PRODUCTS

DIOCTYL SULFOSUCCINATE SODIUM SALT (DOCUSATE SODIUM)

Dioctyl sulfosuccinate sodium salt is the sodium salt of docusate, a dioctyl salt and an emollient laxative with stool-softening activity.
Dioctyl sulfosuccinate sodium salt decreases surface tension and emulsification of fecal matter and allows water to penetrate and mix with stool.
As a result, Dioctyl sulfosuccinate sodium salt softens the stool.

CAS: 577-11-7
European Community (EC) Number: 209-406-4

IUPAC Name: sodium;1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonate

Molecular Formula: C20H37NaO7S
Molecular Weight: 444.6 g/mol

Physical Description: Commercially available in rolls of very thin wax-like solid
Odor: CHARACTERISTIC ODOR
Solubility: SOL IN WATER (G/L): 15 (25 °C), 23 (40 °C), 30 (50 °C), 55 (70 °C);
SOL IN CARBON TETRACHLORIDE, PETROLEUM ETHER, NAPHTHA, XYLENE, DIBUTYL PHTHALATE, LIQUID PETROLATUM, ACETONE, ALCOHOL, VEGETABLE OILS;
VERY SOL IN WATER-MISCIBLE ORGANIC SOLVENTS
Stability / Shelf Life: STABLE IN ACID & NEUTRAL SOLN; HYDROLYZES IN ALKALINE SOLN
Surface Tension: (DYNES/CM) IN WATER at 25 DEG: 62.8% (0.001%); 28.7 (0.1%); 26.0 (1.0%)

Docusate Sodium (Dioctyl sulfosuccinate sodium salt) is a laxative used to for the research of constipation, for constipation due to the use of opiates it maybe used with a stimulant laxative, can be taken by mouth or rectally.

Diethylhexyl Sodium Sulfosuccinate is a sodium salt of the diester of 2-ethylhexyl alcoholand sulfosuccinic acid.

All-purpose surfactant, wetting agent, and solubilizer used in the drug, cosmetics, and food industries.
Dioctyl sulfosuccinate sodium salt has also been used in laxatives and as cerumenolytics.
Dioctyl sulfosuccinate sodium salt is usually administered as either the calcium, potassium, or sodium salt.

Medical use

Constipation
The main medical use of dioctyl sulfosuccinate sodium salt is to treat constipation, acting as a laxative and stool softener.
In painful anorectal conditions such as hemorrhoid and anal fissures, Dioctyl sulfosuccinate sodium salt can help avoid pain caused by straining during bowel movements.

When administered by mouth, a bowel movement often occurs in 1 to 3 days, while rectal use may be effective within 20 minutes.

Dioctyl sulfosuccinate sodium salt is recommended as a stool softener for children.

The medication may be given to people who are receiving opioid medication, although prolonged use may cause irritation of the gastrointestinal tract.

Other medical uses
Dioctyl sulfosuccinate sodium salt, when used with ear syringing, may help with earwax removal, particularly in the case of impaction.

Dioctyl sulfosuccinate sodium salt is also used as a lubricant in the production of tablets and as an emulsifier in topical preparations and other suspensions.

Docusate sodium (dioctyl sodium sulfosuccinate) and docusate calcium (dioctyl calcium sulfosuccinate) act like detergents and are used to soften the stool when it is desirable to lessen the discomfort or the strain of defecation.

Dioctyl sulfosuccinate sodium salt is a stool softener often used as the initial treatment for chronic constipation, and it is FDA approved for this purpose.
Although only useful as a single agent in mild to moderate constipation, Dioctyl sulfosuccinate sodium salt can be used in conjunction with other agents in cases of refractory constipation.
The medication is typically dosed at 100 mg twice daily.

Mechanism of action
Dioctyl sulfosuccinate sodium salt is an anionic surfactant, which works by reducing the surface tension of the stool, allowing more intestinal water and fat to combine with the stool.
This decreases the strain and discomfort associated with constipation.

Dioctyl sulfosuccinate sodium salt does not stay in the gastrointestinal tract, but is absorbed into the bloodstream and excreted via the gallbladder after undergoing extensive metabolism.

The effect of Dioctyl sulfosuccinate sodium salt may not necessarily be all due to its surfactant properties.
Perfusion studies suggest that Dioctyl sulfosuccinate sodium salt inhibits fluid absorption or stimulates secretion in the portion of the small intestine known as the jejunum.

Food additive
Dioctyl sodium sulfosuccinate has been approved by the US FDA as a "generally recognized as safe" (GRAS) additive.
Dioctyl sulfosuccinate sodium salt is used in a variety of food products, as a surface active agent, stabilizer, thickener, wetting agent, processing aid, solubilizing agent, emulsifier, and dispersant.
The highest amount found in food products is 0.5% by weight, which include pasteurized cheese spreads, cream cheeses and salad dressings.
The FDA also approved its use as a wetting agent or solubilizer for flavoring agents in carbonated and non-carbonated drinks at levels up to 10 parts per million.

Chemistry

Structure and properties
The structural formula of the Dioctyl sulfosuccinate sodium salt is R−O−C(=O)−CH(SO−3)−CH2−C(=O)−O−R, where R is the 2-ethylhexyl group H3C−(CH2)3−C(−CH2−CH3)H−CH2−.
The conjugate acid can be described as the twofold carboxylate ester of sulfosuccinic acid with 2-ethylhexanol.

Dioctyl sulfosuccinate sodium salt is a white, wax-like, plastic solid, with an odor suggestive of octyl alcohol.
Dioctyl sulfosuccinate sodium salt starts to decompose at about 220 °C.

Solubility of dioctyl sodium sulfosuccinate in water is 14 g/L at 25 °C, increasing to 55 g/L at 70 °C.
Solubility is better in less polar solvents: 1:30 in ethanol, 1:1 in chloroform and diethylether, and practically unlimited in petroleum ether (25 °C).
Dioctyl sulfosuccinate sodium salt also is highly soluble in glycerol, although this is a rather polar solvent.
Dioctyl sulfosuccinate sodium salt is also highly soluble in xylene, oleic acid, acetone, diacetone alcohol, methanol, isopropanol, 2-butanol, methyl acetate, ethyl acetate, furfurol, and vegetable oils.

The ester groups are easily cleaved under basic conditions, but are stable against acids.

Synthesis
Sodium dioctyl sulfosuccinate can be obtained by treating dioctyl maleate with sodium bisulfite. The bisulfite anion adds to the double bond:

Dioctyl sulfosuccinate sodium salt is a synthetic chemical compound that can be described simply as a dioctyl sulfosuccinate as the sodium salt (empirical formula: C20H37NaO7S; molecular weight 444.6 g/mol).
Dioctyl sulfosuccinate sodium salt is a surface-active agent and is hygroscopic.
Docusate sodium is available as a white or whitish waxy or plastic solid-like substance with a characteristic aromatic odour.

Dioctyl sulfosuccinate sodium salt is a surfactant used to prepare reverse micelles.
Dioctyl sulfosuccinate sodium salt is an effective laxative used to treat constipation.
Acting as an ionic surfactant, Dioctyl sulfosuccinate sodium salt enhances water content within the intestinal lumen, leading to softer stool and facilitating bowel movements.
By elevating the surface tension between the stool and intestinal wall, Dioctyl sulfosuccinate sodium salt promotes easier expulsion of the stool, thereby alleviating constipation.

Sodium salt of Docusate, used for the treatment of constipation, acting as a laxative or stool softener.
Dioctyl sulfosuccinate sodium salt is also used in the synthesis of electrospun fibres for tailored and controlled antibiotic drug release.

Dioctyl sulfosuccinate sodium salt is a wetting and emulsifying agent that is slowly soluble in water, having a solubility of 1 g in 70 ml of water.
Dioctyl sulfosuccinate sodium salt functions as a wetting agent in fumaric acid-containing powdered fruit drinks to help the acid dissolve in water.
Dioctyl sulfosuccinate sodium salt is used as a stabilizing agent on gums at not more than 0.5% by weight of the gum.
Dioctyl sulfosuccinate sodium salt is used as a flavor potentiator in canned milk where it improves and maintains the flavor of the sterilized milk during storage.
Dioctyl sulfosuccinate sodium salt also functions as a processing aid in the manufacture of unrefined sugar.
Dioctyl sulfosuccinate sodium salt is also termed sodium dioctylsulfosuccinate.

Dioctyl sulfosuccinate sodium salt is a laxative used to treat constipation by absorbing into the bloodstream and excreted via the gallbladder after undergoing extensive metabolism.

Dioctyl sulfosuccinate sodium salt (DSS) is a surfactant that is used in the formulation of aerosol products.
Dioctyl sulfosuccinate sodium salt can be used as a matrix for the analytical determination of enzyme activities such as glutathione reductase and cytochrome p450, which are involved in the metabolism of xenobiotics.
Dioctyl sulfosuccinate sodium salt has been shown to have an optimum concentration of 0.1% and fluorescence probe with a pH range between 7-9.
Dioctyl sulfosuccinate sodium salt also shows ionotropic gelation properties at concentrations greater than 1%.

Dioctyl sulfosuccinate sodium salt is used to make stools softer and easier to pass.
Dioctyl sulfosuccinate sodium salt is used in symptomatic treatment of constipation, and in painful anorectal conditions such as hemorrhoids and anal fissures for people avoiding straining during bowel movements.
Patients taking docusate should drink plenty of water to irrigate the bowel, thereby increasing motility.
Given orally, the effects are usually seen 1 to 3 days after the first dose.
Given rectally, as an enema or suppository, a bowel movement usually occurs within 5 to 20 minutes.

The drug may be used in people who are undergoing opioid pain therapy, are opioid dependent, or on opioid replacement therapy, though prolonged use may cause irritation of the gastrointestinal tract.

Docusate, or dioctyl sulfosuccinate, is a stool softener indicated for the treatment of constipation.
Dioctyl sulfosuccinate sodium salt acts by increasing the amount of water the stool absorbs in the gut, making the stool softer and easier to pass.
Dioctyl sulfosuccinate sodium salt can be orally or rectally administered.
Dioctyl sulfosuccinate sodium salt is on the World Health Organization's List of Essential Medicines.

Wetting and solubilizing agent.
Dioctyl sulfosuccinate sodium salt is used as a surfactant, wetting agent and in the preparation of reverse micelles.
Dioctyl sulfosuccinate sodium salt is utilized in electrophoresis detection of natural and synthetic estrogens.
Dioctyl sulfosuccinate sodium salt also finds use in the drug, cosmetics, food industry and as a laxative to treat constipation.
Further, Dioctyl sulfosuccinate sodium salt is used as a food additive, emulsifier and dispersant.
Dioctyl sulfosuccinate sodium salt plays an important role as an excipient in the production of tablets and suspensions.

Dioctyl Sodium Sulfosuccinate (DOSS) (CAS- 577-11-7) also called docusate sodium or sodium dioctyl sulfosuccinate is a 2-ethyl hexyl diester of succinic acid with a sulphonic acid group as a salt in the sodium form.
Dioctyl sulfosuccinate sodium salt has a molecular weight of 444.6 and molecular formula C20H37NaO7S.
Dioctyl sulfosuccinate sodium salt on the WHO list of essential medicines and is used for palliative care (emollient laxative with stool-softening activity) in oral form as a liquid or capsule.
Dioctyl sulfosuccinate sodium salt is also used as food additive for its emulsifying and humectant activity and in cosmetics.
Dioctyl sulfosuccinate sodium salt has effective wetting property which makes the industrial use in adhesives and sealants, cleaning and furnishing care products(fabric, textile, and leather products), ink, toner, and colorant products (pigment dispersion); laundry and dishwashing products; lubricants and greases; paints and coatings&paper products.
Dioctyl sulfosuccinate sodium salt has fire extinguishing properties since in solutions it generates foam and allows water spreading to contain fires.
Dioctyl sulfosuccinate sodium salt has been generally recognized as safe (GRAS)for use in carbonated and non-carbonated beverages functioning as a wetting agent or solubilizer for flavor emulsion stabilizers at levels up to 10 ppm.

Dioctyl sulfosuccinate sodium salt APPLICATIONS IN POLYMER RESEARCH

Bis (2‐ethylhexyl) sulfosuccinate sodium salt is used both as dopant and hydrophobizing agent in the oxidative polymerization of pyrole and the polypyrrole grains are used as light-responsive liquid marble stabilizer.
In conducting polymers made from polyaniline, use of Dioctyl sulfosuccinate sodium salt as dopant improves the metallic-type conductivity, elongations and thermally more stable than material made with other dopants.

SYNONYMS:

Docusate sodium
577-11-7
Dioctyl sodium sulfosuccinate
Aerosol OT
Dioctyl sulfosuccinate sodium salt
Dioctylal
Diotilan
Disonate
Molatoc
Regutol
Velmol
Doxol
Nevax
Constonate
Dialose
Doxinate
Soliwax
Molcer
Waxsol
Adekacol EC 8600
Docusate (Sodium)
Mervamine
Clestol
Defilin
Obston
Requtol
Colace
Docusate sodium salt
Diox
Modane Soft
Alcopol O
Sulfimel DOS
Manoxal OT
Manoxol OT
Aerosol AOT
Aerosol GPG
Wetaid SR
Aerosol OT-A
Laxinate 100
Sanmorin OT 70
Triton GR 7
Triton GR-5
Aerosol OT 70PG
Aerosol OT 75
Celanol DOS 65
Celanol DOS 75
Coloxyl
Comfolax
Coprola
Dioctyl
Docolace
Docuprene
Dulcivac
Eurowet
Humifen WT 27G
Solusol-75%
Silace
Bloat treatment
Docusato sodico
Nikkol OTP 70
Aerosol A 501
Alkasurf SS-O 75
Bis(2-ethylhexyl) sulfosuccinate sodium salt
Solusol-100%
Docusate sodique
Nekal WT-27
Berol 478
Docusatum natricum
Empimin op70
Sanmorin ot 70n
Natrii dioctylsulfosuccinas
Tex-Wet 1001
Airrol ct-1
Doc Q Lace
Mackanate dos-70
Nikkol otp-75
Gemtex pa-70
Rapisol a 30
Triton gr-pg 70
Sodium dioctyl sulphosuccinate
Nissan rapisol a 30
Jamylene
Sodium 2-ethylhexylsulfosuccinate
HSDB 3065
Ins no.480
Monawet mo 65-150
Diethylhexyl Sodium Sulfosuccinate
2-Ethylhexyl sulfosuccinate sodium
EINECS 209-406-4
Ins-480
Dioctyl sodium sulphosuccinat
UNII-F05Q2T2JA0
Dioctyl ester of sodium sulfosuccinate
Bis(2-ethylhexyl)sodium sulfosuccinate
Bis(2-ethylhexyl) sodium sulfosuccinate
Di-(2-ethylhexyl) sodium sulfosuccinate
Sodium di-(2-ethylhexyl) sulfosuccinate
Docusate sodique [INN-French]
Docusato sodico [INN-Spanish]
F05Q2T2JA0
Docusatum natricum [INN-Latin]
DTXSID8022959
Dioctyl ester of sodium sulfosuccinic acid
AI3-00239
Sodium 1,4-bis(2-ethylhexyl) sulfosuccinate
Sodium sulfodi-(2-ethylhexyl)-sulfosuccinate
CHEMAX DOSS/75E
MFCD00012455
NSC-760404
Butanedioic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt
CHEBI:4674
DTXCID102959
Bis-2-ethylhexylester sulfojantaranu sodneho
E 480
E-480
sodium 1,4-bis[(2-ethylhexyl)oxy]-1,4-dioxobutane-2-sulfonate
EC 209-406-4
Sol sodowej sulfobursztynianu dwu-2-etyloheksylowego
sodium docusate
1,4-Bis(2-ethylhexyl)sulfobutanedioate, sodium salt
NSC 760404
Docusate sodium [USAN:USP:INN:BAN]
SBO
Sodium Di(2-ethylhexyl) Sulfosuccinate
Diomedicone
Complemix
Dioctlyn
Diosuccin
Dulsivac
Laxinate
Molofac
Sobital
Coprol
Diovac
Konlax
Kosate
Softil
Revac
AEC DIETHYLHEXYL SODIUM SULFOSUCCINATE
Alphasol OT
DOCUSATE SODIUM (II)
DOCUSATE SODIUM [II]
Docusate sodique (INN-French)
Docusato sodico (INN-Spanish)
DESS
Monawet MD 70E
DOCUSATE SODIUM (MART.)
DOCUSATE SODIUM [MART.]
Docusatum natricum (INN-Latin)
DOCUSATE SODIUM (USP-RS)
DOCUSATE SODIUM [USP-RS]
Geriplex
Unilax
Sodium bis(2-ethylhexyl) sulfosuccinate
Dioctyl sodium sulfosuccinate (JAN)
Dialose Plus
Senokot S
Correctol Caplets
Correctol Tablets
DOCUSATE SODIUM (USP IMPURITY)
DOCUSATE SODIUM [USP IMPURITY]
Senokap DSS
Docusate sodium (USAN:USP:INN:BAN)
DOCUSATE SODIUM (USP MONOGRAPH)
DOCUSATE SODIUM [USP MONOGRAPH]
D-S-S
CAS-577-11-7
DIOCTYL SODIUM SULFOSUCCINATE [JAN]
Correctol Extra Gentle Tablets
DEH Na SS
DEH-Na-SS
NCGC00164140-03
SV 102
Promolaxin
Colistat
Prenexa
Purgasol
Vinacol
Dioctylsulphosuccinate, Sodium
natrii docusas
Bis(2-ethylhexyl) S-sodium sulfosuccinate
Dioctyl Sulfosuccinate, Sodium
DocuSol
Colace Clear
DocQLace
Docusate Sod
Enemeez Kids
Sodium 1,4-bis((2-ethylhexyl)oxy)-1,4-dioxobutane-2-sulfonate
Docu Liquid
Single-Use
Sodium 1,4-bis(2-ethylhexyl)sulfosuccinate
1,4-Bis(2-ethylhexyl) sodium sulfosuccinate
DocuSol Kids
Senexon-S
docusato de sodio
Folca[s care pme
Folcal DHA
Senna-S
Di(2-ethylhexyl)sulfosuccinic acid, sodium salt
Sodium Sulfosuccinate, Diethylhexyl
Sulfosuccinate, Diethylhexyl Sodium
Betr stool softener
Bis(ethylhexyl) ester of sodium sulfosuccinic acid
CVS Stool Softener
Docusate Mini Enema
HEB Stool Softener
Bis-2-ethylhexylester sulfojantaranu sodneho [Czech]
Colace (TN)
Laxa-basic 100
Sodium di(2-ethylhexyl)sulfosuccinate
Clear Stool Softener
ENEMEEZ
Winco Stool Softener
Gentle Stool softener
Sulfosuccinic acid, bis(2-ethylhexyl)ester sodium salt
Kroger Stool Softener
Stool Softener Liquid
BLOAT RELEASE
STOOL SOFTNER
Docusate Sodium Liquid
PET-ENEMA
Topcare Stool Softener
DISPOSABLE ENEMA
Dulcolax Stool Softener
FELINE PET-EMA
PET-EMA
Phillips Stool Softener
Stool Softener Laxative
H E B Stool Softener
Sol sodowej sulfobursztynianu dwu-2-etyloheksylowego [Polish]
Docusate sodium (USP)
Docusate Sodium 100mg
Docusate Sodium 250mg
Walgreens Stool Softener
basic care stool softener
good sense stool softener
PlusPHARMAStool Softener
Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt
NCGC00183136-01
CVS Health Stool Softener
Stool SoftenerGentle Relief
betr remedies stool softener
SCHEMBL4113
Gentle Relief Stool Softner
Gentle Relief Stool Softnet
DQZATE STOOL SOFTENER
healthy mamaMOVE IT ALONG
Dulcolax Pink Stool Softener
Good Neighbor Stool Softener
Harris Teeter Stool Softener
DOCUSATE SODIUM [MI]
exchange select stool softener
H E B Stool Softenerlaxative
MLS004773938
Quality Choice Stool Softener
DOCUSATE SODIUM [INN]
Stool SoftenerRegular Strength
Topcare Stool Softenerlaxative
CVS Stool SoftenerFruit Punch
Stool Softener Docusate Sodium
DOCUSATE SODIUM [HSDB]
DOCUSATE SODIUM [USAN]
DOCUSATE SODIUM 50 MG
DOCUSATE SODIUM 100 mg
Stool Softener Regular Strength
STOOL SOFTENERExtra Strength
Sulfosuccinic acid bis(2-ethylhexyl) ester sodium salt
DOCUSATE SODIUM [VANDF]
GeriCare Docusate Sodium Liquid
Preferred Stool Softenerlaxative
CHEMBL1905872
CVS Health Stool Softener Clear
Kroger Stool SoftenerFruit Punch
A06AA02
Correctol Stool Softener Laxative
DOCUSATE SODIUM [WHO-DD]
Non-Habit Forming Stool Softener
Sulfosuccinic acid, di-(2-ethylhexyl) ester, sodium salt
APSBXTVYXVQYAB-UHFFFAOYSA-M
HMS3264P07
HMS3885B10
BCP31325
HY-B1268
Walgreens Stool SoftenerFruit Punch
4-(4-Bromophenoxymethyl)benzoicacid
EXTRA STRENGTH STOOL SOFTENER
Good Neighbor Stool Softenerlaxative
Phillips Stool SoftenerBulk Docusate
Sodium dioctyl sulfosuccinate (INN)
Tox21_112087
Tox21_113469
Tox21_201342
Tox21_300496
DOCUSATE SODIUM 100mg Two-Tone
Quality Choice Stool Softenerlaxative
s4588
Stool Softener LaxativeExtra Strength
DIOCTYL DISODIUM SULFOSUCCINATE
AKOS015901806
CCG-213234
CS-4813
DOCUSATE SODIUM, EXTRA STRENGTH
Docusate sodium salt, BioXtra, >=99%
Docusate Sodium-Stool Softener Laxative
Dioctyl sulfosuccinate sodium salt, 96%
DOK EXTRA STRENGTH STOOL SOFTENER
NCGC00164140-01
NCGC00254414-01
NCGC00258894-01
AS-13347
E480
SMR001595510
SY010813
DIOCTYL SODIUM SULFOSUCCINATE [FCC]
Bis(2-ethylhexyl) sulfosuccinatesodium salt
Dioctyl sulfosuccinate sodium salt, >=97%
EXTRA STRENGTH STOOL SOFTENER LAXATIVE
FT-0689234
STOOL SOFTENER DOCUSATE SODIUM 50 MG
DOCUSATE SODIUM, EXTRA STRENGTH250 MG
D00305
Docusate sodium salt, p.a., 99.0-100.5%
E77584
DIETHYLHEXYL SODIUM SULFOSUCCINATE [INCI]
Docusate sodium salt, purum, >=96.0% (TLC)
Docusate sodium salt, BioUltra, >=99.0% (TLC)
Docusate sodium, meets USP testing specifications
Q2815334
W-105447
F8880-5559
Docusate sodium, British Pharmacopoeia (BP) Reference Standard
Docusate sodium, European Pharmacopoeia (EP) Reference Standard
sodium 1,4-bis(2-ethylhexyloxy)-1,4-dioxobutane-2-sulfonate
Docusate sodium, United States Pharmacopeia (USP) Reference Standard
1,4-bis(2-ethylhexyl)sodiumsulfosuccinate pound>>Dioctyl sulfosuccinate sodium salt
Butanedioic acid, 2-sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt (1:1)
Docusate sodium; Sodium 1,4-bis[(2-ethylhexyl)oxy]-1,4-dioxobutane-2-sulfonate
Yal