PRODUCTS

DIETHYL SUCCINATE

DIETHYL SUCCINATE
(Diethyl butanedioate=Butanedioic acid)

IUPAC Name: 1,4-diethyl butanedioate
CAS Number: 123-25-1
EC Number: 204-612-0
MDL Number: MFCD00009208
Chemical formula: C8H14O4
Molecular Formula: C8H14O4 or CH3CH2OCO(CH2)2COOCH2CH3
SMILES string: CCOC(=O)CCC(=O)OCC
InChI Identifier: 1S/C8H14O4/c1-3-11-7(9)5-6-8(10)12-4-2/h3-6H2,1-2H3
InChI Key: DKMROQRQHGEIOW-UHFFFAOYSA-N
FDA UNII: ELP55C13DR

Diethyl succinate (DES) is a diethyl ester with succinate molecules.
Diethyl succinate has two ester groups and is majorly used in fragrances.
Diethyl succinate belongs to the class of organic compounds known as fatty acid esters.
The character of Diethyl succinate is very mild, predominantly fruity, with hints of leaf green and cooked apples.
Because diethyl succinate is a diester, it has a relatively high molecular weight for a chemical with such a light, fruity aroma character.

Diethyl succinate is also relatively polar for a flavor chemical with such a high molecular weight.
Succinic Acid (Butanedioic Acid) is a dicarboxylic acid of four carbon atoms.
Diethyl succinate plays a significant role in intermediary metabolism (Krebs cycle) in the body.
Succinic acid is a colourless crystalline solid with a melting point of 185 -187 C soluble in water slightly dissolved in ethanol, ether, acetone and glycerine not dissolved in benzene, carbon sulfide, carbon tetrachloride and oil ether.
Diethyl succinate is a Stobbe condensation ester reagent.

Diethyl succinate is the diethyl ester of succinate.
Diethyl succinate is a colorless liquid with the formula (CH2CO2Et)2
The organic molecule Diethyl succinate contains two ester groups.
Diethyl succinate participates in acyloin condensation to give 2-hydroxycyclobutanone.

Via condensation with oxalate esters, Diethyl succinate serves as a precursor to ketoglutaric acid.
Diethyl succinate belongs to the class of organic compounds known as fatty acid esters which are carboxylic ester derivatives of a fatty acid.
Diethyl succinate is an aliphatic acyclic compound.
Diethyl succinateis a colourless mobile liquid with faint pleasant odour.

APPLICATIONS AND USES

Diethyl succinate can be used as a flavoring agent and food additive.
Diethyl succinate is used as in the cotton, fabric, floral, fruit, and wine industry.
Diethyl succinate is used as flavoring agent or adjuvant.
Diethyl succinate is used in cleaning products and household care as air freshener, laundry and fabric treatment as fabric protectant.

Diethyl succinate is used as emollient
Diethyl succinate and 1-octanol can be blended with B5 palm oil biodiesel to improve the oxygen content and achieve a greener emission of combustion gases.
Diethyl succinate may also be used as a novel and highly efficient solvent to capture carbon dioxide(CO2) which can be potentially used as a technique to reduce carbon emission.
Diethyl succinate’s applications are fragrance, plasticisers ,skin conditioning, emollient and
solvents.

Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle.
Diethyl succinate is known to be non-toxic and used in fragrances and flavoring.
Diethyl succinate is useful primarily because it subtly deepens and rounds out taste effects.
Diethyl succinate also is useful in applications involving heat because it is much more heat stable than most ingredients with a similar odor profile.
Diethyl succinate surves as an analytical reagent.

Diethyl succinate is valuable as a solvent and as an intermediate feedstock.
Diethyl Succinate Modulates Microglial Polarization and Activation by Reducing Mitochondrial Fission and Cellular ROS.
Diethyl succinate is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, frozen dairy, hard/soft candy, gelatins, and puddings.
Diethyl succinate have been used as ashless dispersants and detergent additives for lubricating oils.

Diethyl succinate is used commonly in fragrances and food flavorings.
Diethyl succinate (DES) is a new and highly efficient carbon dioxide (CO2) absorption solvent.
Diethyl succinate is used in the production of preservatives, emulsifiers and coatings.
Diethyl succinate can be used as solvent, catalyst, dye, medicine, surfactant intermediate.

PHYSICAL AND CHEMICAL PROPERTIES

Diethyl succinate is a colourless liquid with characteristic odour.
Diethyl succinate is a colourless mobile liquid with faint pleasant odour.
Diethyl succinate is soluble in alcohol, fixed oils, water 5547 mg/L @ 25 °C (est), water 1.91E+04 mg/L @ 25 °C.
Diethyl succinate has a faint, pleasant odor.
Aroma characteristics of diethyl succinate at 1.0%: fruity, waxy, floral and slightly musty.
Diethyl succinate is insoluble in paraffin oil

Molar mass: 174.196 g·mol−1
XLogP3: 1.2
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 7
Exact Mass: 174.08920892
Monoisotopic Mass: 174.08920892
Topological Polar Surface Area: 52.6 Å²
Heavy Atom Count: 12
Formal Charge: 0
Complexity: 135
Isotope Atom Count:0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Physical State: Liquid
Boiling Point: 217.00 - 218.00°C at 760.00 mmHg
Melting Point: -21°C
Flash Point: 90 °C
Specific Gravity: 1.04
Solubility: 19.1 mg/mL at 25 °C
Miscible in alcohol, ether, oils
Density: 1.04 g/cm³
Relative vapor density (air = 1): 6.01
Vapor Pressure: 0.04 mmHg, 0.133 kPa at 55 °C
Appearance: Colorless liquid
Solubility in water: Slightly soluble
Density: 1.047 g/mL
Melting point: −20 °C (−4 °F; 253 K)
Boiling point: 218 °C (424 °F; 491 K)
Magnetic susceptibility (χ): -105.07·10−6 cm3/mol
Std enthalpy of combustion : 24.22 kJ/g
Storage: Store below +30°C
Vapor density: 6 (vs air)
Refractive index: n20/D 1.42 (lit.)
Acid Value: 2.00 max. KOH/g
Odor Strength: low
Odor Description: apple; apricot; chocolate; cranberry; grape; musty; floral; fruity; peach; pear; waxy; wine-like; earthy.
Taste Description: fruity tart tropical floral passion fruit
pKa (Strongest Basic): -6.7
Refractivity: 42.57 m³·mol⁻¹
Polarizability: 18.38 Å³
Assay Percent Range: 97.5% min.

PRODUCTION

Diethyl succinate is a human metabolite
Diethyl succinate is formed by Fisher esterification of succinic acid and ethanol.
Diethyl succinate is produced by the esterification of succinic acid with ethanol.
Diethyl succinate is continuously produced from succinic acid and ethanol in a 6-m tall, elevated pressure reactive distillation column.
Esterification of diethyl succinate is carried out in excess ethanol such that water and ethanol are produced in the distillate and diethyl succinate is produced in the bottoms stream.

Diethyl succinate is produced by esterification of succinic acid with ethanol via reactive distillation.
Succinic acid complete conversion is achieved and >98.5% purity diethyl succinate is obtained as bottom product.
Diethyl succinate is obtained by the direct esterification of a carboxylic acid and an alcohol in the presence of concentrated H2SO4 in benzene solution.
Diethyl succinate occurs naturally in apple, raspberry, cognac, rum, whiskey, cider, sherry, plum brandy, apple brandy, grape brandy, cherry brandy, cocoa, arrack and red, white, port, strawberry and sparking wines.
Diethyl succinate occurs naturally in plant and animal tissues.
The common method of synthesis of succinic acid is the catalytic hydrogenation of maleic acid or its anhydride.

SYNONYMS

1,4-DIETHYL BUTANEDIOATE
123-25-1
2,2-diethylbutanedioate
204-612-0MFCD00009208
4-02-00-01914
52089-62-0
68989-32-2
ACMC-209aod
ACN-051076
AI3-00682
AKOS000269055
BRN 0907645
butanedioic acid diethyl ester
Butanedioic acid, 1,4-diethyl ester
Butanedioic acid, di-C8-26-alkyl esters
CAS-123-25-1
CHEBI:169507
CHEMBL369243
Clorius
DIETHYLSUCCINATE
diethyl butane-1,4-dioate
Diethyl butanedioate
Diethyl butanoate
Diethyl ester of butanedioic acid
Diethyl ethanedicarboxylate
diethyl succinate 99%
Diethyl succinate-2,2,3,3-d4
Diethyl Succinate-d4
Diethyl succinate, >=99%, FCC, FG
Diethyl succinate, 98%
diethyl succinate, 99%
Diethylester kyseliny jantarove
Diethylsuccinate
DS-7133
DSSTox_CID_18732
DSSTox_GSID_38732
DSSTox_RID_79389
DTXSID2038732
DTXSID601022558
EINECS 204-612-0
ELP55C13DR
EN300-18004
Ethyl succinate
F0001-0363
FEMA No. 2377
FT-0653029
HY-Y0836
MCULE-1960920420
MFCD00009208
NCGC00247986-01
NSC8875
Q-100106
Q1978959
s6209
SBB040923
SCHEMBL22780
ST5214529
STL194305
Succinic acid, diethyl ester
SY011286
Tox21_300286
UNII-ELP55C13DR
WLN: 2OV2VO2
Z57127474
ZINC1648294