DIMETHYLGLUCAMINE

Dimethylglucamine has the chemical formula C7H17NO5 and consists of a glucose molecule (a type of sugar) with two methyl groups (-CH3) and an amine group (-NH2) attached to it.
Dimethylglucamine is a tertiary amine derived from the monosaccharide glucose as a renewable raw material.
Dimethylglucamine is derived from glucose and belongs to a class of chemicals known as alkanolamines. 

CAS Number: 76326-99-3
Molecular Formula: C8H19NO5
Molecular Weight: 209.24
EINECS Number: 810-394-3

Because of its basic character, methyl meglumine is used as a low-odour, non-corrosive, environmentally and health-friendly neutralizing agent in water-based emulsion paints and varnishes and in liquid preparations for body care and cosmetics.
Dimethylglucamine, also known as N,N-dimethylglucamine or DMG, is a chemical compound that is often used as a buffering agent, a pH regulator, and an excipient in various pharmaceutical and chemical applications. 

In aqueous solution, Dimethylglucamine is reacted with dimethylamine during hydrogenation over a heterogeneous ruthenium catalyst in a 95% yield (along with small amounts of sorbitol and N -methyl- D -glucamine ) to form dimethylglucamine.
Depending on the reaction temperature and the catalyst/glucose ratio, a retroaldol reaction to form the cleavage products Dimethylglucamine and tetramethylethylenediamine TMEDA can also take place. 

The adduct obtained in the reductive amination of Dimethylglucamine - obtained from glucose and methylamine on a ruthenium catalyst in 96% yield - known as the Leuckart-Wallach reaction - with formaldehyde HCHO is an Raney nickel almost quantitatively hydrogenated to methyl meglumine.
Gentle process conditions, e.g. B. Reaction and hydrogenation at 30 to 40 °C, followed by post-hydrogenation at 90 °C, produce light yellow instead of brown reaction solutions which contain only traces of formaldehyde and methanol formed therefrom by hydrogenation and are also suitable for cosmetic preparations.

When the aqueous reaction solution is concentrated, dimethylglucamine is usually obtained as a yellow to brown syrup, which crystallizes out as a colorless solid on cooling.
For purification, the raw substance can be recrystallized from ethyl acetate. 
Dimethylglucamine is readily soluble in water, so that clear, low-viscosity, light yellow ( Hazen color number <250) 50% aqueous solutions can also be prepared. 

Dimethylglucamine is suitable as a low-odour and anti-corrosive substitute for the synthetic pH value regulator aminomethylpropanol (AMP) for water-based varnishes and paints, especially in interior applications. 
In addition, Dimethylglucamine increases the thermal stability of the color dispersions and their color strength.

Dimethylglucamine is frequently employed as a buffering agent in pharmaceutical formulations. 
Dimethylglucamine helps maintain a stable pH level in solutions and can be used to adjust the acidity or alkalinity of various pharmaceutical products.
Dimethylglucamine is used to adjust the pH of solutions in a controlled manner, making it an important ingredient in a variety of pharmaceuticals, including injectable drugs, where precise pH control is crucial for stability and safety.

Dimethylglucamine serves as an excipient in pharmaceutical formulations. 
Excipients are inactive substances that are added to pharmaceuticals to aid in the manufacturing process, enhance drug stability, or improve the drug's performance.
Dimethylglucamine can form salts with various acids, resulting in compounds with specific properties and uses.

Sodium dimethylglucamine salicylate is used as an analgesic and anti-inflammatory agent.
In some cases, dimethylglucamine is used as an antidote for poisoning by certain chemicals. 
Dimethylglucamine can form stable complexes with toxic substances, aiding in their removal from the body.

Dimethylglucamine is used in chemical research and analysis as a reagent and chelating agent due to its ability to form stable complexes with metal ions.
Dimethylglucamine is used in the pharmaceutical industry to improve the solubility of poorly water-soluble drugs. 
When added to drug formulations, it can help increase the drug's dissolution rate, making it more bioavailable.

Dimethylglucamine can be found in some topical pharmaceutical preparations, such as creams and ointments, where it may serve as a pH adjuster and excipient.
In cosmetic and personal care products, dimethylglucamine can be used as a pH regulator, stabilizer, or buffering agent to maintain the desired pH level of the product.

Melting point: 137-139°C
Boiling point: 453.1±45.0 °C(Predicted)
Density: 1.333±0.06 g/cm3(Predicted)
vapor pressure: 0.001-0.002Pa at 20-50℃
solubility: Methanol ()Slightly, Heated, Water (Slightly)
form: Solid
pka: 13.47±0.20(Predicted)
color: White
LogP: -1.8 at 20℃
Dissociation constant: 9.2 at 23℃

The Dimethylglucaminee , derived from the renewable raw material sugar in large proportions (approx. 75%), forms with fatty acids such as e.g. B. oleic acid , the corresponding ammonium salts , which form homogeneous solutions even at low degrees of neutralization and are characterized by very low viscosities. 
In this way, highly concentrated liquid detergents and liquid soaps that are easy to handle and dose can be realised.

Dimethylglucamine is used in veterinary medicine in a manner similar to its use in human pharmaceuticals. 
Dimethylglucamine can be included in veterinary drug formulations to adjust pH, enhance solubility, and aid in drug delivery.
Dimethylglucamine can be utilized in the production of diagnostic reagents and test kits for medical and clinical purposes. 

Dimethylglucamine may play a role in stabilizing and controlling the pH of these reagents.
One common salt derived from dimethylglucamine is dimethylglucamine hydrochloride. 
This salt has its own set of applications and is used in various pharmaceutical and chemical processes.

Some antifungal medications use dimethylglucamine as an excipient or to enhance drug solubility. 
This is particularly important for developing effective formulations of poorly water-soluble antifungal drugs.
Dimethylglucamine is utilized in laboratory settings for various purposes, including chemical synthesis, separation techniques, and as a reagent in chemical reactions.

Dimethylglucamine is hygroscopic, meaning it has a tendency to absorb moisture from the surrounding environment. 
This property can be useful in some applications where moisture control is important.
In the pharmaceutical industry, dimethylglucamine may be used in compatibility testing to assess the interaction of drugs with various excipients and packaging materials, helping ensure product stability.

While dimethylglucamine is generally considered safe for its intended uses, proper handling and storage practices should be followed, particularly when working with concentrated solutions or powdered forms of the compound.
Dimethylglucamine-containing pharmaceutical products are subject to regulatory oversight and must comply with safety and quality standards established by regulatory agencies in different countries.
Pharmaceutical scientists and formulators often rely on excipients like dimethylglucamine to optimize drug formulations, improve drug delivery, and enhance the overall performance of medications.

Uses Of Dimethylglucamine:
Dimethylglucamine is used as a reagent in the synthesis of N,N-dimethyl-N-alkyl-D-glucaminium bromides which exhibit antimicrobial activity.
Dimethylglucamine can be found in cosmetic and personal care products, such as skincare creams and lotions, where it may serve as a pH adjuster or a component used to improve the stability and texture of the product.

Dimethylglucamine can be used in cleaning products, including detergents and surface cleaners, as a chelating agent to help remove mineral deposits and stains.
In the oil and gas industry, dimethylglucamine can be utilized as a corrosion inhibitor in drilling fluids and for pipeline maintenance. 
Dimethylglucamine helps protect metal surfaces from corrosion caused by acidic compounds.

Dimethylglucamine can be employed in water treatment processes to control pH levels and reduce the acidity of water, making it less corrosive to pipes and equipment.
Dimethylglucamine may be used as an auxiliary agent to modify the properties of dyes, improve color fastness, and enhance dyeing processes.
Dimethylglucamine may be used as a flavoring agent in the food industry, although its use in this context is not as common as its applications in pharmaceuticals and chemicals.

Dimethylglucamine has been studied for its potential as an additive in concrete to improve its performance and durability. 
It may help reduce the permeability of concrete and enhance its resistance to water penetration.
Dimethylglucamine can serve as a component in polymer formulations, aiding in the dispersion of particles and enhancing the properties of the polymer.

In metal finishing processes, such as electroplating and metal cleaning, dimethylglucamine can be used as an additive to control pH levels and improve the efficiency of the processes.
In mineral processing and ore beneficiation, dimethylglucamine can be employed as a flotation reagent to separate minerals from ore through selective attachment to air bubbles.

Dimethylglucamine can be used as a pH regulator and buffer in the printing industry, helping to control the acidity of ink formulations and maintain stable printing conditions.
In traditional photography, dimethylglucamine has been used as a component in developing solutions to adjust pH and enhance image development.
Dimethylglucamine can assist in waste treatment processes by neutralizing acidic waste streams, making them less harmful to the environment and easier to treat.

Dimethylglucamine may find applications in the paper and pulp industry to control pH levels during papermaking processes and improve the quality of the paper products.
Dimethylglucamine can be used as an additive in electroplating solutions to maintain the pH levels required for the deposition of metal coatings on various substrates.
In gas purification processes, dimethylglucamine can be employed to remove acidic impurities from gases, ensuring that the gases meet purity standards.

In chemical laboratories and research settings, dimethylglucamine may serve as a reagent or auxiliary compound in various chemical syntheses and reactions.
Dimethylglucamine is used in biotechnology and cell culture applications to help maintain the pH of cell culture media, which is crucial for cell growth and viability.
In textile printing, dimethylglucamine can be used as a component in dye fixation processes, ensuring that the dyes adhere to fabric fibers effectively.

Dimethylglucamine can be utilized in medical diagnostic tests and assays as a buffer or pH control agent, aiding in accurate and consistent test results.
Dimethylglucamine may be employed in chemical analysis and titration procedures to control and adjust pH levels during the determination of chemical concentrations.
Dimethylglucamine is available as a laboratory-grade reagent for a wide range of chemical and biochemical experiments and analyses.

Dimethylglucamine is often used as an alkalizing agent in pharmaceutical formulations. 
Dimethylglucamine can be added to acidic drugs to increase their solubility and improve their palatability for oral administration. 
This is particularly important for medications designed for pediatric or geriatric patients who may have difficulty swallowing tablets or capsules.

In medical applications, dimethylglucamine can be used in the preparation of dialysis solutions to maintain proper pH levels during the dialysis process, which is crucial for the removal of waste products and toxins from the bloodstream.
Dimethylglucamine is used in laboratories and industrial settings as a neutralizing agent for acids. 
Dimethylglucamine can help safely neutralize spills of hazardous acids, making it a valuable tool for chemical safety.

Dimethylglucamine exhibits a high buffering capacity, which means it can effectively resist changes in pH when acids or bases are added to a solution. 
This property is particularly valuable in maintaining the stability of pharmaceutical and chemical formulations.
Dimethylglucamine is considered environmentally friendly because it is biodegradable. 

Dimethylglucamine breaks down naturally in the environment over time, reducing its environmental impact.
Dimethylglucamine can be found in some hygiene and personal care products, such as mouthwashes and oral rinses, where it may serve as a pH adjuster and contribute to product efficacy.
In the pharmaceutical and chemical industries, dimethylglucamine is used in quality control processes to ensure that products meet specified pH requirements and standards.

Manufacturers of pharmaceuticals and chemicals that contain dimethylglucamine must adhere to regulatory guidelines and safety standards established by health and safety authorities in different countries.
Dimethylglucamine's biodegradability and its role in improving the solubility and bioavailability of drugs can contribute to more sustainable pharmaceutical formulations.
Dimethylglucamine is sometimes used as a component in packaging materials, coatings, or films to help maintain the freshness and quality of packaged goods by controlling pH and moisture levels.

Safety Of Dimethylglucamine:
Dimethylglucamine can cause skin and eye irritation upon direct contact. 
Avoid skin contact by wearing appropriate protective clothing, including gloves, and use safety goggles or a face shield to protect the eyes. 
In case of contact, rinse the affected area with plenty of water.

Inhalation of dust or mist containing dimethylglucamine should be avoided, as it may cause respiratory irritation or discomfort. 
Work in well-ventilated areas, and consider using respiratory protection, such as a dust mask, if needed.
Dimethylglucamine is not intended for ingestion and should be kept away from the mouth. 

Ingesting significant amounts of Dimethylglucamine can be harmful and may lead to gastrointestinal distress.
Dimethylglucamine itself is not highly flammable. 
However, some of the solvents or materials it may be mixed with for specific applications could be flammable. 

Environmental Impact Of Dimethylglucamine:
While dimethylglucamine is biodegradable, it should be disposed of in accordance with local environmental regulations to minimize any potential impact on the environment.
Dimethylglucamine may react with certain incompatible chemicals, such as strong acids or bases. 
Avoid mixing it with substances that may cause hazardous reactions.

Allergic Reactions Of Dimethylglucamine: 
While allergic reactions to dimethylglucamine are rare, individuals with known sensitivities to chemicals should exercise caution and use personal protective equipment when handling this compound.

Synonyms Of Dimethylglucamine:
76326-99-3
N,N-dimethyl-D-glucamine
N, N-Dimethylglucamine
D-Glucitol, 1-deoxy-1-(dimethylamino)-
methylmeglumine
(2R,3R,4R,5S)-6-(dimethylamino)hexane-1,2,3,4,5-pentol
SCHEMBL120420
CUGDYSSBTWBKII-LXGUWJNJSA-N
DTXSID201015492