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D-Panthenol (also called panthenol) is the alcohol analogue of pantothenic acid (vitamin B5), and is thus a provitamin of B5. In organisms, it is quickly oxidized to pantothenic acid. It is a viscous transparent liquid at room temperature. Panthenol is used as a moisturizer and to improve wound healing in pharmaceutical and cosmetic products.
CAS NO: 81-13-0
EC Number: 201-327-3
IUPAC NAMES:
2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide
(2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide
D-Panthenol
D-Panthenol
dexpanthenol
Dexpanthenol
SYNONYMS:
R)-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide, (R)-2,4-Dihydroxy-3,3-dimethylbutyric 3-hydroxypropylamide, D-Pantothenyl alcohol, Dexpanthenol, Provitamin B;(+)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide;2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide;Bepanthen;butanamide, 2,4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethyl-, (+--)-;Corneregel;D-panthenol;dexpanthenol;Dexpanthenol Heumann;DL-panthenol;Ilopan;Marolderm;NasenSpray ratiopharm Panthenol;Nasicur;Otriven Dexpanthenol;Pan Rhinol;Pan-Ophta;panthenol;Panthenol Braun;Panthenol Jenapharm;Panthenol LAW;Panthenol Lichtenstein;panthenol von ct;Panthenol-ratiopharm;Panthoderm;Panthogenat;pantothenol;Repa-Ophtal;Rhinoclir;Siozwo SANA;Ucee D;Urupan;Wund- und Heilsalbe LAW;DL-Panthenol;panthenol;16485-10-2;DL-Pantothenol;DL-Pantothenyl alcohol;2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide;Panthenolum;Pantenol;Pantenolo;(+-)-Pantothenyl alcohol;Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-;Alcool DL-pantotenilico;Panthenol, racemic;MFCD00002944;Penthenol;Varitan;D-(+)-Panthenol;Provitamin B5;D-(+)-Pantothenyl alcohol;Dexpantenol;Dexpanthenolum;2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide;DL-Pantothenol;DL-Pantothenyl alcohol;62507-76-0;Panthenol , DL-form;Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (+)- (9CI);Pantenolo [DCIT];Pantenol [INN-Spanish];Panthenolum [INN-Latin];component of Zentinic;Panthenol, (+)-;SMR000857333;N-Pantoyl-3-propanolamine;Alcool DL-pantotenilico [Italian];SR-05000001760;EINECS 240-540-6;NSC302962;d,l- panthenol;Fancol DL;NCGC00186658-01;pantothenylol alcohol;ACMC-20ajzi;Dexpanthenol [USAN);DL-Panthenol 99%;Panthenol [USAN:USP:INN:BAN:JAN];2,3-dimethylbutyramide;DL-Panthenol, 99%;ACMC-209pkr;Panthenol (USP/INN);(+-)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide;ACMC-1AYN9;compnent of ilopan-Choline;EC 240-540-6;DSSTox_CID_24598;DSSTox_RID_80341;DSSTox_GSID_44598;SCHEMBL15567;MLS001336015;MLS001336016;(R)-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide;CHEMBL1371937;D-(+)-2,3-dimethylbutyramide;DTXSID3044598;HMS2093B1;HMS2234M16;HMS3371M11;Pharmakon1600-01505420;Pharmakon1600-01505656,HY-B1024;Tox21_302660;ANW-22120;Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (+-)-;Butyramide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, DL-;NSC759127;NSC759899;s4566;STL453540;AKOS0158415;CCG-213502;CS-4541;EBD2293971;MCULE-2403906933;NSC-302962;NSC-759127;NSC-759899;VC31151;NCGC00256864-01;AK-60852;AK113720;AS-56363;DA-09547;P992;SBI-0206818.P001;CAS-16485-10-2;DB-056494;FT-0625499;FT-0625596;FT-0693817;P1318;A19436;D03726;AB00918367_05;A810597;Butyramide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3;Q196473;Q-201031;SR-05000001760-1;SR-05000001760-3;RD-A59413292-001-04-1;Butanamide,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-;3,3-dimethyl-2,4-bis(oxidanyl)-N-(3-oxidanylpropyl)butanamide
-2,4-Dihydroxy-3,3-dimethyl-N-(3-hydroxypropyl)butyramide;Butanamide,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (R)-;Butyramide,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, D-(+)-;Panthenol, racemic, United States Pharmacopeia (USP) Reference Standard;Dexpanthenol;D-Panthenol;81-13-0;Pantothenol;Ilopan;D-Pantothenyl alcohol;Bepanthen;(+)-Panthenol;Bepanthene;Bepantol;Pantol;Provitamin B;Panthoderm;Thenalton;Motilyn;Panadon;Zentinic;Cozyme;d-Pantothenol;Pantothenyl alcohoZ;d panthenol;D-P-A Injection;D(+)-Panthenol;Pantenyl;Synapan;Urupan;D(+)-Pantothenyl alcohol;D-Panthenol 50;Pantothenylol;Intrapan;(2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide;Dextro pantothenyl alcohol;Panthenol (D);Propanolamine, N-pantoyl-;(R)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide;Alcopan-250;N-Pantoyl-propanolamine;Dexpanthenol;;Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (2R);UNII-1O6C93RI7Z;Panthenol (JAN);Prestwick_529;Dexpanthenol (1.20 g/mL);Ilopan (TN);Provitamin B5;MFCD00065006;NSC 302962;D-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide;Dexpantenol;Dexpanthenolum;Penthenol;Varitan;1O6C93RI7Z;CHEBI:27373;Pro-vitamin B5;component of Pantho-F;NCGC00142622-03;D-Panthenol, 98+%;2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide, (R)-;2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide, D-(+)-;Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (R)-;Butyramide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, D-(+)-;DSSTox_CID_2906;DSSTox_RID_76783;DSSTox_GSID_22906;(R)-2,4-Dihydroxy-3,3-dimethylbutyric 3-hydroxypropylamide;Sinecort;(R)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide;component of Zentinic;Panthenol, (+)-;Pantothenol, D-;N-Pantoyl-3-propanolamine;Dexpantenol [INN-Spanish];Dexpanthenolum [INN-Latin];CCRIS 3947;HSDB 296;NSC302962;CAS-81-13-0;NCGC00186658-01;Dexpanthenol [USAN:USP:INN:BAN];EINECS 201-327-3;Dexpanthenol (USP);BAY 81-2996;BRN 1724947;Panthenol, (+ )-;Prestwick0_000022;Prestwick1_000022;Prestwick2_000022;Prestwick3_000022;Dexpanthenol (USP/INN);D-Panthenol USP/BP/IP;bmse000445;
Pharmacology
D-Panthenol readily penetrates into the skin and mucous membranes (including the intestinal mucosa), where it is quickly oxidized to pantothenic acid. Pantothenic acid is extremely hygroscopic, that is, it binds water effectively. It is also used in the biosynthesis of coenzyme A, which plays a role in a wide range of enzymatic reactions and thus in cell growth.
PHYSICAL AND CHEMICAL PROPERTIES
Dexpanthenol
D-Panthenol is an odourless, slightly bitter, highly viscous, transparent and colourless liquid at room temperature, but salts of pantothenic acid (for example sodium pantothenate) are powders (typically white). It is easily soluble in water and alcohol, moderately soluble in diethyl ether, soluble in chloroform (1:100), in propylene glycol, and slightly soluble in glycerin.
D-Panthenol benefits for skin
D-Panthenol is a nutrient from the B vitamin family that helps manage the negative results that oxidative stress can have on our skin, such as redness, fine lines, skin roughness and more. Pantothenic acid, also known as vitamin B5, works to support the skin in numerous ways, first by maintaining the strength of the skin’s outer barrier, then by infusing skin cells with nutrients that go to work to fight the environmental toxins that are also stressors to our skin.
D-Panthenol helps nourish and add vital moisture to the skin, first by sealing in hydration by boosting the skin barrier, but also by helping to rejuvenate and revitalize skin cells, helping to defy the ageing process.
One of the most important ways D-Panthenol is believed to be effective as a skin-friendly nutrient is its ability to manage the healthy levels of fibroblasts the cells that are most prolific in our skin’s connective tissue which in turn boosts collagen and elastin the proteins that help keep skin luminous, elastic and even-toned.
This form of vitamin B5 easily penetrates the skin, allowing it to promote recovery and revitalization of skin cells.
Uses of D-Panthenol
In addition to skincare, D-Panthenol is often used in hair care products because its humectant properties help increase elasticity while boosting the moisture content to keep strands looking healthy and radiant with a deep shine.
Source and sustainability of D-Panthenol
Because D-Panthenol is derived from pantothenic acid (known as vitamin B5), which is often extracted from honey, it is a sustainable, environmentally friendly product.
D-Panthenol acts as a skin moisturiser, helping to keep skin soft, smooth and healthy. It also acts as an anti-inflammatory by stimulating your skin's healing processes. It is deeply hydrating and it even helps to keep skin moist by absorbing moisture from the air
D-panthenol is the dextrorotatory form (form in which biological activity is the greatest) of vitamin B5, which is metabolized into pantothenic acid in the epidermis. D-panthenol is a small molecule which, although very hydrosoluble, easily penetrates the skin (unlike pantothenic acid), leaving a fine film on the surface.
Its acid form is found in all living cells as it is also found in the composition of coenzyme A (CoA) and acetyl CoA. These two elements are essential to the Krebs cycle, the source of cell energy. Pantothenic acid is therefore involved in lucid, lipid and protein metabolism. Deficiency in vitamin B5, which is omnipresent in food (particularly abundant in meat, fish, yeasts, vegetables and eggs), may cause physiological and dermatological disorders.
Numerous lip treatments already contain D-panthenol to repair cracks and moisturize the lips.
ACTION MECHANISMS
D-panthenol easily penetrates the epidermis.
D-panthenol induces the synthesis of a precursor of fatty acids and sphingolipids, which are essential in forming the lipid bilayer of the stratum corneum. D-panthenol helps to repair the cutaneous barrier, improve moisturization, reduce roughness and indirectly reduce inflammation (as the barrier function is restored, it will thus restrict the penetration of potentially irritant agents), and this at a concentration of 5%.
The cicatrizing property of D-panthenol is due to its mitotic activity on the fibroblasts. The mitotic activity of its metabolization product in the epidermis, pantothenic acid, has also been proven on cultured human fibroblasts. By stimulating cell growth, D-panthenol reduces wound cicatrization time.
Through its hygroscopic property, D-panthenol improves skin moisturization as of 1% with no significant difference compared with the placebo, whereas, at 2%, this difference is significant.
D-Panthenol is the precursor of coenzyme A and is much more stable than the latter. The metabolic chain targeted is that of lipid metabolism. In this respect, its role in cell repair, skin moisturization and inflammation has been revealed in vivo. Its association with cysteine may also be justified (biosynthesis of coenzyme A). Its amphiphilic makes it a good skin conditioner that helps moisturization and the barrier effect. Nothing in the literature makes it possible to specify an exact effect/dose ratio. We may consider a non-specific "metabolic recharge" activity and skin conditioning.
Concentrations higher than 1% are documented. We may therefore consider a concentration of 5% as regards effectiveness in mono-active use.
D-Panthenol is the provitamin of D-pantothenic acid. The substance, also known as pro-vitamin B5, is valued in skin and hair care for its moisturising properties and strengthening and moisturising conditioner for hair care products, especially conditioners. Panthenol is hygroscopic, since it acts as a humectant and adheres strongly to the cuticle and penetrates deep into the cortex of the hair shaft, thus improving the resistance of hair to mechanical stress.
However, the influence of panthenol on the tissue repair process together with its anti-inflammatory properties also make it ideal for soothing sensitive or irritated skin.
In cosmetics,D- panthenol is a humectant, emollient and moisturiser. It binds to the hair shaft readily and is frequently used in shampoos and hair conditioners (in concentrations of 0.1-1%).
It coats the hair and seals its surface, lubricating the hair shaft and making strands appear shiny. It is also recommended by many tattoo artists for inclusion in moisturising cream for new tattoos.
Panthenol is a substantive strengthening and moisturising conditioner for the hair. Because it is hygroscopic, it acts as a humectant and adheres strongly to the cuticle and penetrates deep into the cortex of the hair shaft, thus improving the resistance of hair to mechanical stress.
Panthenol can also substantially increase moisture in nails and so can improve their flexibility and stability.
Ethyl Panthenol is easier to use than Panthenol and has been shown to give a greater deposition on the hair and superior strengthening properties.
USES
In pharmaceuticals, cosmetics and personal-care products, panthenol is a moisturizer and humectant, used in ointments, lotions, shampoos, nasal sprays, eye drops, lozenges, and cleaning solutions for contact lenses.
In ointments, it is used for the treatment of sunburns, mild burns, minor skin injuries and disorders (in concentrations of up to 2–5%). It improves hydration, reduces itching and inflammation of the skin, improves skin elasticity, and accelerates epidermal wounds' rate of healing. For this purpose, it is sometimes combined with allantoin.
It binds to the hair shaft readily; so, it is a common component of commercial shampoos and hair conditioners (in concentrations of 0.1–1%). It coats the hair and seals its surface, lubricating the hair shaft and giving it a shiny appearance.
It is also recommended by tattoo artists as a post-tattooing moisturising cream.
USE AREAS
* Drug product, the manufacturing of drugs modified by veterinary, animal, or pet.
* Tanning salon or hair salon
* Soaps, cleaning the hands or body, and soaps/detergents for cleaning products, homes, etc
* Body oils
* Moisturizers, lotions, and creams for primarily treating the face.
* Facial cleansing products containing exfoliating particles
* Facial cleansing products (excluding scrubs and products for acne)
* hair conditioners (excluding combo shampoo/conditioner products)
* Hairstyling products for hold, shine, or texture
* Sunscreens and blocks (spray or aerosol formulations specified)
* Products specifically designed for use by babies (includes diapers, baby toys, baby clothing, baby food, etc., with appropriate modifiers)
* Personal care products used on the face (includes facial treatments, oil and blemish control, make-up removers, facial cleansers)
* General products related to the hair (hair tools, hair salons, shampoo, conditioner, hair dye); more specific modifiers included when known
* Personal care and cosmetics, lotions and moisturizers for consumer use
* Subcategory of personal care and cosmetics, related to nail products (nail polish, artificial nails)
* General products related to the hair (hair tools, hair salons, shampoo, conditioner, hair dye); more specific modifiers included when known
* Personal care products used on the hands, such as soaps, lotions, sanitizers
* Personal care products for general use on the body (body makeup, body powder, body treatments, body cleansers)
* Hairstyling products for hold, shine, or texture (gel and spray formulation indicated)
* General products related to the hair (hair tools, hair salons, shampoo, conditioner, hair dye)
* Agricultural, including the raising and farming of animals and growing of crops.
* Animals (but non-veterinary) e.g., animal husbandry, farming of animals/animal production, raising of animals for food or fur, animal feed, products for household pets.
* Products used on crops, or related to the growing of crops.
* Drug product, or related to the manufacturing of drugs; modified by veterinary, animal, or pet if indicated by the source.
* Veterinary activities or veterinary drugs.
* Includes spices, extracts, colourings, flavours, etc added to food for human consumption.
* General flavouring agents used in foods, including condiments and seasonings
* food packaging, paper plates, cutlery, small appliances such as roasters, etc.
* Detergents with a wide variety of applications; modifiers included when known
* Personal care products, including cosmetics, shampoos, perfumes, soaps, lotions, toothpaste, etc
* The fragrance used as a personal care product
* Soaps, includes personal care products for cleansing the hands or body, and soaps/detergents for cleaning products, homes, etc
* Eyeliners or brow colouring products.
* Hair dye, to colour the hair.
* Personal care products, including scouring cream, hand creams, shaving cream, and tanning cream
D-Panthenol is often called Provitamin B5 and is widely used in the cosmetics world because it is so effective when used at sufficient levels
Once in the skin, it rapidly converts to vitamin B5 (Pantothenic Acid) which is a major constituent of Coenzyme A, which has a key role in the repair mechanism of cells and tissues. It soothes and softens skin by locking in moisture thus preventing dehydration and dry skin and reducing Transepidermal Water Loss.
It maintains the elasticity of the skin. It also works with DMAE in the body to produce acetylcholine which tones and firms the skin. It promotes the stimulation of epithelialization and granulation in the skin whilst minimising itching.
This is excellent for any skin repair situation as it also smoothes roughness and dryness. Its anti-inflammatory effect is also useful in eczema-prone skin products. Suitable for all skin types and especially age-defying and mature skin products. In cuticle gels, it penetrates the top layer of the nails and holds moisture there to make the nail bed healthier.
D-Panthenol is an alcoholic analogue of D-pantothenic acid and cholinergic agent. D-Panthenol acts as a precursor of coenzyme A necessary for acetylation reactions and is involved in the synthesis of acetylcholine. Although the exact mechanism of the actions of D-Panthenol is unclear, it may enhance the effect of acetylcholine. D-Panthenol acts on the gastrointestinal tract and increases lower intestinal motility. It is also applied topically to the skin to relieve itching and to promote healing.
D-Panthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium. D-Panthenol is enzymatically cleaved to form pantothenic acid, which is an essential component of Coenzyme A, which acts as a cofactor in many enzymatic reactions that are important for protein metabolism in the epithelium. Due to its good penetration and high local concentrations, D-Panthenol is used in many topical products, such as ointments and lotions for the treatment of dermatological conditions to relieve itching or promote healing. Dermatological effects of the topical use of D-Panthenol include increased fibroblast proliferation and accelerated re-epithelialization in wound healing. Furthermore, it acts as a topical protectant, moisturizer, and has demonstrated anti-inflammatory properties. D-Panthenol is also available as a racemic mixture containing both the dextrorotatory form (dexpanthenol) and the levorotatory form (levopanthenol) as [DB11204]. While pantothenic acid is optically active, only the dextrorotatory form (dexpanthenol) is biologically active.
Pantothenol is a monocarboxylic acid amide that is 3,3-dimethylbutanamide substituted by hydroxy groups at positions 2 and 4 and a 3-hydroxypropyl group at the carbomyl nitrogen. It has a role as a cholinergic drug and a provitamin. It is amino alcohol and a monocarboxylic acid amide.
D-panthenol is an alcoholic analogue of D-pantothenic acid and cholinergic agent. D-panthenol acts as a precursor of coenzyme A necessary for acetylation reactions and is involved in the synthesis of acetylcholine. Although the exact mechanism of the actions of d-panthenol is unclear, it may enhance the effect of acetylcholine. D-panthenol acts on the gastrointestinal tract and increases lower intestinal motility. It is also applied topically to the skin to relieve itching and to promote healing.
D-Panthenol acts as a moisturizer by drawing water from deeper layers of the skin into the upper layers of the skin. It helps with softness and elasticity and is anti-inflammatory. It stimulates skin regeneration and boosts healing.
In hair care it is a small enough molecule to penetrate the hair and moisturize it, helping increase elasticity/reduce breakage. It makes hair softer and shinier and reduces static.
D-Panthenol is a B vitamin precursor (pro-vitamin B5) and substantially involved in regenerative metabolic processes of the skin. Because of its high compatibility, it is often used for baby care products, also in healing diaper creams. It has a moisture-binding, anti-inflammatory, regenerative and healing effect. Panthenol also strengthens the barrier function of the skin and improves its elasticity, promoting new cell formation in wounds. This is why it is also be used in cases of injuries or sunburn. Since the blood flow is reduced, skin redness subsides quickly and itching is reduced. Also, surfactant-or sun-damaged skin can recover quickly with the help of panthenol.
In hair care products, Panthenol moisturizes and smoothes. It can penetrate into the hair shaft and retain moisture there, or be included as a provitamin over the scalp in the hair roots. When used in nail care it promotes flexibility and has a water-binding effect.
D-Panthenol (pantothenol) is an alcohol form of the B5 vitamin pantothenic acid. It easily penetrates the skin retaining water and is a humectant, emollient and moisturizer. D-Panthenol mitigates signs of inflammation and stimulates epithelization. Panthenol comes in two enantiomers, D and L. Only D-panthenol (dexpanthenol) is biologically active, however, both forms have moisturizing properties. Because of the ability to attract and hold moisture panthenol is used in skincare products as a humectant. It also has a role as a provitamin (called pro-vitamin B5) and is used as a vitamin supplement in complex and alone, and as a cholinergic drug. D-Panthenol is a highly viscous transparent liquid at room temperature, but salts of pantothenic acid (sodium pantothenate) are powders (typically white). It is soluble in water, alcohol, propylene glycol, ether and chloroform, and slightly soluble in glycerin. Panthenol mixes readily with many different types of ingredients, making it a versatile ingredient to be used in formulas because it improves skin’s barrier function and maintains the proliferation of fibroblasts. In organisms, it is quickly oxidized to pantothenate (pantothenic acid). The deficiency of Vitamin B5 results in much dermatological disorder. Due to the fact that only D-Panthenol is converted to Vitamin B5 and not L-Panthenol, the racemic mixture of D- and L- panthenol (DL-panthenol) has only half of the physiological activity of the D-Panthenol. These include stimulation of epithelisation, wound healing effect and anti-inflammatory effect.
D-Panthenol is a different name for provitamin B5 which, after being absorbed by the skin, transforms into vitamin B5. It is indispensable in the functioning of our skin and its deficiency results in excessive exfoliation of the epidermis, cornification and depigmentation.
Penetrating the skin deeply, improves its moistening, makes it more elastic and firm. It alleviates all irritations and inflammatory conditions, what is more, it also accelerates the regeneration of the epidermis and the healing of injuries. Owing to a high chemical affinity to keratin, it is one of the best preparations for enhancing hair condition.
Use:
body creams and emulsions with moistening, regenerative and anti-ageing properties,
hair preparations: shampoos, conditioners, including highly regenerative ones.
D-panthenol alcohol. Acts as a moisturizing, healing and anti-inflammatory active. It is the provitamin of D-Pantothenic acid(Vitamin B5), which plays a key role in the human intermediary metabolism. It is hygroscopic in nature. It stimulates epithelization and prevents hair damage. It thickens hair & improves lustre and sheen. Increases hydration and imparts flexibility to nails. Used in skincare, hair care and nail care products.
D-Panthenol is an active ingredient for sophisticated cosmetic skincare and hair care products. It improves the appearance of skin, hair and nails. D-Panthenol Care is the provitamin of D-Pantothenic acid (Vitamin B5). D-Pantothenic acid plays a key role in the human intermediary metabolism. It is a part of the Coenzyme A. Deficiency of Vitamin B5 results in much dermatological disorder.
Coenzyme A is important for:
* structure and function of living tissue
* resistance of the mucous membrane
* growth and pigmentation of hair
Role in the skin:
* deep penetrating moisturizer
* stimulates epithelisation
* has wound-healing effect
* has an anti-inflammatory effect
Role in the hair:
* long-lasting moisturizer
* prevents hair damage
* thickens hair
* improves lustre and sheen
Role in nail care:
* improves hydration
* imparts flexibility
D-Panthenol is also applied in the pharmaceutical industry. The main areas of pharmaceutical application are syrups, drops, ampoules, creams, gels and capsules. In liquid multi-vitamin and Vitamin B complex preparations D-Panthenol is nearly always preferred to the D-Pantothenates because it is usually considerably more stable at the pH values below 5 usually employed in these preparations.
Lastly, it is also used in oral care for its soothing properties.
The gold standard moisturizer for skin and hair care. D-Panthenol (pro-vitamin B5) is a viscous liquid. D-Panthenol (or D-Panthenol 75L) is the form best suited for biological or physiological activity such as wound healing and soothing, stimulation of epithelization, etc. Beneficial for very dry, cracked, and rough skin. For detailed regulatory or quality information, please contact the supplier.
Cosmetic Ingredient Functions
* Anti-Ageing Agent
* Anti-Inflammatory Agent
* Conditioner
* Hair Straightening Agent
* Healing Agent
* Humectant
* Hydrophilic Agent
* Moisturizing Agent
* Protective Agent
* Skin Barrier Protectants
* Smoothing Agent
* Soothing Agent
Benefit Claims
* Anti-Ageing
* Anti-Inflammatory
* Conditioning
* Hair Straightening
* Healing
* Humectant
* Moisturizing
* Skin Protection
* Smoothing
* Soothing
Product Highlights
Increases stratum corneum hydration by inducing long-lasting skin moisturization
Maintains a healthy skin: the right balance between the stem cell renewal and the cell differentiation
Key Attributes
* Regenerates healthy skin maintaining cell stemness
* Improvement symptoms of sensitive skin:
* dryness, roughness, redness, pruritus
* Accelerates wound healing
* Moisturizes hair strengthens damaged hair and reduces split ends
* Reinforces the nails
* Improves hydration and maintain skin softness and elasticity
D-Panthenol, also called pro-vitamin B5, is naturally presented in skin and hair. It is part of the coenzyme A, necessary for the structure and regeneration of epithelial lipids and of the mucous.
Topical D-panthenol acts like a moisturizer, improving stratum corneum hydration, reducing transepidermal water loss and maintaining skin softness and elasticity. Moreover, it activates fibroblast proliferation and accelerates re-epithelization in wound healing. This substance has been also shown to have an anti-inflammatory effect on experimental ultraviolet-induced erythema. Beneficial effects of D-panthenol have been particularly observed in patients who have undergone scar treatment, or therapy for burn injuries and different dermatoses. It is a calming agent.
D-Panthenol is essential for the normal function of epithelial tissues. Dexpanthenol, applied to the skin and hair, quickly is converted into its bioactive form vitamin B5 accelerating cell regeneration. It helps to repair
General description
D-Panthenol is an alcohol analogue of pantothenic acid and an important component of parenteral, local cosmetic preparations and multi-vitamins. It has as much biological activity as pantothenic acid and is found to be stable in an aqueous solution.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Application
D-Panthenol may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using high-performance liquid chromatography technique.
D-panthenol is an extremely well-tolerated natural active substance. It is a derivative of pantothenic acid, also known as vitamin B5, and is appreciated for its wound repair promoting properties. Thus d-panthenol has long been used as a reliable active substance in the treatment of external skin lesions. Used in a nasal spray dexpanthenol accelerates the healing of the irritated nasal mucosa and is, therefore, a valued substance, as rhinitis always poses a test of endurance for the sensitive nasal mucosa.
The nose performs a variety of functions - it cleans the air we breathe in, moistens or warms it, and enables us to smell. The nasal cavity is lined with the nasal mucosa, which performs an important immune function and, when fully intact, keeps germs in our airways at bay.
Particularly during the colder months, the nasal mucosa can perform its defence function only to a limited degree when it is dried out due to heating and low temperatures and has a reduced blood supply. Then viruses can easily penetrate the nasal mucosa and multiply here. In an attempt to remove the pathogens, the body reacts by boosting the blood supply to the nasal mucosa and producing more mucus. The nasal mucosa is irritated and swollen, and the nose feels blocked, sore and dry.
This is where d-panthenol comes into play. It is a real "provitamin" that supports the normal epithelial function.
It accelerates wound healing, reduces dryness of the nasal mucosa, and diminishes the emergence of annoying scabs.
In sum, d-panthenol accelerates the healing of the irritated nasal mucosa. Rhinitis is therefore soon forgotten and the nasal mucosa is able to resume its function as a natural protective barrier more quickly.
D-panthenol is also a well-suited and valuable active substance for children. This is a huge advantage considering children's rhinitis, as children suffer from rhinitis more often than adults and perceive a sore and painful nose as more intense.
Applications: D-Panthenol is applied in almost all kinds of cosmetic preparations. It cares for hair, skin and nails. The trend in modern cosmetics is formulations containing ingredients that provide therapeutic effectiveness. The effect of locally applied Panthenol has been confirmed in many studies. D-Panthenol is a biologically stable, active form of Pantothenic acid, Vitamin B5. It is the provitamin of D-Pantothenic acid, which plays a key role in human intermediate metabolism. Vitamin B5 deficiency can result in dermatological diseases. Panthenol solutions are easier to process than pure Panthenols due to their lower viscosity. Its role in the skin; Deep penetrating moisturizer, stimulates epithelization, wound healing and anti-inflammatory effect. Its role in hair; It is a long-lasting moisturizer, protects hair from damage, thickens it, and improves its dullness and shine. Role in nail care; It regulates hydration (water retention) and gives flexibility. Application areas of ND-Panthenol in drugs; syrups, pills, ampoules, creams, gels and capsules. D-Panthenol is preferred over D-pantothenates in liquid multivitamin and Vitamin B complex preparations because D-Panthenol is remarkably more stable below pH 5. Locally applied Panthenol is absorbed by the skin and turns into pathothenic acid. A cream containing panthenol prevents the skin rash caused by U.V rays. A cream containing 5% Panthenol has been found to heal wounds on the skin up to 30%. A cream containing Panthenol applied regularly to the skin improves the moisture content of dry skin. High water content protects hair from damage caused by combing, brushing, drying and perm.
D-panthenol belongs to a derivative of pantothenic acid (vitamin B5). It can penetrate the skin and mucous membrane to be quickly oxidized to pantothenic acid. The latter one is extremely hygroscopic and binds water effectively. Therefore, D-panthenol can be used as a moisturizer. It is added to pharmaceutical and cosmetic products to relieve itching and improve wound healing. In ointments, it can be used for the treatment of sunburns, mild burns, minor skin injuries and disorders. It is also immediately applied after major abdominal surgery to minimize the possibility of paralytic ileus. In addition, it can also be supplemented into commercial shampoos and hair conditioners to lubricate the hair shaft and give the hair a shiny appearance. The exact mechanism of action of D-panthenol is still unclear, perhaps through its enhancing effect on acetylcholine.
