DL-Pantothenyl alcohol; AKOS015841508; API0002452; CCG-213502; CS-4541; EBD2293971; MCULE-2403906933; NSC-302962; NSC-759127; NSC-759899; VC31151; NCGC00256864-01; AS-56363; DA-09547; LS-47635; LS-47636; P992; SBI-0206818.P001; CAS-16485-10-2; DB-056494; FT-0625499; FT-0625596; FT-0693817; NS00000985; P1318; A19436; D03726; AB00918367_05; A810597; Butyramide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3; Q196473; SR-05000001760-1; SR-05000001760-3; 3-(2,4-Dihydroxy-3,3-dimethylbutyramido)-1-propanol; BRD-A59413292-001-04-1; Butanamide,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-; 3,3-dimethyl-2,4-bis(oxidanyl)-N-(3-oxidanylpropyl)butanamide; D-2,4-Dihydroxy-3,3-dimethyl-N-(3-hydroxypropyl)butyramide; Butanamide,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (R)-; Butyramide,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, D-(+)-; Panthenol, racemic, United States Pharmacopeia (USP) Reference Standar; dpantenol; d pantenol; d-panten;

D-PANTHENOL

Panthenol (also called pantothenol) is the alcohol analog of pantothenic acid (vitamin B5), and is thus a provitamin of B5. In organisms it is quickly oxidized to pantothenic acid. It is a viscous transparent liquid at room temperature. Panthenol is used as a moisturizer and to improve wound healing in pharmaceutical and cosmetic products.

Uses

In pharmaceuticals, cosmetics and personal-care products, panthenol is a moisturizer and humectant, used in ointments, lotions, shampoos, nasal sprays, eye drops, lozenges, and cleaning solutions for contact lenses.

In ointments it is used for the treatment of sunburns, mild burns, minor skin injuries and disorders (in concentrations of up to 2–5%). It improves hydration, reduces itching and inflammation of the skin, improves skin elasticity, and accelerates epidermal wounds' rate of healing. For this purpose, it is sometimes combined with allantoin.

It binds to the hair shaft readily; so, it is a common component of commercial shampoos and hair conditioners (in concentrations of 0.1–1%). It coats the hair and seals its surface,[citation needed] lubricating the hair shaft and giving it a shiny appearance.

It is also recommended by tattoo artists as a post-tattooing moisturising cream.

Adverse effects

Panthenol is generally well tolerated. In rare cases, skin irritation and contact allergies have been reported.

Pharmacology

Panthenol readily penetrates into the skin and mucous membranes (including the intestinal mucosa), where it is quickly oxidized to pantothenic acid. Pantothenic acid is extremely hygroscopic, that is, it binds water effectively. It is also used in the biosynthesis of coenzyme A, which plays a role in a wide range of enzymatic reactions and thus in cell growth.

Physical and chemical properties

Dexpanthenol

Panthenol is an odourless, slightly bitter, highly viscous, transparent and colourless liquid at room temperature, but salts of pantothenic acid (for example sodium pantothenate) are powders (typically white). It is easily soluble in water and alcohol, moderately soluble in diethyl ether, soluble in chloroform (1:100), in propylene glycol, and slightly soluble in glycerin.

Panthenol's expanded chemical formula is HO–CH2–C(CH3)2–CH(OH)–CONH–CH2CH2CH2–OH.

Stereochemistry

Panthenol comes in two enantiomers, D and L. Only D-panthenol (dexpanthenol) is biologically active, however both forms have moisturizing properties. For cosmetic use, panthenol comes either in D form, or as a racemic mixture of D and L (DL-panthenol).

D-PANTHENOL Application

1. The effect of D-panthenol on the skin

Promote the metabolism of human body protein, fat, carbohydrates, protect the skin and mucous membranes, prevent and control small wrinkles, inflammation, sun, and erosion. It is a non-sticky moisturizing ingredient with a strong moisturizing effect. Penetrates and infiltrates the stratum corneum on the surface of the skin, making the skin soft, effectively preventing rough skin, achieving skin moisturizing and tissue repairing effects, and giving skin radiance.

2.D-panthenol on hair

Improve hair gloss, prevent hair loss, promote hair growth, keep hair moist, reduce hair splitting, prevent crispness and breakage, and protect, repair and care for hair.

Widely used in medicine, food, feed, cosmetics industries.

As vitamin B5 has the same metabolic process in the body.

In the food industry: it is used as a nutritional supplement and fortifier to promote the metabolism of human proteins, fats, sugars, maintain skin and mucous membranes, improve hair gloss, improve immunity, and prevent disease.

In the cosmetics industry: the skin care effect is expressed as a deeply penetrated humectant, which stimulates the growth of epithelial cells, promotes wound healing, and plays an anti-inflammatory role.

The nursing effect on the hair is manifested as a long-lasting moisturizing function, preventing hair splitting and damage, increasing the density of the hair and improving the gloss of the hair.

The care of the nails is to improve the hydration of the nails and to give the nails flexibility.

Dexpanthenol is an alcoholic analogue of D-pantothenic acid and cholinergic agent. Dexpanthenol acts as a precursor of coenzyme A necessary for acetylation reactions and is involved in the synthesis of acetylcholine. Although the exact mechanism of the actions of dexpanthenol is unclear, it may enhance the effect of acetylcholine. Dexpanthenol acts on the gastrointestinal tract and increases lower intestinal motility. It is also applied topically to the skin to relieve itching and to promote healing.

Dexpanthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium. Dexpanthenol is enzymatically cleaved to form pantothenic acid, which is an essential component of Coenzyme A, which acts as a cofactor in many enzymatic reactions that are important for protein metabolism in the epithelium. Due to its good penetration and high local concentrations, dexpanthanol is used in many topical products, such as ointments and lotions for treatment of dermatological conditions to relieve itching or promote healing. Dermatological effects of the topical use of dexpanthenol include increased fibroblast proliferation and accelerated re-epithelialization in wound healing. Furthermore, it acts as a topical protectant, moisturizer, and has demonstrated anti-inflammatory properties. Dexpanthenol is also available as a racemic mixture containing both the dextrorotatory form (dexpanthenol) and the levorotatory form (levopanthenol) as [DB11204]. While pantothenic acid is optically active, only the dextrorotatory form (dexpanthenol) is biologically active.

Pantothenol is a monocarboxylic acid amide that is 3,3-dimethylbutanamide substituted by hydroxy groups at positions 2 and 4 and a 3-hydroxypropyl group at the carbomyl nitrogen. It has a role as a cholinergic drug and a provitamin. It is an amino alcohol and a monocarboxylic acid amide.

Product name: Vitamin B5 / d-calcium pantothenate / d-pantelenyl alcohol

Chenical name: D - (+) - 2,4-dihydroxy-n- (3-hydroxypropyl) -3,3-dimethylbutyramide

CAS: 81-13-0

Molecular formula: C9H19NO4

Characteristics: d-panthenol is a colorless, viscous clear liquid, soluble in water, methanol, propylene glycol and ethanol, insoluble in oils and oils.

Uses: d-panthenol plays an important role in human intermediate metabolism. Vitamin B5 deficiency can cause many dermatological disorders. D-panthenol is applied in the pharmaceutical industry and almost all kinds of cosmetic preparations.

It cares for hair, skin and nails.

D-panthenol is applied in almost all kinds of cosmetic preparations. It cares for hair, skin and nails. D-pantothenol is the provider of d-pantothenic acid (vitamin B5), which plays an important role in human metabolism. Vitamin B5 deficiency can cause many dermatological disorders.

Description: D-pantothenol (Dexpanthenol) D-pantothenol (99%) is the precursor of vitamin B5, so it is also called vitamin B5 with a content of vitamin D not less than 99%, D-pantothenol; it is colorless to slightly yellow transparent viscous liquid with a slight specific odor

Product's feature :

1.Protecting the skin and mucous membranes, enhancing the shine of hair, enhancing immunity, preventing disease

2.Moisture Deep penetration, promote the growth of epithelial cells, promote wound healing, anti-inflammatory effect

3. Deep moisturizing

Application:

1. It is widely used in medicine, food, feed, cosmetics industry.

2.In the food industry, used as a nutritional supplement and supplement, promote body protein, fat, carbohydrate metabolism, skin and mucous membrane, increase hair shine, improve immunity, prevent the onset of disease

3.In the cosmetic industry, as an excellent moisturizing agent

4. Other skin Care Products and Hair products

Properties: D-Panthenol, as a 75% solution in water, is used as an active substance for further processing in the cosmetic industry. It has a lower viscosity than pure D-Panthenol. It mixes easily with water, ethanol, methanol and propylene glycol. They are insoluble in fats and oils.

Applications: D-Panthenol is applied in almost all kinds of cosmetic preparations. It cares for hair, skin and nails. The trend in modern cosmetics is formulations containing ingredients that provide therapeutic effectiveness. The effect of locally applied Panthenol has been confirmed in many studies. D-Panthenol is a biologically stable, active form of Pantothenic acid, Vitamin B5. It is the provitamin of D-Pantothenic acid, which plays a key role in human intermediate metabolism. Vitamin B5 deficiency can result in dermatological diseases. Panthenol solutions are easier to process than pure Panthenols due to their lower viscosity. Its role in the skin; Deep penetrating moisturizer, stimulates epithelization, wound healing and anti-inflammatory effect. Its role in hair; It is a long-lasting moisturizer, protects hair from damage, thickens it, and improves its dullness and shine. Role in nail care; It regulates hydration (water retention) and gives flexibility. Application areas of ND-Panthenol in drugs; syrups, pills, ampoules, creams, gels and capsules. D-Panthenol is preferred over D-pantothenates in liquid multivitamin and Vitamin B complex preparations because D-Panthenol is remarkably more stable below pH 5. Locally applied Panthenol is absorbed by the skin and turns into pathothenic acid. A cream containing panthenol prevents the skin rash caused by U.V rays. A cream containing 5% Panthenol has been found to heal wounds on the skin up to 30%. A cream containing Panthenol applied regularly to the skin improves the moisture content of dry skin. High water content protects hair from damage caused by combing, brushing, drying and perm.

D-Panthenol Stability and Storage:

D-Panthenol is highly resistant to air and light.

D-Panthenol is hygroscopic and heat sensitive; Over 70 ° C warming can cause racing duty.

Shelf life is 36 months from the date of production when stored at room temperature (below 25 ° C) in its unopened original package. The "best use first" details stated on the label.

In aqueous solutions, D-Panthenol is significantly more stable than salts of pantothenic acid, especially at a pH of 3 to 6.

D-Panthenol can adjust protein, carbohydrate and fat metabolism, protect mucous membrane on skin

It prevents diseases with the surface and shine of the hair (and hairs).

Usage of D-Panthenol:

D-Panthenol is applied in almost all kinds of cosmetic preparations. It holds the hair, skin and nails.

D-Panthenol is the provitamin of D-Pantothenic acid (Vitamin B5), which plays an important role in humans.

intermediate metabolism. Vitamin B5 deficiency can cause many dermatological diseases.

Role in skin: 1, deep penetrating moisturizer 2, stimulate epithelization (fibroblast proliferation and normal keratinization) 3, wound healing effect 4, anti-inflammatory e.