PRODUCTS

DIMETHYLETHANOLAMINE/DMEA/DMAE

CAS Number:108-01-0

EC Number:203-542-8

DIMETHYETHANOLAMINE (Dimethylaminoethanol, DMAE, DMEA, Dimethyl ethanol amine) is an organic compound with the formula (CH₃) ₂NCH₂CH₂OH. It is bifunctional, involving both tertiary amine and high alcohol conductivity. It is a colorless viscous liquid. It is used in skin care products. It is prepared by the ethoxylation of dimethylamine.

SYNONYMS:

108-01-0; 1209235; 2- (Dimethylamino) -1-ethanol; 2- (Dimethylamino) ethanol; 2- (Dimethylamino) ethanol; 2- (Dimethylamino) ethanol; 203-542-8; 2-DIMETHYLAMINOETHANOL; 2-Dwumetyloaminoethanol; 2N6K9DRA24; 4-11-00-00122; Deanol; Dimethyl (2-hydroxyethyl) amine; Dimethyl (hydroxyethyl) amine; Dimethylaethanolamine; Dimethylaminoaethanol;DMAE; DMEA; Ethanol, 2- (dimethylamino) -KK6125000; MFCD00002846; N- (2-Hydroxyethyl) dimethylamine; N, N-Dimethyl-2-aminoethanol; N, N-Dimethyl-2-hydroxyethylamine; N, N-Dimethylethanolamine; N, N-Dimethyl-N- (2-hydroxyethyl) amine; N, N-Dimethyl-N- (-hydroxyethyl) amine; UNII-2N6K9DRA24; p-Dimethylaminoethyl alcohol; p-Hydroxyethyldimethylamine; (2-Hydroxyethyl) dimethylamine; (CH3) 2NCH2CH2OH; (Dimethylamino) ethanol; 116134-09-9 alternative RN; 2- (Dimethylamino) ethanol; 2- (dimethylamino) ethan-1-ol; 2- (Dimethylamino) -ethanol; 2- (N, N-Dimethylamino) ethanol; 2-Dimethylamino ethanol; 2-Dimethylamino-ethanol; Amietol M 21; Bimanol; Demanol, Dimethylaminoethanol; Dimethylethanoiamine; Dimethylethanolamine; Dimethylmonoethanolamine; Kalpur P; Liparon; N- (Dimethylamino) ethanol; N, N-Dimethylethanolamine; N, N-Dimethyl ethanolamine; N, N-Dimethyl (2-hydroxyethyl) amine; N, N-dimethylaminoethanol; N, N'-Dimethylethanolamine; N, N-Dimethyl-N- (-hydroxyethyl) amine; N, N-Dimethyl-N- (-hydroxyethyl) amine; N, N-Dimethyl-N-ethanolamine; N, N-Dimethyl-N-ethanolamine; N, N-Dimethyl-p-hydroxyethylamine; N, N-Dimethyl-p-hydroxyethylamine; N-Benzyloxycarbonyl-L-tyrosine; N-dimethyl aminoethanol; N-DimethylaminoethanolNorcholine; Propamine A; Q2N1 & 1; Texacat; DME; UN 2051; Varesal; - (dimethylamino) ethanol; β - (dimethylamino) ethyl alcohol; p-dimethylaminoethyl alcohol; p-hydroxyethyldimethylamine; -(Dimethylamino) ethanol; -(Dimethylamino) ethyl alcohol; p-Dimethylaminoethyl alcohol; p-Hydroxyethyldimethylamine; 391263_ALDRICH; 471453_ALDRICH; AI3-09209; BRN 1209235; CCRIS 4802; HSDB 1329; MFCD00035067; NCGC00159413-02; NSC 2652; NSC2652; PubChem Item ID 32975581; ST5214432; UN2051; UNII: 2N6K9DRA24

DIMETHYETHANOLAMINE (DMEA) Presentation:

Dimethylaminoethanol respectively (DMEA OR DMAE), also known as dimethylethanolamine, is an organic component produced industrially by the reaction of ethylene oxide with dimethylamine.

It contains both an amine group and a hydroxyl group and can therefore react as an amine or an alcohol.

It is a transparent, pale yellow liquid.

APPLICATIONS: Dimethylaminnoethanol is used as a catalyst, corrosion inhibitor, paint remover, boiler water, additive to amino resins and is used in cosmetic and biomedical products.

DMAE (DIMethylaminoethanol) is a compound known as a mental health compound. It does this by reducing its accumulation known as age pigment, which impairs cognitive function and is associated with cognitive decline with age. Also, memory can increase the levels of the acetylcholine-containing compound.

DMAE (DIMETHYLAMINOETHANOL) is also found in a variety of face and body creams and can tighten the skin and improve skin quality. Dimethylaminoethanol DMAE is a new ingredient originally used to treat hyperkinetic disorders and to improve memory. It is now used in cosmeceutical products and is gaining popularity from its activity as an acetylcholine precursor. Originally used as a firming and anti-aging product, new functions have now been clarified, including anti-inflammatory and antioxidant activities. In vitro, DMAE inhibits IL-2 and IL-6 secretion in addition to its effects as a free radical scavenger. Although the exact mechanism of action of DMAE is not clear, its acetylcholine-like functions increase the contraction and cell adhesion in the epidermis and dermis, resulting in a firmer skin appearance.Double-blind trials with 3% DMAE facial gel improve the firmness and muscle tone of the facial skin as evidenced by reduced neck sagging. showed that it increased. Topical formulations with a low irritation profile are now also available. There are several well-controlled studies documenting its long-term efficacy and toxicity. Discharge into the environment must be avoided.

To execute the full range of specific RMM and OC required to fulfill commitment under community environmental legislation.Adequately control the impact of MEA on the environment is given in the exposure scenarios, annexed to the SDS. The product is not intended for use in the home.

Health benefits: DMAE is supposed to increase the production of acetylcholine (a chemical that helps nerve cells transmit signals). Because acetylcholine plays an important role in many brain functions such as learning and memory, supporters claim that taking DMAE in supplement form can boost brain health by raising acetylcholine levels. Drugs that increase acetylcholine levels have been used to treat Alzheimer's disease, so some studies have looked at DMAE as a potential Alzheimer's treatment. However, they haven't shown any promising results so far.DMAE has been used in some way to treat attention deficit / hyperactivity disorder (ADHD), but there is only weak evidence behind this use. A 2011 study on nutritional treatments noted that it "probably had a minor effect." Additionally, DMAE has been studied to improve athletic performance, elevate mood, and address symptoms of depression.

Skin Care Products: DMAE cream, lotion and other skin care products are said to provide anti-aging benefits by reducing the appearance of wrinkles, dark under-eye circles and sagging neck skin. While research on the effectiveness of DMAE is very limited, there is some evidence that using DMAE-based products can help improve skin. For example, a review published in the American Journal of Clinical Dermatology states that DMAE can help increase skin firmness and reduce inflammation in the skin. In an analysis of previously published research, the authors of the review found that DMAE can help reduce fine wrinkles on the forehead and around the eyes and improve the overall appearance of aging skin. What's more, the authors of the review noted that DMAE did not cause common side effects such as redness, peeling, and dryness.

Cognitive Function: In a study published in the Journal of Alzheimer's Disease in 2012, 242 people (all diagnosed with early-stage Alzheimer's disease) took a placebo or an oral DMAE extract known as V0191 every day for 24 weeks. At the end of the study, there was no significant difference in cognitive function between the two groups. Studies noted that there may be a few issues in the study design, including a relatively short treatment duration, lack of valid measures to evaluate study participants, and problems with assessing changes in cognitive function over time, and there is no evidence that oral DMAE supplements can treat depression or improve sports performance.

Possible side effects: Little is known about the safety of DMAE supplements. However, there is some concern that DMAE may trigger certain side effects, including increased blood pressure, stomach upset, headache, muscle tension, lethargy, confusion, and irritability. DMAE should not be taken because of concern it might cause. Also, people with bipolar disorder or epilepsy should not use DMAE. You can find tips on using supplements here.

When used topically, DMAE may cause skin irritation.

Dosage and Preparation: There is insufficient scientific evidence to determine a safe or effective DMAE dosage.There have been doses used in scientific studies. For example, in a study examining the athletic performance benefits of DMAE, study participants took 300 to 2000 mg of Deanol per day.The safe and effective dose for you may depend on variables including your age, gender, and medical history. Talk to your healthcare provider for personalized advice. Avoid sources of ignition such as heat, sparks and open flames. No smoking. Keep container tightly closed. Use non-sparking tools. When reloading electrostatically sensitive items, ground and connect the container and receiver. Explosion proof electrical equipment, ventilation equipment, lighting equipment, etc. Use it. Take precautionary measures against electrostatic discharge. Wash hands thoroughly after use. Do not inhale mist, vapors or sprays.

Use only outdoors or in well ventilated areas. Wear suitable protective gloves and clothing. Use suitable protective glasses and protective surfaces. Keep dirty work clothes away from the work place. Avoid release to the environment. Discharge into the environment must be avoided.

To execute the full range of specific RMM and OC required to fulfill commitment under community environmental legislation.

Adequately control the impact of MEA on the environment is given in the exposure scenarios, annexed to the SDS. The product is not intended for use in the home.

First aid: If it adheres to skin or hair, remove or remove all contaminated clothing immediately. Rinse skin with running water or shower. If it gets on your skin, wash with plenty of water and soap. In case of fire, use appropriate fire extinguishing. Wash contaminated clothing before reuse. If inhaled, take victim to a place with fresh air and rest in a breathable position. contact.

In case of contact with eyes, rinse carefully with water for a few minutes. Then, if you wear contact lenses and can easily remove them, take them off. After that, continue to clean. If swallowed, rinse mouth. If skin adheres to skin, in eyes, swallows, or is pale, seek medical advice immediately. If skin adheres or skin irritation or rash occurs, seek medical attention and treatment. If you feel unwell, seek medical attention and treatment.

Storage: Keep container in a tightly closed and well-ventilated place. Store in a well-ventilated cool place. Lock and keep safe.

Disposal: Consign the contents and containers to a private waste disposal company licensed by the governorship.

Textile-Leather

The acid dyeing ability of polyacrylonitrile is improved by copolymerization of acrylonitrile with DMAE esters such as dimethylaminoethyl acrylate.

Cellulose modified with the homopolymer of dimethylaminoethyl methacrylate can be dyed with ester salts of a leuco vat dye.

Long chain alkyphosphates of DMAE form anti-static agents for non-cellulose hydrophobic textile materials.

Paints, Coating Inks

DMAE is perfect for neutralizing free acidity in water soluble coating resins.

The resin can be acrylic, alkyd or styrene-maleic.

In flexographic inks, DMAE can be used to dissolve resins and inoxes.

DMAE is generally preferred to triethylamine when lower volatility is required, such as in electrodeposition.

It also increases the wettability of the pigment.

Medicines and Pharmacy

DMAE is generally converted to dimethylaminoethylchloride HCl by chlorination.

Some of the befenium hydroxynaphthoate, brompheniramine, carboxamine, chloropyramine, chlorphenamine, chlorphenoxamine, dibenzepine, diltiazem, dimethindene, diphenhydramine, doxylamine, meclophenoxate, mepiramine, phenyloxylamine, mepiramine, phenyloxylamine can be synthesized.

Industrial Uses

As a precursor to other chemicals. nitrogen mustard 2-dimethylaminoethyl chloride. [3] acrylate ester is used as a flocculating agent.

Related compounds are used in gas purification, eg. removal of hydrogen sulfide from acidic gas streams.

Security Profile:

Moderately toxic by ingestion, inhalation, skin contact, intraperitoneal and subcutaneous routes.

Irritating to skin and eyes.

It is used medically as a central nervous system stimulant.

Flammable liquid when exposed to heat or flame; Reacts violently with oxidizing agents.

Cellulose with high surface area ignites spontaneously when it comes into contact with nitrate.

Use alcohol foam, foam, CO2, dry chemical to fight fire.

Emits toxic NOx fumes when heated to decomposition.

(DMAE): Applications

Use in the preparation of water reducing coating formulations.

Boiler water can be used to control corrosion in the condensation return lines.

Use in the preparation of textile assistants.

Use in the preparation of catalysts to polymerize olefin oxides and sulfides.

Use in the preparation of an antistatic agent for polystyrene.

Use in the preparation of ion exchange resins.

The drug is used as intermediates for the production of antihistamines and local anesthetics.

Storage and transportation: protect against physical damage. Store in a cool, dry, well-ventilated place. Clean carbon steel is satisfactory as a building material for storage tanks and transfer systems, adequate precautions must be observed to protect against rust contamination. Eliminate all ignition sources in case of leakage and leakage.

To execute the full range of specific RMM and OC required to fulfill commitment under community environmental legislation.

Adequately control the impact of MEA on the environment is given in the exposure scenarios, annexed to the SDS. The product is not intended for use in the home.

Storage: Keep container in a tightly closed and well-ventilated place. Store in a well-ventilated cool place. Lock and keep safe.

Disposal: Consign the contents and containers to a private waste disposal company licensed by the governorship.

APPLICATIONS
Alkanolamines have the combined physical and chemical characteristics of both alcohols and amines in one molecule, which makes them useful intermediates in the synthesis of various target molecules for the use in many diverse areas such as pharmaceutical, urethane catalysts, coatings, personal care, products, Water treatments, corrosion inhibitors, and gas treating industries. There are 1°, 2º or 3º nitrogen atom and one hydroxyl group at least in alkanolamines. Alkanolamines react with inorganic acids carboxylic acids to form salts, soaps, esters, or amides. Alkanolamines are used in both water- based and solvent-based coatings to enhance the solubility, reducibility, pigment dispersing and pH stability.

They are used in cathodic electrodeposition systems and as a catalyst for chain-extend. Alkanolamines are used to prepare surface-active soaps through reaction with fatty acids. Surface-active soaps are used commercially as a emulsifier, lubricants, detergents, pesticides and personal care products. Alkanolamines maintain a constant alkalinity in the boiling water flows and condensate not to form solid products which would impede line flow. This function is applied for corrosion Inhibits. Alkanolamines are widely employed in the preparation of water soluble cationic flocculants and ion exchange resins which adsorb solid and colloidal particles by electrostatic attraction. They are used for water treatment industry.

Alkanolamines and their derivatives are widely used as intermediates for the production of active pharmaceutical ingredients such as procaine, antihistamines analgesics from N,N-dimethylethanolamine or N-methyldiethanolamine. Alkanolamines are used to remove Hydrogen sulfide (H2S) and CO2 gas from gas streams in natural and refinery gas operations. Dimethylaminoethanol used for the synthesis of dyestuffs, textile auxiliaries, pharmaceuticals (such as procaine), and corrosion inhibitors. It is used as an antidepressant for water treatment. It is used as an emulsifier and as a catalyst of urethane foaming. N,N-dimethylethanolamine is used in making sulfurized oils for extreme-pressure lubricants and to lower down the pour point of lubricating oils. N,N-dimethylethanolamine is one of major raw materials to prepare water-soluble ion exchange resins and cationic polymeric flocculants.
Pharmaceutical grade of dimethylethanolamine, called Deanol, is used as an antidepressive or antidyskinesia agent to treat movement disorders. Dyskinesia is can be caused by long-term use of antipsychotic drugs or dopamine antagonists.

CHARACTERISTICS OF DIMETHYETHANOLAMINE

Chemical formula: C 4 H 11 N O

Molar mass: 89.138 gmol −1

Appearance: Colorless liquid

Smell Fishy: ammonia

Density: 890 mg mL −1

Melting point: -59.00 ° C; -74.20 ° F; 214.15 K

Boiling point: 134.1 ° C; 273.3 ° F; 407.2 K Daily P: −0.25

Vapor pressure: 816 Pa (at 20 ° C)

Acidity (p K a): 9.23 (at 20 ° C)

Basicity (p K b): 4.77 (at 20 ° C)

Refractive index (n D): 1.4294

DIMETHYETHANOLAMINE DANGER

GHS Signal word: Danger

GHS hazard statements: H226, H302, H312, H314, H332

GHS precautionary statements: P280, P305 + 351 + 338, P310

Flash point: 39 ° C (102 ° F; 312 K)

Explosive limits: 1.4--12.2%

Lethal dose or concentration (LD, LC): LD 50 (mean dose): 1.214 g kg-1 (dermal, rabbit) 2 g kg-1 (oral, rat)

IUPAC NAME:

2- Dimethylaminoethanol

2- (Dimethylamino) ethanol

2- (dimethylamino) -ethanol

2- (dimethylamino) ethan-1-ol

2- (Dimethylamino) ethanol

2- (dimethylamino) ethanol

2-Dimethylaminoethanol

2-dimethylaminoethanol

2-Dimethylaminoethanol

2-dimethylaminoethanol

TRADE NAMES:

(2-Hydroxyethyl) dimethylamine

(Dimethyla mino) e thanol

(N, N-Dimethylamino) ethanol

.beta .- (Dim

ethylamino) ethanol

.beta.-Dimethylaminoethyl alcohol

.beta.-Hydroxyethyldimethylamine

2- (Dimethylamino) -1-ethanol

2- (Dimethylamino) ethanol

2- (N, N-Dimethylamino) ethanol

2-Dimethylaminoethanol (DMAE)

Amietol M 21

Amietol M21

Bimanol

Deanol

Dimettol

Dimethyl (2-hydroxyethyl) amine

Dimethyl (hydroxyethyl) amine

Dimethylethanolamine

Dimethylmonoethanolamine

DMAE

DMEA

Ethanol, 2- (dimethylamino) - (8CI, 9CI)

Kalpur P

Liparon

N, N-Dimethyl (2-hydroxyethyl) amine

N, N-Dimethyl-p-hydroxyethylamine

N, N-Dimethyl-2-aminoethanol

N, N-Dimethyl-N - (. Beta.-hydroxyethyl) amine

N, N-Dimethyl-N- (2-hydroxyethyl) amine

N, N-Dimethylethanolamine

N- (2-Hydroxyethyl) dimethylamine

Norcolin

Propamine A

Texacat DME

Ethanol, 2- (dimethylamino) -

DIMETHYETHANOLAMINE PRODUCT INFORMATION

Substance Name: (DIMETHYLAMINO)

DIMETHYETHANOLAMINE Other names: deanol, dimethylaminoethanol, dimethylaminoethanol

DIMETHYETHANOLAMINE CAS No: 108-01-0

DIMETHYETHANOLAMINE Abbreviations: DMAE, DMEA

DIMETHYETHANOLAMINE Beilstein Reference: 1209235

ChEBI CHEBI: 271436

ChEMBL ChEMBL: 1135

ChemSpider: 13854944

ECHA Info Card: 100.003.221

EC Number: 203-542-8

KEGG: D07777

MeSH: Deanol

PubChem Client ID: 7902

RTECS number: KK6125000

UNII: 2N6K9DRA24

DIMETHYETHANOLAMINE UN number: 2051

CompTox Control Panel (EPA): DTXSID2020505