Dipotassium Glycyrrhizate, an active ingredient derived from the root of the leguminous plant licorice (Glycyrrhizauralensis Fisch.), is an off-white to light yellow powder that is odorless and has a distinct sweet taste that lasts for a long time.
Dipotassium Glycyrrhizate is approximately 150 times sweeter than sucrose and is easily soluble in water, dilute ethanol, glycerin, and propylene glycol.
Dipotassium Glycyrrhizate is slightly soluble in absolute ethanol and ether. DPG finds extensive utilization in medicine, food, beverage, and healthcare products.
CAS Number: 68797-35-3
Molecular Formula: C42H63KO16
Molecular Weight: 863.05
EINECS Number: 272-296-1
Synonyms: Dipotassium glycyrrhizinate, 68797-35-3, Glycyrrhizinate dipotassium, Glycyrrhizic acid dipotassium, CA2Y0FE3FX, dipotassium;(2S,3S,4S,5R,6R)-6-((2S,3R,4S,5S,6S)-2-(((3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl)oxy)-6-carboxylato-4,5-dihydroxyoxan-3-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylate, dipotassium;(2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxylato-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate, RefChem:37953, MELAO AFTER SHAVE COLOGNE, GLYCYRRHIZINATE DIPOTASSIUM 0.5%, THE SKIN HOUSE EGF COLLAGEN AMPOULE, Hydrolyzed Collagen (GLYCYRRHIZINATE DIPOTASSIUM), 272-296-1, alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, potassium salt (1:2), alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, dipotassium salt, Dipotassium glycyrrhizate, Glycyrrhizicaciddipotassiumsalt,hydrate, Dipotassium glycyrrhizinate (JAN), C42H60K2O16, Neubormitin (TN), Glycyrrhizin Dipotassium Salt, orb1220687, orb1301604, orb3139873, SCHEMBL2390606, CHEMBL1923952, CHEBI:79402, BIVBRWYINDPWKA-VLQRKCJKSA-L, DTXSID501015077, Glycyrrhizic Acid Dipotassium Salt, MSK40377, AKOS037515318, CCG-270565, .alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, dipotassium salt, 18beta-Glycyrrhizic acid dipotassium salt, FD166891, G0270, T5666, D02264, F17684, Q11300469, .alpha.-D-Glucopyranosiduronicacid,(3.beta.,20.beta.),20-carboxy-11-oxo-30-norlean, Dipotassium (3beta,20beta)-20-carboxy-11-oxo-30-norlean-12-en-3-yl-2-O-beta-D-gucopyranuronosyl-alpha-D-glucopyranosiduronate, dipotassium;(2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxylato-4,5-dihydroxy-tetrahydropyran-3-yl]oxy-3,4,5-trihydroxy-tetrahydropyran-2-carboxylate, potassium (2S,3S,4S,5R,6S)-6-(((3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl)oxy)-5-(((2R,3R,4S,5S,6S)-6-carboxylato-3,4,5-trihydroxytet, alpha.-D-Glucopyranosiduronicacid,(3.beta.,20.beta.),20-carboxy-11-oxo-30-norlean;GLYCYRRHIZINIC ACID, DIPOTASSIUM SALT;GLYCYRRHIZIC ACID DIPOTASSIUM SALT;GLYCYRRHIZIC ACID DIPOTASSIUM SALT HYDRATE;DIPOTASSIUM GLYCYRRHIZINATE;Dipotassium glycyrhetate;Diapotassium;.alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, dipotassium salt
Dipotassium Glycyrrhizate, also known as Dipotassium Glycyrrhizinate or Glycyrrhizic Acid Dipotassium Salt, is the dipotassium salt of glycyrrhizic acid, also called glycyrrhizin.
Dipotassium Glycyrrhizate is a defined chemical compound associated with licorice-derived materials and is widely used as a functional ingredient in cosmetic and personal-care formulations.
Dipotassium Glycyrrhizate has the molecular formula C42H60K2O16 and a molecular weight of approximately 899.1 g/mol.
Dipotassium Glycyrrhizates CAS number is 68797-35-3, while its EINECS/EC number is 272-296-1.
Chemically, the molecule consists of a glycyrrhizic acid-derived organic anion associated with two potassium ions.
Its structure contains a large triterpenoid portion together with two glucuronic-acid-derived sugar units, giving the molecule both hydrophilic and hydrophobic structural regions.
Dipotassium Glycyrrhizate is closely related to glycyrrhizin, the characteristic sweet-tasting saponin constituent associated with licorice.
Dipotassium Glycyrrhizate should not, however, be confused with whole licorice extract because it is a defined salt rather than a mixture containing all of the plant's natural constituents.
Dipotassium Glycyrrhizate is commonly obtained from licorice-derived glycyrrhizic acid and can therefore be incorporated into formulations where a standardized glycyrrhizate ingredient is preferred.
Licorice species of the genus Glycyrrhiza are recognized sources of glycyrrhizic acid and related compounds.
The molecule contains multiple oxygen-rich functional groups, including hydroxyl and carboxyl-derived groups.
These structural features contribute to its interaction with water and help explain its usefulness in aqueous cosmetic and personal-care formulations.
In its raw material form, Dipotassium Glycyrrhizate is generally described as a white to pale yellow or off-white solid powder.
Commercial appearance can vary depending on purity, processing, moisture content, and the specific grade supplied.
The material has good relevance to water-based formulations because glycyrrhizate salts can be incorporated into aqueous systems.
This makes Dipotassium Glycyrrhizate particularly convenient for creams, lotions, gels, serums, and other cosmetic products containing a significant water phase.
One of its best-known functional characteristics is its skin-soothing and anti-inflammatory activity.
These properties have made it a popular functional ingredient in cosmetic formulations designed for irritated, sensitive, or redness-prone skin.
Dipotassium Glycyrrhizate is also associated with antioxidant activity.
Its glycyrrhizate structure has attracted interest in formulations intended to help protect skin from processes associated with oxidative stress.
In cosmetic ingredient classifications, Dipotassium Glycyrrhizate is recognized for functions including skin conditioning and humectant activity.
These functions allow it to contribute not only to the active profile of a formulation but also to the overall condition and feel of the skin.
Dipotassium Glycyrrhizate has also been investigated for its biological effects beyond topical cosmetics.
Experimental studies have examined Dipotassium Glycyrrhizate in relation to inflammatory pathways, oxidative stress, intestinal mucosal healing, and epithelial barrier function.
Its biological activity is partly related to the broader pharmacological properties of glycyrrhizin and its metabolites.
Glycyrrhizic acid can be metabolized to glycyrrhetinic acid, which is an important compound when considering the biological behavior of glycyrrhizate-containing materials.
Dipotassium Glycyrrhizate is therefore used in several types of personal-care and cosmetic products.
Its combination of skin-conditioning, soothing, humectant, and antioxidant-related properties makes it suitable for formulations targeting skin comfort and appearance.
The ingredient has also been incorporated into products intended for sensitive and reactive skin.
Its formulation role is particularly relevant when the product is designed to reduce the visible appearance of redness or provide a calming effect after exposure to environmental or cosmetic stressors.
From a formulation perspective, Dipotassium Glycyrrhizate is valuable because it provides a standardized glycyrrhizate source without requiring the complete chemical complexity of crude licorice extracts.
This allows formulators to incorporate a defined active ingredient into products while controlling the overall composition of the formulation.
The Cosmetic Ingredient Review has evaluated Dipotassium Glycyrrhizate as part of its safety assessment of glycyrrhizic-acid derivatives used in cosmetics.
The assessment reported Dipotassium Glycyrrhizate as safe under the evaluated cosmetic use conditions, with the historical assessment reporting use concentrations of up to 1% in cosmetics.
Dipotassium Glycyrrhizate is a licorice-derived potassium salt of glycyrrhizic acid with strong relevance to cosmetic and personal-care formulations.
Its combination of water-compatible behavior, skin-conditioning properties, soothing activity, and antioxidant-related functionality makes it an important ingredient for modern skincare and other topical formulations.
Melting point: >215oC (dec.)
Density: 1.277 at 20℃
vapor pressure: 0Pa at 20℃
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly)
form: Solid
color: White to Off-White
Stability: Hygroscopic
Cosmetics Ingredients Functions: SKIN CONDITIONING
HUMECTANT
Cosmetic Ingredient Review (CIR): Dipotassium glycyrrhizinate (68797-35-3)
InChIKey: BIVBRWYINDPWKA-VLQRKCJKSA-L
Surface tension: 55.4mN/m at 880mg/L and 20℃
Dipotassium Glycyrrhizate is an organic molecular entity.
Dipotassium glycyrrhizinate is a liquorice derivative that helps reduce skin redness and inflammation, thanks to its anti-irritant, calming, and soothing properties.
Its sebum-regulating properties inhibit the excessive production of skin lipids by the sebaceous glands.
Dipotassium Glycyrrhizate can be incorporated successfully into sensitive skin products, while also appearing to help improve oily skin.
Dipotassium Glycyrrhizate is suitable not only for hair and skin care but also for oral hygiene.
Dipotassium Glycyrrhizate has a relatively large molecular structure because it combines a triterpenoid aglycone with two glucuronic acid-derived sugar units.
This structural arrangement gives the molecule a substantial number of oxygen-containing groups, including hydroxyl and carboxyl-derived functionalities, which contribute to its polarity and interactions with water.
Dipotassium Glycyrrhizate has a topological polar surface area of approximately 273 Ų.
Its relatively high polarity is consistent with its ability to participate in hydrogen bonding and interact with aqueous formulation components.
Dipotassium Glycyrrhizate contains six hydrogen-bond donor sites and sixteen hydrogen-bond acceptor sites according to calculated molecular descriptors.
These features are important when considering its behavior in cosmetic formulations and its interactions with other polar ingredients.
The molecule also has considerable stereochemical complexity.
Dipotassium Glycyrrhizates defined stereocenter count reflects the multiple stereochemically defined structural elements inherited from the glycyrrhizic acid framework and carbohydrate units.
Dipotassium Glycyrrhizate is structurally related to glycyrrhizin, which is the principal sweet saponin associated with licorice.
The dipotassium form represents the salt form of this glycyrrhizate structure and is therefore chemically distinct from simply using an unstandardized licorice extract.
The potassium salt form is particularly useful when a formulation requires a defined glycyrrhizate ingredient.
Compared with crude botanical extracts, a defined salt can provide greater control over the amount of the targeted functional compound incorporated into a formulation.
In cosmetic applications, Dipotassium Glycyrrhizate is classified primarily as a skin-conditioning and humectant ingredient.
These functions allow it to contribute to skin moisture management while supporting the desired sensory and conditioning properties of the finished product.
Its soothing characteristics make it particularly relevant to formulations developed for sensitive or reactive skin.
Dipotassium Glycyrrhizate is frequently incorporated into products intended to calm the appearance of redness and discomfort associated with environmental or cosmetic stress.
The ingredient is also found in moisturizing formulations.
Its humectant classification reflects its role in helping retain moisture within the formulation and supporting moisture-related skin-conditioning effects.
Dipotassium Glycyrrhizate can therefore appear in products such as facial creams, lotions, serums, masks, and other leave-on skincare formulations.
Its combination of conditioning and soothing functions allows it to be incorporated into products with different textures and formulation formats.
Dipotassium Glycyrrhizate is also associated with formulations targeting uneven skin appearance.
Cosmetic products containing Dipotassium Glycyrrhizate may use its soothing properties alongside other active ingredients intended to improve the appearance of redness, irritation, or uneven tone.
Its presence in personal-care products is not limited to facial skincare.
Dipotassium Glycyrrhizate has been identified in consumer personal-care products and can be used in formulations designed for broader skin-conditioning purposes.
Dipotassium Glycyrrhizate has also attracted interest because of the broader biological activity associated with glycyrrhizate compounds.
Research into glycyrrhizin-derived substances has examined mechanisms involving inflammatory responses, oxidative processes, and epithelial barrier functions, although these biological findings should not automatically be interpreted as clinical effects of every cosmetic formulation.
The ingredient's regulatory profile is also relevant to its use in cosmetics.
Available regulatory data indicate that Dipotassium Glycyrrhizate is not classified as a GHS hazardous chemical in the compiled hazard reports, while specific cosmetic-use restrictions can still apply depending on jurisdiction and formulation.
For example, an Australian assessment covers its use as a component of dermal cosmetic products at concentrations up to 0.2% and specifies that it should not be used in topical products intended for the eye.
This illustrates why the safety of the finished formulation must be considered separately from the general hazard classification of the raw ingredient.
Dipotassium Glycyrrhizate has also been evaluated in the context of cosmetic safety assessments.
Available assessments have reported it as safe under the evaluated practices of cosmetic use and concentration, supporting its continued use as a cosmetic functional ingredient.
Dipotassium Glycyrrhizate combines the chemical characteristics of a highly oxygenated glycyrrhizate structure with the formulation advantages of a potassium salt.
Its molecular polarity, skin-conditioning function, humectant properties, and soothing profile explain why it is widely associated with skincare and personal-care formulations.
Uses Of Dipotassium Glycyrrhizate:
Dipotassium Glycyrrhizinate is used in improving the dissolution property of amphotericin B (AMB) and the bioavailability of the drug incorporated in suppositories.
Dipotassium Glycyrrhizate is primarily used in cosmetic and personal-care formulations as a skin-conditioning and humectant ingredient.
Its functional profile makes it particularly suitable for products designed to improve skin comfort, maintain moisture, and support sensitive skin.
One of its most common applications is in facial skincare products.
It can be incorporated into creams, lotions, serums, gels, masks, and other topical formulations where soothing and skin-conditioning properties are desired.
Dipotassium Glycyrrhizate is widely used in products for sensitive skin.
Dipotassium Glycyrrhizate association with anti-inflammatory and soothing activity makes it suitable for formulations intended to reduce the appearance of redness, irritation, and discomfort.
It is also used in moisturizing products.
As a recognized humectant, it can contribute to moisture retention and help support the hydration characteristics of skincare formulations.
Another important application is in anti-irritation formulations.
Dipotassium Glycyrrhizate can be combined with other soothing ingredients in products developed for skin exposed to environmental stress, cosmetic irritation, or dryness.
The ingredient is also found in acne-care and blemish-oriented cosmetic formulations.
Dipotassium Glycyrrhizate anti-inflammatory positioning makes it useful as a supporting ingredient alongside established acne-care actives rather than necessarily serving as the primary acne treatment itself.
Dipotassium Glycyrrhizate can be incorporated into after-sun and skin-recovery products.
Its soothing characteristics make it relevant to formulations intended to provide comfort to skin following environmental exposure and temporary irritation.
Another use is in anti-redness skincare.
Formulators may combine Dipotassium Glycyrrhizate with moisturizing, barrier-supporting, and antioxidant ingredients in products intended to improve the appearance of irritated or visibly stressed skin.
It is also used in body-care formulations.
The ingredient can be included in body lotions, creams, and other leave-on products where skin conditioning and moisture retention are important.
Dipotassium Glycyrrhizate is relevant to hand-care products as well.
Its conditioning and humectant functions can complement formulations designed for dry or frequently washed hands.
Dipotassium Glycyrrhizate can also be incorporated into cleansing products.
Its presence in facial washes and other rinse-off formulations can provide a soothing component alongside surfactants and other cleansing ingredients.
Another application is in personal-care products designed for acne-prone skin.
Ingredient databases identify Dipotassium Glycyrrhizate in acne-treatment product categories, including formulations such as spot-treatment products and facial preparations.
Dipotassium Glycyrrhizate is also used in dermatological and topical preparations.
Its biological activity has led to investigation of formulations intended to support inflammatory skin conditions and epithelial barrier function, although research findings should not automatically be interpreted as proven clinical efficacy for every cosmetic product.
Another area of application is oral-care formulations.
Research has investigated Dipotassium Glycyrrhizate in relation to oral microbial communities and inflammatory processes, creating interest in its potential incorporation into toothpaste, mouth-care, and related oral formulations.
The ingredient can also be used in specialized skin-treatment formulations where multiple functional ingredients are combined.
In these systems, Dipotassium Glycyrrhizate may provide a soothing component while other ingredients supply moisturizing, antimicrobial, exfoliating, or barrier-supporting functions.
Dipotassium Glycyrrhizate is particularly useful in formulations that seek to combine moisture management with skin soothing.
Its humectant and skin-conditioning classifications allow it to contribute to both the hydration profile and functional positioning of the finished product.
It can also be incorporated into multi-active cosmetic formulations.
Formulators may combine it with botanical extracts, peptides, humectants, antioxidants, and other cosmetic actives to create products targeting several aspects of skin appearance and comfort simultaneously.
Another emerging area is the development of advanced anti-inflammatory cosmetic formulations.
Recent experimental work continues to investigate Dipotassium Glycyrrhizate in cellular models of inflammatory skin responses, supporting continued interest in the ingredient for specialized cosmetic research and development.
Dipotassium Glycyrrhizate is mainly used as a skin-conditioning, humectant, soothing, and anti-inflammatory-oriented ingredient.
Its applications include facial skincare, moisturizers, sensitive-skin products, anti-redness formulations, acne-care products, body care, cleansing products, after-sun preparations, dermatological preparations, and emerging oral-care applications.
Dipotassium Glycyrrhizate is also used in toners, essences, and lightweight facial treatments.
Dipotassium Glycyrrhizate water-compatible nature makes it suitable for aqueous formulations where a soothing and skin-conditioning ingredient is required without adding a heavy or oily character to the product.
Another application is in facial masks and intensive skincare treatments.
It can be incorporated into water-based masks and treatment formulations designed to provide moisture while supporting a more comfortable feel on sensitive or stressed skin.
The ingredient is also used in anti-aging skincare formulations.
In these products, Dipotassium Glycyrrhizate generally serves as a supporting soothing and conditioning ingredient alongside other actives rather than functioning as the primary anti-aging active.
Dipotassium Glycyrrhizate is relevant to skin-barrier-support formulations.
Experimental work has investigated its effects on markers associated with epidermal differentiation and barrier function, including involucrin and transglutaminase-1 production.
It is also used in products formulated for skin discomfort and stinging sensations.
A human stinging-test study using a formulation containing 0.2% Dipotassium Glycyrrhizate found reduced sensory discomfort under the test conditions, supporting its interest in sensitive-skin product development.
Another application is rough and irritated skin care.
Its inclusion in cosmetic formulations can complement moisturizing and barrier-support ingredients intended to improve the feel and appearance of skin exposed to dryness or environmental stress.
Dipotassium Glycyrrhizate can also be incorporated into hair-care products.
Commercial cosmetic ingredient portfolios identify hair-care applications for the ingredient, where it can be used as a supporting conditioning and soothing component in formulations intended for the scalp and hair-care routine.
It has particular relevance to scalp-care formulations.
The soothing positioning of glycyrrhizate ingredients makes Dipotassium Glycyrrhizate suitable for products developed for dry, sensitive, or uncomfortable scalp conditions, although cosmetic use should not be equated with treatment of a scalp disease.
Another application is mild cleansing products.
It can be included in facial cleansers and other personal-care cleansing systems to provide a conditioning or soothing component alongside the cleansing agents.
Dipotassium Glycyrrhizate is also used in baby-care formulations.
Its inclusion in gentle personal-care products reflects the interest in glycyrrhizate ingredients for mild, soothing-oriented formulations.
The ingredient can be found in dermatological topical formulations as well.
Its anti-inflammatory-oriented properties have led to its investigation and incorporation into topical products intended to support irritated or sensitive skin.
Another area of interest is oral-care formulation.
Dipotassium Glycyrrhizate has been investigated for incorporation into products such as toothpaste and mouthwash, where glycyrrhizate-related biological activity may provide an additional functional role.
Dipotassium Glycyrrhizate can also appear in specialized pharmaceutical and medical formulations.
Patent and formulation literature includes Dipotassium Glycyrrhizate in compositions designed for topical and oral delivery, although the presence of Dipotassium Glycyrrhizate in an experimental or patented formulation does not by itself establish a therapeutic indication.
Dipotassium Glycyrrhizate has also been investigated as a formulation-supporting component for drug delivery.
Experimental research has reported effects on intestinal absorption of certain compounds, indicating that its functional behavior can extend beyond its conventional cosmetic role.
Dipotassium Glycyrrhizate is additionally relevant to multi-functional cosmetic formulations combining soothing and moisture-support properties.
This allows formulators to pair it with humectants, emollients, botanical ingredients, antioxidants, and other active ingredients in products designed for several cosmetic objectives at once.
Another application is in products specifically formulated for sensitive-skin consumers.
Dipotassium Glycyrrhizate has been described as a frequently used active ingredient in sensitive-skin products, and experimental studies have examined its potential to reduce sensory discomfort associated with skin sensitivity.
It is also useful in low-dose active cosmetic formulations.
Historical cosmetic safety data reported Dipotassium Glycyrrhizate use at concentrations up to 1%, while individual commercial products and newer formulations may use different levels depending on grade, product type, and regulatory requirements.
Dipotassium Glycyrrhizate extend from conventional skincare into sensitive-skin care, barrier-support products, scalp and hair care, baby care, cleansing formulations, oral care, and specialized topical formulations.
Its main commercial value comes from combining skin-conditioning and humectant functionality with a well-established soothing-oriented profile in cosmetic formulation development.
Safety Profile Of Dipotassium Glycyrrhizate:
Dipotassium Glycyrrhizate is generally considered to have a low hazard profile under standard GHS classification.
Current aggregated classification data report that it does not meet GHS hazard criteria, although individual supplier documentation can differ depending on product grade, purity, and formulation.
The available cosmetic safety assessment also supports its use at the concentrations evaluated in cosmetic formulations.
The assessment concluded that Dipotassium Glycyrrhizate and related glycyrrhizate ingredients were safe under the reported cosmetic practices of use and concentration.
Skin irritation is not considered a major inherent hazard for Dipotassium Glycyrrhizate at typical cosmetic concentrations.
Safety testing reported no significant phototoxicity or photosensitization for Dipotassium Glycyrrhizate at concentrations up to 5% under the tested conditions.
Nevertheless, direct contact with the concentrated raw material should be minimized.
Commercial chemical-handling documentation recommends washing the skin with soap and water following accidental contact, particularly when handling research-grade powders.
Dipotassium Glycyrrhizate Procurement and Technical Support:
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