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DHA Dehydroacetic acid is a synthetic preservative used in amounts of 0.6% or less where it’s proven to be safe and effective.
DHA Dehydroacetic acid is an organic compound primarily serving as a preservative in cosmetics and personal care industry.
DHA Dehydroacetic acid is particularly effective against molds and yeasts, helping to prevent microbial contamination and maintain product integrity over time.
CAS Number: 520-45-6
EC Number: 208-293-9
Molecular Formula: C8H8O4
Molecular Weight: 168.15 g/mol
Synonyms: Dehydroacetic acid sodium salt, Dehydroacetic acid (sodium salt), MFCD00040583, SCHEMBL41960, CHEMBL2107528, ZPNRBQVNNIDJHX-UHFFFAOYSA-M, HMS5085K12, SODIUM DEHYDROACETATE [FCC], SODIUM DEHYDROACETATE [HSDB], SODIUM DEHYDROACETATE [MART.], AKOS037643347, Dehydroacetic acid, sodium salt; >98%, AS-14861, D0040, ST50405589, sodium;3-acetyl-6-methyl-2-oxo-pyran-4-olate, 3-Acetyl-4-hydroxy-6-methyl-2-pyrone Sodium Salt, 3-acetyl-4-hydroxy-6-methyl-2-oxopyran, sodium salt, Sodium 3-Acetyl-4-hydroxy-6-methyl-2-oxo-4(2H)-pyranolate
DHA Dehydroacetic acid is a synthetic organic compound widely used as a preservative in cosmetic, personal care, and some industrial formulations due to its strong antifungal and antibacterial properties.
DHA Dehydroacetic acid is particularly effective against molds and yeasts, helping to prevent microbial contamination and maintain product integrity over time.
DHA Dehydroacetic acid works by disrupting microbial cell activity, thereby inhibiting growth and reproduction of unwanted microorganisms.
DHA Dehydroacetic acid is valued for its stability, compatibility with a wide range of ingredients, and effectiveness at relatively low concentrations.
As a result, DHA Dehydroacetic acid plays an important role in extending shelf life, preserving product quality, and ensuring safety in formulations where microbial control is essential.
DHA Dehydroacetic acid is a synthetic preservative used in amounts of 0.6% or less where it’s proven to be safe and effective.
DHA Dehydroacetic acid is characterized as a white to cream crystalline powder.
Sometimes its salt form is used, as DHA Dehydroacetic acid is more soluble in certain types of cosmetic formulas.
DHA Dehydroacetic acid is most effective on fungi.
DHA Dehydroacetic acid can Inhibit microbial growth activities and prevent product deterioration.
DHA Dehydroacetic acid has strong antifungal effect.
Therefore, DHA Dehydroacetic acid can be recommended to use as preservative in cosmetic products.
DHA Dehydroacetic acid is defined as an important biologically active compound known for its antimicrobial activities and as a powerful antiseptic agent in aqueous mediums.
DHA Dehydroacetic acid is utilized in the food industry for preserving vegetables and fish products, and its metal complexes have applications as fungicides, bactericides, herbicides, and insecticides.
DHA Dehydroacetic acid is an organic compound which has several industrial applications.
DHA Dehydroacetic acid is classified as a pyrone derivative.
DHA Dehydroacetic acid presents as an odorless, colorless to white crystalline powder, almost insoluble in water and moderately soluble in most organic solvents.
DHA Dehydroacetic acid is one of the food additives found in red wine and was determined by ultra-fast liquid chromatography-tandem quadrupole mass spectrometry (UFLC-MS/MS).
DHA Dehydroacetic acid is an organic compound primarily serving as a preservative in cosmetics and personal care industry.
DHA Dehydroacetic acid fights off the growth of microorganisms such as bacteria, yeast, and mold in products, thus increasing the shelf life.
DHA Dehydroacetic acid is compatible with other preservatives when combined for added efficiency - making it a versatile choice.
In its raw form, DHA Dehydroacetic acid appears as a white crystalline powder that is odorless.
Further, DHA Dehydroacetic acid is a safe ingredient and is well tolerated by most skin types.
The chemical formula of DHA Dehydroacetic acid is C8H8O4.
DHA Dehydroacetic acid is an organic compound which has several industrial applications.
DHA Dehydroacetic acid is classified as a pyrone derivative.
DHA Dehydroacetic acid presents as an odorless, colorless to white crystalline powder, almost insoluble in water and moderately soluble in most organic solvents.
DHA Dehydroacetic acid is used as a preservative in cosmetics.
DHA Dehydroacetic acid kills microorganisms and prevents their growth and reproduction, thus protecting cosmetics and personal care products from spoilage.
DHA Dehydroacetic acid is a pyrone derivative.
DHA Dehydroacetic acid has antibacterial, antifungal and phytotoxic activities.
DHA Dehydroacetic acid can be added to cosmetics, food and beverages for preservation and other purposes.
DHA Dehydroacetic acid can also be used to synthesize various heterocycles and cycloaddition products.
Uses of DHA Dehydroacetic Acid:
DHA Dehydroacetic acid is used as a preservative in cosmetic and personal care products such as creams, lotions, shampoos, conditioners, and deodorants to prevent the growth of microorganisms.
DHA Dehydroacetic acid is also used in formulations to inhibit the development of molds and yeasts, thereby maintaining product stability and extending shelf life.
Additionally, DHA Dehydroacetic acid is applied in some industrial and surface treatment products where microbial control is required to protect product quality and performance.
DHA Dehydroacetic acid and Benzyl Alcohol are ia an organic compound which is accepted for use in natural cosmetics, offering a broad spectrum of stability at a wide range of pH values.
DHA Dehydroacetic acid is water soluble with an effective pH from pH 2–6; it is most efficient at pH levels below 5.5.
Typical recommended use is 0.2–1%.
As a preservative DHA Dehydroacetic acid is used in the formulation of a wide variety of products, including bath, skin care, suntan, sunscreen, fragrance, shaving, hair and nail care products, as well as eye and facial makeup.
DHA Dehydroacetic acid is used as an intermediate in the synthesis of preservatives and clopidols
DHA Dehydroacetic acid is a broad-spectrum feed preservative that can inhibit the growth of mold, yeast, and bacteria.
As a food additive, DHA Dehydroacetic acid is allowed to be used in cheese, butter, margarine, cool drinks, fermented milk, etc.
DHA Dehydroacetic acid is also used in daily cosmetics and fiber products
DHA Dehydroacetic acid is widely used in the cosmetic industry as an effective preservative.
DHA Dehydroacetic acid prevents the growth of harmful bacteria and fungi in formulations to make them last longer.
DHA Dehydroacetic acid is commonly found in lotions, creams, shampoos, conditioners, and other water-based formulations where microbial contamination is a concern.
Additionally, DHA Dehydroacetic acid serves as an antimicrobial agent, ensuring product safety and integrity.
DHA Dehydroacetic acid's broad-spectrum efficacy, stability in various formulations, and compatibility with other preservatives make it a versatile choice for maintaining the quality and safety of cosmetic and personal care products.
Industrially, DHA Dehydroacetic acid has several uses which include the following:
DHA Dehydroacetic acid is used as a fungicide and bactericide.
The sodium salt, DHA Dehydroacetic acid is often used in place of DHA Dehydroacetic acid because of its greater solubility in water.
DHA Dehydroacetic acid is used as a food preservative to prevent pickle bloating in squash and strawberries.
When used as a food additive, DHA Dehydroacetic acid is referred to using the International Numbering System for Food Additives or E number 265.
DHA Dehydroacetic acid is used as a plasticizer in synthetic resins.
DHA Dehydroacetic acid is used as an antienzyme in toothpastes.
DHA Dehydroacetic acid is used as a precursor for dimethyl-4-pyridones.
DHA Dehydroacetic acids are synthesized when DHA Dehydroacetic acid is exposed to aqueous solutions containing primary amines.
Preparation of DHA Dehydroacetic Acid:
DHA Dehydroacetic acid is prepared by the base-catalysed dimerization of diketene.
Commonly used organic bases include imidazole, DABCO, and pyridine.
Origin of DHA Dehydroacetic Acid:
DHA Dehydroacetic acid is synthesized through the reaction of diketene and acetic acid.
Diketene, a highly reactive compound, reacts with acetic acid under controlled conditions to form DHA Dehydroacetic acid.
This process involves careful temperature regulation and purification steps to ensure the purity of the final product.
The synthesized DHA Dehydroacetic acid is then crystallized and dried for use in cosmetics.
Stability and Reactivity of DHA Dehydroacetic Acid:
Chemical stability:
DHA Dehydroacetic acid is stable under normal temperature and storage conditions.
Reactivity:
DHA Dehydroacetic acid may react with strong bases.
DHA Dehydroacetic acid may also react with strong oxidizing agents.
Conditions to avoid:
Excessive heat.
Strong alkaline conditions.
Incompatible materials:
Strong bases.
Strong oxidizers.
Hazardous decomposition products:
Thermal decomposition may produce carbon oxides (CO, CO₂).
Handling and Storage of DHA Dehydroacetic Acid:
Handling:
Handle in well-ventilated areas.
Avoid inhalation of dust.
Avoid contact with eyes and skin.
Storage:
Store in tightly closed containers in a cool, dry place.
Keep away from incompatible substances.
First Aid Measures of DHA Dehydroacetic Acid:
Inhalation:
Move the affected person to fresh air.
Seek medical attention if symptoms persist.
Skin contact:
Wash the affected area thoroughly with water.
Remove contaminated clothing.
Eye contact:
Rinse cautiously with water for several minutes.
Seek medical advice if irritation continues.
Ingestion:
Rinse mouth with water.
Seek medical advice if necessary.
Firefighting Measures of DHA Dehydroacetic Acid:
Suitable extinguishing media:
Water spray.
Foam.
Carbon dioxide (CO₂).
Dry chemical powder.
Specific hazards:
Combustion may produce carbon oxides.
Irritating fumes may be released.
Protective equipment:
Firefighters should wear self-contained breathing apparatus (SCBA).
Wear protective clothing.
Accidental Release Measures of DHA Dehydroacetic Acid:
Personal precautions:
Ensure adequate ventilation.
Avoid contact with skin and eyes.
Prevent dust inhalation.
Environmental precautions:
Prevent large quantities from entering drains, soil, or water systems.
Methods for cleaning up:
Carefully sweep or collect to avoid dust formation.
Place in suitable containers for disposal.
Exposure Controls / Personal Protection of DHA Dehydroacetic Acid:
Engineering controls:
Provide adequate ventilation to control exposure.
Eye/face protection:
Use safety goggles.
Skin protection:
Wear protective gloves.
Wear suitable work clothing.
Respiratory protection:
Use a dust mask or appropriate respiratory protection if airborne particles are present.
Hygiene measures:
Wash hands thoroughly after handling.
Avoid eating, drinking, or smoking during use.
Identifiers of DHA Dehydroacetic Acid:
CAS Number: 520-45-6.
EC Number: 208-293-9.
INCI Name: DHA Dehydroacetic acid.
IUPAC Name: 3-acetyl-6-methyl-2H-pyran-2,4(3H)-dione.
Molecular Formula: C8H8O4.
Molecular Weight: 168.15 g/mol.
PubChem CID: 10211.
CAS: 520-45-6
IUPAC Name: 3-acetyl-6-methyl-3,4-dihydro-2H-pyran-2,4-dione
Molecular Formula: C8H8O4
InChI Key: PGRHXDWITVMQBC-UHFFFAOYNA-N
SMILES: CC(=O)C1C(=O)OC(C)=CC1=O
Molecular Weight (g/mol): 168.15
Product Number: D0039
Purity / Analysis Method : >98.0%(GC)(T)
Molecular Formula / Molecular Weight: C8H8O4 = 168.15
Physical State (20 deg.C): Solid
Storage Temperature : Room Temperature (Recommended in a cool and dark place, <15°C)
CAS RN: 520-45-6
Reaxys Registry Number: 6129
PubChem Substance ID: 87566792
SDBS (AIST Spectral DB): 3497
Merck Index (14): 2865
MDL Number: MFCD00066709
CAS Number: 520-45-6 / 771-03-9 / 16807-48-0
Chem/IUPAC Name: 3-Acetyl-6-methyl-2H-pyran-2,4(3H)-dione
EINECS/ELINCS No: 208-293-9 / 212-227-4 / -
COSING REF No: 33185
Empirical Formula (Hill Notation): C8H8O4
CAS Number: 520-45-6
Molecular Weight: 168.15
UNSPSC Code: 12352100
NACRES: NA.22
PubChem Substance ID: 57648475
EC Number: 208-293-9
Beilstein/REAXYS Number: 6129
MDL number: MFCD00066709
Assay: ≥98.0% (T)
Form: powder
CAS Number: 520-45-6
Abbreviations: DHAA
ChEBI: CHEBI:137426
ChEMBL: ChEMBL284127
ChemSpider: 10177
ECHA InfoCard: 100.007.541
EC Number: 208-293-9
E number: E265 (preservatives)
MeSH: dehydroacetic+acid
PubChem CID: 122903
UNII: 2KAG279R6R
CompTox Dashboard (EPA): DTXSID801015814 DTXSID6020014, DTXSID801015814
InChI: InChI=1S/C8H8O4/c1-4-3-6(10)7(5(2)9)8(11)12-4/h3,11H,1-2H3
Key: JEQRBTDTEKWZBW-UHFFFAOYSA-N
SMILES: CC(=O)C1=C(O)OC(C)=CC1=O
Properties of DHA Dehydroacetic Acid:
Chemical formula: C8H8O4
Molar mass: 168.148 g·mol−1
Appearance: White crystals
Melting point: 109 °C; 228 °F; 382 K
Boiling point: 270 °C; 518 °F; 543 K
Appearance: White to off-white crystalline powder.
Odor: Odorless or faint characteristic odor.
pH: Slightly acidic.
Melting Point: ~109–111°C.
Solubility: Slightly soluble in water, soluble in alcohol and organic solvents.
Stability: Stable under normal conditions.
Quality Level: 100
assay: ≥98.0% (T)
form: powder
bp:270 °C (lit.)
mp: 111-113 °C (lit.)
functional group: ester, ketone
SMILES string: CC(=O)C1C(=O)OC(C)=CC1=O
InChI: 1S/C8H8O4/c1-4-3-6(10)7(5(2)9)8(11)12-4/h3,7H,1-2H3
InChI key: PGRHXDWITVMQBC-UHFFFAOYSA-N
Melting Point: 111 °C
Boiling Point: 270 °C
Solubility in water: Insoluble
Degree of solubility in water: 690 mg/l 25 °C
Solubility (soluble in): Acetone, Ether, Ethanol, Benzene, Methanol
Specifications of DHA Dehydroacetic Acid:
Appearance: White to Light yellow to Light orange powder to crystal
Purity(GC): min. 98.0 %
Purity(Neutralization titration): min. 98.0 %
Melting point: 109.0 to 113.0 °C
Solubility in Acetone: almost transparency
Form: Powder
Assay (GC): ≥97.5%
Appearance (Color): White to cream or pale yellow
Assay (Aqueous acid-base Titration): ≥97.5% to ≤102.5%
Identification (FTIR): Conforms
Melting Point: 109.0-114.0°C
Names of DHA Dehydroacetic Acid:
Preferred IUPAC name:
3-Acetyl-2-hydroxy-6-methyl-4H-pyran-4-one
Other names:
Biocide 470F
Methylacetopyronone
