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Diazolidinyl urea is a colorless, odorless, stable, and water-soluble preservative.
Diazolidinyl urea is reported to have a wider antimicrobial spectrum than imidazolidinyl urea, which is structurally related.
Diazolidinyl urea is effective against gram-negative and gram-positive bacteria, molds, and yeast but has limited activity against fungi.
CAS Number: 78491-02-8
Molecular Formula: C8H14N4O7
Molecular Weight: 278.22
EINECS Number: 278-928-2
Synonyms:DIAZOLIDINYL UREA, 78491-02-8, Diazolidinylurea, 1-(1,3-Bis(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)-1,3-bis(hydroxymethyl)urea, 1-[1,3-bis(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-1,3-bis(hydroxymethyl)urea, N,N'-Bis(hydroxymethyl) urea, N-(1,3-Bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-N,N'-bis(hydroxymethyl)urea, N9VX1IBW6K, n-[1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-n,n'-bis(hydroxymethyl)urea, DTXSID0029559, Germall II, MFCD03547942, Urea, N-(1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-N,N'-bis(hydroxymethyl)-, Germall 11, DTXCID009559, Imidazolidinyl urea 11, Diazolidinyl Urea (Technical Grade), Urea, N-[1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-N,N'-bis(hydroxymethyl)-, CAS-78491-02-8, EINECS 278-928-2, UNII-H5RIZ3MPW4, UNII-N9VX1IBW6K, N-[1,3-Bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-N,N'-bis(hydroxymethyl)urea; Diazolidinylurea; Germaben II-E; Germall II; N-Hydroxymethyl-N-[1,3-di(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-N'-hydroxymethylurea, H5RIZ3MPW4, EC 278-928-2, Diazolidinyl urea, >=95%, N-(Hydroxymethyl)-N-(1,3-dihydroxymethyl-2,5-dioxo-4-imidazolidinyl)-N'-(hydroxymethyl) urea, N-(Hydroxymethyl)-N-(1,3-dihydroxymethyl-2,5-dioxo-4-imidazolidinyl)-N'-(hydroxymethyl)urea, SCHEMBL34370, CHEMBL3187032, N-(1,3-Bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-, CHEBI:136014, SOROIESOUPGGFO-UHFFFAOYSA-N, Tox21_202068, Tox21_303365, AC1192, s5292, AKOS016010254, CCG-267223, CS-W010066, DB14173, HY-W009350, 1-[1,3-bis(hydroxymethyl)-2,5-dioxo-imidazolidin-4-yl]-1,3-bis(hydroxymethyl)urea, Urea, N-(1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl-N,N'-bis(hydroxymethyl)-, NCGC00249159-01, NCGC00257237-01, NCGC00259617-01, AS-73729, N-[1,3-bis(hydroxymethyl)-2,5-dioxo(1,3-diazolidin-4-yl)]-N-(hydroxymethyl)[(hydroxymethyl)amino]carboxamide, SY033470, DB-056316, D3769, NS00001993, EN300-18632140, Q5272201, W-104279, 1,3-Bis(hydroxymethyl)-5-[1,3-bis(hydroxymethyl)ureido]hydantoin, N,N'-BIS(HYDROXYMETHYL)-N'-(1,3-BIS(HYDROXYMETHYL)-2,5-DIOXO-4-IMIDAZOLIDINYL)UREA, N-hydroxymethyl-N-(1,3-di(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)-N'-hydroxy-methylurea, N-[1,3-Bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-N,N'-bis(hydroxymethyl)urea
Diazolidinyl urea was first introduced in 1982 (Sutton Labs, Chatham, New Jersey).
Diazolidinyl urea, a formaldehyde re1easer, is mainly contained in cosmetics and toiletries, and can be found in barrier creams.
Diazolidinyl urea is a synthetic preservative used in various preparations.
Diazolidinyl urea releases formaldehyde in the process of using a product, which makes its use little objectionable.
Diazolidinyl urea is an antimicrobial preservative used in cosmetics.
Diazolidinyl urea is chemically related to imidazolidinyl urea which is used in the same way.
Diazolidinyl urea acts as a formaldehyde releaser.
It is used in many cosmetics, skin care products, shampoos and conditioners, as well as a wide range of products including bubble baths, baby wipes and household detergents.
Diazolidinyl urea is found in the commercially available preservative Germaben.
Diazolidinyl Urea is a mixture of different formaldehyde addition products including polymers.
Diazolidinyl urea is chemically related to imidazolidinyl urea.
Diazolidinyl urea is an antimicrobial preservative commonly used in cosmetics and personal care products to protect them from bacterial and fungal contamination.
Diazolidinyl urea releases formaldehyde, which helps to prevent the growth of microbes, thereby extending the shelf life of these products.
Diazolidinyl urea is a white, odorless crystalline powder.
Its chemical formula is C8H14N4O7.
Diazolidinyl urea is primarily used in cosmetics, such as lotions, shampoos, conditioners, and other personal care products.
Diazolidinyl urea can also be found in some pharmaceutical products.
Diazolidinyl urea works by slowly releasing formaldehyde, a potent antimicrobial agent, which inhibits the growth of bacteria, yeast, and mold.
Diazolidinyl urea is effective in preventing microbial growth, its use is sometimes controversial due to the formaldehyde release.
Formaldehyde can be an allergen and irritant, and in high concentrations, it is a known carcinogen.
However, the levels of formaldehyde released by Diazolidinyl urea in cosmetic products are typically low and regulated to be within safe limits.
Commercial Diazolidinyl urea is a mixture of different formaldehyde addition products including polymers.
Diazolidinyl urea is a preservative commonly used in cosmetics and personal care products.
Diazolidinyl urea may release formaldehyde and cross-reactions to other formaldehyde-releasing substances may occur.
Diazolidinyl urea was poorly characterized until recently and the single Chemical Abstracts Service structure assigned to it is probably not the major one in the commercial material.
Instead, new data indicate that one of the hydroxymethyl functional groups of the imidazolidine ring is attached to the carbon, rather than on the urea nitrogen atom.
Diazolidinyl Urea is a synthetic preservative that protects formulations against harmful bacteria and fungi.
Diazolidinyl urea works by releasing formaldehyde in the products which prevents contamination - increasing the shelf life of the cosmetic products.
In its raw form, Diazolidinyl Urea appears as a fine white powder and acts as a crucial background ingredient in the beauty world.
However, it has considerable risks of allergies especially when used in higher concentrations. Proper formulation is necessary for its safe use.
Diazolidinyl Urea is a widely utilized preservative in the cosmetic industry, ensuring product stability and safety.
Its antimicrobial properties inhibit the growth of bacteria, yeast, and mold, extending the shelf life of various formulations, including creams, lotions, shampoos, and makeup.
By preventing microbial contamination, Diazolidinyl Urea helps maintain product integrity and efficacy, preserving the quality of cosmetics over time.
Despite some concerns about potential sensitivities, its effectiveness in preventing spoilage makes it a valuable ingredient in cosmetic formulations.
Diazolidinyl Urea is synthesized from two primary ingredients: allantoin and formaldehyde.
Allantoin, a compound found in plants and animals, undergoes a chemical reaction with formaldehyde under alkaline conditions to produce Diazolidinyl Urea.
An antimicrobial preservative that helps your products not to go wrong too quickly.
Diazolidinyl urea works especially well against bacteria, specifically gram-negative species, yeast, and mold.
Somewhat controversial, it belongs to an infamous family of formaldehyde-releasers.
That is, it slowly breaks down to form formaldehyde when it is added to a formula.
Diazolidinyl urea written more about formaldehyde-releasing preservatives and the concerns around them at Dmdm Hydantoin, but do not get too scared, those are more theories than proven facts.
Diazolidinyl urea is used as a preservative in cosmetics and medicated products.
Diazolidinyl urea can be found in creams, lotions, hair products and over-the-counter topical drugs such as medicated ointments.
Further research may identify additional product or industrial usages of this chemical.
Diazolidinyl urea, a broad spectrum preservative, is a formaldehyde-releasing compound that releases formaldehyde through its decomposition.
Diazolidinyl urea is effective against most contaminating microorganisms, especially Pseudomonas.
Diazolidinyl Urea is a water soluble preservative, providing broad spectrum anti-bacterial activity against both gram positive and gram negative bacteria.
Diazolidinyl Urea acts as a preservative.
Diazolidinyl urea provides broad-spectrum activity against gram-positive and gram-negative bacteria.
It delivers efficient antimicrobial power and balanced, synergistic & boasting broad-spectrum protection.
Moreover, it is compatible with many other cosmetic ingredients.
Diazolidinyl urea is effective at low dose and can be used to bolster other preservatives.
Diazolidinyl Urea preservative finds application in formulating leave-on & rinse-off formulas, hair-care products (conditioners, gels, mousses, novel stylers, shampoos, styling lotions/creams), body-care, color cosmetics, face & body washes, facial care & wipes and sun-care products (after-sun, self-tanning, and sun-protection).
Found in products like moisturizers, sunscreens, shampoos, conditioners, body washes, and makeup.
Pharmaceuticals: Used as a preservative in some topical drugs.
Household Products: Included in some cleaning products and detergents to prevent microbial growth.
Diazolidinyl urea functions as a formaldehyde releaser.
When incorporated into formulations, it decomposes slowly over time to release small amounts of formaldehyde.
This formaldehyde acts as a broad-spectrum antimicrobial agent, killing or inhibiting the growth of bacteria, yeast, and mold.
Although effective as a preservative, the release of formaldehyde has raised safety concerns.
Diazolidinyl urea is a known carcinogen and can cause allergic reactions and skin irritation in sensitive individuals.
Regulatory agencies such as the FDA and the European Commission have established maximum allowable concentrations of formaldehyde in cosmetics.
For example, the European Union limits the concentration of free formaldehyde to 0.2% in cosmetic products.
People with formaldehyde allergies or sensitivities are advised to avoid products containing formaldehyde releasers like Diazolidinyl urea.
Due to the concerns surrounding formaldehyde-releasing preservatives, there is a growing trend towards using alternative preservatives.
Diazolidinyl urea a common preservative used in place of formaldehyde releasers.
Though controversial for other reasons, they do not release formaldehyde.
Such as essential oils, although they may not be as effective in all formulations.
Diazolidinyl urea is considered to be biodegradable.
Diazolidinyl urea is generally regarded as safe for the environment when used in recommended concentrations.
Diazolidinyl urea trade name for Diazolidinyl urea, often used in cosmetic formulations.
A combination of Diazolidinyl urea with other preservatives for enhanced efficacy.
Boiling point: 421.04°C (rough estimate)
Density: 1.4734 (rough estimate)
vapor pressure: 0Pa at 20℃
refractive index: 1.6590 (estimate)
storage temp.: 2-8°C
solubility: Water (Slightly)
form: Solid
pka: 11.22±0.46(Predicted)
color: White to Off-White
Water Solubility: 1000g/L at 20℃
Merck: 14,3000
Stability: Stable. Incompatible with strong oxidizing agents.
InChIKey: SOROIESOUPGGFO-UHFFFAOYSA-N
LogP: 0.9 at 20℃
Diazolidinyl urea is an antimicrobial preservative used in cosmetics.
Diazolidinyl urea is chemically related to diazolidinyl urea which is used in the same way.
Diazolidinyl urea acts as a formaldehyde releaser.
A study examined the effects of various cosmetic preservatives, including Diazolidinyl Urea, on healthy human skin cells, highlighting the cellular responses and potential implications for skin health.
An extensive clinical review discussed allergic contact dermatitis caused by formaldehyde and formaldehyde releasers such as Diazolidinyl Urea, providing insights into allergic reactions and safety concerns in dermatological practice.
Research on potential carcinogens in makeup cosmetics included Diazolidinyl Urea, emphasizing the safety and regulatory aspects concerning its use in cosmetic formulations.
A study integrated Diazolidinyl Urea in a patch test series to evaluate skin sensitization and allergic reactions in patients, aiding in the assessment of its allergenic potential.
Diazolidinyl urea is an antimicrobial preservative that acts as a formaldehyde releaser in cosmetics and personal care products.
Diazolidinyl Urea prevents or retards bacterial growth, and thus protects cosmetics and personal care products from spoilage.
Follow this link for more information about how preservatives protect cosmetics and personal care products.
Diazolidinyl urea is a formaldehyde-releasing preservative used in cosmetics and personal-care products, which has been identified as a sensitizing agent in contact dermatitis.
To determine whether DIAZ sensitization is secondary to formaldehyde release or due to its own allergenic properties, we reviewed 708 consecutive patch tests of patients with various dermatologic complaints.
Diazolidinyl urea is a water-soluble preservative.
This preservative is considered safe for use at concentrations up to 0.5%, although it’s usually present at lower concentrations because it’s typically part of a blend with other preservatives (such as parabens).
Diazolidinyl urea can be a formaldehyde-releasing preservative.
Although that sounds scary, the amount of formaldehyde released is well below the recommended limits of exposure.
Moreover, other ingredients (such as proteins) in a product cause the free formaldehyde to evaporate and become inactive before it could possibly harm skin.
Diazolidinyl urea was poorly characterized until recently and the single Chemical Abstracts Service structure assigned to it is probably not the major one in the commercial material.
Instead, new data indicate that the hydroxymethyl functional group of each imidazolidine ring is attached to the carbon, rather than on the nitrogen atom.
Diazolidinyl urea, also known as eczema, describes a type of inflammation of the skin.
Contact dermatitis or contact eczema is a term used when this inflammation is caused by direct or indirect skin contact with something in your environment.
Allergic contact dermatitis occurs when immune system causes allergy to a very specific chemical or substance that has been in contact with the skin.
Diazolidinyl urea is synthesized through a multi-step chemical process that involves the reaction of urea with formaldehyde and other reagents.
The specific steps can vary, but a general method includes:
Urea reacts with formaldehyde to form Diazolidinyl urea derivatives.
The Diazolidinyl urea derivatives undergo cyclization to form the imidazolidine ring structure.
The resulting product is Diazolidinyl urea, which contains the imidazolidine ring and multiple hydroxymethyl groups.
The FDA regulates the use of preservatives in cosmetics under the Federal Food, Drug, and Cosmetic Act.
Diazolidinyl urea is allowed in cosmetic products, provided it meets safety requirements.
The European Union's Cosmetic Regulation (EC) No 1223/2009 sets maximum allowable concentrations for formaldehyde in cosmetic products.
Diazolidinyl urea must be used in concentrations that ensure the free formaldehyde content does not exceed 0.2% in the final product.
Similar to the EU, Health Canada regulates the allowable levels of formaldehyde in cosmetics, ensuring safety for consumers.
Helps prevent microbial contamination in products that contain water and are prone to spoilage.
Preserves the product during prolonged storage and use.
Extends the shelf life of products like foundation, mascara, and eye shadows.
Ensures the product remains effective and safe for use over time.
Diazolidinyl urea is used in topical creams and ointments that require preservation against microbial contamination.
Included in some cleaning solutions and detergents to prevent bacterial and fungal growth during storage.
Individuals with formaldehyde sensitivity may experience allergic reactions such as contact dermatitis when exposed to products containing Diazolidinyl urea.
Manufacturers are required to use Diazolidinyl urea within regulated limits to ensure consumer safety.
Products must be tested for their formaldehyde content to comply with safety standards.
A glycol ether often used as a preservative in cosmetics and pharmaceuticals.
Diazolidinyl urea is effective against bacteria and yeast but less so against mold.
A class of preservatives that includes methylparaben, ethylparaben, propylparaben, and butylparaben.
Despite their effectiveness, parabens have faced scrutiny over potential health risks.
Preservatives like sorbic acid, benzoic acid, and their salts (potassium sorbate, sodium benzoate) are used for their antimicrobial properties.
Natural preservatives such as tea tree oil, lavender oil, and rosemary extract, although they may not be as potent and can affect the product's scent and stability.
Uses Of Diazolidinyl urea:
Diazolidinyl urea is an antiseptic and deodorizer.
Diazolidinyl urea is also a broadspectrum preservative against bacteria and fungi.
Generally, it is used in concentrations of 0.03 to 0.3 percent.
It has been found that diazolidinyl urea is a stronger sensitizer than imidazolidinyl urea for people sensitive or allergic to formaldehyde.
Diazolidinyl urea is a preservative used in cosmetic creams, lotions, shampoos, hair gels, etc.
Diazolidinyl urea is used as a preservative in self-care products like creams, lotions, baby wipes, hand washes, bubble bath, shampoos.
It is however used in safe concentration n any product to improve shelf life or stability of a product.
Diazolidinyl urea can be considered as a broad-spectrum antiseptic for bacteria as well as fungi.
Diazolidinyl urea is also used as a deodorizer because it helps by eliminating bacteria that produce foul smell in the sweat.
Diazolidinyl urea is commonly used in a wide range of cosmetic and personal care products to prevent microbial contamination, thereby extending the shelf life of these products.
Diazolidinyl urea keeps water-based creams and lotions free from bacteria and mold.
Prevents the growth of microorganisms that can spoil the Diazolidinyl urea.
Maintains product integrity by preventing microbial growth.
Diazolidinyl urea is used in products like foundations, mascaras, eye shadows, and blushes to prevent contamination.
Ensures the product remains effective and safe for use over time.
Preserves the product to ensure it remains safe for skin application.
Diazolidinyl urea is used in some pharmaceutical formulations, especially topical products that require preservation against microbial contamination.
Ensures the product remains free from microbial contamination during use.
Prevents microbial growth in therapeutic shampoos.
This preservative is also found in various household items where microbial contamination is a concern.
Included in formulations like sprays and detergents to prevent bacteria and mold.
Helps maintain the product’s integrity by preventing microbial growth during storage.
In some industrial settings, Diazolidinyl urea is used to preserve products that may be stored for extended periods.
Diazolidinyl urea is used to prevent microbial growth in water-based paints and coatings.
Ensures the longevity and safety of water-based adhesives by preventing microbial contamination.
Certain specialized products also benefit from the preservative properties of Diazolidinyl urea.
Helps in preventing microbial growth in fabric treatments.
Diazolidinyl urea is used in shampoos and other grooming products for pets to prevent contamination.
Although less common, Diazolidinyl urea can be used in certain food packaging materials to prevent microbial growth, thereby extending the shelf life of the packaged goods.
Diazolidinyl urea is extensively used in the cosmetic and personal care industry due to its effectiveness as a preservative.
Diazolidinyl urea prevents the growth of bacteria and fungi in hydrating and anti-aging products.
Maintains the safety and effectiveness of facial washes and cleansing oils.
Diazolidinyl urea preserves the integrity of water-based toners and astringents.
Ensures shampoos remain free from microbial contamination.
Diazolidinyl urea keeps conditioners safe for extended use.
Diazolidinyl urea found in gels, mousses, and sprays to prevent spoilage.
Prevents microbial growth in liquid and powder foundations.
Diazolidinyl urea ensures eye makeup remains safe and free from bacteria.
Diazolidinyl urea preserves the product's integrity and safety.
Maintains the safety and effectiveness of body moisturizers.
Keeps these products free from contamination.
Diazolidinyl urea prevents microbial growth in products that are applied to sensitive areas.
Diazolidinyl urea ensures these products remain effective and free from contamination.
In the pharmaceutical industry, Diazolidinyl urea is used in topical formulations to prevent microbial contamination, which is crucial for patient safety.
Diazolidinyl urea keeps ointments free from additional bacterial contamination.
Maintains the integrity and safety of creams used for treating inflammation.
Ensures lotions for skin conditions remain uncontaminated.
Diazolidinyl urea is used in various household cleaning and maintenance products.
Prevents the growth of bacteria and mold in multi-surface cleaners.
Diazolidinyl urea ensures products used in high-moisture environments remain effective.
Diazolidinyl urea maintains the efficacy of liquid detergents over time.
Preserves the integrity and effectiveness of dishwashing soaps.
In industrial settings, Diazolidinyl urea helps maintain the quality of products that are prone to microbial contamination.
Safety profile Of Diazolidinyl urea:
Diazolidinyl Urea has considerable risks involved in the form of skin sensitivities like irritation and redness, especially when used in concentrations higher than 0.5%.
Due to its formaldehyde-releasing nature, it can exacerbate symptoms in those sensitive to formaldehyde.
Individuals with existing skin conditions or compromised skin barriers may be more susceptible to these side effects.
Patch testing before use is mandated.
The Cosmetic Ingredient Review Expert Panel evaluated the safety of diazolidinyl urea and found that the ingredient is safe for current uses and concentrations, and it has low eye irritation potential.
However, it has not been found to be sensitive to the skin or produce phototoxic effects.
Diazolidinyl urea’s use is restricted to maximum concentrations of 0.5%.
This limit in concentration is mostly due to mild irritation that can occur on the skin in concentrations greater that this maximum.
Some people have a contact allergy to Diazolidinyl urea causing dermatitis.
Such people are often also allergic to diazolidinyl urea.
In addition to being an allergen, it is a formaldehyde releaser, since it generates formaldehyde slowly as it degrades.
Although the formaldehyde acts as a bactericidal preservative, it is a known carcinogen.
In 2005–06, Diazolidinyl urea was the 14th-most-prevalent allergen in patch tests (3.7%).
