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CAS NUMBER: 127-19-5
EC NUMBER: 204-826-4
MOLECULAR FORMULA: CH3CON(CH3)2
MOLECULAR WEIGHT: 87.12
Dimethylacetamide is the organic compound with the formula CH3C(O)N(CH3)2.
This colorless, water-miscible, high-boiling liquid is commonly used as a polar solvent in organic synthesis.
Dimethylacetamide is miscible with most other solvents, although it is poorly soluble in aliphatic hydrocarbons.
Dimethylacetamide is widely used to compose the solvent mixtures for cellulose.
Dimethylacetamide is a member of the class of acetamides that is acetamide in which the hydrogens attached to the N atom have been replaced by two methyl groups respectively.
Dimethylacetamide has a role as a human metabolite.
Dimethylacetamide is a member of acetamides and a monocarboxylic acid amide.
Dimethylacetamide derives from an acetamide.
Dimethylacetamide appears as a clear colorless liquid with a faint odor similar to ammonia.
About the same density as water.
Flash point 145°F.
Vapors heavier than air.
Dimethylacetamide is a colorless, high boiling, polar, hygroscopic liquid.
Dimethylacetamide is a good solvent for a wide range of organic and inorganic compounds and it is miscible with water, ethers, esters, ketones and aromatics compounds.
Dimethylacetamide is used in the production of polyacrylonitrile and polyurethane based fibers, films and coatings.
The polar nature of Dimethylacetamide enables it to act as a combined solvent and reaction catalyst in many reactions producing high yields and pure product in short time periods.
Dimethylacetamide is a dipolar aprotic solvent used for many organic reactions and industrial applications.
Dimethylacetamide is a versatile solvent due to its high boiling point and good thermal and chemical stability.
Dimethylacetamide is a synthetic organic compound that is produced from a reaction of dimethylamine and acetic acid or acetic anhydride.
Dimethylacetamide is a colorless to yellow liquid with a faint odor resembling ammonia.
Dimethylacetamide has similar density to water and is miscible with water and organic substances.
Dimethylacetamide is commonly associated with many industrial uses, either as a starting material or an intermediate.
Dimethylacetamide is a good solvent that is used in polymer dissolution, especially in the fiber industry.
Dimethylacetamide is a colorless, polar solvent.
Dimethylacetamide is a colorless, water-miscible solvent used in the synthesis of vinyl resins, styrenes, and linear polyesters.
Dimethylacetamide is a combustible, organic compound that is miscible with most solvents.
Dimethylacetamide is a polar Lewis basic solvent used in organic synthesis, pharmaceutical and plasticizer production, gel permeation chromatography of cellulose, etc.
Dimethylacetamide is an organic compound that has been utilized as a non-polar solvent.
Dimethylacetamide is a useful as a medium for strong bases such as sodium hydroxide.
Dimethylacetamide is commonly used as a solvent for fibers or in the adhesive industry.
Dimethylacetamide is also employed in the production of pharmaceuticals and plasticizers as a reaction medium.
Dimethylacetamide is a highly polar aprotic solvent, micro ammonia odor, very strong dissolving power, soluble wide, miscible with water, aromatics, esters, ketones, alcohols, ether, benzene and chloroform and other arbitrary and enable activation of molecular compounds.
Dimethylacetamide is widely used as a solvent and a catalyst.
The solvent, with high boiling point, flash point, thermal stability and chemical stability of the solvent, is used for polyacrylonitrile spinning solvent, synthetic resin and natural resins, formic acid vinyl ester resin, vinyl pyridine copolymer and aromatic carboxylic acid.
The catalyst can be used in the process of urea heating to produce the reaction of cyanide, sodium halide and metal cyanide to produce the reaction of alkyl acetylene, organic halide and isocyanate.
Dimethylacetamide also can be used as electrolytic solvent and photography with coupler solvent, de paint agent, organic synthesis of raw materials, pesticide and pharmaceutical raw materials.
Separation of styrene from C8 fraction, extraction, distillation, solvent, etc.
USES OF DIMETHYLACETAMIDE:
However, Dimethylacetamide is resistant to bases.
For this reason Dimethylacetamide is useful solvent for reactions involving strong bases such as sodium hydroxide.
Dimethylacetamide is commonly used as a solvent for fibers (e.g., polyacrylonitrile, spandex) or in the adhesive industry.
Dimethylacetamide is also employed in the production of pharmaceuticals and plasticizers as a reaction medium.
A solution of lithium chloride in Dimethylacetamide can dissolve cellulose.
Unlike many other cellulose solvents, Dimethylacetamide gives a molecular dispersion, i.e. a "true solution". For this reason, it is used in gel permeation chromatography to determine the molar mass distribution of cellulose samples.
Dimethylacetamide is also used as an excipient in drugs, e.g. in Vumon (teniposide), Busulfex (busulfan) or Amsidine.
Dimethylacetamide has been employed as an organic solvent for the liquid-phase exfoliation of pristine graphene from bulk graphite.
Dimethylacetamide may be used to compose the solvent system along with lithium chloride for the dissolution of commercial rayon grade cellulose.
Dimethylacetamide solvent mixtures have been used for the preparation of chitin, cellulose and polyimide fibers and films.
Dimethylacetamide may be used in the preparation of α-lithio Dimethylacetamide.
Dimethylacetamide along with palladium chloride forms an efficient catalytic system for the oxidation of several internal olefins to carbonyl compounds without undergoing isomerization.
Dimethylacetamide is mainly used as synthetic fibers (acrylonitrile) and polyurethane spinning synthetic polyamide resin and a solvent, but also it is used for separating styrene from the C8 fraction extractive distillation solvent, and it is widely used in the aspects of polymer films, coatings and medicine.
Currently Dimethylacetamide is used to synthesize a large number of antibiotics and pesticides in the pharmaceutical and pesticide.
The catalyst can also be used for the reaction, electrolytic solvent, paint scavengers and various crystalline solvent adducts and complexes.
Used as the reaction solvent of pharmaceutical synthesis, synthetic fiber spinning solvents and synthetic resins, photographic chemicals chromogenic agent solvents, paints and other solvents, catalyst.
-Acrylic fibres:
Dimethylacetamide is applied as solvent in wet spinning processes for the production of acrylic fibres.
-Elasthane fibres:
In the production of polyurethane-based elasthane fibres, Dimethylacetamide is the solvent of choice given its evaporation speed, whether it is used in wet or dry spinning processes.
-Pharmaceuticals:
Dimethylacetamide can be used both as a solvent and as a reagent in the production of various pharmaceuticals.
In the production of novel x-ray contrast media, Dimethylacetamide is used as a solvent.
Dimethylacetamide, which are among one of the leading classes of antibiotics, are partly produced from derivatives of 7-ADCA (7-aminodeacetoxy-cephalosporanic acid).
Dimethylacetamide is used in the manufacturing process.
-Various polymers:
Dimethylacetamide is a good solvent for polyimide resins, both in coating and film production.
Dimethylacetamide is also the ideal solvent for the production of dialyser membranes, based on polysulfones.
A mixture of Dimethylacetamide and lithium chloride is a useful solvent for cellulose fibres in several applications.
APPLICATIONS OF DIMETHYLACETAMIDE:
Dimethylacetamide is used as a polar solvent in organic synthesis as well as in reactions involving strong bases such as sodium hydroxide.
Dimethylacetamide is also used as a solvent for fibers like polyacrylonitrile, spandex, as an excipient in drugs viz. vumon, busulfex and in the adhesive industry.
Dimethylacetamide finds application as a reaction medium in the production of pharmaceuticals, agrochemicals, dyes and plasticizers.
Dimethylacetamide is widely used in polymer industry due to its high solving power for high molecular-weight polymers and synthetic resins.
Dimethylacetamide plays an important role as a catalyst in various reactions viz. cyclization, halogenation, cynidation, alkylation and dehydrogenation and increases the yield of main products.
Dimethylacetamide is also used as an extracting agent for oil and gases, in paint removers, in the production of photo-resist stripping compounds and as booster solvent in coatings.
Dimethylacetamide is primarily used as an industrial solvent and intermediate in the manufacture of pharmaceuticals, fine chemicals, agrochemicals, polymers, and resins.
Dimethylacetamide is also used as a spinning solvent in the production of fibers of various polymers, including acrylic, polyurethane, polyurea copolymer, and meta-aramid.
Moreover, this aprotic dipolar solvent is also used in X-ray and photographic products and in the production of polyimide films.
The polyimide films are produced for a variety of industries, including consumer electronics, solar photovoltaic and wind energy, aerospace, automotive, and industrial applications.
Dimethylacetamide has other minor uses, including removal of ink, stripping of paint, and also for laboratory use.
Dimethylacetamide is an important industrial solvent for polyacrylonitrile, vinyl resins, cellulose derivatives, styrene polymers and linear polyesters.
-Fibers
-HTF pharmaceutical processing
-Process solvents
-Plastic, resin, gum and solvents for electrolytes.
-Catalyst, paint remover, high purity solvent for crystallization and refining processes.
-Polymer solvent in production of acrylic fiber.
PROPERTIES OF DIMETHYLACETAMIDE:
-Quality Level: 100
-vapor density: 3 (vs air)
-vapor pressure: 2 mmHg ( 25 °C) 4 mmHg ( 38 °C)
-product line: ReagentPlus
-assay: ≥99%
-form: liquid
-autoignition temp.: 914 °F
-expl. lim.: 1.8 %, 100 °F 11.5 %, 160 °F
-refractive index: n20/D 1.437 (lit.)
-pH: 4 (20 °C, 200 g/L)
PHYSICAL AND CHEMICAL PROPERTIES OF DIMETHYLACETAMIDE:
-Boiling point: 165 - 166 °C (1013 hPa)
-Density: 0.94 g/cm3 (20 °C)
-Explosion limit: 1.7 - 11.5 %(V)
-Flash point: 64 °C
-Ignition temperature: 400 °C
-Melting Point: -20 °C
-pH value: 4 (200 g/l, H₂O, 20 °C)
-Vapor pressure: 2 hPa (21.7 °C)
-Solubility: >1000 g/l soluble
PRODUCTION OF DIMETHYLACETAMIDE:
Dimethylacetamide is prepared commercially by the reaction of dimethylamine with acetic anhydride or acetic acid.
The separation and purification of the product is carried out by multistage distillation in rectification columns.
Dimethylacetamide is obtained with essentially quantitive (99%) yield referred to methyl acetate.
Dimethylacetamide has been produced by the reaction of acetic acid with dimethylamine.
STORAGE OF DIMETHYLACETAMIDE:
Ventilation along the floor.
Separated from strong oxidants.
Dimethylacetamide should be stored in an airtight container, protected from light, in a cool, dry place.
Dimethylacetamide has an almost unlimited shelf-life when kept in closed containers and under nitrogen.
Dimethylacetamide is combustible.
SYNONYM:
127-19-5
Dimethylacetamide
Acetamide, N,N-dimethyl-
Dimethylacetamide
Acetdimethylamide
Dimethyl acetamide
N,N-Dimethyl acetamide
Dimethylamide acetate
N,N-Dimethylethanamide
Dimethylacetone amide
Acetic acid, dimethylamide
NSC 3138
N.N-Dimethylacetamide
MFCD00008686
Hallucinogen
CBC 510337
SK 7176
