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D-Panthenol, also known as provitamin B5, is a biologically active alcohol analog of pantothenic acid (vitamin B5).
This highly versatile, water-soluble compound is widely used in personal care, pharmaceutical, and cosmetic formulations for its moisturizing, soothing, and healing properties.
D-Panthenol is renowned for its ability to improve skin hydration, promote wound healing, and enhance hair strength and shine.
CAS Number: 81-13-0
EC Number: 201-327-3
Molecular Formula: C₉H₁₉NO₄
Molecular Weight: 205.25 g/mol
Synonyms: D-Panthenol, Dexpanthenol, Provitamin B5, D-Pantothenyl Alcohol, Pantothenol, Panthenyl Alcohol, Alcohol Analog of Pantothenic Acid, Vitamin B5 Precursor, Dexpanthenol Solution
APPLICATIONS
D-Panthenol is widely used in skincare products such as moisturizers, serums, and creams to enhance hydration and improve skin barrier function.
D-Panthenol is included in facial cleansers and toners for its soothing and conditioning properties.
D-Panthenol is employed in anti-aging formulations to improve skin elasticity and reduce the appearance of fine lines.
D-Panthenol is utilized in wound healing creams and ointments for its tissue repair and regenerative effects.
D-Panthenol is applied in sun care products and after-sun lotions to soothe and restore sun-exposed skin.
D-Panthenol is found in lip balms and glosses to prevent dryness and improve lip texture.
D-Panthenol is used in hair care products such as shampoos, conditioners, and leave-in treatments to strengthen hair, reduce breakage, and enhance shine.
D-Panthenol is incorporated in hair masks and scalp treatments to moisturize the scalp and improve hair elasticity.
D-Panthenol is included in baby care products like creams, lotions, and shampoos for its gentle, non-irritating properties.
D-Panthenol is utilized in hand creams and foot balms to reduce dryness and enhance skin softness.
D-Panthenol is found in deodorants and shaving products to prevent irritation and soothe sensitive skin.
D-Panthenol is used in eye care formulations such as eye gels and creams to reduce puffiness and hydrate delicate skin.
D-Panthenol is included in personal hygiene products like body washes, intimate care products, and lotions to improve skin comfort.
D-Panthenol is used in pharmaceutical formulations, including nasal sprays, cough syrups, and wound dressings for its healing and moisturizing effects.
D-Panthenol is applied in veterinary products for topical skin and coat treatments.
D-Panthenol is widely used in the cosmetic and personal care industry as a moisturizing agent in lotions, creams, and shampoos, where it helps to hydrate and improve the skin's softness and elasticity.
D-Panthenol is employed in hair care products, such as conditioners and serums, where it strengthens hair, reduces split ends, and adds shine by penetrating the hair shaft and improving moisture retention.
D-Panthenol is used in the formulation of wound healing products, such as ointments and gels, where it promotes faster healing and reduces inflammation by improving skin regeneration and hydration.
D-Panthenol is used in sunscreens and after-sun care products, where it helps soothe and repair the skin after sun exposure, reducing redness and irritation while maintaining moisture balance.
D-Panthenol is applied in the formulation of baby care products, including baby lotions and diaper creams, where it helps to prevent and heal diaper rash and keeps the skin moisturized.
D-Panthenol is used in shaving creams and gels, where it helps to soothe and hydrate the skin, reducing irritation and providing a smooth shaving experience.
D-Panthenol is used in oral care products, such as toothpaste and mouthwash, where it helps improve the overall health of gums and prevents irritation in the mouth.
D-Panthenol is employed in facial skincare products like anti-aging creams, where it promotes skin regeneration, reducing the appearance of fine lines and wrinkles by improving skin elasticity and hydration.
D-Panthenol is used in hand creams and foot creams, where it helps to prevent dryness and cracking, keeping the skin soft and hydrated.
D-Panthenol is employed in deodorants and antiperspirants, where it helps to soothe the skin and reduce irritation caused by shaving or environmental stressors.
D-Panthenol is used in hair styling products such as gels, mousses, and hair sprays, where it improves hair texture and adds moisture, giving hair a healthy, shiny appearance.
D-Panthenol is applied in acne treatments, where it helps to heal the skin, reduce inflammation, and prevent dryness or irritation caused by acne medications.
D-Panthenol is used in lip care products, such as lip balms, where it helps to keep lips hydrated, smooth, and prevent chapping.
D-Panthenol is used in the formulation of bath oils and bubble baths, where it helps to keep the skin moisturized and prevent drying out while enhancing the overall skin feel.
D-Panthenol is employed in hair color products, where it helps improve the moisture content of the hair, leaving it soft and shiny after the coloring process.
D-Panthenol is used in body lotions and creams, where it provides deep hydration and smooths rough skin, making it appear more youthful and radiant.
D-Panthenol is used in deodorizing and anti-chafing products, where it helps soothe irritated skin and reduce friction during physical activity.
D-Panthenol is applied in wound care products, particularly in gel form, where it promotes skin healing and regeneration after minor burns, cuts, or abrasions.
D-Panthenol is used in the formulation of facial masks and treatments, where it helps rejuvenate and hydrate dry or sensitive skin, providing a soothing and moisturizing effect.
D-Panthenol is employed in products for pet care, such as shampoos and conditioners, where it helps to moisturize and maintain the health of pets' fur and skin.
D-Panthenol is used in foot care products, where it helps soothe dry and cracked skin, leaving feet feeling soft and hydrated.
D-Panthenol is used in the formulation of cosmetic powders and foundations, where it helps create a smooth, even application and improves skin feel.
D-Panthenol is employed in the production of industrial skin care products, where it helps to repair and protect the skin from damage caused by harsh chemicals and environmental factors.
D-Panthenol is used in scalp treatments, where it helps soothe irritation, hydrate the scalp, and promote healthy hair growth.
D-Panthenol is used in hair repair treatments, where it strengthens and nourishes hair, improving its overall health and texture.
DESCRIPTION
D-Panthenol is a clear, colorless to slightly yellow, viscous liquid with a faint characteristic odor.
It is a stable alcohol analog of pantothenic acid and acts as a precursor to vitamin B5 upon skin contact.
D-Panthenol penetrates deeply into the skin and hair, where it is converted into pantothenic acid, offering long-term hydration and regeneration.
D-Panthenol enhances skin barrier function and reduces transepidermal water loss (TEWL), making it ideal for dry and sensitive skin types.
It improves skin elasticity and softness while reducing redness and irritation.
D-Panthenol is also known for accelerating the healing process in minor wounds and abrasions.
In hair care, D-Panthenol forms a thin protective film on the hair shaft, increasing moisture retention and providing a glossy finish.
It enhances combability and reduces hair brittleness, promoting healthier, stronger hair.
D-Panthenol is compatible with a wide range of formulation types including emulsions, aqueous gels, and serums.
D-Panthenol is biodegradable, non-toxic, and dermatologically well-tolerated, making it a safe and effective ingredient in personal care and pharmaceutical products.
It is suitable for use in both rinse-off and leave-on applications and is compliant with global cosmetic regulatory standards.
D-Panthenol, also known as pro-vitamin B5, is a water-soluble vitamin that is commonly used in skincare, hair care, and wound healing products for its moisturizing, soothing, and healing properties.
D-Panthenol is a derivative of pantothenic acid (vitamin B5), which is converted into pantothenic acid in the skin, providing a wide range of benefits such as hydration, skin regeneration, and strengthening.
D-Panthenol is a clear, colorless, and odorless liquid that is easily absorbed by the skin, making it ideal for use in products aimed at improving skin hydration and healing.
D-Panthenol is known for its ability to deeply moisturize the skin by drawing moisture from the air and binding it to the skin, which helps to maintain skin's natural moisture balance.
D-Panthenol promotes skin regeneration and healing, making it a key ingredient in many products designed for wound care, as it accelerates the healing of minor cuts, burns, and abrasions.
D-Panthenol improves hair health by penetrating the hair shaft, improving moisture retention, and preventing damage, making it a common ingredient in hair care products such as conditioners, hair masks, and serums.
D-Panthenol helps to improve the elasticity of the skin, reducing the appearance of fine lines and wrinkles and promoting a smoother, more youthful complexion.
D-Panthenol is considered non-toxic and safe for use in both cosmetic and pharmaceutical products, even for sensitive skin and delicate formulations like baby care and wound healing products.
PROPERTIES
Chemical Formula: C₉H₁₉NO₄
Molecular Weight: 205.25 g/mol
Common Name: D-Panthenol / Dexpanthenol
Appearance: Clear, colorless to pale yellow viscous liquid
Odor: Faint, characteristic odor
Solubility: Soluble in water and alcohols; insoluble in oils
pH (10% solution): Approx. 6.0–8.0
Density: Approx. 1.2 g/cm³
Boiling Point: Approx. 118°C (at 4 mmHg)
Reactivity: Stable under normal conditions
Chemical Stability: Stable across a broad pH range (4–7)
Storage Temperature: Store between 10–25°C in a dry, dark place
Shelf Life: 24–36 months in sealed packaging
FIRST AID
Inhalation:
Move affected individual to fresh air.
Seek medical attention if respiratory discomfort develops.
Skin Contact:
Wash skin with water and soap.
D-Panthenol is generally non-irritating, but consult a physician if irritation occurs.
Eye Contact:
Flush eyes with water for 15 minutes.
Seek medical attention if symptoms persist.
Ingestion:
Rinse mouth and drink water.
Seek medical attention if large amounts are ingested, though D-Panthenol is generally regarded as safe.
Note to Physicians:
Treat symptomatically.
No specific antidote is required.
HANDLING AND STORAGE
Handling:
Wear gloves and safety goggles in industrial handling settings.
Avoid direct contact with eyes and prolonged skin exposure.
Use in a well-ventilated area.
Spill and Leak Procedures:
Wipe or absorb spill with inert material (e.g., cloth, sand) and dispose of properly.
Clean area with water and detergent.
Storage:
Store D-Panthenol in a tightly closed container in a cool, dry, and dark place.
Protect from light, heat, and moisture.
Keep away from incompatible materials such as strong oxidizing agents.
Handling Cautions:
Avoid contamination during use.
Follow GMP guidelines for handling active cosmetic ingredients.
Ensure product containers are clearly labeled and securely stored.
