PRODUCTS

DIMETHYLFORMAMIDE (DMF)

Dimethylformamide (DMF) is unstable (especially at high temperatures) in the presence of a strong base such as sodium hydroxide or a strong acid such as hydrochloric acid or sulfuric acid, and is hydrolyzed to formic acid and dimethylamine.
Dimethylformamide (DMF) is the commonly employed solvent for chemical reactions.
Dimethylformamide (DMF) is a useful solvent employed for the isolation of chlorophyll from plant tissues.

CAS Number: 68-12-2
Molecular Formula: C3H7NO
Molecular Weight: 73.09
EINECS Number: 200-679-5

Synonyms: Dimethylformamide (DMF), Dimethylformamide, 68-12-2, Dimethyl formamide, N,N-Dimethylmethanamide, N-Formyldimethylamine, Formamide, N,N-dimethyl-, Dimethylformamid, DMF, DMFA, Dimetilformamide, Dwumetyloformamid, Formyldimethylamine, N,N-Dimethyl formamide, Dimetylformamidu, DMF (amide), Dimethylforamide, NCI-C60913, N,N Dimethylformamide, Dimethylamid kyseliny mravenci, Caswell No. 366A, dimethyl-Formamide, n,n,dimethylformamide, N,N-Dimetilformamida, HSDB 78, CCRIS 1638, DTXSID6020515, U-4224, NSC 5356, NSC-5356, Formic acid, amide, N,N-dimethyl-, EINECS 200-679-5, MFCD00003284, EPA Pesticide Chemical Code 366200, UNII-8696NH0Y2X, CHEBI:17741, AI3-03311, n,n-dimethyl-Formamide, NSC5356, N,N- Dimethylformamide, 8696NH0Y2X, N,N-Dimethylformaldehyde, DTXCID20515, EC 200-679-5, N,N-Dimethylformamid, DIMETHYLFORMAMIDE (MART.), DIMETHYLFORMAMIDE [MART.], Dimetylformamidu [Czech], Dimethylformamid [German], Dimethylformamide (DMF) (IARC), Dimethylformamide (DMF) [IARC], 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N-dimethylformaldehyde, bmse000709, D.M.F, HCON(CH3)2, Dynasolve 100 (Salt/Mix), BIDD , WLN: VHN1&1, CHEMBL268291, D.M.F., Dimethylformamide (DMF), 99.8%, Dimethylformamide (DMF), anhydrous, Dimethylformamide (DMF) HPLC grade, Dimethylformamide (DMF), ACS grade, Dimethylformamide (DMF) [MI], Dimethylformamide (DMF), HPLC Grade, Tox21_201259, Tox21_300039, Dimethylformamide (DMF) [HSDB], Dimethylformamide (DMF), biotech grade, s6192, STL264197, Dimethylformamide (DMF), LR, >=99%, AKOS000121096, FORMIN ACID,AMIDE,N,N-DIMETHYL, DB01844, Dimethylformamide (DMF) [USP-RS], Dimethylformamide (DMF) [WHO-DD], UN 2265, Dimethylformamide (DMF), p.a., 99.8%, USEPA/OPP Pesticide Code: 366200, Dimethylformamide (DMF), AR, >=99.5%, NCGC00090785-01, NCGC00090785-02, NCGC00090785-03, NCGC00090785-04, NCGC00090785-05, NCGC00254093-01, NCGC00258811-01, SY010600, Dimethylformamide (DMF), analytical standard, Dimethylformamide (DMF), anhydrous, 99.8%, 1ST000746-1000A, D0722, D0939, Dimethylformamide (DMF), 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Dimethylformamide (DMF) is used as solvent, catalyst and gas absorbent.
React violently with concentrated sulfuric acid, fuming nitric acid and can even explode.
Dimethylformamide (DMF) is widely employed reagent in organic synthesis.

Dimethylformamide (DMF) plays multiple roles in various reactions such as solvent, dehydrating agent, reducing agent as well as catalyst.
It is a multipurpose building block for the synthesis of compounds containing O, -CO, -NMe2, -CONMe2, -Me, -CHO as functional groups.
Dimethylformamide (DMF) is a polar solvent commonly used in organic synthesis.

Dimethylformamide (DMF) also acts as a multipurpose precursor for formylation, amination, aminocarbonylation, amidation and cyanation reactions.
Dimethylformamide (DMF) is an organic compound with the chemical formula HCON(CH3)2.
Its structure is HC(=O)−N(−CH3)2.

Commonly abbreviated as Dimethylformamide (DMF) (although this initialism is sometimes used for dimethylfuran, or dimethyl fumarate), this colourless liquid is miscible with water and the majority of organic liquids.
Dimethylformamide (DMF) is a common solvent for chemical reactions.
Dimethylformamide (DMF) is odorless, but technical-grade or degraded samples often have a fishy smell due to impurity of dimethylamine.

Dimethylformamide (DMF) degradation impurities can be removed by sparging samples with an inert gas such as argon or by sonicating the samples under reduced pressure.
As its name indicates, it is structurally related to formamide, having two methyl groups in the place of the two hydrogens.
Dimethylformamide (DMF) is a polar (hydrophilic) aprotic solvent with a high boiling point.

Dimethylformamide (DMF) facilitates reactions that follow polar mechanisms, such as SN2 reactions.
Dimethylformamide (DMF) is a member of the class of formamides that is formamide in which the amino hydrogens are replaced by methyl groups.
It has a role as a polar aprotic solvent, a hepatotoxic agent and a geroprotector.

Dimethylformamide (DMF) is a volatile organic compound and a member of formamides.
It is functionally related to a formamide.
Two processes are used commercially to produce Dimethylformamide (DMF).

In the direct or one-step process, Dimethylformamide (DMF) and carbon monoxide react at 100°C and 200 psia in the presence of a sodium methoxide catalyst to make dimethylformamide.
The homogenous catalyst is separated from the crude Dimethylformamide (DMF), which is then refined to the final product.
In the indirect process, methyl formate is isolated, and then reacted with dimethylamine to form Dimethylformamide (DMF).

To obtain methyl formate, two methods may be used - dehydrogenation of methanol and esterification of formic acid.
The two-step process for the synthesis of Dimethylformamide (DMF) differs from direct synthesis because methyl formate is prepared separately and introduced in the form of ca. 96% pure (commercialgrade) material.
Equimolar amounts of methyl formate and Dimethylformamide (DMF) are subjected to a continuous reaction at 60-100°C and 0.1 – 0.3 MPa.

The resulting product is a mixture of Dimethylformamide (DMF) and methanol.
The purification process involves distillation and is analogous to that described for direct synthesis.
However, no separation of salts is required because no catalysts are involved in the process.

According to the corrosive properties of both starting materials and products, stainless steel has to be used as material of construction for production facilities.
Industrial production of Dimethylformamide (DMF) is via three separate processes.
Dimethylformamide (DMF) in methanol is reacted with carbon monoxide in the presence of sodium methoxide or metal carbonyls at 110-150°C and high pressure.

Alternately, methyl formate is produced from carbon monoxide and methanol under high pressure at 60-100°C in the presence of sodium methoxide.
The resulting methyl formate is distilled and then reacted with Dimethylformamide (DMF) at 80-100°C and low pressure.
The third process involves reaction of carbon dioxide, hydrogen and Dimethylformamide (DMF) in the presence of halogen-containing transition metal compounds to yield DMF.

Dimethylformamide (DMF) is hydrolyzed by strong acids and bases, especially at elevated temperatures.
With sodium hydroxide, DMF converts to formate and dimethylamine.
Dimethylformamide (DMF) undergoes decarbonylation near its boiling point to give dimethylamine.

Distillation is therefore conducted under reduced pressure at lower temperatures.
In one of its main uses in organic synthesis, Dimethylformamide (DMF) is a reagent in the Vilsmeier–Haack reaction, which is used to formylate aromatic compounds.
The process involves initial conversion of DMF to a chloroiminium ion, [(CH3)2N=CH(Cl)]+, known as a Vilsmeier reagent, which attacks arenes.

Organolithium compounds and Grignard reagents react with DMF to give aldehydes after hydrolysis in a reaction called Bouveault aldehyde synthesis.
Dimethylformamide (DMF) is an organic compound with the chemical formula HCON(CH3)2.
Its structure is HC(=O)−N(−CH3)2. Commonly abbreviated as Dimethylformamide (DMF) (although this initialism is sometimes used for dimethylfuran, or dimethyl fumarate), this colourless liquid is miscible with water and the majority of organic liquids.

Dimethylformamide (DMF) is a common solvent for chemical reactions.
Dimethylformamide (DMF) is odorless, but technical-grade or degraded samples often have a fishy smell due to impurity of dimethylamine.
Dimethylformamide (DMF) degradation impurities can be removed by sparging samples with an inert gas such as argon or by sonicating the samples under reduced pressure.

As its name indicates, it is structurally related to formamide, having two methyl groups in the place of the two hydrogens.
Dimethylformamide (DMF) is a polar (hydrophilic) aprotic solvent with a high boiling point.
It facilitates reactions that follow polar mechanisms, such as SN2 reactions.

This compound belongs to the class of organic compounds known as tertiary carboxylic acid amides.
These are compounds containing an amide derivative of carboxylic acid, with the general structure RN(R1)C(R2)=O (R1-R2 any atom but H).
Dimethylformamide (DMF) is toxic and can cause skin, eye, and respiratory irritation. Long-term exposure can damage the liver and kidneys.

Although not highly flammable, DMF can ignite if exposed to a strong ignition source.
Dimethylformamide (DMF) should be handled in well-ventilated areas with appropriate protective gear, including gloves and goggles.
Dimethylformamide (DMF) is miscible with water and many organic solvents.

Dimethylformamide (DMF) is relatively stable but can degrade under acidic or basic conditions.
It can react with strong oxidizing agents and halogens.
Dimethylformamide (DMF) is a member of the amide family, with a formamide core where both hydrogen atoms are substituted with methyl groups.

Dimethylformamide (DMF) is a highly polar aprotic solvent, meaning it has a significant dipole moment but lacks acidic hydrogen atoms.
This property allows it to stabilize ions and dissolve ionic compounds, making it very useful in a variety of reactions where polar solvation is beneficial.
Due to the nitrogen atom in its structure, Dimethylformamide (DMF) can engage in hydrogen bonding with other compounds, enhancing its ability to dissolve both organic and inorganic materials.

Dimethylformamide (DMF) is often used in peptide synthesis because of its polar and aprotic nature, which aids in the coupling reactions necessary for creating peptide bonds.
Dimethylformamide (DMF) is essential in palladium-catalyzed cross-coupling reactions, which are common in the synthesis of complex organic molecules.
It stabilizes the reactive intermediates and solubilizes many organometallic reagents.

Dimethylformamide (DMF) is sometimes used in the manufacture of lithium batteries and other electronic components due to its ability to dissolve certain salts and conductive polymers.
In polymer processing, Dimethylformamide (DMF) acts as a carrier for dissolving resins, dyes, and other components used in paints, coatings, and adhesives, as it evaporates smoothly and evenly.
Dimethylformamide (DMF) serves as an intermediate and solvent in drug synthesis, where it is used in reactions that need to be free of water and other proton-donating solvents.

Its solvating properties make it suitable for creating fine chemical intermediates for drugs.
It is also employed in drug delivery research, particularly in developing pharmaceutical coatings and certain injectable formulations.
Inhalation or skin exposure can cause irritation to the respiratory tract, skin, and eyes. Long-term exposure to Dimethylformamide (DMF) can lead to central nervous system issues, liver damage, and kidney impairment.

Dimethylformamide (DMF) is not only toxic to humans but also harmful to aquatic life.
It is classified as a "priority pollutant" in certain countries due to its potential for environmental harm.
Dimethylformamide (DMF) is not easily biodegradable, so disposal requires careful methods to prevent contamination of water and soil.

Specialized industrial processes or high-temperature incineration are often used to degrade it safely.
Pure Dimethylformamide (DMF) is odorless, but industrial grade or modified Dimethylformamide has a fishy smell because it contains impurities of Dimethylamine.
Dimethylformamide (DMF) is used as a solvent for liquids,gases, and as a gasoline additive.

Dimethylformamide (DMF) is a colorless, organic solvent with the chemical formula C₃H₇NO.
Dimethylformamide (DMF) is commonly used in chemical research, industry, and laboratories because of its ability to dissolve both polar and nonpolar substances, making it a versatile solvent.
Dimethylformamide (DMF) is a flammable, colorlessliquid with a fishy, unpleasant, amine-like odor at relativelylow concentrations.

Dimethylformamide (DMF) haspowerful solvent properties for a wide range of organiccompounds.
Because of its physical properties, this chemical has been used when solvents with a slow rate of evaporation are required.
Dimethylformamide (DMF) finds particular usage in themanufacture of polyacrylic fibers, butadiene, purified acetylene, pharmaceuticals, dyes, petroleum products, and otherorganic chemicals.

Dimethylformamide (DMF) is a colorless or slightly yellow liquid with a boiling point of 153°C and a vapor pressure of 380 Pa at 20°C.
It is freely soluble in water and soluble in alcohols, acetone and benzene.

Melting point: -61 °C (lit.)
alpha: 0.94 º
Boiling point: 153 °C (lit.)
Density: 0.944 g/mL (lit.)
vapor density: 2.5 (vs air)
vapor pressure: 2.7 mm Hg ( 20 °C)
refractive index: n20/D 1.430(lit.)
Flash point: 136 °F
storage temp.: Store at +5°C to +30°C.
solubility: water: miscible
form: liquid
pka: -0.44±0.70(Predicted)
color: APHA: ≤15
Odor: Faint, ammonia-like odor detectable at 100 ppm
Relative polarity: 0.386
PH: 7 (200g/l, H2O, 20℃)
explosive limit 2.2-16%(V)
Odor Threshold: 1.8ppm
Water Solubility: soluble
Sensitive: Hygroscopic
λmax: λ: 270 nm Amax: 1.00
λ: 275 nm Amax: 0.30
λ: 295 nm Amax: 0.10
λ: 310 nm Amax: 0.05
λ: 340-400 nm Amax: 0.01
Merck: 14,3243
BRN: 605365
Exposure limits NIOSH REL: TWA 10 ppm (30 mg/m3), IDLH 500 ppm; OSHA PEL: TWA 10 ppm; ACGIH TLV: TWA 10 ppm (adopted).
Dielectric constant: 36.710000000000001
InChIKey: ZMXDDKWLCZADIW-UHFFFAOYSA-N
LogP: -1.010

Dimethylformamide (DMF) solvents are suitable for a broad spectrum of classical lab applications, and are frequently used in regulated and highly demanding lab applications.
Dimethylformamide (DMF) provides worldwide best and most extensive product specifications.
Due to its volatile nature and toxicity, Dimethylformamide (DMF) should be handled in a fume hood with proper ventilation.

Personal protective equipment (PPE) such as gloves, goggles, and lab coats are essential.
Regulatory agencies like OSHA and ACGIH set strict exposure limits for DMF due to its toxic effects, requiring that workplace exposure remains below these thresholds.
Dimethylformamide (DMF) should be stored in a cool, dry place, away from sources of ignition and incompatible materials, particularly strong oxidizing agents.

At elevated temperatures or in the presence of strong acids or bases, Dimethylformamide (DMF) can decompose, releasing dimethylamine and formaldehyde, which are also hazardous.
Dimethylformamide (DMF) can react with halides and certain alcohols to produce various derivatives used in organic synthesis, making it a versatile reagent.
Due to its toxicity, industries are increasingly exploring less toxic alternatives, such as dimethyl sulfoxide (DMSO) or acetonitrile, depending on the application.

Dimethylformamide (DMF) remains irreplaceable in certain reactions due to its unique balance of polarity and low reactivity.
Many countries regulate DMF usage, with disposal guidelines to prevent environmental contamination.
Efforts are ongoing to develop Dimethylformamide (DMF) alternatives or reduce its use through green chemistry principles, such as solvent recycling or using catalytic methods that minimize the need for high solvent volumes.

Dimethylformamide (DMF) is predominantly produced in a single-step reaction between dimethylamine and carbon monoxide under pressure at high temperatures and in the presence of basic catalysts such as sodium methoxide.
The crude product contains methanol and Dimethylformamide (DMF) with increased purity (up to 99.9%) is obtained by multiple distillations.
Alternatively, it can be produced by a two-step process in which methyl formate is prepared separately and, in a second step, reacts with dimethylamine under similar conditions as those described for the single-step reaction.

This is an organic solvent for vinyl resins and acetylene, butadiene, and acid gases.
Dimethylformamide (DMF) caused contact dermatitis in a technician at an epoxy resin factory and can provoke alcohol-induced flushing in exposed subjects.
Dimethylformamide (DMF) in natural seawater resulted in the compound mineralizing to carbon dioxide.

The rate of carbon dioxide formation was inversely proportional to the initial concentration.
Chemical. Reacts with acids or bases forming formic acid and dimethylamine
Dimethylformamide (DMF) clear, colorless to light yellow, hygroscopic, mobile liquid with a faint, characteristic, ammonialike odor.

Though stable at normal temperatures and storage conditions, Dimethylformamide (DMF) may react violently with halogens, acyl halides, strong oxidizers, and polyhalogenated compounds in the presence of iron.
Decomposition products include toxic gases and vapors such as Dimethylformamide (DMF) and carbon monoxide.
Dimethylformamide (DMF) will attack some forms of plastics, rubber, and coatings.

Dimethylformamide (DMF) may react violently with a broad range of chemicals, e.g.: alkaline metals (sodium, potassium), azides, hydrides (sodium borohydride, lithium aluminum hydride), bromine, chlorine, carbon tetrachloride, hexachlorocyclohexane, phosphorus pentaoxide, triethylaluminum, magnesium nitrate, organic nitrates.
Forms explosive mixtures with lithium azide.
Oxidation by chromium trioxide or potassium permanganate may lead to explosion
The acute toxicity of DMF is low by inhalation, ingestion, and skin contact.

Contact with liquid Dimethylformamide (DMF) may cause eye and skin irritation.
Dimethylformamide (DMF) is an excellent solvent for many toxic materials that are not ordinarily absorbed and can increase the hazard of these substances by skin contact.
Exposure to high concentrations of DMF may lead to liver damage and other systemic effects.

Dimethylformamide (DMF) is listed by IARC in Group 2B ("possible human carcinogen").
It is not classified as a "select carcinogen" according to the criteria of the OSHA Laboratory Standard.
Repeated exposure to Dimethylformamide (DMF) may result in damage to the liver, kidneys, and cardiovascular system

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids.
If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water.
Dimethylformamide (DMF) has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped.

When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting.
Dimethylformamide (DMF) should be used only in areas free of ignition sources, and quantities greater than 1 liter should be stored in tightly sealed metal containers in areas separate from oxidizers.

Uses:
Dimethylformamide (DMF) is used in the production of acrylic fibers and plastics.
It is also used as a solvent in peptide coupling for pharmaceuticals, in the development and production of pesticides, and in the manufacture of adhesives, synthetic leathers, fibers, films, and surface coatings.
Dimethylformamide (DMF) is used as a reagent in the Bouveault aldehyde synthesis and in the Vilsmeier-Haack reaction, another useful method of forming aldehydes.

Dimethylformamide (DMF) is a common solvent in the Heck reaction.
Dimethylformamide (DMF) is a common catalyst used in the synthesis of acyl halides, in particular the synthesis of acyl chlorides from carboxylic acids using oxalyl or thionyl chloride.
The catalytic mechanism entails reversible formation of an imidoyl chloride (also known as the 'Vilsmeier reagent').

Dimethylformamide (DMF) penetrates most plastics and makes them swell. Because of this property DMF is suitable for solid phase peptide synthesis and as a component of paint strippers.
Dimethylformamide (DMF) is used as a solvent to recover olefins such as 1,3-butadiene via extractive distillation.
Dimethylformamide (DMF) is used in the manufacturing of solvent dyes as an important raw material.

Dimethylformamide (DMF) is consumed during reaction.
Pure acetylene gas cannot be compressed and stored without the danger of explosion.
Industrial acetylene is safely compressed in the presence of Dimethylformamide (DMF), which forms a safe, concentrated solution.

The casing is also filled with agamassan, which renders it safe to transport and use.
As a cheap and common reagent, Dimethylformamide (DMF) has many uses in a research laboratory.
Dimethylformamide (DMF) is effective at separating and suspending carbon nanotubes, and is recommended by the NIST for use in near infrared spectroscopy of such.

Dimethylformamide (DMF) can be utilized as a standard in proton NMR spectroscopy allowing for a quantitative determination of an unknown compound.
In the synthesis of organometallic compounds, it is used as a source of carbon monoxide ligands.
Dimethylformamide (DMF) is a common solvent used in electrospinning.

Dimethylformamide (DMF) is commonly used in the solvothermal synthesis of metal–organic frameworks.
Dimethylformamide (DMF)-d7 in the presence of a catalytic amount of potassium tert-butoxide under microwave heating is a reagent for deuteration of polyaromatic hydrocarbons.
Dimethylformamide (DMF) is used in the following products: laboratory chemicals and pH regulators and water treatment products.

Dimethylformamide (DMF) is used in the following areas: scientific research and development and health services.
Dimethylformamide (DMF) is used for the manufacture of: .
Release to the environment of Dimethylformamide (DMF) can occur from industrial use: in processing aids at industrial sites and as an intermediate step in further manufacturing of another substance (use of intermediates).

Other release to the environment of Dimethylformamide (DMF) is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).
Dimethylformamide (DMF) is used in the following products: adhesives and sealants, coating products, leather treatment products, plant protection products, laboratory chemicals, perfumes and fragrances, pharmaceuticals, polymers and textile treatment products and dyes.
Release to the environment of Dimethylformamide (DMF) can occur from industrial use: formulation of mixtures.

Dimethylformamide (DMF) is used in the following products: laboratory chemicals, adhesives and sealants, coating products, leather treatment products, plant protection products, perfumes and fragrances, pharmaceuticals, polymers and textile treatment products and dyes.
Dimethylformamide (DMF) has an industrial use resulting in manufacture of another substance (use of intermediates).
Dimethylformamide (DMF) is used for the manufacture of: chemicals, , textile, leather or fur, plastic products, mineral products (e.g. plasters, cement) and furniture.

Release to the environment of Dimethylformamide (DMF) can occur from industrial use: in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates), of substances in closed systems with minimal release and as processing aid.
Dimethylformamide (DMF) is commonly used as a solvent in organic synthesis, especially in reactions involving nucleophilic substitutions.
Dimethylformamide (DMF) is used in the production of synthetic fibers, films, and surface coatings.

Dimethylformamide (DMF) plays a role in pharmaceutical applications, aiding in the synthesis of various drug compounds.
Dimethylformamide (DMF) is sometimes used as a solvent for HPLC because of its ability to dissolve a wide range of compounds.
Dimethylformamide (DMF) is commonly used in the synthesis of peptides as a solvent, enabling the coupling of amino acids.

Dimethylformamide (DMF) is an ideal solvent for palladium-catalyzed cross-coupling reactions, essential for synthesizing complex organic molecules in pharmaceuticals and materials science.
Its polar aprotic nature makes it suitable for reactions where polar solvency without hydrogen-bond donors is needed, such as in nucleophilic substitutions and Grignard reagent reactions.
Dimethylformamide (DMF) is involved in the synthesis of various active pharmaceutical ingredients (APIs) because it can dissolve a wide range of organic and inorganic compounds.

Dimethylformamide (DMF)’s ability to dissolve bioactive compounds allows its use in formulations, coatings, and research on drug delivery methods, especially in injectables and certain pharmaceutical coatings.
Dimethylformamide (DMF)is used as a solvent in the production of polyacrylonitrile fibers, which are precursors to carbon fiber materials.
Dimethylformamide (DMF) is essential in dissolving and processing polymers for synthetic leather, spandex, and other stretchy or durable materials.

In the production of paints and coatings, Dimethylformamide (DMF) is a solvent for resins, pigments, and dyes, providing an even, controlled application and smooth finish.
Due to its solvency power, Dimethylformamide (DMF) is used in the production of adhesives, particularly for industrial applications where strong bonding is required.
Dimethylformamide (DMF) can be used in the manufacture of lithium-ion batteries and other electronics, where it acts as a solvent for certain conductive polymers and lithium salts.

Dimethylformamide (DMF) is used as a cleaning solvent and processing agent in the production of printed circuit boards and other electronic components.
Dimethylformamide (DMF) is a solvent in HPLC applications, particularly for substances that need high solvency power for separation.
In analytical chemistry, Dimethylformamide (DMF) is used in spectroscopy and as a solvent for analytical standards due to its purity and compatibility with various analytes.

Dimethylformamide (DMF) is used in the synthesis of certain pesticides and herbicides, as well as for dissolving active ingredients in formulations.
Dimethylformamide (DMF)’s high boiling point and polarity make it a suitable solvent for certain catalysts and reagents, often facilitating more efficient or faster reactions.
Dimethylformamide (DMF) is used in the dyeing and finishing of textiles due to its ability to dissolve dyes and enhance color binding on synthetic fibers.

Dimethylformamide (DMF) is a common solvent in biochemical research, especially in experiments where high solubility for polar compounds is necessary.
Researchers use DMF for fabricating advanced materials, such as nanoparticles, and in research on materials with specific conductive or thermal properties.

Dimethylformamide (DMF) is a clear liquid that has been widely used in industries as a solvent, an additive, or an intermediate because of its extensive miscibility with water and most common organic solvents.
Dimethylformamide (DMF) solutions are used toprocess polymer fibers, films, and surface coatings; to permit easy spinning of acrylic fibers; to produce wire enamels, and as a crystallization medium in the pharmaceutical industry.
Dimethylformamide (DMF) can also be used for formylation with alkyllithium or Grignard reagents.

Dimethylformamide (DMF) is used as a reagent in Bouveault aldehyde synthesis and also in Vilsmeier-Haack reaction.
It acts as a catalyst in the synthesis of acyl chlorides.
Dimethylformamide (DMF) is used for separating and refining crude from olefin gas.

Dimethylformamide (DMF) along with methylene chloride acts as a remover of varnish or lacquers.
It is also used in the manufacture of adhesives, fibers and films.
The principal applications of Dimethylformamide (DMF) are as a solvent and as an extractant, particularly for salts and compounds with high molecular mass.

This role is consistent with its interesting combination of physical and chemical properties: low molecular mass, high dielectric constant, electron-donor characteristics, and ability to form complexes.
The use of Dimethylformamide (DMF) as a component in synthesis is of relatively minor significance, at least commercially.
Dimethylformamide (DMF) has been used as solvent for the synthesis of cytotoxic luteinizing hormone-releasing hormone (LH-RH) conjugate AN-152 (a chemotherapeutic drug) and fluorophore C625 [4-(N,N-diphenylamino)-4′-(6-O-hemiglutarate)hexylsulfinyl stilbene].

Dimethylformamide (DMF) may be employed as solvent medium for the various organic reduction reactions.
World production capacity of Dimethylformamide (DMF) is about 225 x 103 tons per year.
The main application of Dimethylformamide (DMF) is as solvent in industrial processes, especially for polar polymers such as Polyvinylchloride, polyacrylonitrile and polyurethanes.

Dimethylformamide (DMF) solutions of high molecular weight polymers are processed to fibers, films, surface coatings and synthetic leathers.
Since salts can be dissolved and dissociated in Dimethylformamide (DMF), the solutions are used in electrolytic capacitors and certain electrolytic processes (Eberling 1980).
Dimethylformamide (DMF) is as a solvent with low evaporation rate.

Safety Profile:
Dimethylformamide (DMF) can be absorbed through the skin, causing irritation and possibly systemic toxicity.
Repeated or prolonged skin exposure may result in liver damage and other health effects.
Dimethylformamide (DMF) can cause severe eye irritation, leading to redness, pain, and possibly long-term damage with high exposure.

Long-term exposure to Dimethylformamide (DMF), even at low levels, has been linked to liver toxicity, resulting in possible liver enzyme changes, hepatitis, or more severe liver issues.
Studies on animals have shown that DMF may have reproductive toxicity and teratogenic effects, meaning it could potentially harm fetal development.
Dimethylformamide (DMF) is not classified as a known human carcinogen, but some studies suggest it might have carcinogenic potential, especially with prolonged exposure.

Regulatory bodies like IARC classify it as Group 2B (possibly carcinogenic to humans), so caution is advised.
Dimethylformamide (DMF) has a flash point of around 58°C (136°F), meaning it can ignite if exposed to a flame or spark at relatively low temperatures.
It’s classified as a flammable liquid, so it should be kept away from open flames, sparks, and hot surfaces.

When exposed to high temperatures, Dimethylformamide (DMF) can decompose, releasing toxic gases such as dimethylamine, carbon monoxide, and nitrogen oxides, which are hazardous if inhaled.
Dimethylformamide (DMF) is harmful to aquatic life and can cause long-term adverse effects in the aquatic environment.
It’s not easily biodegradable and may persist, leading to accumulation in water bodies.

Spills of Dimethylformamide (DMF) can contaminate soil and water sources.
Due to its persistence, it may require specialized treatments to remove it from the environment and prevent long-term harm to ecosystems.

Dimethylformamide (DMF) vapor exposure has shown reduced alcohol tolerance and skin irritation in some cases.
On 20 June 2018, the Danish Environmental Protective Agency published an article about Dimethylformamide (DMF)'s use in squishies.
The density of the compound in the toy resulted in all squishies being removed from the Danish market.

All squishies were recommended to be thrown out as household waste.
Breathing in Dimethylformamide (DMF) vapors can cause respiratory irritation, dizziness, nausea, and headache.
Prolonged inhalation at high concentrations may lead to liver and kidney damage.