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CAS No.: 25637-84-7
Molecular Weight: 620.99
EC No.: 247-144-2
Beilstein No.: 1730341
A technical grade of azelaic acid which typically contains 79% azelaic acid, 19% other dibasic acids and 2% monobasic acids.
DEHYLUB 4008 MY PE Dioleate has found extensive application in the preparation of lowtemperature and polymeric type vinyl plasticizers, ester-based synthetic lubricants, and lithium complex grease.
A grade of DEHYLUB 4008 MY PE Dioleate which typically contains 85% azelaic acid, 15% other dibasic acids and 0.1% monobasic acids.
DEHYLUB 4008 MY PE Dioleate has found extensive application in the preparation of low-temperature and polymeric type vinyl plasticizers, ester-based synthetic lubricants, and lithium complex grease.
DEHYLUB 4008 MY PE Dioleate is the purest grade of azelaic acid commercially available, and was developed specifically for the preparation and modification of high molecular weight polymers.
DEHYLUB 4008 MY PE Dioleate contains approximately 89% azelaic acid, 11% other dibasic acids, and a maximum monobasic acid content of 0.05%.
The introduction of a linear odd-carbon structure of EMEROX® 1144 usually improves the polymer low-temperature impact strength, without sacrificing high temperature performance.
For example, 6,9 nylons based on EMEROX® 1144 possess excellent abrasion resistance, low water absorption, high impact resistance, and an excellent overall balance of properties.
Functional esters of DEHYLUB 4008 MY PE Dioleatecan be used as components in urethanes and as a source of soft segments in co-polyester fibers, imparting good low temperature performance and hydrolytic resistance.
Reactions of DEHYLUB 4008 MY PE Dioleate
Reactions of the carboxyl groups of DEHYLUB 4008 MY PE Dioleate are by far the most important and are typical of any aliphatic carboxylic acid.
Since DEHYLUB 4008 MY PE Dioleate is difunctional, mixed derivatives such as acid esters, acid amides, and amide esters can be prepared.
In addition, polymers can be formed by the reaction of DEHYLUB 4008 MY PE Dioleate with polyols or polyamines.
Applications of DEHYLUB 4008 MY PE Dioleate
LUBRICANTS & GREASES
Since petroleum oils fail to function efectively over extremely wide temperature ranges, such as those encountered in the operation of aircraft gas turbine engines, demand for ester-based synthetic lubricants have shown steady growth.
Synthetic basestocks made from DEHYLUB 4008 MY PE Dioleate exhibit extremely good viscosity/temperature relationships and therefore outperform petroleum oils in this area.
Among other important advantages of DEHYLUB 4008 MY PE Dioleate are low viscosity rise during oxidation, a low order of corrosive breakdown products, excellent overall lubricity, low coking characteristics, high flash points, good additive response and low peroxide values.
Compounded lubricants and greases incorporating azelate basestocks are used in military and commercial aircraft engines of the turbojet, turbofan, and turboprop varieties for stationary jet engines, for electrical and other power requirements, for aircraft and space vehicle instruments, and for other equipment and instrumentation requiring maximum lubrication performance over a broad temperature range.
DEHYLUB 4008 MY PE Dioleate is finding increasing application as a complexing agent for lithium complex grease.
Other Applications of DEHYLUB 4008 MY PE Dioleate
Among the many miscellaneous applications of DEHYLUB 4008 MY PE Dioleate are dielectric fluids, heattransfer fluids, metal to glass fluxes, emulsion breakers, fungicides, mothproofing agents, insecticides, polyurethane foams, waxes, hydraulic fluids, tobacco sheet plasticizers, special alkyd resins, hot-melt coatings and adhesives, and water soluble coating resins.
The number of additional patents issued which are related to the use of DEHYLUB 4008 MY PE Dioleate has grown from year to year.
APPLICATIONS of DEHYLUB 4008 MY PE Dioleate
Synthetic Lubricants
The linear, highly saturated and oddcarbon structure of DEHYLUB 4008 MY PE Dioleate makes DEHYLUB 4008 MY PE Dioleate particularly suitable as the major acid component in TMP (trimethylolpropane), PE (pentaerythritol) and NPG (neopentyl glycol) polyol esters.
These classic DEHYLUB 4008 MY PE Dioleate dominate jet engine lubricant technology, and are becoming more important in synthetic lubricants for industrial and land transportation applications.
Amine Condensates
Amine condensates prepared by reacting DEHYLUB 4008 MY PE Dioleate with low molecular weight amines such as monoethanolamine or isopropanolamine are characterized with good water solubility.
The water solubility characteristics of DEHYLUB 4008 MY PE Dioleate can be extended to blends made with other amine condensates.
Thus, the gellation tendencies of other low molecular weight DEHYLUB 4008 MY PE Dioleate can be reduced by partial replacement with the pelargonic acid counterpart.
Appearance: Yellow to amber liquid
Chemical Name: DEHYLUB 4008 MY PE Dioleate
CAS No.: 9005-07-6
Key Applications of DEHYLUB 4008 MY PE Dioleate
extrusion; calendared film, profile extrusion; injection molding; color concentrate; mold release
Product Description of DEHYLUB 4008 MY PE Dioleate
Derived from natural fats and oils, this is often used as internal lubricant in PVC, and can also be used as an antifogging agent, flow modifier and dispersing agent.
Computed Properties of DEHYLUB 4008 MY PE Dioleate
Molecular Weight: 604.8
XLogP3-AA: 4.8
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 10
Rotatable Bond Count: 31
Exact Mass: 604.41864811
Monoisotopic Mass: 604.41864811
Topological Polar Surface Area: 133 Ų
Heavy Atom Count: 42
Formal Charge: 0
Complexity: 632
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 2
Undefined Atom Stereocenter Count: 2
Defined Bond Stereocenter Count: 1
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Electronics of DEHYLUB 4008 MY PE Dioleate
DEHYLUB 4008 MY PE Dioleate is used as a drug solubilizer and penetration enhancer in parenteral and injectable dosage forms, specifically in veterinary products.
DEHYLUB 4008 MY PE Dioleate is also used for solvency, adhesion enhancement and solubility in paints and coatings and printing inks.
DEHYLUB 4008 MY PE Dioleate is used for solvency, adhesion enhancement and solubility in paints and coatings and printing inks.
DEHYLUB 4008 MY PE Dioleate is also used as a drug solubilizer and penetration enhancer in parenteral and injectable dosage forms, specifically in veterinary products.
Chemical & Physical Properties of DEHYLUB 4008 MY PE Dioleate
DEHYLUB 4008 MY PE Dioleate are similar in many of the physical and chemical properties to other liquid fatty acids.
Being completely saturated, however, DEHYLUB 4008 MY PE Dioleate have no double bonds as points of instability.
Solubility
DEHYLUB 4008 MY PE Dioleate is sparingly soluble in water, but readily soluble in most organic solvents.
Reactions of DEHYLUB 4008 MY PE Dioleate
The chemical reactions of DEHYLUB 4008 MY PE Dioleate at the carboxyl group involve basic fatty acid chemistry.
The lower molecular weight and odd-carbon chain length of DEHYLUB 4008 MY PE Dioleate result in compounds that have markedly diferent physical and chemical properties from those obtained from acids of higher molecular weight, such as lauric, myristic, palmitic and stearic.
The alkali metal salts of DEHYLUB 4008 MY PE Dioleate are very soluble in water, but are insoluble in most organic solvents even with an excess of fatty acid.
Detergency of the short chain length salts is quite limited.
The calcium and heavy metal salts are insoluble in water.
Comparison of DEHYLUB 4008 MY PE Dioleate
DEHYLUB 4008 MY PE Dioleate is an NPG polyol diester that provides lubricity, detergency, and additive compatibility in a wide range of applications.
DEHYLUB 4008 MY PE Dioleate is optimal in terms of oxidation, and is useful as a base oil and additive for most applications requiring high temperature stability such as compressor/gear oils, hydraulic fluids, grease formulations, as well as 2 and 4 stroke oils.
Quick Details of DEHYLUB 4008 MY PE Dioleate
ProName: Glyceryl dioleate Manufacturer/High qu...
CasNo: 25637-84-7Molecular Formula: C39H72O5
Appearance: detailed see
specifications
Application: It is an important raw material and in...
DeliveryTime: prompt
PackAge: according to the clients requirement
Transportation: by sea or by air
LimitNum: 1 Kilogram
Grade: Industrial Grade
Quick Details of DEHYLUB 4008 MY PE Dioleate
Classification: Daily Chemicals
Cas NO.: 86893-19-8
Name: ETHOXYLATED METHYL GLUCOSIDE DIOLEATE
Molecular Formula: C6H10N2Na2O6
Purity: 95%
EINECS: 617-932-4
Purity: 95%
Appearance:white crystal
Packaging & Delivery
Packaging Detail: Packaging MeG DOE-120T is packed in 25...
Delivery Detail: 15days
Detailed Description
Description of DEHYLUB 4008 MY PE Dioleate
Note: Descriptions are shown in the official language in which they were submitted.
FIELD OF THE INVENTION of DEHYLUB 4008 MY PE Dioleate
The present invention relates to drug delivery systems, and in particular to pharmaceutical compositions for the improved delivery of ionizable hydrophobic compounds and methods therefor.
BACKGROUND of DEHYLUB 4008 MY PE Dioleate
Hydrophobic therapeutic agents, i.e., therapeutic compounds having poor solubility in aqueous solution, present difficult problems in formulating such compounds for effective administration to patients.
A well-designed formulation must, at a minimum, be capable of presenting a therapeutically effective amount of the hydrophobic compound to the desired absorption site, in an absorbable form.
Even this minimal functionality is difficult to achieve when delivery of the hydrophobic therapeutic agent requires interaction with aqueous physiological environments, such as gastric fluids and intestinal fluids.
Pharmaceutical compositions for delivery of such hydrophobic therapeutic agents must carry the hydrophobic compound through the aqueous environment, while maintaining the hydrophobic compound in an absorbable form, and avoiding the use of physiologically harmful solvents or excipients.
A number of approaches to formulating hydrophobic therapeutic agents for oral or parenteral delivery are known.
Such approaches include, for example, formulations in which the hydrophobic therapeutic agent is present in an oil-in-water emulsion, a microemulsion, or a solution of micelles, liposomes, or other multi-lamellar carrier particles.
While such approaches may be appropriate for some ionizable as well as nonionizable hydrophobic therapeutic agents, they fail to take advantage of the unique acid- base chemical properties, and associated solubility properties, of ionizable compounds.
In particular, unlike non-ionizable hydrophobic therapeutic agents, ionizable hydrophobic therapeutic agents can be rendered soluble in aqueous solution if the pH of the solution is adjusted to ionize the therapeutic agent.
Such an approach is well known in the art.
The resultant drug/cyclodextrin/base complexes reportedly are readily soluble in water in high concentrations.
DEHYLUB 4008 MY PE Dioleate discloses a pharmaceutical carrier system for an acidic, basic or amphoteric pharmaceutical agent in which the pharmaceutical agent is partially ionized by an acid or base in a polyethylene glycol-based solvent system.
DEHYLUB 4008 MY PE Dioleate reportedly shows enhanced solubility in the partially ionized form.
DEHYLUB 4008 MY PE Dioleate also discloses that addition of glycerin, propylene glycol and/or polyvinylpyrrolidone further enhances the solubility of the pharmaceutical agent in the polyethylene glycol base.
However, DEHYLUB 4008 MY PE Dioleateis limited to polyethylene glycol-based solvent systems and a narrow range of ionizing agent concentration, and there is no disclosure of other solvent systems.
Thus, DEHYLUB 4008 MY PE Dioleate's utility is severely limited.
DEHYLUB 4008 MY PE Dioleate includes a pharmaceutical agent, an ionizing species, and a solvent system.
DEHYLUB 4008 MY PE Dioleate can be diethylene glycol monoethyl ether, glycerol caprylate/caprate, polyglycerol oleate, alpha-hydro-w-hydroxypoly(oxyethylene)-poly(oxypropylene)-poly(oxyethylene) block copolymers, or mixtures of those components.
DEHYLUB 4008 MY PE Dioleate can also be a mixture of polyethylene glycol and a polyoxyethylene sorbitan ester.
DEHYLUB 4008 MY PE Dioleate include water, glycerin, propylene glycol, and polyvinylpyrrolidone.
However, DEHYLUB 4008 MY PE Dioleate is limited to these particular compounds and a narrow range of ionizing agent concentration, rendering its utility severely limited.
Moreover, some of the solvent system components show poor or questionable biocompatibility, and thus would be impractical for drug delivery to a patient.
A further problem with conventional approaches to solubilizing ionizable hydrophobic therapeutic agents is the difficulty in maintaining the solubilized therapeutic agent in solubilized form.
Thus, for example, while ionizing an acidic therapeutic agent with a base may increase its solubility, the therapeutic agent is prone to precipitation in the gastrointestinal tract due to the acidic pH conditions encountered upon administration to a patient, and the approximately 10 to 100-fold dilution expected in gastrointestinal or intestinal fluids.
DEHYLUB 4008 MY PE Dioleate is particularly disadvantageous, since the precipitated therapeutic agent is essentially unavailable for absorption, leading to difficulties in controlling dosages, and a need to administer large doses of the therapeutic agent to ensure that a therapeutically effective amount reaches the absorption site in
Such difficulties necessarily result in increased costs, and compromised patient safety and therapeutic effectiveness.
Thus, there is a need for versatile and effective pharmaceutical compositions that overcome these deficiencies in the prior art.
SUMMARY OF DEHYLUB 4008 MY PE Dioleate
DEHYLUB 4008 MY PE Dioleate provides pharmaceutical compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents.
DEHYLUB 4008 MY PE Dioleate, the invention is directed to a pharmaceutical composition including an ionizable hydrophobic therapeutic agent and a carrier.
The carrier includes an ionizing agent to ionize the therapeutic agent, and a surfactant.
Optionally, the carrier also includes solubilizers, triglycerides and neutralizing agents.
In another embodiment, the invention is directed to a pharmaceutical composition including a hydrophobic therapeutic agent having at least one ionizable functional group, and a carrier.
The carrier includes an ionizing agent capable of ionizing the functional group, a surfactant, and a triglyceride.
In another embodiment, the invention is directed to a pharmaceutical composition including a hydrophobic therapeutic agent having at least one ionizable functional group and a carrier, wherein the carrier includes an ionizing agent capable of ionizing the ionizable functional group and present in a pre-reaction amount of greater than about 1.5 mole equivalents per mole of ionizable functional group, and a surfactant.
In a further aspect of this embodiment, the composition further includes a neutralizing agent capable of neutralizing a portion of the ionizing agent.
DEHYLUB 4008 MY PE Dioleate, the invention is directed to a pharmaceutical composition including a hydrophobic therapeutic agent having at least one ionizable functional group, and a carrier, wherein the carrier includes an ionizing agent capable of ionizing the ionizable functional group, a surfactant, and a solubilizer present in an amount of greater than about 10% by weight, based on the total weight of the composition.
DEHYLUB 4008 MY PE Dioleate, the surfactant includes at least one compound from the group consisting of alkylglucosides; alkylmaltosides; alkylthioglucosides; lauryl macrogolglycerides; polyoxyethylene alkyl ethers; fatty acids; lower alcohol fatty acid esters; polyoxyethylene alkylphenols; polyethylene glycol fatty acids esters; polypropylene glycol fatty acid esters; glycerol fatty acid esters; acetylated glycerol fatty acid esters; polyethylene glycol glycerol fatty acid esters; polyglyceryl fatty acid esters;
Synonyms of DEHYLUB 4008 MY PE Dioleate
Dioleoyl phosphatidylethanolamine
DOPEA
Dioleoylphosphatidylethanolamine
2462-63-7
DOPE
CHEBI:60285
1,2-dioleoyl phosphatidylethanolamine
[3-[2-aminoethoxy(hydroxy)phosphoryl]oxy-2-[(Z)-octadec-9-enoyl]oxypropyl] (Z)-octadec-9-enoate
PE 36:2
1,2-Dioleoyl-sn-Glycero-3-Phosphatidylethanolamine
4004-05-1
LipofectACE
1,2-Dioleoylphosphatidylethanolamine
DL-DOPE
Dioleoyl (glycerophospho)ethanolamine
1,2-Dioleoyl phosphatidyl ethanolamin
1,2-di-Olein 2-aminoethyl hydrogen phosphate
Epitope ID:136781
SCHEMBL3290885
COATSOME ME-8181 (DOPE)
Ethanol, 2-amino-, dihydrogen phosphate (ester), monoester with 1,2-diolein
DIOLEOYL PHOSPHATIDYL ETHANOLAMINE
L-alpha-Phosphatidylethanolamine, dioleoyl
004D051
A912198
Olein, 1,2-di-, 2-aminoethyl hydrogen phosphate
1,2-di-O-oleoyl-sn-glycero-3-phosphatidyleth
Q27127165
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, >=97.0% (TLC)
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, >=98.0% (TLC)
(Z)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dioleate
(Z)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyldioleate
L-alpha-Phosphatidylethanolamine, dioleoyl, >=99% (GC), >=98% (TLC), lyophilized powder
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, >=99.0% (10 mg phospholipid per ml CHCl3, TLC)
3-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-[(9Z)-octadec-9-enoyloxy]propyl (9Z)-octadec-9-enoate
9-Octadecenoic acid (9Z)-, 1-((((2-aminoethoxy)hydroxyphosphinyl)oxy)methyl)-1,2-etanediyl ester
