D-PANTHENOL

D-Panthenol is also called pantothenol.
D-Panthenol is the alcohol analogue of pantothenic acid.
D-Panthenol is a provitamin B5.
D-Panthenol is rapidly oxidized to pantothenic acid in organisms.

CAS Number: 81-13-0
EC Number: 201-327-3
IUPAC Name: 2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide[1]
Chemical Formula: C9H19NO4

Other names: DL-Panthenol, panthenol, 16485-10-2, 2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide, DL-Pantothenol, DL-Pantothenyl alcohol, Panthenolum, Panthenol, racemic, Pantenol, Pantenolo, Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, 62507-76-0, Alcool DL-pantotenilico, Pantenol [INN-Spanish], Panthenolum [INN-Latin], UNII-WV9CM0O67Z, EINECS 240-540-6, WV9CM0O67Z, MFCD00002944, 2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide, NSC-759899, DTXSID3044598, PANTHENOL, DL-, DTXCID1024598, (+-)-Pantothenyl alcohol, EC 240-540-6, DL-Pantothenol;DL-Pantothenyl alcohol, NSC 759899, Panthenol [USAN:USP:INN:BAN], Pantenol (INN-Spanish), Butyramide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, DL-, Panthenolum (INN-Latin), PANTHENOL (MART.), PANTHENOL [MART.], Pantenolo [DCIT], Panthenol, DL-form, PANTHENOL (USP MONOGRAPH), PANTHENOL [USP MONOGRAPH], PANTHENOL, RACEMIC (USP-RS), PANTHENOL, RACEMIC [USP-RS], pantothenylol alcohol, component of Zentinic, Panthenol (USAN:USP:INN:BAN), Dexpanthenol [USAN), SMR000857333, Alcool DL-pantotenilico [Italian], SR-05000001760, Purple Toner, d,l- panthenol, NCGC00186658-01, ELF Perm, Roota Re F Tonic, Roota Re V Tonic, AAPE Hair Ampoule, Roota Re F for men, BREXTEM H, Roota Re V for women, 2,3-dimethylbutyramide, DL-Panthenol, 99%, Panthenol (USP/INN), PANTHENOL [INN], PANTHENOL [USAN], (+-)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide, PANTHENOL [VANDF], Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (+)- (9CI), DL-PANTHENOL [FCC], PANTHENOL [WHO-DD], NGF 574H HAIR, SCHEMBL15567, DL-PANTHENOL [VANDF], MLS001336015, MLS001336016, SHINMO SAENGBALEUM HAIR, NGF 574H HAIR TONIC, (R)-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide, CHEMBL1371937, D-(+)-2,3-dimethylbutyramide, HMS2093B14, HMS2234M16, HMS3371M11, Pharmakon1600-01505420, Pharmakon1600-01505656, SHINMO SAENGBALEUM TREATMENT, (+/-)-PANTOTHENYL ALCOHOL, HY-B1024, Tox21_302660, Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (+-), NSC759127, NSC759899, s4566, STL453540, AKOS015841508, Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (+-), CCG-213502, CS-4541, NSC-759127, SB44496, ReOrganic Eyelash Growth Boosting Serum, NCGC00256864-01, AS-56363, DA-09547, SBI-0206818.P001, CAS-16485-10-2, DB-056494, ZHANGGUANG 101 HAIR FOLLICLE TONIC, NS00000985, P1318, D03726, H11256, AB00918367_05, Q196473, Q-201031, SR-05000001760-1, SR-05000001760-3, 3-(2,4-Dihydroxy-3,3-dimethylbutyramido)-1-propanol, BRD-A59413292-001-04-1, BRD-A59413292-001-08-2, Butanamide, 4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (+/-)-2,4-Dihydroxy-3,3-dimethylbutyric 3-hydroxypropylamide, D-2,4-Dihydroxy-3,3-dimethyl-N-(3-hydroxypropyl)butyramide, (+/-)-2,4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethylbutyramide, Butanamide, 4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (R)-, Butyramide, 4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, D-(+)-, Panthenol, racemic, United States Pharmacopeia (USP) Reference Standard, (+/-)-alpha,gamma-Dihydroxy-N-(3-hydroxypropyl)-beta,beta-dimethylbutyramide, BUTYRAMIDE, .ALPHA.,.GAMMA.-DIHYDROXY-N-(3-HYDROXYPROPYL)-.BETA.,.BETA.-DIMETHYL-, BUTYRAMIDE, 2,4-DIHYDROXY-N-(3-HYDROXYPROPYL)-3,3-DIMETHYL-

D-Panthenol is a viscous transparent liquid at room temperature.
D-Panthenol is used in pharmaceutical and cosmetic products as a humectant and to improve wound healing.
D-Panthenol is used in pharmaceuticals, cosmetics and personal care products.

D-Panthenol is also a moisturizing ingredient used in eye drops, lozenges, and cleaning solutions for contact lenses.
D-Panthenol is used in ointments to treat sunburns and ailments.
D-Panthenol Increases hydration.

D-Panthenol reduces skin itching and inflammation.
D-Panthenol increases skin elasticity.
D-Panthenol also accelerates the healing rate of epidermal wounds.
D-Panthenol is sometimes combined with allantoin for this purpose.

D-Panthenol easily binds to the hair strand.
Hence, it is a common ingredient of shampoos and conditioners.
D-Panthenol covers the hair and its surface.
D-Panthenol lubricates the hair shaft and gives it a shiny appearance.
D-Panthenol is also recommended by tattoo artists as a post-tattoo moisturizing cream.

Panthenol is generally well tolerated.
D-Panthenol has been reported in rare cases of skin irritation and contact allergies.
Panthenol easily penetrates the skin and mucous membranes.

D-Panthenol is oxidized to pantothenic acid.
Pantothenic acid is extremely hygroscopic.
D-Panthenol is also used in the biosynthesis of coenzyme A, which plays a role in a wide variety of enzymatic reactions and cell growth.

Appearance: Highly viscous, colourless liquid
Density: 1.2 g mL−1 (at 20 °C)
Melting point: 66 to 69 °C
Boiling point: 118 to 120 °C at 2.7 Pa

log P: −0.989
Acidity (pKa): 13.033
Basicity (pKb): 0.964
Molecular Weight: 205.25 g/mol

XLogP3-AA: -0.9
Hydrogen Bond Donor Count: 4
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 6

Exact Mass: 205.13140809 g/mol
Monoisotopic Mass: 205.13140809 g/mol
Topological Polar Surface Area: 89.8Ų

Heavy Atom Count: 14
Complexity: 182
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

D-Panthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium.
D-Panthenol exists as a racemic mixture containing both the dextrorotatory form (dexpanthenol) and the levorotatory form (levopanthenol).

While pantothenic acid is optically active, only the dextrorotatory form ([DB09357]) is biologically active.
D-Panthenol, the active form of panthenol, is enzymatically cleaved to form pantothenic acid (Vitamin B5), which is an essential component of Coenzyme A that acts as a cofactor in many enzymatic reactions that are important for protein metabolism in the epithelium.

Due to its good penetration and high local concentrations, dexpanthanol is used in many topical products, such as ointments and lotions for treatment of dermatological conditions to relieve itching or promote healing.
Dermatological effects of the topical use of dexpanthenol include increased fibroblast proliferation and accelerated re-epithelialization in wound healing.
Furthermore, it acts as a topical protectant, moisturizer, and has demonstrated anti-inflammatory properties.

D-Panthenol is a transparent and colorless liquid at room temperature.
However, pantothenic acid salts are typically white powders.
D-Panthenol is odorless.
D-Panthenol is easily soluble in water and alcohol.
D-Panthenol is moderately soluble in diethyl ether.
D-Panthenol is soluble in chloroform, propylene glycol and slightly soluble in glycerin.
The expanded chemical formula of D-Panthenol is HO–CH2 –C (CH3) 2 –CH (OH)–CONH– CH2CH2CH2 –OH.

Panthenol comes in two enantiomers.
These are D and L.
Only D -panthenol (dexpanthenol) is biologically active.
However, both forms have moisturizing properties.
For cosmetic use, panthenol comes either in the D form or as a racemic mixture of D and L (DL-panthenol).

D-Panthenol (Dexpanthenol) is a versatile and extremely useful compound known for its numerous applications in the cosmetic and pharmaceutical industries.
D-Panthenol, the alcohol analog and biological precursor of D-pantothenic acid, offers a wide range of benefits.
D-Panthenol plays an important role in improving the condition of the skin and hair.

D-Panthenol reduces dryness by providing deep moisture to the skin and hair.
D-Panthenol improves the general condition of the body.
This compound contributes to a youthful appearance by increasing the elasticity and smoothness of the skin.
D-Panthenol helps wound healing and scar prevention by promoting skin cell regeneration.
As a humectant, D-Panthenol attracts and retains moisture.
D-Panthenol provides long-term moisturizing to the skin and hair.

D-Panthenol increases the strength and flexibility of hair.
D-Panthenol helps prevent hair breakage and split ends.
D-Panthenol improves the general condition of the hair.
D-Panthenol acts as a protective barrier, protecting skin and hair from environmental pollutants and harmful UV radiation.

D-Panthenol effectively relieves skin irritation and reduces redness and inflammation with its soothing properties.
D-Panthenol is an important ingredient in creams, lotions, serums, moisturizers, shampoos, conditioners, hair masks and styling products.
These products take advantage of the numerous benefits that D-Panthenol provides for hair and skin.

Adding D-Panthenol to pharmaceutical formulations such as ointments and creams aids wound healing.
D-Panthenol relieves skin irritations and prevents dryness.
D-Panthenol is applied in sun care products to provide additional protection against harmful UV rays.
D-Panthenol offers gentle and moisturizing properties for sensitive baby skin.
D-Panthenol is included in toothpaste and mouthwash.

Panthenol is an organic compound with the chemical formula C9H19NO4.
The molar mass of this compound is 205.25 g/mol.
D-Panthenol appears as a highly viscous, colorless liquid.
The density of this liquid is 1.2 g/cm3.
The melting point of this compound can vary between 66-69 degrees Celsius.

The boiling point can range from 118 to 120 degrees Celsius.
D-Panthenol is the alcohol analogue of pantothenic acid.
Therefore, we can say that it is the provitamin B5.
In some organisms, panthenol undergoes rapid oxidation to form pantothenic acid.
The main uses of this compound are in the manufacture of pharmaceutical and cosmetic products as a moisturizer and to improve wound healing.

Considering the use of this compound in the pharmaceutical industry, cosmetics production, and other personal care products, it is important as a humectant and humectant.
D-Panthenol is used in ointments, lotions, shampoos, nasal sprays, eye drops, lozenges, and contact lens cleaning solutions.

We can use ointments containing panthenol to treat sunburns, minor burns, minor skin injuries and disorders.
Moreover, it can improve moisture and reduce skin itching and inflammation.
When used as an ingredient in shampoos, panthenol can easily bind to the hair strand.
D-Panthenol can coat the hair and cover the surface of the hair, giving it a shiny appearance.

Typically, panthenol molecules can easily penetrate the skin and mucous membranes, including the intestinal mucosa.
D-Panthenol is rapidly oxidized to pantothenic acid.
Pantothenic acid is extremely hygroscopic.
D-Panthenol is also useful in the biosynthesis of coenzyme A, which tends to play a role in a wide variety of reactions involving enzymes in cell growth.

D-Panthenol serves as a precursor to coenzyme A, which is necessary for acetylation reactions.
D-Panthenol plays a role in acetylcholine synthesis.
Although the exact mechanism of D-Panthenol's effects is unclear, it may enhance the effect of acetylcholine.
D-Panthenol acts on the gastrointestinal system and increases lower intestinal motility.
D-Panthenol is also applied topically to the skin to relieve itching and speed healing.

D-Panthenol is suitable for all skin types.
D-Panthenol is especially beneficial for those with dry or sensitive skin.
D-Panthenol can help restore the skin's natural moisture balance, lock in moisture and protect it from environmental pollutants.
D-Panthenol is also an effective skin soothing agent for atopy-prone skin and irritated and sunburned skin.

Hand and nail creams make nails strong, hard, smooth, shiny and unbreakable.
D-Panthenol supports the treatment and regeneration of the skin after minor dermatological procedures.
It is also used in dermatitis, lip herpes, blistering, skin blistering diseases with epidermis defects.
Eye and contact lens drops moisturize the eyes.
For example, it protects against discomfort such as dryness, fatigue and irritation that may occur when looking at a computer screen for a long time.