DIETHYLTOLUAMIDE

Diethyltoluamide provides dependable protection against a broad range of biting insects and arthropods in outdoor and travel applications.
Diethyltoluamide's liquid form and compatibility with many formulation ingredients make it suitable for diverse personal-care and repellent products.
Diethyltoluamide remains one of the most established active ingredients for achieving consistent and extended insect-repellent performance.

CAS Number: 134-62-3
EC Number: 205-149-7
Molecular Formula: C12H17NO
Molecular Weight: 191.27 g/mol

Synonyms: Diethyltoluamide, DEET, 134-62-3, N,N-Diethyl-3-methylbenzamide, N,N-Diethyl-m-toluamide, Diethyl toluamide, Metadelphene, Dieltamid, Flypel, Delphene, Detamide, Autan, 3-Methyl-N,N-diethylbenzamide, m-Delphene, Benzamide, N,N-diethyl-3-methyl-, Repudin-Special, M-Det, Naugatuck DET, m-DETA, Repel, Repper DET, Repper-DET, Dietiltoluamida, Diethyl-m-toluamide, Diethyltoluamidum, m-Toluic acid diethylamide, Amincene C-EM, N,N-Diethyl-meta-toluamide, Mgk diethyltoluamide, Amincene C 140, m-Toluamide, N,N-diethyl-, Bepper DET, DET (insect repellant), ENT 22542, NSC 33840, Caswell No. 346, Oristar deet, ENT 20,218, FB0C1XZV4Y, AI 3-22542, ENT-20218, ENT-22542, NSC-33840, N,n-diethyl 3-methyl benzamide, Deet n,n-diethyl-meta-toluamide, CHEBI:7071, N,N Diethyltoluamide, RefChem:5751, MOSQUITO BUG OFF, N,N Diethyl m toluamide, DEET-DI ETHYL TOLUAMIDE, N,N Diethyl 3 methylbenzamide, P03BX01, DTXSID001014729, INSECT REPELLENT INSECT BLOCK, R209, R 209, 205-149-7, N,N-Diethyltoluamide, Muscol, N,N-diethyl-3-methyl-benzamide, DETA-20, DTXSID2021995, Off, MFCD00009046, DEET;N,N-Diethyl-m-toluamide, NCGC00091219-02, A.I. 3-22542, DTXCID601995, CAS-134-62-3, SMR000777931, Diethyltoluamidum [INN-Latin], Dietiltoluamida [INN-Spanish], CCRIS 6018, N,N-Diethyl-m-toluamide, analytical standard, HSDB 1582, EINECS 205-149-7, UNII-FB0C1XZV4Y, EPA Pesticide Chemical Code 080301, BRN 2046711, Diethyltoluamide [USP:INN:BAN], DE3, Off!, Spectrum_001989, 3n7h, (N,N-diethyltoluamide), m-Toluamide,N-diethyl-, n,n-diethyl m-toluamide, DEET (Diethyltoluamide), Spectrum2_001072, Spectrum4_000439, Spectrum5_002076, N,N-Diethyl-meta-toluamide and other isomers, DEET, analytical standard, DEET [MI], Diethyltoluamide (USP/INN), SCHEMBL29976, KBioGR_000798, KBioSS_002555, MLS001333179, MLS001333180, MLS002207091, MLS002415750, DIETHYLTOLUAMIDE [INN], DivK1c_000157, SPECTRUM1601020, SPBio_001084, Benzamide,N-diethyl-3-methyl-, DEET,N,N-Diethyl-m-toluamide, DIETHYLTOLUAMIDE [HSDB], orb1226493, orb1310340, SCHEMBL1531067, SCHEMBL8541272, CHEMBL1453317, DIETHYLTOLUAMIDE [MART.], SCHEMBL29374310, DEET 10 microg/mL in Methanol, HMS500H19, KBio1_000157, KBio2_002546, KBio2_005114, KBio2_007682, DIETHYLTOLUAMIDE [USP-RS], DIETHYLTOLUAMIDE [WHO-DD], DIETHYLTOLUAMIDE [WHO-IP], NINDS_000157, WLN: 2N2 & VR C1, DEET 100 microg/mL in Methanol, HMS2094E11, HMS2231H11, HMS3372F07, HMS5083J05, Pharmakon1600-01601020, HY-B0978, MSK20422, NSC33840, Tox21_111103, Tox21_201980, Tox21_300917, EBC-03516, NSC759564, s4521, AKOS003852835, N,N-Diethyl-3-methylbenzamide(DEET), N,N-Diethyl-3-methylbenzamide, 97%, N,N-Diethyl-3-methylbenzamide, DEET, Tox21_111103_1, CCG-213639, CS-4468, DB11282, FD36510, N,N-diethyl(3-methylphenyl)carboxamide, NSC-759564, DIETHYLTOLUAMIDE [USP MONOGRAPH], DIETHYLTOLUAMIDUM [WHO-IP LATIN], IDI1_000157, NCGC00091219-01, NCGC00091219-03, NCGC00091219-04, NCGC00091219-05, NCGC00091219-06, NCGC00091219-08, NCGC00254820-01, NCGC00259529-01, AC-11315, DEET, PESTANAL(R), analytical standard, DS-13831, SY048762, SBI-0051886.P002, DB-042245, D0097, NS00000221, ST50406384, T0731, EN300-15589, D02379, AB00052406_06, DEET N,N-DIETHYL-META-TOLUAMIDE [VANDF], F236702, Q408389, SR-05000001887, SR-05000001887-1, BRD-K94080537-001-05-5, BRD-K94080537-001-09-7, Z31723661, Diethyltoluamide, United States Pharmacopeia (USP) Reference Standard

Diethyltoluamide is an active seller in many repellent products.
Diethyltoluamides are commonly used to repel biting pests such as ticks.
Diethyltoluamide is effective against flies, biting gnats (gnats, gnats, deer flies, wasps, black flies), ticks, harvest mites, and fleas.

Diethyltoluamide is an organic compound widely used as an active ingredient in insect-repellent formulations.
Diethyltoluamide is generally supplied as a colorless to pale yellow oily liquid with a mild characteristic odor and good compatibility with many cosmetic and topical formulation systems.

Diethyltoluamide is highly effective at repelling mosquitoes, ticks, biting flies, fleas, and several other arthropods.
Diethyltoluamide works mainly by interfering with the sensory mechanisms insects use to locate humans and animals.

Diethyltoluamide is commonly incorporated into sprays, lotions, creams, aerosols, wipes, and other personal insect-repellent products.
Diethyltoluamide's concentration in formulations varies according to the required duration of protection, intended application, and applicable regulatory requirements.

Diethyltoluamide is the primary active ingredient in insect and arthropod repellent formulations.
Diethyltoluamide is considered the reference standard in products providing protection against mosquitoes, ticks, and other vector insects.

Diethyltoluamide is the primary active ingredient in repellent products in spray, lotion, cream, and impregnated wipe forms for both consumer and professional segments; concentration directly determines the duration of protection and the target user profile.
Diethyltoluamide is a standard active ingredient in formulations used in protection programs against vector-borne diseases such as malaria, dengue fever, and Lyme disease.

High-concentration formulations are preferred in professional repellent products requiring long-term protection in military and field conditions.
Diethyltoluamide is also used in combined protection protocols as a complement to permethrin-based systems applied to clothing and equipment.
Diethyltoluamide is supplied in liquid form; purity typically ranges from 95% to 99%.

Diethyltoluamide is a widely used insecticide.
Diethyltoluamide is sprayed on skin or clothing to prevent insect bites.

Diethyltoluamide also contains human sweat and breath and works by blocking 1-octen-3-ol, which blocks insect olfactory receptors.
The more popular theory is that Diethyltoluamide causes insects to effectively lose their special sense of smell toward humans or animals.

Contrary to what people initially assumed, Diethyltoluamide did not affect the insect's ability to smell carbon dioxide.
Diethyltoluamide is a colorless or light yellow liquid at room temperature.

Diethyltoluamide can be made from diethyl and methyl benzoic acid.
Diethyltoluamide can also be made from acid chloride and ethylamine.
Therefore, the ability of mosquitoes to find targets with their special sense of smell can be largely eliminated, but not completely.

Diethyltoluamide is a chemical (N,N-diethyl-meta-toluamide) used as the active ingredient in many insect repellent products.
Diethyltoluamide was developed by the U.S. Army in 1946 and was registered for use by the general public in 1957.

Diethyltoluamide is now widely used, with approx. 30% of the U.S. population using it repellents each year.
Diethyltoluamide products are currently available in a variety of forms: liquids, lotions, sprays, and even impregnated materials, such as wristbands.

Diethyltoluamide appears as clear colorless or faintly yellow slightly viscous liquid.
Diethyltoluamide is a monocarboxylic acid amide resulting from the formal condensation of the carboxy group of m-toluic acid with the nitrogen of diethylamine.

First developed by the U.S. Army in 1946 for use by military personnel in insect-infested areas, Diethyltoluamide is the most widely used insect repellent worldwide.
Diethyltoluamide has a role as a xenobiotic, an insect repellent and an environmental contaminant.

Diethyltoluamide is a member of benzamides and a monocarboxylic acid amide.
Diethyltoluamide is functionally related to a m-toluic acid.

Uses of Diethyltoluamide:
Diethyltoluamide is used in the production of mosquito repellent sprays, gels, and other devices.
Diethyltoluamide is primarily used in the production of various liquids, lotions, sprays, and towels that repel pests, ticks, and insects.
Diethyltoluamide is used in insect repellants in concentrations ranging from 4% to 100%.

Diethyltoluamide is primarily used as an active ingredient in personal insect-repellent formulations.
Diethyltoluamide is widely applied in sprays, lotions, creams, aerosols, wipes, and roll-on products.

Diethyltoluamide helps repel mosquitoes, ticks, biting flies, fleas, and other nuisance arthropods.
Diethyltoluamide is used in outdoor, travel, camping, military, and occupational protection products.

Diethyltoluamide may be incorporated into formulations designed for use on exposed skin or clothing according to applicable regulations.
Diethyltoluamide's concentration can be adjusted to provide different durations and levels of insect-repellent protection.

Production of Diethyltoluamide:
Diethyltoluamide is produced by two consecutive reactions.

The reactions are as follows:
M-toluic acid reacts with thionyl chloride to form m-toluic acid chloride,
M-toluic acid chloride reacts with diethyl amine in the presence of a base to form N,N-diethyl-m-toluamide.

Stability and Reactivity of Diethyltoluamide:

Chemical Stability:
Stable under recommended storage and handling conditions.

Reactivity:
May react with strong oxidizing agents and other incompatible substances.

Conditions to Avoid:
Excessive heat, flames, sparks, ignition sources, and prolonged exposure to incompatible materials.

Incompatible Materials:
Strong oxidizing agents, strong acids, and strong bases.

Handling and Storage of Diethyltoluamide:

Safe Handling:
Avoid contact with eyes and prolonged skin exposure and prevent unnecessary vapor or mist formation.

Storage Conditions:
Store tightly closed in a cool, dry, well-ventilated place away from heat, ignition sources, and incompatible materials.

First Aid Measures of Diethyltoluamide:

Inhalation:
Move the affected person to fresh air and seek medical attention if symptoms persist.

Skin Contact:
Wash thoroughly with soap and water and remove contaminated clothing.

Eye Contact:
Rinse cautiously with plenty of water for several minutes and obtain medical attention if irritation continues.

Ingestion:
Rinse mouth and seek medical advice if a significant amount has been swallowed.

Firefighting Measures of Diethyltoluamide:

Suitable Extinguishing Media:
Use foam, dry chemical, carbon dioxide, or water spray as appropriate.

Specific Hazards:
Combustion may produce carbon oxides, nitrogen oxides, and irritating fumes.

Protective Equipment:
Firefighters should wear suitable protective clothing and self-contained breathing apparatus.

Accidental Release Measures of Diethyltoluamide:

Personal Precautions:
Avoid direct contact, ensure adequate ventilation, and eliminate ignition sources.

Cleanup Methods:
Absorb with inert material such as sand, earth, or vermiculite and transfer to a suitable waste container.

Environmental Precautions:
Prevent large quantities from entering drains, soil, or surface waters.

Exposure Controls/Personal Protection of Diethyltoluamide:

Engineering Controls:
Provide adequate general or local exhaust ventilation.

Eye Protection:
Wear chemical safety goggles.

Hand Protection:
Wear suitable chemical-resistant gloves.

Skin Protection:
Wear appropriate protective clothing.

Respiratory Protection:
Use suitable respiratory protection where ventilation is inadequate or significant vapor or mist exposure may occur.

Identifiers of Diethyltoluamide:
Chemical Name: DEET
Chemical Formula: C₁₂H₁₇NO
Molecular Weight: 191.27 g/mol
Density: 0.985 g/cm3
Freezing Point: -45 °C
Boiling Point: 292 °C
Flash Point: 155 °C
Solubility: Insoluble in water and glycerol. Soluble in ethanol.
Appearance: Colorless or light yellow liquid
Cas Number: 134-62-3

CAS Number: 134-62-3
EC Number: 205-149-7
Molecular Formula: C12H17NO
Molecular Weight: 191.27 g/mol
IUPAC Name: N,N-Diethyl-3-methylbenzamide
Chemical Family: Aromatic amide

Properties of Diethyltoluamide:
Melting Point -45 °C
Boiling Point 160 °C @ Press: 19 Torr
Density 0.996 g/cm³ @ Temp: 20 °C
Flash Point >230 °F
Appearance Colorless to amber liquid
Color Clear
Odor Mild, neutral odor
Water Solubility Not apparent
Vapor Pressure <0.01 mm Hg (25 °C)
Refractive Index n 20/D 1.523 (lit.)

Appearance: Colorless to pale yellow oily liquid
Odor: Mild characteristic odor
Physical Form: Liquid
Molecular Weight: 191.27 g/mol
Solubility: Slightly soluble in water; soluble in alcohols and many organic solvents
Density: approx. 0.99–1.00 g/cm³
Melting Point: approx. -45°C
Boiling Point: approx. 288–292°C
Flash Point: approx. 150–160°C
Vapor Pressure: Low at room temperature
Refractive Index: approx. 1.52

Molecular Weight: 191.27 g/mol
XLogP3: 2
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 3
Exact Mass: 191.131014166 Da
Monoisotopic Mass: 191.131014166 Da
Topological Polar Surface Area: 20.3 Ų
Heavy Atom Count: 14
Complexity: 187
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes