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Dioctyl sulfosuccinate sodium salt is on the WHO list of essential medicines and is used for palliative care (emollient laxative with stool-softening activity) in oral form as a liquid or capsule.
Dioctyl sulfosuccinate sodium salt is also used as food additive for its emulsifying and humectant activity and in cosmetics.
Dioctyl sulfosuccinate sodium salt has effective wetting property which makes the industrial use in adhesives and sealants, cleaning and furnishing care products(fabric, textile, and leather products), ink, toner, and colorant products (pigment dispersion); laundry and dishwashing products; lubricants and greases; paints and coatings&paper products.
CAS Number: 577-11-7
Molecular Formula: C20H37O7S.Na
Molecular Weight: 444.56
EINECS Number: 209-406-4
Synonyms: Docusate sodium, 577-11-7, Aerosol OT, Dioctyl sodium sulfosuccinate, Dioctyl sulfosuccinate sodium salt, Dioctylal, Diotilan, Disonate, Molatoc, Regutol, Velmol, Doxol, Nevax, Constonate, Dialose, Doxinate, Soliwax, Colace, Molcer, Waxsol, Adekacol EC 8600, Docusate (Sodium), Mervamine, Clestol, Defilin, Obston, Requtol, Docusate sodium salt, Diox, Modane Soft, Alcopol O, Sulfimel DOS, Manoxal OT, Manoxol OT, Aerosol AOT, Aerosol GPG, Wetaid SR, Aerosol OT-A, Laxinate 100, Sanmorin OT 70, Triton GR 7, Triton GR-5, Aerosol OT 70PG, Aerosol OT 75, Celanol DOS 65, Celanol DOS 75, Coloxyl, Comfolax, Coprola, Dioctyl, Docolace, Docuprene, Dulcivac, Eurowet, Humifen WT 27G, Solusol-75%, Silace, Bloat treatment, Nikkol OTP 70, Aerosol A 501, Alkasurf SS-O 75, Bis(2-ethylhexyl) sulfosuccinate sodium salt, Solusol-100%, Nekal WT-27, Berol 478, Docusatum natricum, Empimin op70, Sanmorin ot 70n, Natrii dioctylsulfosuccinas, Tex-Wet 1001, Airrol ct-1, Doc Q Lace, Mackanate dos-70, Nikkol otp-75, Gemtex pa-70, Rapisol a 30, Triton gr-pg 70, D-S-S, Sodium dioctyl sulphosuccinate, Nissan rapisol a 30, Jamylene, Sodium 2-ethylhexylsulfosuccinate, Sodium bis(2-ethylhexyl) sulfosuccinate, HSDB 3065, Ins no.480, Monawet mo 65-150, 2-Ethylhexyl sulfosuccinate sodium, Dioctyl ester of sodium sulfosuccinic acid, EINECS 209-406-4, Ins-480, Dioctyl sodium sulphosuccinat, UNII-F05Q2T2JA0, Dioctyl ester of sodium sulfosuccinate, Bis(2-ethylhexyl)sodium sulfosuccinate, Bis(2-ethylhexyl) sodium sulfosuccinate, Di-(2-ethylhexyl) sodium sulfosuccinate, Sodium di-(2-ethylhexyl) sulfosuccinate, Docusate sodique [INN-French], Docusato sodico [INN-Spanish], F05Q2T2JA0, DTXSID8022959, AI3-00239, Diethylhexyl Sodium Sulfosuccinate, Sodium 1,4-bis(2-ethylhexyl) sulfosuccinate, Sodium sulfodi-(2-ethylhexyl)-sulfosuccinate, CHEMAX DOSS/75E, Di(2-ethylhexyl)sulfosuccinic acid, sodium salt, NSC-760404, Bis(ethylhexyl) ester of sodium sulfosuccinic acid, Butanedioic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt, Sulfosuccinic acid, bis(2-ethylhexyl)ester sodium salt, CHEBI:4674, DTXCID102959, Bis-2-ethylhexylester sulfojantaranu sodneho, E 480, E-480, sodium 1,4-bis[(2-ethylhexyl)oxy]-1,4-dioxobutane-2-sulfonate, EC 209-406-4, DIOCTYL SULFOSUCCINATE, Sol sodowej sulfobursztynianu dwu-2-etyloheksylowego, sodium docusate, 1,4-Bis(2-ethylhexyl)sulfobutanedioate, sodium salt, NSC 760404, AOT, Sulfosuccinic acid, di-(2-ethylhexyl) ester, sodium salt, Diomedicone, Complemix, Dioctlyn, Diosuccin, Dulsivac, Laxinate, Molofac, Sobital, Coprol, Diovac, Kosate, Softil, Revac, AEC DIETHYLHEXYL SODIUM SULFOSUCCINATE, Alphasol OT, DOCUSATE SODIUM (II), DOCUSATE SODIUM [II], Docusate sodique (INN-French), Docusato sodico (INN-Spanish), DESS, Monawet MD 70E, DOCUSATE SODIUM (MART.), DOCUSATE SODIUM [MART.], DOCUSATE SODIUM (USP-RS), DOCUSATE SODIUM [USP-RS], Geriplex, Unilax, Docusato sodico, Dioctyl sodium sulfosuccinate (JAN), Docusate sodique, Dialose Plus, Senokot S, Correctol Caplets, Correctol Tablets, DOCUSATE SODIUM (USP IMPURITY), DOCUSATE SODIUM [USP IMPURITY], Senokap DSS, DOCUSATE SODIUM (USP MONOGRAPH), DOCUSATE SODIUM [USP MONOGRAPH], CAS-577-11-7, Yal, DIOCTYL SODIUM SULFOSUCCINATE [JAN], Correctol Extra Gentle Tablets, Docusatum natricum [INN-Latin], NCGC00164140-03, SV 102, Prenexa, Purgasol, Vinacol, natrii docusas, Bis(2-ethylhexyl) S-sodium sulfosuccinate, Docusate Sod, Sodium 1,4-bis((2-ethylhexyl)oxy)-1,4-dioxobutane-2-sulfonate, Sodium 1,4-bis(2-ethylhexyl)sulfosuccinate, 1,4-Bis(2-ethylhexyl) sodium sulfosuccinate, Senexon-S, docusato de sodio, Folca[s care pme, Folcal DHA, Senna-S, Bis-2-ethylhexylester sulfojantaranu sodneho [Czech], Colace (TN), MFCD00012455, Sodium di(2-ethylhexyl)sulfosuccinate, Docusate sodium [USAN:USP:INN:BAN], DEH Na SS, DEH-Na-SS, Sol sodowej sulfobursztynianu dwu-2-etyloheksylowego [Polish], Docusate sodium (USP), Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt, NCGC00183136-01, SCHEMBL4113, DOCUSATE SODIUM [MI], C20H37O7S.Na, Dioctylsulphosuccinate, Sodium, MLS004773938, DOCUSATE SODIUM [INN], Dioctyl Sulfosuccinate, Sodium, DOCUSATE SODIUM [HSDB], DOCUSATE SODIUM [USAN], Sulfosuccinic acid bis(2-ethylhexyl) ester sodium salt, DOCUSATE SODIUM [VANDF], CHEMBL1905872, A06AA02, Correctol Stool Softener Laxative, DOCUSATE SODIUM [WHO-DD], APSBXTVYXVQYAB-UHFFFAOYSA-M, HMS3264P07, HMS3885B10, Sodium Sulfosuccinate, Diethylhexyl, Sulfosuccinate, Diethylhexyl Sodium, BCP31325, HY-B1268, 4-(4-Bromophenoxymethyl)benzoicacid, Sodium dioctyl sulfosuccinate (INN), Tox21_112087, Tox21_113469, Tox21_201342, Tox21_300496, s4588, DIOCTYL DISODIUM SULFOSUCCINATE, AKOS015901806, CCG-213234, CS-4813, Sodium Di(2-ethylhexyl) Sulfosuccinate, Dioctyl Sulfosuccinic Acid, Sodium Salt, Docusate sodium salt, BioXtra, >=99%, Dioctyl sulfosuccinate sodium salt, 96%.
Dioctyl sulfosuccinate sodium salt is the dioctyl ester of sodium sulfosuccinate (bis-2-ethyl-hexyl sodium sulfosuccinate).
Dioctyl sulfosuccinate sodium salt dissolves slowly in water; at 25°C to the extent of 1.5 gm/100cc; at 70°C, 5.5 gm/100cc.
Dioctyl sulfosuccinate sodium salt dissolves in oils, hydrocarbons, fats and waxs by heating above 75°C and remains in solution when cooled to room temperature.
Dioctyl sulfosuccinate sodium salt is readily soluble in most organic solvents, both polar and non-polar.
Dioctyl sulfosuccinate sodium salt also called docusate sodium or sodium dioctyl sulfosuccinate is a 2-ethyl hexyl diester of succinic acid with a sulphonic acid group as a salt in the sodium form.
Dioctyl sulfosuccinate sodium salt has a molecular weight of 444.6 and molecular formula C20H37NaO7S.
Dioctyl sulfosuccinate sodium salt has fire extinguishing properties since in solutions it generates foam and allows water spreading to contain fires.
Dioctyl sulfosuccinate sodium salt has been generally recognized as safe (GRAS)for use in carbonated and non-carbonated beverages functioning as a wetting agent or solubilizer for flavor emulsion stabilizers at levels up to 10 ppm.
Dioctyl sulfosuccinate sodium salt) was one of the main components of Corexit EC9500A, a chemical dispersant formulation used at the surface and at depth during the response to the Deepwater Horizon incident (2010) which significantly facilitated biodegradation of the spilled oil.
Dioctyl sulfosuccinate sodium salt is an anionic surfactant substance that traditionally has been recommended as a laxative and stool softener for a variety of vertebrates ranging from humans to rodents.
Dioctyl sulfosuccinate sodium salt has been advocated for the same use in reptiles.
Dioctyl sulfosuccinate sodium salt is the dioctyl ester of sodium sulfosuccinate.
The pure compound is a white waxy solid, soluble in many organic solvents and in water.
Dioctyl sulfosuccinate sodium salt is an anionic surface active compound, which has marked wetting characteristics.
Its detergent properties make it useful for cleaning and peeling fruits and vegetables and cleaning food packaging.
Dioctyl sulfosuccinate sodium salt is a laxative used to for the research of constipation, for constipation due to the use of opiates it maybe used with a stimulant laxative, can be taken by mouth or rectally.
Dioctyl sulfosuccinate sodium salt, commonly known by its brand name Docusate Sodium, is a medication and stool softener used to treat constipation and to prevent straining during bowel movements.
Dioctyl sulfosuccinate sodium salt belongs to a class of drugs called laxatives.
Dioctyl sulfosuccinate sodium salt is also used in various pharmaceutical products.
Dioctyl sulfosuccinate sodium salt is on the World Health Organization's List of Essential Medicines.
Salts of this anion, especially docusate sodium, are widely used in medicine as laxatives and as stool softeners, by mouth or rectally.
In 2020, it was the 163rd most commonly prescribed medication in the United States, with more than 3 million prescriptions.
Some studies claim that docusate is not more effective than a placebo for improving constipation.
Other docusate salts with medical use include those of calcium and potassium.
Dioctyl sulfosuccinate sodium salts are also used as food additives, emulsifiers, dispersants, and wetting agents, among other uses.
Dioctyl sulfosuccinate sodium salt and docusate calcium (dioctyl calcium sulfosuccinate) act like detergents and are used to soften the stool when it is desirable to lessen the discomfort or the strain of defecation.
The structural formula of the Dioctyl sulfosuccinate sodium salt is R−O−C(=O)−CH(SO− 3)−CH2−C(=O)−O−R, where R is the 2-ethylhexyl group H3C−(CH2)3−C(−CH2−CH3)H−CH2−.
The conjugate acid can be described as the twofold carboxylate ester of sulfosuccinic acid with 2-ethylhexanol.
The compound is a white, wax-like, plastic solid, with an odor suggestive of octyl alcohol.
Dioctyl sulfosuccinate sodium salt starts to decompose at about 220 °C.
Solubility of Dioctyl sulfosuccinate sodium salt in water is 14 g/L at 25 °C, increasing to 55 g/L at 70 °C.
Solubility is better in less polar solvents: 1:30 in ethanol, 1:1 in chloroform and diethylether, and practically unlimited in petroleum ether (25 °C).
Dioctyl sulfosuccinate sodium salt also is highly soluble in glycerol, although this is a rather polar solvent.
Dioctyl sulfosuccinate sodium salt is also highly soluble in xylene, oleic acid, acetone, diacetone alcohol, methanol, isopropanol, 2-butanol, methyl acetate, ethyl acetate, furfurol, and vegetable oils.
The ester groups are easily cleaved under basic conditions, but are stable against acids.
Dioctyl sulfosuccinate sodium salt, is a stool softener indicated for the treatment of constipation.
Dioctyl sulfosuccinate sodium salt acts by increasing the amount of water the stool absorbs in the gut, making the stool softer and easier to pass.
Dioctyl sulfosuccinate sodium salt can be orally or rectally administered.
Dioctyl sulfosuccinate sodium salt is on the World Health Organization's List of Essential Medicines10.
However the effectiveness of docusate in treating constipation remains unclear, as several studies report docusate to be no more effective than placebo for increasing the frequency of stool or stool softening 6,2,5.
Recently there has been pressure to stop prescribing docusate as it has been identified as an ineffective medicine3,5,9.
Dioctyl sulfosuccinate sodium salt does not appear to lessen symptoms associated with constipation such as abdominal cramps.
Still docusate is available in over-the-counter products as a common laxative.
Dioctyl sulfosuccinate sodium saltis not considered a rapid-acting laxative.
Dioctyl sulfosuccinate sodium salt may take a day or more to produce a noticeable softening of the stool and relief from constipation.
Dioctyl sulfosuccinate sodium salt is typically used for its gentle and gradual stool-softening effect.
Dioctyl sulfosuccinate sodium salt is sometimes combined with other active ingredients in stool softener or laxative products.
Dioctyl sulfosuccinate sodium salt may also be used in pediatric medicine to treat constipation in children.
However, the dosage and form of the medication will be adjusted according to the child's age and weight.
Always follow the guidance of a pediatrician when giving any medication to children.
Dioctyl sulfosuccinate sodium salt is generally considered safe for use during pregnancy and breastfeeding when used as directed.
However, Dioctyl sulfosuccinate sodium salt's important for pregnant or breastfeeding individuals to consult with a healthcare provider before using any medication to ensure it is appropriate for their specific circumstances.
In addition to using medications like Dioctyl sulfosuccinate sodium salt, healthcare providers often recommend lifestyle changes to prevent or manage constipation.
These may include increasing dietary fiber intake, drinking plenty of water, regular physical activity, and maintaining a regular bathroom routine.
Dioctyl sulfosuccinate sodium salt's important to avoid overreliance on laxatives, including docusate sodium, to manage constipation.
Long-term and excessive use of laxatives can lead to a condition known as laxative dependency, where the body becomes reliant on laxatives to have bowel movements.
If constipation is a persistent issue, it should be discussed with a healthcare provider to identify and address underlying causes.
Dioctyl sulfosuccinate sodium salt is generally considered safe and well-tolerated, but like any medication, it can interact with other drugs.
Dioctyl sulfosuccinate sodium salt is a white or almost white, waxlike, bitter tasting, plastic solid with a characteristic octanol-like odor.
Dioctyl sulfosuccinate sodium salt is hygroscopic and usually available in the form of pellets, flakes, or rolls of tissuethin material.
Dioctyl sulfosuccinate sodium salt is the common chemical and pharmaceutical name of the anion bis(2 ethylhexyl) sulfosuccinate, also commonly called dioctyl sulfosuccinate (DOSS).
Melting point: 173-179 °C(lit.)
Boiling point: 82.7°C
Density: 1.1
vapor pressure: 0Pa at 25℃
storage temp.: Inert atmosphere,Room Temperature
solubility: methanol: 0.1 M at 20 °C, clear, colorless
form: Waxy Solid
color: White
Specific Gravity: 1.005_PERCENT VOLATILE: 40
Water Solubility: 1.5 g/100 mL (25 ºC)
Sensitive: Hygroscopic
λmax: λ: 260 nm Amax: 0.1
λ: 280 nm Amax: 0.05
Merck: 14,3401
BRN: 4117588
Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey: APSBXTVYXVQYAB-UHFFFAOYSA-M
LogP: 1.998 at 20℃
Dioctyl sulfosuccinate sodium salt may also be found in combination with other medications in certain stool softener or laxative products.
Depending on the formulation and strength, Dioctyl sulfosuccinate sodium saltcan be available both as an over-the-counter (OTC) medication and by prescription.
OTC versions are often used for short-term relief of constipation, while prescription versions may be used in specific medical situations.
Dioctyl sulfosuccinate sodium salt is generally considered safe when used as directed.
Dioctyl sulfosuccinate sodium salt is typically well-tolerated, but like any medication, it can have side effects.
Common side effects may include diarrhea or stomach cramps.
Serious allergic reactions are rare but possible.
Dioctyl sulfosuccinate sodium salt is usually taken by mouth as directed by a healthcare provider or following the instructions on the product label.
Dosage and frequency of use may vary depending on individual circumstances and the specific product being used.
It is important to use Dioctyl sulfosuccinate sodium salt only as directed and not exceed the recommended dose.
If constipation persists or worsens despite treatment, or if experience any concerning symptoms, consult a healthcare provider.
Dioctyl sulfosuccinate sodium salt is typically recommended for short-term use to alleviate acute constipation.
For chronic or recurrent constipation, it is essential to consult a healthcare provider for a thorough evaluation and to discuss appropriate management strategies.
Dioctyl sulfosuccinate sodium salt is an anionic surfactant, which works by reducing the surface tension of the stool, allowing more intestinal water and fat to combine with the stool.
This decreases the strain and discomfort associated with constipation.
Dioctyl sulfosuccinate sodium salt does not stay in the gastrointestinal tract, but is absorbed into the bloodstream and excreted via the gallbladder after undergoing extensive metabolism.
The effect of Dioctyl sulfosuccinate sodium salt may not necessarily be all due to its surfactant properties.
Perfusion studies suggest that Dioctyl sulfosuccinate sodium salt inhibits fluid absorption or stimulates secretion in the portion of the small intestine known as the jejunum.
Dioctyl sulfosuccinate sodium salt is also known by other trade names and generic names, including Colace, Dioctyl Sodium Sulfosuccinate, and Sodium Dioctyl Sulfosuccinate.
Dioctyl sulfosuccinate sodium salt can be used by adults, children, and even infants under the guidance of a healthcare provider.
The appropriate dosage and form (e.g., liquid or tablet) may vary depending on age and individual needs.
Some individuals with chronic constipation or certain medical conditions may require ongoing use of stool softeners like Dioctyl sulfosuccinate sodium salt as part of their long-term management plan.
Dioctyl sulfosuccinate sodium salt according to the instructions on the product label.
Typically, Dioctyl sulfosuccinate sodium salt should be kept at room temperature, away from moisture and direct sunlight.
While Dioctyl sulfosuccinate sodium salt is considered gentle and safe for most people, overuse or misuse can lead to side effects like diarrhea, cramps, and electrolyte imbalances.
Dioctyl sulfosuccinate sodium salt's important to use it as directed and not exceed the recommended dose.
Healthcare providers often provide patient education when prescribing or recommending Dioctyl sulfosuccinate sodium salt.
This may include instructions on proper use, potential side effects, and when to seek medical attention if constipation persists or worsens.
Dioctyl sulfosuccinate sodium salt is crucial to consult with a healthcare provider.
They can help diagnose any underlying conditions and recommend appropriate treatment options, which may include Docusate Sodium or other interventions.
When using Dioctyl sulfosuccinate sodium salt, it's important to drink an adequate amount of fluids, as increasing water intake can help support the softening of stool and relieve constipation.
The onset of action of Dioctyl sulfosuccinate sodium salt can vary from person to person.
Dioctyl sulfosuccinate sodium salt may take a day or more to see the desired effect, so it's essential to be patient and consistent with its use.
Once constipation has resolved, it is typically advisable to discontinue the use of Dioctyl sulfosuccinate sodium salt, as prolonged and unnecessary use of laxatives may not be recommended.
History Of Dioctyl sulfosuccinate sodium salt
Dioctyl sulfosuccinate sodium salt was patented in 1937 by Coleman R. Caryl and Alphons O. Jaeger for American Cyanamid, which commercialized it for many years as a detergent under the brand name Aerosol OT.
Dioctyl sulfosuccinate sodium salts use for the treatment of constipation was first proposed in 1955 by James L. Wilson and David G. Dickinson, and quickly popularized under the name Doxinate.
Dioctyl sulfosuccinate sodium salt is the dioctyl ester of sodium sulfosuccinate (bis-2-ethyl-hexyl sodium sulfosuccinate).
Dioctyl sulfosuccinate sodium salt dissolves slowly in water; at 25°C to the extent of 1.5 gm/100cc; at 70°C, 5.5 gm/100cc.
Dioctyl sulfosuccinate sodium salt dissolves in oils, hydrocarbons, fats and waxs by heating above 75°C and remains in solution when cooled to room temperature.
At room temperature, Dioctyl sulfosuccinate sodium salt is readily soluble in most organic solvents, both polar and non-polar.
soluble in carbon tetrachloride, petroleum ether, naphtha, xylene, dibutyl phthalate, liquid petroleum, acetone, alcohol, vegetable oils.
Dioctyl sulfosuccinate sodium salt works by increasing the penetration of water into the stool, which makes it softer and more slippery.
This helps to ease the passage of stool through the intestines.
Dioctyl sulfosuccinate sodium salt is primarily used to relieve constipation, including cases of occasional constipation and constipation associated with certain medical conditions, such as postoperative recovery or bedridden patients.
Dioctyl sulfosuccinate sodium salt is also sometimes used to prevent straining during bowel movements, which can be important for individuals with certain medical conditions, such as hemorrhoids or after surgery.
Dioctyl sulfosuccinate sodium salt is available in various forms, including oral capsules, tablets, and liquid solutions.
Uses Of Dioctyl sulfosuccinate sodium salt:
Dioctyl sulfosuccinate sodium salt is used to make stools softer and easier to pass.
Dioctyl sulfosuccinate sodium salt is used in symptomatic treatment of constipation, and in painful anorectal conditions such as hemorrhoids and anal fissures for people avoiding straining during bowel movements.
Patients taking docusate should drink plenty of water to irrigate the bowel, thereby increasing motility.
Given orally, the effects are usually seen 1 to 3 days after the first dose.
Given rectally, as an enema or suppository, a bowel movement usually occurs within 5 to 20 minutes.
The drug may be used in people who are undergoing opioid pain therapy, are opioid dependent, or on opioid replacement therapy, though prolonged use may cause irritation of the gastrointestinal tract.
Data supporting its efficacy in treating chronic constipation is lacking.
The main medical use of Dioctyl sulfosuccinate sodium salt is to treat constipation, acting as a laxative and stool softener.
In painful anorectal conditions such as hemorrhoid and anal fissures, it can help avoid pain caused by straining during bowel movements.
When administered by mouth, a bowel movement often occurs in 1 to 3 days, while rectal use may be effective within 20 minutes.
Sodium docusate is recommended as a stool softener for children.
Dioctyl sulfosuccinate sodium salt effectiveness for constipation is poorly supported by evidence.
Multiple studies have found docusate to be no more effective than a placebo for improving constipation.
Others have found it to be less useful for the treatment of chronic constipation than psyllium.
The medication may be given to people who are receiving opioid medication, although prolonged use may cause irritation of the gastrointestinal tract.
Dioctyl sulfosuccinate sodium salt, when used with ear syringing, may help with earwax removal, particularly in the case of impaction.
Dioctyl sulfosuccinate sodium salt is also used as a lubricant in the production of tablets and as an emulsifier in topical preparations and other suspensions.
Dioctyl sulfosuccinate sodium salt is approved and recommended as safe during pregnancy and breastfeeding.
Dioctyl sulfosuccinate sodium salt is a pesticide used popularly for crops of olives, almonds, wine grapes, corn and oranges.
Dioctyl sulfosuccinate sodium salt is used as an excipient in the production of tablets (as a lubricant) and suspensions (as an emulsifier).
Dioctyl sulfosuccinate sodium salt is the most widely used surfactant in reverse micelle encapsulation studies.
Dioctyl sulfosuccinate sodium salt, when used in conjunction with irrigation, is also an effective means of earwax removal.
Dioctyl sulfosuccinate sodium salt is commonly used to provide relief from constipation.
Dioctyl sulfosuccinate sodium salt helps make the stool softer and more comfortable to pass, thereby alleviating the discomfort and straining associated with constipation.
Dioctyl sulfosuccinate sodium salt is sometimes used to prevent straining during bowel movements, which can be beneficial for individuals with certain medical conditions, such as hemorrhoids, anal fissures, or after surgical procedures.
Dioctyl sulfosuccinate sodium salt is often used as part of postoperative care to prevent constipation in patients recovering from surgery.
Surgery and anesthesia can slow down bowel movements, leading to constipation, and Docusate Sodium can help mitigate this.
In cases of chronic or recurrent constipation, Dioctyl sulfosuccinate sodium salt may be prescribed or recommended by healthcare providers as part of a long-term management plan.
However, Dioctyl sulfosuccinate sodium salt is important to use it under the guidance of a healthcare professional for chronic conditions.
Dioctyl sulfosuccinate sodium salt can also be used in pediatric medicine to treat constipation in children.
The dosage and form of the medication will be adjusted according to the child's age and weight.
Always follow the guidance of a pediatrician when giving any medication to children.
Dioctyl sulfosuccinate sodium salt may be used in combination with other laxatives or medications, such as sennosides, to provide comprehensive relief from constipation through multiple mechanisms.
Dioctyl sulfosuccinate sodium salt is generally considered safe for use during pregnancy and breastfeeding when used as directed.
However, it's important for pregnant or breastfeeding individuals to consult with a healthcare provider before using any medication to ensure it is appropriate for their specific circumstances.
In addition to using medications like Dioctyl sulfosuccinate sodium salt, healthcare providers often recommend lifestyle changes to prevent or manage constipation.
These may include increasing dietary fiber intake, drinking plenty of water, regular physical activity, and maintaining a regular bathroom routine.
Dioctyl sulfosuccinate sodium salt may be used as part of bowel preparation regimens before certain medical procedures or surgeries, such as colonoscopies.
Dioctyl sulfosuccinate sodium salt helps soften stool to ensure effective cleansing of the colon.
When using Docusate Sodium, it's important to monitor its effectiveness in relieving constipation.
If constipation persists or worsens despite treatment, such as blood in the stool, consult a healthcare provider for further evaluation and guidance.
Once constipation has resolved, it is typically advisable to discontinue the use of Dioctyl sulfosuccinate sodium salt, as prolonged and unnecessary use of laxatives may not be recommended.
Healthcare providers often provide patient education when prescribing or recommending Docusate Sodium.
This may include instructions on proper use, potential side effects, and when to seek medical attention if constipation persists or worsens.
When using Dioctyl sulfosuccinate sodium salt in children, especially infants and young children, it is crucial to follow dosing instructions provided by a pediatrician.
The dosage and form of the medication will be adjusted based on the child's age and weight.
Dioctyl sulfosuccinate sodium salt is not effective or not recommended for a specific individual, healthcare providers may consider other treatments for constipation, including dietary changes, fiber supplements, other types of laxatives, or addressing underlying medical conditions.
Dioctyl sulfosuccinate sodium salt is not recommended in people with appendicitis, acute abdomen, or ileus.
Dioctyl sulfosuccinate sodium salt is used both as dopant and hydrophobizing agent in the oxidative polymerization of pyrole and the polypyrrole grains are used as light-responsive liquid marble stabilizer.
In conducting polymers made from polyaniline, use of Dioctyl sulfosuccinate sodium salt as dopant improves the metallic-type conductivity, elongations and thermally more stable than material made with other dopants.
Dioctyl sulfosuccinate sodium salt is a wetting and emulsifying agent that is slowly soluble in water, having a solubility of 1 g in 70 ml of water.
Dioctyl sulfosuccinate sodium salt functions as a wetting agent in fumaric acid-containing powdered fruit drinks to help the acid dissolve in water.
Dioctyl sulfosuccinate sodium salt is used as a stabilizing agent on gums at not more than 0.5% by weight of the gum.
Dioctyl sulfosuccinate sodium salt is used as a flavor potentiator in canned milk where it improves and maintains the flavor of the sterilized milk during storage.
Dioctyl sulfosuccinate sodium salt also functions as a processing aid in the manufacture of unrefined sugar.
Dioctyl sulfosuccinate sodium salt is also termed sodium dioctylsulfosuccinate.
Dioctyl sulfosuccinate sodium salt, used for the treatment of constipation, acting as a laxative or stool softener.
Also used in the synthesis of electrospun fibres for tailored and controlled antibiotic drug release.
Dioctyl sulfosuccinate sodium salt is a mild surfactant used as a cleans ing agent.
Dioctyl sulfosuccinate sodium salts are widely used as anionic surfactants in pharmaceutical formulations.
Dioctyl sulfosuccinate sodium salt is mainly used in capsule and direct-compression tablet formulations to assist in wetting and dissolution.
Dioctyl sulfosuccinate sodium salt is stable in the solid state when stored at room temperature.
Dilute aqueous solutions of Dioctyl sulfosuccinate sodium salt between pH 1–10 are stable at room temperature.
However, at very low pH (<1) and very high pH (>10) Dioctyl sulfosuccinate sodium salt solutions are subject to hydrolysis.
The solid material is hygroscopic and should be stored in an airtight container in a cool, dry place.
Safety Profile Dioctyl sulfosuccinate sodium salt:
Dioctyl sulfosuccinate sodium salts are absorbed from the gastrointestinal tract and excreted in bile; they may cause alteration of the gastrointestinal epithelium.
The gastrointestinal or hepatic absorption of other drugs may also be affected by docusate salts, enhancing activity and possibly toxicity.
Dioctyl sulfosuccinate sodium salt should not be administered with mineral oil as it may increase the absorption of the oil.
Dioctyl sulfosuccinate sodium salts are used in oral formulations as therapeutic agents for their fecal softening and laxative properties.
As a laxative in adults, up to 500mg of Dioctyl sulfosuccinate sodium salt is administered daily in divided doses; in children over 6 months old, up to 75 mg in divided doses is used.
The quantity of Dioctyl sulfosuccinate sodium salt used as an excipient in oral formulations should therefore be controlled to avoid unintended laxative effects.
Adverse effects associated with Dioctyl sulfosuccinate sodium salt include diarrhea, nausea, vomiting, abdominal cramps, and skin rashes.
As with the chronic use of laxatives, the excessive use of Dioctyl sulfosuccinate sodium salt may produce hypomagnesemia.
