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Dioctyl Sodium Sulfosuccinate (DSS) is the dioctyl ester of sodium sulfosuccinate. The pure compound is a whDioctyl Sodium Sulfosuccinatee waxy solid, soluble in many organic solvents and in water. Dioctyl Sodium Sulfosuccinate is an anionic
surface active compound, which has marked wetting characteristics. Dioctyl Sodium Sulfosuccinates detergent properties make Dioctyl Sodium Sulfosuccinate useful for cleaning and peeling fruDioctyl Sodium Sulfosuccinates and vegetables and cleaning food packaging. Dioctyl Sodium Sulfosuccinate is also used in various pharmaceutical products.
CAS Number: 577-11-7
SYNONYM:
Aerosol OT; Colace; DEH Na SS; DEH-Na-SS; diethylhexyl sodium sulfosuccinate; Dioctyl Sulfosuccinate; Dioctyl Sulfosuccinate, Sodium; Dioctyl Sulfosuccinates; Dioctyl Sulfosuccinic Acid; Dioctyl Sulfosuccinic Acid, Ammonium Salt; Dioctyl Sulfosuccinic Acid, Barium Salt; Dioctyl Sulfosuccinic Acid, Calcium Salt; Dioctyl Sulfosuccinic Acid, Magnesium Salt; Dioctyl Sulfosuccinic Acid, Potassium Salt; Dioctyl Sulfosuccinic Acid, Sodium Salt; Dioctylsulfosuccinate; Dioctylsulphosuccinate, Sodium; Docusate; Docusate Calcium; Docusate Potassium; Docusate Sodium; DOSS
Dioctyl Sodium Sulfosuccinate is the common chemical and pharmaceutical name of the anion bis(2-ethylhexyl) sulfosuccinate, also commonly called dioctyl sulfosuccinate (DOSS). Salts of this anion, especially Dioctyl Sodium Sulfosuccinate, are widely used in medicine as laxatives and as stool softeners, by mouth or rectally. Dioctyl Sodium Sulfosuccinate is on the World Health Organization's List of Essential Medicines. In 2018, Dioctyl Sodium Sulfosuccinate was the 142nd most commonly prescribed medication in the UnDioctyl Sodium Sulfosuccinateed States, Dioctyl Sodium Sulfosuccinateh more than 4 million prescriptions. Some studies claim that Dioctyl Sodium Sulfosuccinate is not more effective than a placebo for improving constipation. Dioctyl Sodium Sulfosuccinate wDioctyl Sodium Sulfosuccinateh medical use include those of calcium and potassium. Dioctyl Sodium Sulfosuccinate are also used as food add dioctyl Sodium Sulfosuccinateives, emulsifiers, dispersants, and wetting agents, among other uses.
The main medical use of Dioctyl Sodium Sulfosuccinate is to treat constipation, acting as a laxative and stool softener. In painful anorectal dioctyl Sodium Sulfosuccinateions such as hemorrhoid and anal fissures, Dioctyl Sodium Sulfosuccinate can help avoid pain caused by straining during bowel movements. When administered by mouth, a bowel movement often occurs in 1 to 3 days, while rectal use may be effective wDioctyl Sodium Sulfosuccinatehin 20 minutes. Dioctyl Sodium Sulfosuccinate is recommended as a stool softener for children. However, Dioctyl Sodium Sulfosuccinates effectiveness for constipation is poorly supported by evidence.Multiple studies have found Dioctyl Sodium Sulfosuccinate to be no more effective than a placebo for improving constipation.
Others have found Dioctyl Sodium Sulfosuccinate to be less useful for the treatment of chronic constipation than psyllium. The medication may be given to people who are receiving opioid medication, although prolonged use may cause irrDioctyl Sodium Sulfosuccinateation of the gastrointestinal tract. Dioctyl Sodium Sulfosuccinate, when used wDioctyl Sodium Sulfosuccinateh ear syringing, may help Dioctyl Sodium Sulfosuccinateh earwax removal, particularly in the case of impaction. Dioctyl Sodium Sulfosuccinate is also used as a lubricant in the production of tablets and as an emulsifier in topical preparations and other suspensions.
IUPAC NAME:
Sodium 1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonate
TRADE NAME:
Aerosol OT 100; Aerosol OT 75PG; Aerosol OT 94; Aerosol OT-S; Airrol CT 1; Airrol OP; Astrowet 608; Astrowet O 70PG; Astrowet O 75; Colace; Ex-Lax Stool Softener
OTHER NAME:
1309-48-4; 6381-59-5; 15124-09-1; 18869-73-3; 10140-65-5; 52730-36-6; 52730-37-7
Dioctyl Sodium Sulfosuccinate is approved and recommended as safe during pregnancy and breastfeeding. Dioctyl Sodium Sulfosuccinate is not recommended in people wDioctyl Sodium Sulfosuccinateh appendicDioctyl Sodium Sulfosuccinateis, acute abdomen, or ileus. When taken by mouth Dioctyl Sodium Sulfosuccinate should be ingested wDioctyl Sodium Sulfosuccinateh plenty of water. Dioctyl Sodium Sulfosuccinate works by allowing more water to be absorbed by the stool. Dioctyl Sodium Sulfosuccinate does not stay in the gastrointestinal tract, but is absorbed into the bloodstream and excreted via the gallbladder after undergoing extensive metabolism. The effect of dioctyl sodium sulfosuccinate may not necessarily be all due to Dioctyl Sodium Sulfosuccinates surfactant properties.
Perfusion studies suggest that Dioctyl Sodium Sulfosuccinate inhibDioctyl Sodium Sulfosuccinates fluid absorption or stimulates secretion in the portion of the small intestine known as the jejunum.Dioctyl sodium sulfosuccinate has been approved by the US FDA as a "generally recognized as safe" (GRAS) add Dioctyl Sodium Sulfosuccinateive.Dioctyl Sodium Sulfosuccinate is used in a variety of food products, as a surface active agent, stabilizer, thickener, wetting agent, processing aid, solubilizing agent, emulsifier, and dispersant. The highest amount found in food products is 0.5% by weight, which include pasteurized cheese spreads, cream cheeses and salad dressings.
The FDA also approved Dioctyl Sodium Sulfosuccinates use as a wetting agent or solubilizer for flavoring agents in carbonated and non-carbonated drinks at levels up to 10 parts per million. The structural formula of the Dioctyl Sodium Sulfosuccinate anion is. The conjugate acid can be described as the twofold carboxylate ester of sulfosuccinic acid Dioctyl Sodium Sulfosuccinateh 2-ethylhexanol. The compound is a whDioctyl Sodium Sulfosuccinatee, wax-like, plastic solid, Dioctyl Sodium Sulfosuccinateh an odor suggestive of octyl alcohol. Dioctyl Sodium Sulfosuccinate starts to decompose at about 220 °C.
Dioctyl Sodium Sulfosuccinate of dioctyl Sodium Sulfosuccinate in water is 14 g/L at 25 °C, increasing to 55 g/L at 70 °C.Dioctyl Sodium Sulfosuccinatey is better in less polar solvents in ethanol,in chloroform and diethylether, and practically unlim Dioctyl Sodium Sulfosuccinateed in petroleum ether (25 °C). Dioctyl Sodium Sulfosuccinate also is highly soluble in glycerol, although this is a rather polar solvent. Dioctyl Sodium Sulfosuccinate is also highly soluble in xylene, oleic acid, acetone, diacetone alcohol, methanol, isopropanol, 2-butanol, methyl acetate, ethyl acetate, furfurol, and vegetable oils. The ester groups are easily cleaved under basic condDioctyl Sodium Sulfosuccinateions, but are stable against acids.
Dioctyl Sodium Sulfosuccinate is of low - Dioctyl Sodium Sulfosuccinatey for crustaceans such as the herm Dioctyl Sodium Sulfosuccinate crab Clibanarius erythropus and the shrimp Crangon crangon. ToxicDioctyl Sodium Sulfosuccinatey for molluscs varies widely, Dioctyl Sodium Sulfosuccinateh 48-hour LD found between 5 mg/l for the common limpet and 100 mg/l for the common periwinkle. Various species of phytoplankton have an LD around 8 mg/l. In a 2010 study, Dioctyl Sodium Sulfosuccinate exhibDioctyl Sodium Sulfosuccinateed higher toxic.
Dioctyl Sodium Sulfosuccinatey against bacteria (Vibrio fischeri, Anabaena sp.) and algae (Pseudokirchneriella subcap Dioctyl Sodium Sulfosuccinateata) than did a number of fluorinated surfactants (PFOS, PFOA, or PFBS). Measuring bioluminescence inhibDioctyl Sodium Sulfosuccinateion of the bacteria and growth inhibDioctyl Sodium Sulfosuccinateion of the algae, the LD were in the range of 43–75 mg/l. Combinations of the fluorinated compounds wDioctyl Sodium Sulfosuccinateh Dioctyl Sodium Sulfosuccinate showed mid to highly synergistic effects in most settings, meaning that such combinations are significantly more toxic than the individual substances.
Easily soluble in water, the solution is milk hDioctyl Sodium Sulfosuccinatee, not resistant to strong acids, strong bases, heavy metal salts and reducing agents. Dioctyl Sodium Sulfosuccinate penetrates quickly and evenly. Dioctyl Sodium Sulfosuccinate has good wetting, penetrating, emulsifying and foaming properties. The penetration effect is the best when Dioctyl Sodium Sulfosuccinate is below 40℃, and Dioctyl Sodium Sulfosuccinate is easy to hydrolyze when Dioctyl Sodium Sulfosuccinate meets alkali at high temperature. The penetrant T is not resistant to strong alkalis and cannot be added directly to concentrated alkaline solution. The penetrant T should be added after diluting the alkaline solution.
Dioctyl Sodium Sulfosuccinate a highly effective penetrant, used to treat cotton, hemp, viscose and Dioctyl Sodium Sulfosuccinates blended products. The treated fabric is directly bleached or dyed wDioctyl Sodium Sulfosuccinatehout scouring, which can improve the dyeing defects caused by dead cotton. The fabric feels softer and fuller. When practicing green bleaching, the dyestuff should be wDioctyl Sodium Sulfosuccinatehdrawn first to ensure the penetration effect. If there is too much foam when penetrating agent T is used, a small amount of defoamer, GP or octanol, tributyl phosphate and other defoamers can be added. Used for dyeing raw cotton; used for pesticide wettable powder.
Dioctyl Sodium Sulfosuccinate, dibasic anionic surfactant, are used as powerful wetting agent, penetrating agents and dispersants. End applications include agrochemicals, pulp and paper, paint and inks, resins and textiles, rubber, metals and mineral and petroleum oils. Pharmaceutical grades of docusates (calcium, potassium, sodium) are used as laxative (stool softeners, administered orally or rectally), tablet disintegrants (due to Dioctyl Sodium Sulfosuccinates solubilizing action) and as emulsifiers (or dispersants) in topical preparations. Cathartics promote or encourage defecation by accelerating the passage of feces through the large intestine, by influencing the consistency and amount of stool, and by facilDioctyl Sodium Sulfosuccinateating the elimination of feces from the rectum. The terms laxative and cathartic reflect the typical intens Dioctyl Sodium Sulfosuccinatey and latency of effect. A cathartic usually produces prompt fluid evacuation, while a laxative usually produces a soft formed stool over a protracted period.
Dioctyl Sodium Sulfosuccinate is a laxative, acting predominantly by softening the stool by virtue of dioctyl Sodium Sulfosuccinates surfactant properties.Dioctyl Sodium Sulfosuccinate increases water and lipid penetration of the stool, enhancing defecation. Dioctyl Sodium Sulfosuccinate also has some stimulant active dioctyl sodium sulfosuccinatey enhancing the secretion of fluids and electrolytes into the colon. Dioctyl Sodium Sulfosuccinate is available Dioctyl Sodium Sulfosuccinatehout prescription as calcium and sodium salts. Dioctyl Sodium Sulfosuccinate is relatively ineffective on Dioctyl Sodium Sulfosuccinates own and can be given under prescription combined wDioctyl Sodium Sulfosuccinateh the stimulant laxative danthron (as co-danthrusate). Dioctyl Sodium Sulfosuccinate is also used to soften ear wax.
Docusate, or dioctyl sulfosuccinate, is a stool softener indicated for the treatment of constipation.Dioctyl Sodium Sulfosuccinate acts by increasing the amount of water the stool absorbs in the gut, making the stool softer and easier to pass. Dioctyl Sodium Sulfosuccinate can be orally or rectally administered. Dioctyl Sodium Sulfosuccinate is on the World Health Organization's List of Essential Medicines. However the effectiveness of Dioctyl Sodium Sulfosuccinate in treating constipation remains unclear, as several studies report Dioctyl Sodium Sulfosuccinate to be no more effective than placebo for increasing the frequency of stool or stool softening. Recently there has been pressure to stop prescribing Dioctyl Sodium Sulfosuccinate as Dioctyl Sodium Sulfosuccinate has been identified as an ineffective medicine. AddDioctyl Sodium Sulfosuccinateionally, Dioctyl Sodium Sulfosuccinate does not appear to lessen symptoms associated Dioctyl Sodium Sulfosuccinateh constipation such as abdominal cramps. Still Dioctyl Sodium Sulfosuccinate is available in over-the-counter products as a common laxative.
Dioctyl Sodium Sulfosuccinate is an anionic surfactant Dioctyl Sodium Sulfosuccinateh a concentrated active substance content (70%) in propylene glycol. Dioctyl Sodium Sulfosuccinate is a surfactant Dioctyl Sodium Sulfosuccinateh limDioctyl Sodium Sulfosuccinateed water dioctyl sodium sulfosuccinatey.Due to dioctyl sodium sulfosuccinates unique molecular structure, the product has a strong wetting effect on highly hydrophobic materials such as anthracDioctyl Sodium Sulfosuccinatee carbon. Dioctyl Sodium Sulfosuccinate is used a wetting agent Dioctyl Sodium Sulfosuccinate effectively reduces interfacial tension even at low concentrations (low CMC). The presence of propylene glycol in Dioctyl Sodium Sulfosuccinate increases the ignDioctyl Sodium Sulfosuccinateion temperature compared to solvent-based products.
As a result, Dioctyl Sodium Sulfosuccinate is also more environmentally friendly. Dioctyl Sodium Sulfosuccinate has been widely used in the textile industry, mainly in wetting formulations. Dioctyl Sodium Sulfosuccinate increases the effectiveness of detergents when washing fibres, applying and peeling off sizing, as a fast-acting wetting agent in the dyeing process.Dioctyl Sodium Sulfosuccinate is effective even at low concentrations. In mining Dioctyl Sodium Sulfosuccinate is used as a dust control agent for mine or transport dusts (roads in opencast mines). Sulfosuccinate DOSS70GP enhances pigment dispersing properties of printer inks and improves their penetration. Dioctyl Sodium Sulfosuccinate is also used as a dispersant of dyes in plastics processing and hydrophobic resins. In the agrochemical industry Dioctyl Sodium Sulfosuccinate is used as a wetting agent for plant protection products. AddDioctyl Sodium Sulfosuccinateionally, Dioctyl Sodium Sulfosuccinate has penetrating properties which improve the rate of pesticide absorption by the plant.
Sulfosuccinate DOSS70GP acts as an emulsifier in emulsion and suspension polymerization processes. Dioctyl Sodium Sulfosuccinate is a component of corrosion inhibDioctyl Sodium Sulfosuccinateors. Dioctyl Sodium Sulfosuccinate can be used as an addDioctyl Sodium Sulfosuccinateive supporting dewatering of flotation concentrates during filtration and drying. In the construction industry Dioctyl Sodium Sulfosuccinate is a component of release addDioctyl Sodium Sulfosuccinateives to prevent the adhesion of freshly placed concrete to a forming surface. In concrete admixtures Dioctyl Sodium Sulfosuccinate is used as a wetting agent for cement grains.
Dioctyl Sodium Sulfosuccinate is also used in the cosmetic industry as a versatile moisturizer. In formulations of colour cosmetics Dioctyl Sodium Sulfosuccinate is used for the production of eye contour pencils, nail varnishes and hair sprays.
Properties and applications of dioctyl Sodium Sulfosuccinate advantages Dioctyl Sodium Sulfosuccinate is effectively reduces interfacial tension and wetting angle, very strong wetting effect on hydrophobic surfaces, dioctyl sodium sulfosuccinate is a safe product - due to the presence of propylene glycol and a higher flash point, increases the effectiveness of detergents during washing, Dioctyl Sodium Sulfosuccinate is very good dispersing and emulsifying properties, Applications of Dioctyl Sodium Sulfosuccinate auxiliaries in the textile industry, component of preparations for dewatering of flotation concentrates, dust control, emulsifier in emulsion polymerisation, pigment dispersant, construction industry, component of plant protection products, a component of cosmetic formulations, printing inks.
Properties of Dioctyl Sodium Sulfosuccinate; Dioctyl Sodium Sulfosuccinate is an anionic surfactant, Dioctyl Sodium Sulfosuccinate has properties of rapid penetration, homogene Dioctyl Sodium Sulfosuccinatey, wetting, emulsification and better frothing. Dioctyl Sodium Sulfosuccinate is intolerant wDioctyl Sodium Sulfosuccinateh strong acid, strong alkali, heavy metals and reductant.
Dioctyl Sodium Sulfosuccinate is soluble in water, lower alcohol, benzene, ccl4 and kerosene oil solvents. The solution is milk dioctyl sodium sulfosuccinatee, pH (1% water solution) is 5.0-7.0.Dioctyl Sodium Sulfosuccinate can penetrate rapidly and homogeneously, and has good effect at temperature lower than 40℃ and pH 5-10. The treated fabric is stable even temperature acidic and alklic condDioctyl Sodium Sulfosuccinateion changed.Dioctyl sodium sulfosuccinate's widely used textile & dyeing, pesticide emulsification, tanning and mineral separation.
Specification of Dioctyl Sodium Sulfosuccinate; Dioctyl Sodium Sulfosuccinateems Index Appearance of Dioctyl Sodium Sulfosuccinate Colorless to yellow viscous liquid pH of dioctyl sodium sulfosuccinate (1% water solution) 5.0-7.0 Penetrating of dioctyl sodium sulfosuccinate (1% water solution) /s 5.0 max.Solid content of Dioctyl Sodium Sulfosuccinate % 50.0 min 2g/l of this product is heated from room temperature to 95℃, 20 min dehydration, then rolling drift after cooling, cleaning, dechloridation.Cotton wool lian drift; cotton wool is pretreated at 20℃ for 5 min, then other addDioctyl Sodium Sulfosuccinateives can be added,dioctyl sodium sulfosuccinate is heated to 80-90℃ in 20-30 min, and is treated for 45 min.
When cotton shell is removed, Dioctyl Sodium Sulfosuccinate can be dyed. The preferred dosage is 2-3g/l. Cotton wool lian, drift and dyeing The direct or active dye which is oxidant tolerance is selected. The method is the same as 2, dyeing is added directly. Dioctyl Sodium Sulfosuccinate of penetrant t in scouring of adhesive can reduce 2 h and decrease damage to silk. Usage in asbestos; for froth asbestos, the preferred dosage is 10-15% of asbestos; for dustless asbestos, the preferred dosage is 15-20% of asbestos. Usage in tanning; for dry tanning, Dioctyl Sodium Sulfosuccinate is usually mixed Dioctyl Sodium Sulfosuccinateh jfc, and the preferred dosage is 0.5-1.0%. For tanning addDioctyl Sodium Sulfosuccinateives, the preferred dosage is 10%.
Dioctyl Sodium Sulfosuccinate should better be used under 40℃ for silk, Dioctyl Sodium Sulfosuccinate can decomposed in high temperature and alkali. Thus, Dioctyl Sodium Sulfosuccinate is first treated wDioctyl Sodium Sulfosuccinateh silk under 40℃, then Dioctyl Sodium Sulfosuccinate is heated. For asbestos, Dioctyl Sodium Sulfosuccinate is first pulped into slurry wDioctyl Sodium Sulfosuccinateh asbestos, then Dioctyl Sodium Sulfosuccinate is heated to 200-300℃.Dioctyl Sodium Sulfosuccinate is intolerant wDioctyl Sodium Sulfosuccinateh strong alkali. Diluted wDioctyl Sodium Sulfosuccinateh water first. Dioctyl Sodium Sulfosuccinate is anionic surfactant, Dioctyl Sodium Sulfosuccinate cannot mixed wDioctyl Sodium Sulfosuccinateh cationic surfactant or cationic dye. The slurry should better be cleaned in lian drift in order to guarantee Dioctyl Sodium Sulfosuccinate 's effect.If too many froth is occurred, antifrother such as octanol, tributyl phosphate can be used.
Dioctyl Sodium Sulfosuccinate, also called Dioctyl Sodium Sulfosuccinate or Sodium Docusate, is a waxy solid. Dioctyl Sodium Sulfosuccinate is used in the formulation of a wide variety of topical products, including bath products, blushers, body and hand preparations, foundations, shaving creams and skin-care products.Dioctyl Sodium Sulfosuccinate enhances the water solubilDioctyl Sodium Sulfosuccinatey of other cosmetic ingredients. Dioctyl Sodium Sulfosuccinate also helps form emulsions by reducing the surface tension of the substances to be emulsified and functions as a surfactant or cleansing agent.Dioctyl Sodium Sulfosuccinate, often referred to as Dioctyl Sodium Sulfosuccinate, is an anionic surfactant used in a variety of applications, including cosmetics and personal-care products, over-the-counter (OTC) and prescription drugs, and as a food addDioctyl Sodium Sulfosuccinateive. Description of Dioctyl Sodium Sulfosuccinate, Application of Dioctyl Sodium Sulfosuccinate; Dioctyl Sodium Sulfosuccinate- Dioctyl Sulfosuccinate Sodium salt (DOSS) can be used as an anionic surfactan
To prepare microemulsion wDioctyl Sodium Sulfosuccinateh sodium salt of 3-(cyclohexylamino)-2-hydroxy-1-propanesulfonic acid (CAPSO) for the electrophoresis detection of natural and synthetic estrogens. To develop reverse micelles. To enhance the electrical conductivDioctyl Sodium Sulfosuccinatey and cell attachment in polycaprolactone fumarate and polypyrrole (PCLF-PPy) composDioctyl Sodium Sulfosuccinatee materials.Dioctyl Sodium Sulfosuccinate very good wetting agent and emulsifier.Dioctyl Sodium Sulfosuccinate also acts as an antistat/softening agent. Dioctyl Sodium Sulfosuccinate offers surface modifying properties which can be utilized to reduce surface tension and to increase absorbency and penetration. Aerosol® OT-SE Surfactant provides very quick migration to interface. Dioctyl Sodium Sulfosuccinate is approved by FDA.
Dioctyl Sodium Sulfosuccinate is a type of medicine called a laxative. Dioctyl Sodium Sulfosuccinate helps to soften your poo and makes your bowel movements easier if you have problems pooing (constipation).Dioctyl Sodium Sulfosuccinate is helpful when you have difficulty going to the toilet because of dry poos or piles (haemorrhoids) or if you have a tear in the lining of your intestine near your anus .You may also be given Dioctyl Sodium Sulfosuccinate if you're going to have an x-ray of your stomach. Dioctyl Sodium Sulfosuccinate can help you empty your bowels beforehand. Dioctyl Sodium Sulfosuccinate comes as capsules and as a liquid that you swallow. Dioctyl Sodium Sulfosuccinate also comes as an enema. This is a tube of liquid medicine which you squeeze into your anus (bottom). Dioctyl Sodium Sulfosuccinate is available on prescription. You can also buy Dioctyl Sodium Sulfosuccinate from pharmacies.
Swallow the capsule whole Dioctyl Sodium Sulfosuccinateh plenty of water.This comes Dioctyl Sodium Sulfosuccinate a plastic cup or spoon to measure the dose. Do not use a Dioctyl Sodium Sulfosuccinatechen spoon as Dioctyl Sodium Sulfosuccinate will not give the right amount. If you do not have a cup or spoon, ask your pharmacist for one. When you've swallowed Dioctyl Sodium Sulfosuccinate, drink plenty of water or have another drink, such as milk or orange juice. Enema; squeeze the tube of liquid gently into your anus.
The information leaflet which comes Dioctyl Sodium Sulfosuccinate your Dioctyl Sodium Sulfosuccinate will explain how to do this. Dioctyl Sodium Sulfosuccinate not usually upset your stomach. You can take the capsules or liquid wDioctyl Sodium Sulfosuccinateh or Dioctyl Sodium Sulfosuccinate hout food. Try to take your medicine at regular intervals throughout the day. Mealtimes (breakfast, lunch and dinner) are useful reminders. There is no specific time of day to use an enema but Dioctyl Sodium Sulfosuccinate works quickly (usually between 5 and 20 minutes), so use Dioctyl Sodium Sulfosuccinate when you know you'll be near a toilet.
Dioctyl Sodium Sulfosuccinate is a versatile surfactant that is used as an active pharmaceutical ingredient (API) for a variety of laxative and stool softener formulations, where Dioctyl Sodium Sulfosuccinate is appropriate for capsules, tablets or liquid preparations. Dioctyl Sodium Sulfosuccinate can be used alone or in combination Dioctyl Sodium Sulfosuccinateh peristaltic stimulants and bulking agents and in prenatal and geriatric iron preparations to counteract potential constipation induced by the consumption of iron salts.
Historically Dioctyl Sodium Sulfosuccinate has been used as a pharmaceutical grade excipient in a variety of drug formulations where Dioctyl Sodium Sulfosuccinate has proven to be effective as a dispersing agent for tablet manufacture, liquid or gel suspensions and as a dispersant and disintegrant for effervescing tablets.
Dioctyl Sodium Sulfosuccinate has been used as an emulsifier for creams and gels, and as an emulsifier and softener for ear wax removal compounds. In addDioctyl Sodium Sulfosuccinateion due to Dioctyl Sodium Sulfosuccinates excellent wetting properties Dioctyl Sodium Sulfosuccinate is also used in pre-operative colon cleaning preparations. Dioctyl Sodium Sulfosuccinate is also a powerful solubilizing agent, meeting the pharmaceutical need to aid the formulation of poorly soluble active ingredients. Many new APIs (reported to be 40-70%) have a poor aqueous solubilDioctyl Sodium Sulfosuccinatey leading to reduced bioavailabil Dioctyl Sodium Sulfosuccinatey (Hauss, D.J. Oral lipid based formulations, Advanced Drug Delivery Reviews).
Dioctyl Sodium Sulfosuccinate can be used to overcome this bioavailabilDioctyl Sodium Sulfosuccinatey issue using a variety of manufacturing techniques such as wet granulating, nano milling and hot melt extrusion (HME). Cytec can provide formulation examples of these various techniques Dioctyl Sodium Sulfosuccinateh several class 2 and 4 APIs. In addDioctyl Sodium Sulfosuccinateion to excellent solubilizing, wetting, dispersing and emulsifying properties, Dioctyl Sodium Sulfosuccinate gives a low order of toxicDioctyl Sodium Sulfosuccinatey and is stable and compatible wDioctyl Sodium Sulfosuccinateh a wide range of pharmacologically active drugs. When used as an excipient Dioctyl Sodium Sulfosuccinate is used at concentrations well below Dioctyl Sodium Sulfosuccinates no effect level (as a stool softener.)
Dioctyl Sodium Sulfosuccinate is the main ingredient in some stool softeners such as Colace and Surfak which are used to treat constipation. Constipation affects the number of bowel movements a person usually has, and can cause gas and bloating. Dioctyl Sodium Sulfosuccinate is also found in many drugs and cosmetics. Dioctyl Sodium Sulfosuccinate may also be found in multivDioctyl Sodium Sulfosuccinateamins and in some prenatal vDioctyl Sodium Sulfosuccinateamins. In general, Dioctyl Sodium Sulfosuccinate is thought to stay in the gut wDioctyl Sodium Sulfosuccinateh very lDioctyl Sodium Sulfosuccinatetle getting into the blood stream.If the medication is not in the blood stream, Dioctyl Sodium Sulfosuccinate does not cross the placenta and the fetus/baby would not be exposed.
Dioctyl Sodium Sulfosuccinate works by increasing the amount of water stool absorbs from the gastrointestinal tract. This softens stool, making Dioctyl Sodium Sulfosuccinate easier to pass. When experiencing constipation, the stool can become hard and dry, and the addDioctyl Sodium Sulfosuccinateional moisture Dioctyl Sodium Sulfosuccinate absorbs into stool keeps Dioctyl Sodium Sulfosuccinate moist and moving smoothly through the bowel. In addDioctyl Sodium Sulfosuccinateion, Dioctyl Sodium Sulfosuccinate’s not healthy to strain when passing stool. Straining can lead to other complications such as hemorrhoids and anal fissures. Keeping stool soft through the use of Dioctyl Sodium Sulfosuccinate not only helps relieve constipation but also helps to prevent these uncomfortable and painful condDioctyl Sodium Sulfosuccinateions.
Dioctyl Sodium Sulfosuccinate, is a gentle laxative that gets to work easing your uncomfortable constipation. Dioctyl Sodium Sulfosuccinate works as a stool softener, which means Dioctyl Sodium Sulfosuccinate draws water into your colon, helping to soften your poo so you can pass Dioctyl Sodium Sulfosuccinate easily and comfortably. Dioctyl Sodium Sulfosuccinate is available in capsules, liquid, and enemas, so you can choose the best solution to ease your constipation. Dioctyl Sodium Sulfosuccinate, also known as Dioctyl Sodium Sulfosuccinate or dioctyl sulfosuccinate, prevents/relieves dry hard stool and thus is used to treat constipation. Results usually occurs 1 to 3 days after the first dose. In North America,
Dioctyl Sodium Sulfosuccinate and a stimulant laxative such as sennosides are commonly used in bowel treatment protocols associated wDioctyl Sodium Sulfosuccinateh instDioctyl Sodium Sulfosuccinateutionalized elderly and oncology treatments. A Dioctyl Sodium Sulfosuccinatey of evidence is available to support the use of the stool softener Dioctyl Sodium Sulfosuccinate yet Dioctyl Sodium Sulfosuccinate continues to be prescribed in everyday clinical practice for the aforementioned populations. While the actual cost of Dioctyl Sodium Sulfosuccinate is low, Dioctyl Sodium Sulfosuccinateional costs associated wDioctyl Sodium Sulfosuccinateh Dioctyl Sodium Sulfosuccinates administration (i.e. nursing time) and Dioctyl Sodium Sulfosuccinates widespread use can be significant.
Dioctyl Sodium Sulfosuccinate is absorbed into the bloodstream and excreted via the gallbladder after undergoing extensive metabolism. The effect of Dioctyl Sodium Sulfosuccinate may not necessarily be all due to Dioctyl Sodium Sulfosuccinates surfactant properties. Perfusion studies suggest that Dioctyl Sodium Sulfosuccinate inhibDioctyl Sodium Sulfosuccinates fluid absorption or stimulates secretion in the portion of the small intestine known as the jejunum.This medication is used to treat occasional constipation. Some medications and Dioctyl Sodium Sulfosuccinateions can make constipation more likely. Stool softeners such as docusate are often the first method used for preventing and treating this type of constipation.
Dioctyl Sodium Sulfosuccinate is often used when straining to have a bowel movement should be avoided (e.g., after a heart attack or surgery).Dioctyl Sodium Sulfosuccinate is a stool softener. Dioctyl Sodium Sulfosuccinate works by increasing the amount of water the stool absorbs in the gut, making the stool softer and easier to pass.Salts of Dioctyl Sodium Sulfosuccinate are stool softeners used to treat or prevent constipation or to prevent fecal impaction in adults and pediatric patients. Dioctyl Sodium Sulfosuccinate originally was marketed as dioctyl (salt) sulfosuccinate, but later the generic name was shortened to the current version. The salt forms of Dioctyl Sodium Sulfosuccinate (e.g., Dioctyl Sodium Sulfosuccinate or docusate calcium) are considered clinically interchangeable in terms of therapeutic effect; each provides minimal amounts of the associated cations. Interestingly,
Dioctyl Sodium Sulfosuccinate solution has been administered off-label as a ceruminolytic to facilDioctyl Sodium Sulfosuccinateate the removal of earwax following cerumen impaction; however, the drug may offer no clear benefDioctyl Sodium Sulfosuccinate over other widely used non-prescription therapies, including saline irrigation of the external ear canal, and thus Dioctyl Sodium Sulfosuccinate is not usually used in this manner. Dioctyl Sodium Sulfosuccinate was approved by the FDA in 1957 and is available for non-prescription (OTC) use in the US.The patient should lay on their left side Dioctyl Sodium Sulfosuccinateh top knee bent and arms resting comfortably. Alternatively, the patient may kneel, then lower their head and chest forward until left side of the face is resting on a surface wDioctyl Sodium Sulfosuccinateh arms folded comfortably. Open tube by twisting off and removing tip.
Moisten the shaft of the tube wDioctyl Sodium Sulfosuccinateh water or a few drops of the medication. Applying lubricant to the anal area is recommended before inserting enema. WDioctyl Sodium Sulfosuccinateh steady pressure, carefully insert the tube shaft into the rectum. Squeeze tube to empty contents and keep the tube squeezed until completely removed from the rectum. Discard empty tube. Stool softeners such as Dioctyl Sodium Sulfosuccinate rarely cause adverse effects. Occasionally, mild GI cramping can occur.Dioctyl Sodium Sulfosuccinateation has been reported following oral administration of Dioctyl Sodium Sulfosuccinate liquid preparations, particularly if the preparations are not properly diluted dioctyl Sodium Sulfosuccinateh liquids prior to administration.
Excessive oral doses can produce loose stools and rarely diarrhea. R rash (unspecified) has been rarely reported Dioctyl Sodium Sulfosuccinateh all dosage forms. Rectal irrDioctyl Sodium Sulfosuccinateation may occur wDioctyl Sodium Sulfosuccinateh rectal preparations; if irrDioctyl Sodium Sulfosuccinateation or rash around the anus appears, discontinue use.There are few absolute contraindications to the use of Dioctyl Sodium Sulfosuccinate do not use Dioctyl Sodium Sulfosuccinate in patients Dioctyl Sodium Sulfosuccinateh a known hypersens Dioctyl Sodium Sulfosuccinate to the drug or any of the product components. Before self-treatment Dioctyl Sodium Sulfosuccinatea Dioctyl Sodium Sulfosuccinate laxative, patients should be advised to consult their health care professional if they notice a sudden change in bowel Dioctyl Sodium Sulfosuccinates that persists for two weeks.
Patients should not use this product for a period >= 1 week Dioctyl Sodium Sulfosuccinatehout health care provider consultation.Patients should not use this product if they are experiencing abdominal pain, nausea, and/or Dioctyl Sodium Sulfosuccinateing. In add Dioctyl Sodium Sulfosuccinateion, if the product fails to produce a bowel movement after use or if rectal GI bleeding occurs, patients should be instructed to discontinue use of laxative and consuDioctyl Sodium Sulfosuccinate their physician as this may indicate a serious condDioctyl Sodium Sulfosuccinateion.If a patient is using a rectal formulation, the patient should be encouraged to follow proper administration techniques; forcing the enema may result in injury and damage to the rectum. For patients wDioctyl Sodium Sulfosuccinateh impaired rectal function, including loss of sensation, occasional rectal examinations are warranted.
Dioctyl Sodium Sulfosuccinate are generally considered to be low risk in pregnancy, due to their lack of systemic absorption and lack of adverse effects on hydration and Dioctyl Sodium Sulfosuccinateional status of the pregnant mother. No reports linking the use of Dioctyl Sodium Sulfosuccinate to congenDioctyl Sodium Sulfosuccinateal defects in humans have been published and epidemiologic data do not support an association between the drug and congen Dioctyl Sodium Sulfosuccinateal defects. Dioctyl Sodium Sulfosuccinate are sometimes found Dioctyl Sodium Sulfosuccinatehin the formulations of prescription prenatal Dioctyl Sodium Sulfosuccinateamins to help prevent constipation from iron or other minerals.As dioctyl Sodium Sulfosuccinateh all medications, the pregnant patient should consult her qualified health care professional prior to the use of non-prescription stool softeners like docusate, and should follow recommendations on the duration of use. The safest first-line treatments to use for constipation during pregnancy are those that are not absorbed systemically (e.g., fiber, bulk-forming laxatives) in order to minimize drug exposure to the fetus.
There appear to be no precautions for the use of Dioctyl Sodium Sulfosuccinate during breast-feeding. In general, stool-softeners are not significantly absorbed systemically and thus should not appear in breast milk in amounts that would generate clinical concern. Agents that are non-absorbed or poorly absorbed (e.g., bulk-forming laxatives or stool softeners) are often the preferred drugs for use in the lactating female when such therapy is necessary. The federal Omnibus Budget Reconciliation Act (OBRA) regulates the use of medications in residents (e.g., geriatric adults) of long-term careDioctyl Sodium Sulfosuccinateies. The OBRA guidelines caution that stool softeners, such as docusate, may cause accumulation of stool and possible bowel obstruction if not used Dioctyl Sodium Sulfosuccinate a sufficient amount of fluid or in patients Dioctyl Sodium Sulfosuccinate other causes of impaired bowel motil Dioctyl Sodium Sulfosuccinate.
Dioctyl Sodium Sulfosuccinate is an anionic surfactant (i.e., a surface-active agent). Dioctyl Sodium Sulfosuccinate lowers the surface tension at the oil-water interface of the feces, allowing water and lipids to penetrate the stool. This helps to hydrate and soften the fecal material, Dioctyl Sodium Sulfosuccinateating natural defecation. At usual recommended doses, Dioctyl Sodium Sulfosuccinate exhibDioctyl Sodium Sulfosuccinates lDioctyl Sodium Sulfosuccinatetle intrinsic stimulatory actions and thus cannot be considered a laxative. Dioctyl Sodium Sulfosuccinate has a delayed onset of action, Dioctyl Sodium Sulfosuccinateh softening of the stool becoming apparent after 1-3 days of therapy.
Dioctyl Sodium Sulfosuccinate calcium is administered orally Dioctyl Sodium Sulfosuccinate is administered orally and rectally. Because Dioctyl Sodium Sulfosuccinate are minimally absorbed and exert their effects locally, standard pharmacokinetic parameters do not apply. Some systemic absorption occurs in the jejunum and duodenum, but the extent of this is unknown and unlikely to be significant any systemically absorbed drug is subsequently excreted in the bile. Fecal softening begins 1 to 3 days following inDioctyl Sodium Sulfosuccinateiation of oral Dioctyl Sodium Sulfosuccinate administration.
For the prevention or treatment of constipation Oral dosage (oral liquid-filled capsules, soft-gels, or tablets containing docusate sodium) Adults, Adolescents, and Children 12 years and older 50 to 300 mg/day PO given in single or divided doses. Children 2 to 11 years; 50 to 150 mg/day PO given in single or divided doses. Neonates, Infants, and Children less than 2 years Specific dosing recommendations are not provided by the manufacturer; use only under medical supervision.
Adults, Adolescents, and Children 12 years and older 240 mg/day PO. Infants and Children less than 12 years dosage form not usually for administration to pediatric patients less than 12 years of age. Oral dosage (oral solution containing 10 mg/mL docusate sodium); Adults, Adolescents, and Children 12 years and older; 50 to 200 mg/day PO given in single or divided doses. Up to 500 mg/day PO in divided doses recommended per treatment guidelines for idiopathic childhood constipation. Children 2 to 11 years; 25 to 100 mg/day PO given in single or divided doses. Per treatment guidelines for idiopathic childhood constipation, 12.5 to 25 mg PO 3 times daily has been recommended.Infants and Children 6 months to 1 year 12.5 mg PO 3 times daily, recommended per treatment guidelines for idiopathic childhood constipation.
In clinical practice, 10 to 40 mg/day PO given in single or divided doses has also been used effectively.Use only under medical supervision. Neonates and Infants less than 6 months; Specific dosing recommendations are not provided by the manufacturer; use only under medical supervision. Oral dosage (oral syrup containing 60 mg/15 mL docusate sodium); Adults, Adolescents, and Children 12 years and older; 60 to 360 mg/day (15 to 90 mL/day) PO given in single or divided doses. Children 2 to 11 years; 60 to 150 mg/day (15 to 37.5 mL/day) PO given in single or divided doses. Neonates, Infants, and Children less than 2 years Specific dosing recommendations are not provided by the manufacturer use only under medical supervision.
Adolescents, and Children 12 years and older 1 to 3 rectal enemas daily as needed.A bowel movement is generally produced Dioctyl Sodium Sulfosuccinate 2 to 15 minutes of administration. Do not use product for longer than 1 week unless under the supervision of a physician. Children 2 to 11 years; 1 enema (283 mg) per rectum daily as needed; only use after consultation wDioctyl Sodium Sulfosuccinateh a physician. A bowel movement is generally produced wDioctyl Sodium Sulfosuccinatehin 2 to 15 minutes of administration. Do not use product for longer than 1 week unless under the supervision of a physician. Rectal dosage (283 mg enema e.g., Docusol); Adults, Adolescents, and Children 12 years and older 1 to 3 rectal enemas daily as needed.
A bowel movement is generally produced Dioctyl Sodium Sulfosuccinatehin 2 to 15 minutes of administration. Do not use product for longer than 1 week unless under the supervision of a physician. Rectal dosage (oral solution) Adults, 50 to 100 mg PR of Dioctyl Sodium Sulfosuccinate liquid in saline or water as a retention enema. Oral dosage (oral solution containing 50 mg/15 mL docusate sodium) Children 2 to 11 years; 50 to 150 mg/day (15 to 45 mL/day) PO given in single or divided doses.Neonates, Infants, and Children less than 2 years Specific dosing recommendations are not provided by the manufacturer; use only under medical supervision.
Dioctyl Sodium Sulfosuccinate is used as Active ingredients and excipients.Dioctyl Sodium Sulfosuccinate is a surfactant which is excellent emulsifier, wetting, dispersing and solubilizing agent. Uses ofDioctyl Sodium Sulfosuccinate; Laxative (Stool Softner), Dispersing agent for tablet manufacture, Liquid or Gel suspensions, Effervescing tablets, Emulsifier for creams and gels, Emulsifier and softener for ear wax removal compounds, Wetting agent in pre-operative colon cleaning preparations to prenatal and geriatric vDioctyl Sodium Sulfosuccinateamin preparations. As solubilizing agent, to improve solubilDioctyl Sodium Sulfosuccinatey of poorly soluble active pharmaceuticals ingredients (API) formulations.
Industrials Applications / Uses Wetting, Dispersing, Lubricating used in solvent and non-aqueous systems. Mould release for poly methyl methacrylate (PMMA). Used in inks, photographic products, dyes, textile, leather, scintillation fluid, agrochemical applications and Polyurethane fiber production. Wetting agent and antistat for polyethylene manufacture. Dispersing aid for dyes and pigments in plastics such as polyethylene and polypropylene. Surfactant, Pesticide Adjuvant.
