PRODUCTS

DEXPANTHENOL

Dexpanthenol is added to pharmaceutical and cosmetic products to relieve itching and improve wound healing.
In ointments, Dexpanthenol can be used for the treatment of sunburns, mild burns, minor skin injuries and disorders.
Dexpanthenol is also immediately applied after major abdominal surgery to minimize the possibility of paralytic ileus.

CAS Number: 81-13-0
EC Number: 201-327-3
MDL number: MFCD00065006
Chemical name: (D) - N - (2,4-dihydroxy)- β，β- Dimethylbutyryl)- β- Aminopropanol
Chemical formula: C9H19NO4
Molar mass: 205.254 g·mol−1

SYNONYMS:
(R)-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide, (R)-2,4-Dihydroxy-3,3-dimethylbutyric 3-hydroxypropylamide, D-Pantothenyl alcohol, Dexpanthenol, Provitamin B, Bepanthen, Bepanthene, Bepantol, D-panthenol, D-panthenol 50, D-Pantothenol, D-Pantothenyl alcohol, Dexpantenol, Dexpanthenol, Dexpanthenolum, Pantol, Pantothenyl alcohol, Provitamin B, Dexpanthenol, Provitamin B5, Pantothenyl Alcohol, among others, Butanamide,2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-,(2R)-, Butyramide,2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-,D-(+)-, Butanamide,2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-,(R)-, (2R)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide, Bepanthen, Bepanthene, Bepantol, Cozyme, Dexpanthenol, D(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide, D(+)-α,γ-Dihydroxy-N-(3-hydroxypropyl)-β,β-dimethylbutyramide, Ilopan, D-P-A Injection, Motilyn, Panadon, Panthoderm, Pantol, d-Pantothenol, d-Pantothenyl alcohol, Thenalton, Zentinic, D-Panthenol, Panthenol, Pantothenol, Pantothenyl alcohol, Propanolamine,N-pantoyl-, Panthenol,(+)-, D(+)-Pantothenyl alcohol, D(+)-Panthenol, Synapan, Provitamin B, d-Panthenol, D-Pantothenyl alcohol, Provitamin B5, d-Panthenol 50, Urupan, Alcopan 250, Pantenyl, Intrapan, (+)-Panthenol, NSC 302962, Panthenol 50W, Cornergel, Dolobene, D-Panthenol 75L, Pantogel, (R)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide, (2R)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide, 1113-70-8, 17307-32-3, 50584-68-4, Dexpanthenol, D-Panthenol, 81-13-0, Pantothenol, D-Pantothenyl alcohol, Bepanthen, Ilopan, Pantol, (+)-Panthenol, Bepanthene, Bepantol, Motilyn, Panadon, Thenalton, d-Pantothenol, Pantothenyl alcohol, Panthoderm, Cozyme, Zentinic, Provitamin B, D(+)-Panthenol, Pantenyl, Synapan, D-P-A Injection, Intrapan, Urupan, Pantothenylol, Dexpantenol, D(+)-Pantothenyl alcohol, D-Panthenol 50, Provitamin B5, (2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide, Alcopan-250, (R)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide, Dexpanthenolum, Penthenol, Propanolamine, N-pantoyl-, N-Pantoyl-propanolamine, Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (2R)-, Panthenol, (+)-, DTXSID3022906, D-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide, 1O6C93RI7Z, Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (R)-, Butyramide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, D-(+)-, DTXCID402906, CHEBI:27373, NSC302962, NSC-302962, D(+)-alpha,gamma-Dihydroxy-N-(3-hydroxypropyl)-beta,beta-dimethylbutyramide, dexpantenolo, BABYSONS, RefChem:5737, A11HA30, D03AX03, S01XA12, YOZUM WELL BEING HAIR COLOR, (+)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide, 201-327-3, 2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide, d panthenol, Dextro pantothenyl alcohol, Varitan, Panthenol (D), MFCD00065006, Panthenol (JAN), Prestwick_529, Dexpanthenol (1.20 g/mL), Ilopan (TN), D-(+)-Panthenol, N-Pantoyl-3-propanolamine, NSC 302962, D-(+)-Pantothenyl alcohol, component of Pantho-F, NCGC00142622-03, PANTHENOL [JAN], (R)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide, 2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide, (R)-, 2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide, D-(+)-, Sinecort, (2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-butanamide, d(+)-2,4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethylbutyramide, component of Zentinic, Pantothenol, D-, Alcool DL-pantotenilico, (+-)-Pantothenyl alcohol, DEXPANTHENOL [USAN], Dexpantenol [INN-Spanish], Dexpanthenolum [INN-Latin], UNII-1O6C93RI7Z, CCRIS 3947, HSDB 296, Dexpanthenol CRS, Fancol DL, CAS-81-13-0, NCGC00186658-01, Dexpanthenol [USAN:USP:INN:BAN], EINECS 201-327-3, Dexpanthenol (USP), CORNERGEL, DOLOBENE, BAY 81-2996, BRN 1724947, Panthenol, (+ )-, D-Panthenol (Standard), PANTHENOL 50W, Prestwick0_000022, Prestwick1_000022, Prestwick2_000022, Prestwick3_000022, Dexpanthenol (USP/INN), DEXPANTHENOL [MI], compnent of ilopan-Choline, DEXPANTHENOL [FCC], DEXPANTHENOL [INN], bmse000445, PANTHENOL, (R)-, DEXPANTHENOL [HSDB], EC 201-327-3, ALCOPAN 250, D-PANTHENOL [VANDF], DEXPANTHENOL [VANDF], SCHEMBL15861, BSPBio_000083, DEXPANTHENOL [MART.], (R)-2,4-Dihydroxy-3,3-dimethylbutyric 3-hydroxypropylamide, 4-04-00-01652 (Beilstein Handbook Reference), DEXPANTHENOL [USP-RS], DEXPANTHENOL [WHO-DD], SPBio_002004, BPBio1_000093, orb1308614, CHEMBL1200979, HY-B1391R, DEXPANTHENOL [ORANGE BOOK], HMS1568E05, HMS2094E09, HMS2095E05, HMS3712E05, DEXPANTHENOL [EP MONOGRAPH], (R)-2,4-Dihydroxy-N-(3-hydroxy-propyl)-3,3-dimethylbutanamide, HY-B1391, MSK28210, D-Panthenol, >=98.0% (NT), DEXPANTHENOL [USP MONOGRAPH], Tox21_111563, EBC-26197, LMFA08020198, NA 9:0, O3, s4695, SBB012405, AKOS015841507, AKOS015901947, Tox21_111563_1, CCG-213429, CS-8175, DB09357, FD34938, alpha,gamma-Dihydroxy-N-(3-hydroxypropyl)-beta,beta-dimethylbutyramide, D-(+)-, D-Panthenol 10 |Ig/mL in Acetonitrile, NCGC00142622-01, NCGC00142622-04, AS-14732, D-Panthenol 10 microg/mL in Acetonitrile, ST072186, SY066750, Dexpanthenol, tested according to Ph.Eur., SBI-0206936.P001, NS00076665, P0692, C05944, D00193, D70909, EN300-7414583, F240560, BRD-K71210479-001-05-5, Q47495755, A6CF1A81-5B98-4C28-A379-EA28FA9DD210, (R)-3-(2,4-Dihydroxy-3,3-dimethylbutyramido)-1-propanol, Dexpanthenol, European Pharmacopoeia (EP) Reference Standard, (R)-()-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide, (R)-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide, (R)-2,4-dihydroxy-3,3-dimethyl-N-(3-hydroxypropyl)-butanamide, (R)-2,4-Dihydroxy-N-(3-hydroxy-propyl)-3,3-dimethyl-butyramide, D-(+)-2,4-Dihydroxy-3,3-dimethyl-N-(3-hydroxypropyl)butyramide, D-Panthenol, >=98% (perchloric acid titration), >=98% (TLC), Dexpanthenol, United States Pharmacopeia (USP) Reference Standard, (D)-(+)-2, 4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide, Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (theta)-, D(+)-.ALPHA.,.GAMMA.-DIHYDROXY-N-(3-HYDROXYPROPYL)-.BETA.,.BETA.-DIMETHYLBUTYRAMIDE, Dexpanthenol, Pharmaceutical Secondary Standard, Certified Reference Material, D-Panthenol, (R)-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide, (R)-2,4-Dihydroxy-3,3-dimethylbutyric 3-hydroxypropylamide, D-Pantothenyl alcohol, Dexpanthenol, Provitamin B, D-PANTHENOL, Provitamin B5, D-PANTOTHENYL ALCOHOL, (R)-2,4-DIHYDROXY-N-(3-HYDROXYPROPYL)-3,3-DIMETHYLBUTANAMIDE, (R)-2,4-DIHYDROXY-N-(3-HYDROXYPROPYL)-3,3-DIMETHYLBUTYRAMIDE, D-PANTOTHENOL, Bepanthen, penthenol, D-Pantenol, (2R)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide

Dexpanthenol is a derivative of pantothenic acid (also known as vitamin B5).
Thanks to its ability to easily penetrate the skin, dexpanthenol has long been used in the cosmetic industry in creams, ointments, lotions and haircare products.
While one of its most well-known uses is in nappy creams, Dexpanthenol’s also commonly added to various other skincare products due to its ability to help the natural recovery of skin.

Dexpanthenol is a clear colorless to slightly yellow viscous liquid
Dexpanthenol is a monocarboxylic acid amide that is 3,3-dimethylbutanamide substituted by hydroxy groups at positions 2 and 4 and a 3-hydroxypropyl group at the carbomyl nitrogen.
Dexpanthenol has a role as a cholinergic drug and a provitamin.

Dexpanthenol is an amino alcohol and a monocarboxylic acid amide.
Dexpanthenol is an alcohol analog of pantothenic acid and an important component of parenterals, local cosmetic preparations and multi-vitamins.
Dexpanthenol has as much biological activity as pantothenic acid and is found to be stable in aqueous solution.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Dexpanthenol, also called Panthenol or Provitamin B5, is a biologically active precursor of pantothenic acid, an essential component of coenzyme A, which is crucial for cellular metabolism, fatty acid synthesis, and energy production.

Moreover, Dexpanthenol is a skin-regenerating and hydrating ingredient.
Dexpanthenol is a monocarboxylic acid amide that is 3,3-dimethylbutanamide substituted by hydroxy groups at positions 2 and 4 and a 3-hydroxypropyl group at the carbomyl nitrogen.
Dexpanthenol has a role as a cholinergic drug and a provitamin.

Dexpanthenol is an amino alcohol and a monocarboxylic acid amide.
Dexpanthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium.
Dexpanthenol is enzymatically cleaved to form pantothenic acid, which is an essential component of Coenzyme A, which acts as a cofactor in many enzymatic reactions that are important for protein metabolism in the epithelium.

Dexpanthenol is an alcoholic analogue of D-pantothenic acid and cholinergic agent.
Dexpanthenol acts as a precursor of coenzyme A necessary for acetylation reactions and is involved in the synthesis of acetylcholine.
Although the exact mechanism of the actions of dexpanthenol is unclear, it may enhance the effect of acetylcholine.

Dexpanthenol acts on the gastrointestinal tract and increases lower intestinal motility.
Dexpanthenol is also applied topically to the skin to relieve itching and to promote healing.
Dexpanthenol is a versatile skincare ingredient, acting as a Provitamin B5 (a provitamin that transforms into Vitamin B5) when applied to your skin.

Dexpanthenol belongs to a derivative of pantothenic acid (vitamin B5).
Dexpanthenol, commonly known under trade names such as Bepanthen, Panthenol, and D-Panthenol, is a pharmaceutical compound widely recognized for its therapeutic properties.
Dexpanthenol is a derivative of pantothenic acid (vitamin B5) and plays an essential role in various biological functions.

One of the most notable features of Dexpanthenol is its broad spectrum of indications.
It is crucial for individuals with known hypersensitivity to Dexpanthenol or any of its components to avoid its use.
Dexpanthenol may interact with other medications, although such interactions are relatively uncommon.

Nevertheless, Dexpanthenol is essential to consider potential drug interactions, especially when using systemic formulations.
For instance, concurrent use of Dexpanthenol with other vitamin supplements, particularly those containing vitamin B5, could potentially lead to hypervitaminosis.
Additionally, drugs that affect gastrointestinal motility or absorption may influence the efficacy of orally administered Dexpanthenol.

As with any medication, it is advisable to consult a healthcare professional before combining Dexpanthenol with other treatments to ensure safety and efficacy.
In conclusion, Dexpanthenol is a versatile and effective therapeutic agent with a wide range of applications.
Its ability to promote tissue regeneration and reduce inflammation makes Dexpanthenol a valuable tool in various medical and cosmetic formulations.

Understanding Dexpanthenol's mechanism of action, proper usage, potential side effects, and interactions with other drugs is essential for maximizing its benefits while minimizing risks.
As research continues to uncover new therapeutic potentials for Dexpanthenol, its role in healthcare is likely to expand, offering hope for improved treatment options across multiple medical fields

USES and APPLICATIONS of DEXPANTHENOL:
Dexpanthenol may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques as well as partial least-squares multivariate calibration.
Dexpanthenol is an analogue of pantothenic acid (P190300), a member of the B complex vitamins.
Dexpanthenol is the biologically active enantiomer of Panthenol.

Uses of Dexpanthenol: cholinergic
Uses of Dexpanthenol: immunosuppressant, mitoxantrone analogue less toxic on cardiac tissue antineoplastic
Due to its good penetration and high local concentrations, Dexpanthenol is used in many topical products, such as ointments and lotions for treatment of dermatological conditions to relieve itching or promote healing.

Dermatological effects of the topical use of dexpanthenol include increased fibroblast proliferation and accelerated re-epithelialization in wound healing.
Furthermore, Dexpanthenol acts as a topical protectant, moisturizer, and has demonstrated anti-inflammatory properties.
Dexpanthenol is also available as a racemic mixture containing both the dextrorotatory form (dexpanthenol) and the levorotatory form (levopanthenol) as .

While pantothenic acid is optically active, only the dextrorotatory form (dexpanthenol) is biologically active.
Dexpanthenol is primarily used in dermatology and cosmetology, but its applications extend to other medical fields as well.
If you’ve ever wondered what is Dexpanthenol and what is Dexpanthenol used for, in terms of skincare it’s known for its effectiveness in reducing the symptoms of dry, rough, scaly, or itchy skin.

Dexpanthenol helps to ensure that your skin remains well-hydrated, healthy, and radiant.
So when you're on the lookout for skincare products that can nurture your skin, make sure to look for Dexpanthenol or D Panthenol on the ingredients list so you can really enjoy the Vitamin B5 benefits for skin.

Dexpanthenol can penetrate the skin and mucous membrane to be quickly oxidized to pantothenic acid.
The latter is extremely hygroscopic and binds water effectively.
Therefore, Dexpanthenol can be used as a moisturizer.
Dexpanthenol is added to pharmaceutical and cosmetic products to relieve itching and improve wound healing.

In ointments, Dexpanthenol can be used for the treatment of sunburns, mild burns, minor skin injuries and disorders.
Dexpanthenol is also immediately applied after major abdominal surgery to minimize the possibility of paralytic ileus.
In addition, Dexpanthenol can also be supplemented into the commercial shampoos and hair conditioners to lubricate the hair shaft and give the hair a shiny appearance.

The exact mechanism of action of Dexpanthenol is still unclear, perhaps through its enhancing effect on acetylcholine.
Dexpanthenol is frequently employed to treat and prevent skin conditions such as dermatitis, eczema, and minor burns.
In addition, Dexpanthenol's use in wound healing, particularly postoperative wound care, has garnered significant attention.

Research institutions around the globe have been actively exploring the potential of Dexpanthenol in various medical fields.
Ongoing research aims to expand Dexpanthenol's applicability, with studies investigating its efficacy in treating conditions like radiation dermatitis, mucositis, and even specific gastrointestinal disorders.
Dexpanthenol functions by promoting the synthesis of coenzyme A, a vital cofactor in numerous biochemical reactions within the body.

By being converted into pantothenic acid once absorbed, Dexpanthenol boosts the regeneration of cells and tissues.
This process is particularly beneficial for skin health, as Dexpanthenol enhances the natural repair mechanisms of the epidermis.
Moreover, Dexpanthenol exerts anti-inflammatory and moisturizing effects, which contribute to its therapeutic efficacy.
These properties make Dexpanthenol a versatile agent in both medical and cosmetic formulations.

The administration of Dexpanthenol varies depending on the specific condition being treated.
For topical applications, Dexpanthenol is commonly available in the form of creams, lotions, ointments, and gels.
These formulations are directly applied to the affected area, usually one to three times daily.

The onset of action for topical Dexpanthenol is relatively quick, often providing soothing relief within minutes to hours after application.
For other indications, such as gastrointestinal issues or postoperative care, Dexpanthenol may be administered orally or via injection.
Oral formulations, typically available as capsules or tablets, are taken as prescribed by a healthcare professional.
Injectable forms are used in clinical settings and are administered by medical personnel.

USES AND BENEFITS of DEXPANTHENOL:
As we’ve touched on already, dexpanthenol has moisturising properties and can offer a wide range of skincare benefits.
For example, dexpanthenol can help to:

Hydrate your skin:
When applied topically (onto the skin), dexpanthenol helps to attract and retain moisture in the skin, providing lasting hydration and supporting the skin’s protective barrier.
This may be particularly beneficial if you or your baby have sensitive or dry skin.

Soften the skin and improve elasticity:
Dexpanthenol’s moisturising-like properties can help to maintain the smoothness and elasticity of the skin.

WHAT ARE THE BENEFITS OF DEXPANTHENOL?
Dexpanthenol is a skincare ingredient that’s highly regarded for its numerous benefits.
Incorporating skincare products containing Dexpanthenol or D Panthenol can help you address various skin concerns, making it a valuable addition to your routine.
The Vitamin B5 benefits for skin include:

1-Hydration:
Dexpanthenol is known for its moisturising abilities.
The ingredient can improve your skin's hydration by attracting and retaining water, leaving it feeling softer and more supple.

2-Skin barrier support:
Dexpanthenol helps to reinforce your skin's natural barrier, which is essential for protection against environmental stressors and preventing moisture loss.

3-Anti-inflammatory:
Dexpanthenol has anti-inflammatory properties, making it effective in helping to calm and soothe irritated or sensitive skin.

4-Wound healing:
Dexpanthenol can promote skin healing by supporting cell turnover and tissue repair, which can be beneficial for minor cuts, burns, or skin irritations.

5-Anti-ageing:
Dexpanthenol contributes to a more youthful appearance by helping to reduce the look of fine lines and wrinkles and promoting a smoother skin texture.

WHO SHOULD USE DEXPANTHENOL?
When applied topically (to your skin), dexpanthenol is suitable for a wide range of people and is often used in products designed to protect delicate skin.
For example, you’ll often see Dexpanthenol used as a moisturiser or to help protect skin from the causes of nappy rash.
Dexpanthenol can also help with dry or rough skin.
If you have any of these, speak to your local pharmacist for their advice on using creams with dexpanthenol.

HOW TO USE DEXPANTHENOL?
As mentioned, dexpanthenol is a key ingredient in a wide range of over-the-counter cosmetic and haircare products.
However, one of its most popular uses is as a moisturiser.
To get the most out of your dexpanthenol moisturiser, be sure to follow the instructions on the packaging or as provided by your pharmacist or doctor.

This typically involves:
Only ever using Dexpanthenol on your skin.
Keeping Dexpanthenol away from your mouth, nose, ears and eyes.
Cleaning the affected area of skin before each use and making sure it’s dry.

Applying a thin layer onto the affected skin before gently rubbing it in.
While dexpanthenol rarely causes any severe side effects, if you experience signs of an allergic reaction, like a rash, breathing difficulties or red, swollen, blistered or peeling skin, make sure to seek medical advice as soon as possible.

WHAT’S THE DIFFERENCE BETWEEN DEXPANTHENOL AND PANTHENOL?
While dexpanthenol and panthenol are often used interchangeably, they’re not exactly the same.
Panthenol is a general term used to describe both L-panthenol and D-panthenol (which is also known as dexpanthenol or provitamin B5).
Dexpanthenol is the form of panthenol that our bodies can use.
Once inside our bodies, dexpanthenol is converted into vitamin B5 (pantothenic acid).
Dexpanthenol plays a key role in creating coenzyme A – a molecule needed for many important biochemical processes.

BIOCHEM/PHYSIOL ACTIONS of DEXPANTHENOL:
Dexpanthenol is the alcohol analogue and biological precursor of D-pantothenic acid.
These analogues are precursors in the biosynthesis of coenzyme A.
Dexpanthenol and D-Pantothenic acid are used in a variety of skin protection products.
D-pantothenic acid may have a role in controlling keratinocyte proliferation and differentiation.
Dexpanthenol may be used for studies of skin protection emulsions from UV irradiation and as a humectant.

KEY BENEFITS of DEXPANTHENOL:
Skin Hydration & Barrier Support:
Dexpanthenol enhances moisture retention in the outermost skin layers, strengthening the skin barrier and preventing trans-epidermal water loss.

Regeneration & Wound Healing:
Dexpanthenol stimulates epithelialization, accelerating skin repair and supporting wound healing while soothing irritation.

Anti-Inflammatory & Soothing Properties:
Reduces redness, roughness, and scaling by calming inflammatory responses, making Dexpanthenol particularly beneficial for sensitive and irritated skin.

MANUFACTURING PROCESS of DEXPANTHENOL:
130 parts by weight of d(-)-α-hydroxy-β,β-dimethyl-gamma-butyric acid lactone are dissolved in 150 parts by volume of methyl alcohol.
75 parts by weight of 3-hydroxypropylamine are added, in one portion, to the solution and the mixture is well stirred.
While the reaction sets in, the temperature of the mixture gradually rises by itself to about 50°C and then drops again after about two hours.

To cause completion of the reaction, the mixture is allowed to stand at room temperature for 24 hours.
The so obtained (d+)-α,γdihydroxy-β,β-dimethyl-butyric-acid-(3'-hydroxypropyl)-amide is freed from methyl alcohol in vacuo.
Dexpanthenol is a colorless, viscous oil, easily soluble in water.
Dexpanthenol boils under a pressure of 0.02 mm between 118° and 120°C.

PHYSICAL and CHEMICAL PROPERTIES of DEXPANTHENOL:
Chemical formula: C9H19NO4
Molar mass: 205.254 g·mol−1
Appearance: Highly viscous, colourless liquid
Density: 1.2 g mL−1 (at 20 °C)
Melting point: 66 to 69 °C (151 to 156 °F; 339 to 342 K)[contradictory]
Boiling point: 118 to 120 °C (244 to 248 °F; 391 to 393 K) at 2.7 Pa
log P: −0.989
Acidity (pKa): 13.033

Basicity (pKb): 0.964
Chiral rotation ([α]D): +29° to +30°
Refractive index (nD): 1.499
Physical state: liquid, clear, viscous
Color: colorless
Odor: No data available
Melting point/freezing point: No data available

Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: No data available
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available

Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: No data available
Partition coefficient: n-octanol/water: No data available
Vapor pressure: No data available
Density: 1,2 g/cm3 at 20 °C - lit.
Relative density: No data available

Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Other safety information: No data available
Product Name: (+)-Panthenol
CAS No.: 81-13-0
Molecular Formula: C9H19NO4
InChIKeys: InChIKey=SNPLKNRPJHDVJA-ZETCQYMHSA-N

Molecular Weight: 205.251
Exact Mass: 205.25
EC Number: 201-327-3
UNII: 1O6C93RI7Z
DSSTox ID: DTXSID3022906
NCI Thesaurus Code: C47481
Color/Form: Hygroscopic oil|Viscous liquid
Clear viscous, somewhat hygroscopic liquid

Some crystallization may occur on standing
ATC Code: D03AX03|A - Alimentary tract and metabolism
D - Dermatologicals|S - Sensory organs
HScode: 2924199090
PSA: 89.79
XLogP3: -0.9
Appearance: Transparent colorless to slightly yellow viscous liquid
Density: 1.2 g/cm3 @ Temp: 20 °C
Melting Point: <25 °C

Boiling Point: 119 °C
Flash Point: 246.3ºC
Refractive Index: 1.495-1.502
Water Solubility: In water, 1.6X10+6 mg/L at 25 deg C /miscible/ (est)
Storage Conditions: -20ºC
Vapor Pressure: 1.5X10-8 mm Hg at 25 deg C (est)
Taste: Slightly bitter taste
Henrys Law Constant: Henry's Law constant = 2.8X10-11 cu cm/molec-sec at 25 °C (est)
Collision Cross Section: 144.7 Å² [M+H]+ [CCS Type: DT, Method: sing

CBNumber:CB3169304
Molecular Formula:C9H19NO4
Molecular Weight:205.25
MDL Number:MFCD00065006
MOL File:81-13-0.mol
Empirical Formula (Hill Notation): C9H19NO4
CAS Number: 81-13-0
Molecular Weight: 205.25
UNSPSC Code: 41116107
NACRES: NA.24
PubChem Substance ID: 329823234

EC Number: 201-327-3
Beilstein/REAXYS Number: 1724947
MDL number: MFCD00065006
Molecular Weight: 205.25 g/mol
XLogP3-AA: -0.9
Hydrogen Bond Donor Count: 4
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 6
Exact Mass: 205.13140809 Da
Monoisotopic Mass: 205.13140809 Da
Topological Polar Surface Area: 89.8 Å²

Heavy Atom Count: 14
Formal Charge: 0
Complexity: 182
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 1
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Physical state: viscous
Color: colourless
Odor: No data available
Melting point/freezing point: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: No data available
Autoignition temperature: No data available
Decomposition temperature: No data available

pH: No data available
Viscosity: Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: No data available
Partition coefficient: n-octanol/water: No data available
Vapor pressure: No data available
Density: 1,20 g/cm3 at 20 °C - lit
Relative density: No data available
Relative vapour density: No data available

Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available
Melting point: 64～69℃
alpha: 30.5 º (c=5, H2O on anh. sub)
Boiling point: 118-120 °C (2.7 mmHg)
Density: 1.20 g/mL at 20 °C (lit.)
vapor pressure: 0Pa at 25℃

refractive index: 1.495-1.502
Flash point: 118-120°C/0.02m
storage temp.: 2-8°C
solubility: DMSO (Sparingly), Methanol (Slightly), Water (Sparingly)
form: Viscous Liquid or Semi Solid
pka: 13.03±0.20(Predicted)
color: Clear colorless to slightly yellow
PH: pH (100g/l,25℃) : 8.5～10.5
biological source: synthetic

optical activity: [α]20/D +30±1°, c = 5% in H2O
Water Solubility: soluble
Sensitive: Hygroscopic
Merck: 14,2947
BRN: 1724947
Cosmetics Ingredients Functions: HAIR CONDITIONING
SKIN CONDITIONING
ANTISTATIC
InChI: 1S/C9H19NO4/c1-9(2,6-12)7(13)8(14)10-4-3-5-11/h7,11-13H,3-6H2,1-2H3,(H,10,14)/t7-/m0/s1
InChIKey: SNPLKNRPJHDVJA-ZETCQYMHSA-N
SMILES: CC(C)(CO)C@@HC(=O)NCCCO

LogP: -1.06 at 22℃
Substances Added to Food (formerly EAFUS): D-PANTOTHENYL ALCOHOL
FDA 21 CFR: 310.545; 582.5580
SCOGS (Select Committee on GRAS Substances): D-Pantothenyl alcohol
CAS DataBase Reference: 81-13-0(CAS DataBase Reference)
EWG's Food Scores: 1
FDA UNII: 1O6C93RI7Z
NCI Drug Dictionary: Ilopan
ATC code: A11HA30,D03AX03,S01XA12
NIST Chemistry Reference: Dexpanthenol(81-13-0)
EPA Substance Registry System: (+)-Panthenol (81-13-0)
UNSPSC Code: 41116107
NACRES: NA.28

FIRST AID MEASURES of DEXPANTHENOL:
-Description of first-aid measures:
*General advice:
Consult a physician.
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
If breathed in, move person into fresh air.
Consult a physician.
*In case of skin contact:
Wash off with soap and plenty of water.
Consult a physician.
*In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
*If swallowed:
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.
-Indication of any immediate medical attention and special treatment needed
No data available

ACCIDENTAL RELEASE MEASURES of DEXPANTHENOL:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.

FIRE FIGHTING MEASURES of DEXPANTHENOL:
-Extinguishing media:
*Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Further information:
No data available

EXPOSURE CONTROLS/PERSONAL PROTECTION of DEXPANTHENOL:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Safety glasses with side-shields
*Skin protection:
Handle with gloves.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
Impervious clothing
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of DEXPANTHENOL:
-Precautions for safe handling:
*Hygiene measures:
Wash hands before breaks and at the end of workday.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Keep container tightly closed in a dry and well-ventilated place.
Store in cool place.
*Storage stability:
Recommended storage temperature: 2 - 8 °C
Hygroscopic.
*Storage class:
Storage class (TRGS 510): 12:
Non Combustible Liquids

STABILITY and REACTIVITY of DEXPANTHENOL:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available