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DIPOTASSIUM HYDROGEN PHOSPHATE

DIPOTASSIUM HYDROGEN PHOSPHATE

Dipotassium hydrogen phosphate (K2HPO4) (also dipotassium hydrogen orthophosphate; potassium phosphate dibasic), K2HPO4. It is the inorganic compound with the formula (H2O) x (x = 0, 3, 6). Along with monopotassium phosphate (KH2PO4. (H2O) x) it is often used as a fertilizer, food additive and buffering agent. It is a white or colorless solid that is soluble in water.

CAS No. : 7758-11-4
EC No. : 231-834-5

Synonyms:
Potassium monohydrogen phosphate; Phosphoric acid dipotassium salt; Potassium phosphate dibasic; di-Potassium hydrogen phosphate; Dipotassium Phosphate; Dipotassium hydrogen phosphate; Potassium phosphate dibasic; Dipotassium Phosphate; Dipotassium hydrogen phosphate; 2139900; DIPOTASSIUM PHOSPHATE; Dipotassium hydrogenphosphate; Dibasic potassium phosphate; Potassium phosphate dibasic; Potassium phosphate, dibasic; Potassium dibasic phosphate; Potassium Hydrogen Phosphate; Phosphoric acid, dipotassium salt; Dipotassium monophosphate; Potassium monohydrogen phosphate; Dipotassium hydrogenorthophosphate; K2HPO4; Potassium monophosphate; Isolyte; Dipotassium monohydrogen phosphate; Dipotassium orthophosphate; Hydrogen dipotassium phosphate; Potassium phosphate (dibasic); Dipotassium-O-phosphate; sec.-Potassium phosphate; potassium hydrogenphosphate; MFCD00011383; Phosphoric acid, potassium salt (1:2); UNII-CI71S98N1Z; di-potassium hydrogen phosphate; CCRIS 6544; CI71S98N1Z; HSDB 935; Dipotassium hydrogen orthophosphate; EINECS 231-834-5; Potassium phosphate dibasic, ACS reagent; di-Potassium hydrogen phosphate, anhydrous; DKP; Potassium phosphate, dibasic, 98+%, ACS reagent; Potassium phosphate, dibasic, 1.0M solution in water; dipotassium;hydrogen phosphate; Potassium phosphate, dibasic, 99+%, for analysis, anhydrous; Kali phosphoricum; Leex-A-phos; Mediject P (TN); di potassium phosphate; ACMC-20al4r; Dipotassium acid phosphate; Dipotassiumhydrogenphosphate; Potassium phosphate,dibasic; HK2O4P; dipotasium hydrogen phosphate; Secondary potassium phosphate; KSC492I7F; potassium monohydrogenphosphate; potassium hydrogen monophosphate; INS NO.340(II); CHEMBL1200459; DTXSID8035506; CHEBI:32031; CTK3J2472; INS-340(II); Dipotassium hydrogen monophosphate; CHEBI:131527; KS-00000UL3; E-340(II); dipotassium monohydrogen orthophosphate; potassium dibasic phosphate trihydrate; AKOS015915872; AKOS016371887; DB09414; Potassium phosphate, dibasic (JAN/USP); Potassium phosphate, dibasic [USP:JAN]; Potassium phosphate dibasic, LR, >=98%; Potassium phosphate, dibasic [USAN:JAN]; S293; SC-62444; DI-POTASSIUM HYDROGEN ORTHOPHOSPHATE; LS-186283; Potassium phosphate dibasic solution, 1.0 M; Potassium phosphate dibasic, puriss., >=99%; C13197; D02403; EC 231-834-5; Potassium phosphate dibasic, ACS reagent, >=98%; Potassium phosphate dibasic, USP, 98.0-100.5%; Q403721; Potassium phosphate dibasic, AR, anhydrous, >=99%; Potassium phosphate dibasic, reagent grade, >=98.0%; Potassium phosphate dibasic, 99.95% trace metals basis; Potassium phosphate dibasic, SAJ first grade, >=98.0%; Potassium phosphate dibasic, Trace metals grade 99.95%; Potassium phosphate, dibasic, 99%, for HPLC, anhydrous; Potassium phosphate dibasic, JIS special grade, >=99.0%; Potassium phosphate dibasic, Vetec(TM) reagent grade, 98%; UNII-B7862WZ632 component ZPWVASYFFYYZEW-UHFFFAOYSA-L; Potassium phosphate dibasic, meets USP testing specifications; Dibasic potassium phosphate, United States Pharmacopeia (USP) Reference Standard; Potassium phosphate dibasic, anhydrous, free-flowing, Redi-Dri(TM), ACS reagent, >=98%; Potassium phosphate dibasic, puriss. p.a., ACS reagent, anhydrous, >=99.0% (T); Potassium phosphate dibasic anhydrous, PharmaGrade, USP, Manufactured under appropriate GMP controls for pharma or biopharmaceutical production.; Potassium phosphate dibasic, anhydrous, for luminescence, for molecular biology, BioUltra, >=99.0% (T)

IUPAC NAMES:

Dipotassium hydrogen phosphate
dipotassium hydrogen phosphate
Dipotassium Hydrogenortophosphate
Dipotassium hydrogenphosphate, Dipotassium phosphate, Potassium phosphate dibasic, sec-Potassium phosphate
Dipotassium phosphate
dipotassium; hydrogen phosphate
DKP
phosphoric acid potassium salts (1: 3)
Potassium hydrogen phosphate
Potassiun hydrogen orthophosphate

TRADE NAMES:
Dikaliumphosphaate
Dipotassium hydrogenorthophosphate
Dipotassium phosphate
DKP
Lopon DK
MCTR-256
MCTR-4-75
Potassium phosphate, dibasic
PRAYPHOS DKP TG GR

Dipotassium Hydrogen Phosphate

Dipotassium hydrogen phosphate (K2HPO4) (also dipotassium hydrogen orthophosphate; potassium phosphate dibasic) is the inorganic compound with the formula K2HPO4.(H2O)x (x = 0, 3, 6). Together with monopotassium phosphate (KH2PO4.(H2O)x), it is often used as a fertilizer, food additive, and buffering agent.[1] It is a white or colorless solid that is soluble in water.
It is produced commercially by partiial neutralization of phosphoric acid with two equivalents of potassium chloride:
H3PO4 + 2 KCl → K2HPO4 + 2 HCl

Uses
As a food additive, Dipotassium hydrogen phosphate is used in imitation dairy creamers, dry powder beverages, mineral supplements, and starter cultures.[2] It functions as an emulsifier, stabilizer and texturizer; it also is a buffering agent, and chelating agent especially for the calcium in milk products.
As a food additive, Dipotassium hydrogen phosphate is categorized by the United States Food and Drug Administration as generally recognized as safe (GRAS).

Dipotassium hydrogen phosphate is used in imitation dairy creamers, dry powder beverages, mineral supplements, and starter cultures as an additive. It is used in non-dairy creamers to prevent coagulation. Dipotassium hydrogen phosphate is also used to make buffer solutions and it is used in the production of trypticase soy agar which is used to make agar plates for culturing bacteria.

Dipotassium hydrogen phosphate, Dibasic is the dipotassium form of phosphoric acid, that can be used as an electrolyte replenisher and with radio-protective activity. Upon oral administration, Dipotassium hydrogen phosphate is able to block the uptake of the radioactive isotope phosphorus P 32 (P-32).

Most of the commercial output of Dipotassium hydrogen phosphate is used in conjunction with borates, nitrites, nitrates, and/or silicates as corrosion inhibitor systems in ethylene glycol antifreeze formulations. Its second largest use is as a buffer in coffee creamers to prevent casein protein precipitation by coffee acids. Other uses include specialty fertilizers, paper-processing aids, and saline cathartics.

Residues of Dipotassium hydrogen phosphate are exempted from the requirement of a tolerance when used as a buffer in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest. /Dipotassium hydrogen phosphate/

Dipotassium hydrogen phosphate used as a sequestrant in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice.
Dipotassium hydrogen phosphate used as a sequestrant in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.
Dipotassium hydrogen phosphates (mono-, di-, and tribasic) are indirect food additives for use only as a component of adhesives. 

Synonyms    Dipotassium hydrogen phosphate, Potassium phosphate dibasic, Dipotassium Phosphate
Product Information
CAS number    7758-11-4
EC number    231-834-5
Grade    Ph Eur, BP, E 340
Hill Formula    HK₂O₄P
Chemical formula    K₂HPO₄
Molar Mass    174.18 g/mol
HS Code    2835 24 00
Physicochemical Information
Density    2.44 g/cm3 (20 °C)
pH value    9 (10 g/l, H₂O, 20 °C)
Bulk density    700 - 1000 kg/m3
Solubility    1600 g/l
Toxicological Information
LD 50 oral    LD50 Rat 8000 mg/kg
Safety Information according to GHS
RTECS    TC5580000
Storage class    10 - 13 Other liquids and solids
WGK    WGK 1 slightly water endangering
Disposal    14
Inorganic salts: Container I. Neutral solutions of the these salts: Container D. Before placing in Container D, check the pH with pH-Universal indicator strips (Item No. 109535).
Storage and Shipping Information
Storage    Store at +5 °C to +30 °C.
Specifications
Assay (alkalimetric, calculated on dried substance)    98.0 - 101.0 %
Assay (out of dried substance)    ≥ 98.0 %
Identity    passes test
Appearance of solution    passes test
In water insoluble matter    ≤ 0.2 %
pH-value (1 %, water)    8.7 - 9.4
Chloride (Cl)    ≤ 0.02 %
Fluoride (F)    ≤ 0.0010 %
Sulphate (SO₄)    ≤ 0.1 %
Heavy metals (as Pb)    ≤ 0.0010 %
Al (Aluminium)    ≤ 0.0005 %
As (Arsenic)    ≤ 0.0001 %
Cd (Cadmium)    ≤ 0.0001 %
Fe (Iron)    ≤ 0.0010 %
Hg (Mercury)    ≤ 0.0001 %
Na (Sodium)    ≤ 1.5 %
Pb (Lead)    ≤ 0.0001 %
Potassium dihydrogen phosphate    ≤ 2.5 %
Residual solvents (ICH Q3C)    excluded by manufacturing process
Reducing substances    passes test
Loss on drying (130 °C)    ≤ 2.0 %

What is Dipotassium hydrogen phosphate?
If Dipotassium hydrogen phosphate (DKP) is new to you, there is still a good chance that you might have been making it a part of your diet without realizing – that is, if you haven’t been paying close attention to the list of ingredients on the back of foods in your shopping basket.

Dipotassium hydrogen phosphate is a water-soluble salt that you may have purchased in the commercial form of a food additive, a fertilizer, and also a buffering agent in manufactured foods. On its own, it looks like a colorless, white substance, which, for the health and fitness minded people out there, is notably an awesome source of potassium and phosphorus. It plays a mega role in your body’s production of ATP (adenosine triphosphate), which is a high-energy molecule that your body requires for energy.

The name is just about self-explanatory – though we might also note that it goes under the title of dibasic potassium phosphate, potassium phosphate dibasic, dipotassium hydrogen orthophosphate and dipotassium hydrogen phosphate. The ‘phosphate’ half of its name is phosphate, the charged particle that contains the mineral phosphorus. Phosphorus is highly important in your body for supporting the maintenance, repair and rebuilding of healthy teeth and bones. In the context of muscular performance, phosphate is essential in their normal function and how effectively they contract.

What is Dipotassium hydrogen phosphate used for?
In health supplements, Dipotassium hydrogen phosphate is used for its health benefits, which we’ll get to shortly, as a nutrient supplement and also as a protein stabilizer in weight training drinks and powder mixes. Dipotassium hydrogen phosphate is commonly used as an emulsifier, stabilizer and texturizer.

In the food industry, it is utilized as an effective a buffering agent and chelating agent, which may also be used for yeast food, emulsifying salt, and a synergistic agent of antioxidation.

You will also find Dipotassium hydrogen phosphate, or one of its many aliases, on health supplements and shop packaging due to its use as a food additive. In food, it is used to lower the acid levels in processed goods, and also lowers the sodium levels in low-sodium cheeses. It is also used as a stabilizer in non-dairy creamers to prevent coagulation.

Benefits of taking Dipotassium hydrogen phosphate
The foremost benefit of Dipotassium hydrogen phosphate is the fact it is a quick and convenient source of potassium. Potassium, of course, is incredibly important for your health and sporting performance. Potassium is one of the seven essential macro minerals, of which your body requires at least 100 milligrams on a daily basis in order to sufficiently support its key processes.

A healthy intake of potassium decreases your risk of stroke, lowers your blood pressure, protects you against the loss of muscle mass, preserves your bone mineral density, and reduces the risk of kidney stones. Along with the aforementioned contribution to normal muscle function, weightlifters, bodybuilders and fitness-minded folk can benefit from Dipotassium hydrogen phosphate as an energy supplement. This tends to apply, in particular, to anyone engaged in a training session that is a minimum of 30 minutes long without rests. This means team sports, long-distance running and circuits, high-intensity interval training and endurance orientated weight lifting workouts.

Dipotassium hydrogen phosphate supplementation is beneficial in supporting the recovery of your muscles. As a result, improving your endurance capabilities it essentially means that you will be able to recover faster between burst of energy usage and have the faculty to engage in more lifts when bodybuilding.

Of equal importance is its ability to assist in the process of transporting oxygen around your body – namely, in the context of working out, to your muscles. This is particularly effective for high intensity and strenuous exercises such as heavy lifting and sprints.

How to take Dipotassium hydrogen phosphate
Dipotassium hydrogen phosphate, as a supplement, is best consumed on an empty stomach. We recommend using accurate scales or measures to ensure even dosages, adding 1 gram to fruit juice, whey or water and taken four times a day.

Side effects of Dipotassium hydrogen phosphate
Dipotassium hydrogen phosphate is declared “generally recognized as safe (GRAS)” by the U.S. Food and Drug Administration (FDA). There is material available, however, that may raise an eyebrow to suggest that is use may be considered with an element of caution for people with pre-existing health conditions. Conditions of concern include kidney disease, severe heart and lung disease, thyroid problems, liver disease and Addison’s disease.

Though Dipotassium hydrogen phosphate is regarded as a safe supplement, there are some known side effects, which are mostly associated with prolonged use. This is because using the supplement over a longer period can cause an imbalance to the phosphates in your body, resulting in the following side effects:
Headaches
Constipation
Arterial stiffening
Confusion
Hyperphosphatemia
Nausea
Dizziness
Vomiting
Diarrhoea
Phosphorus overload

Urinary acidification by potassium and sodium phosphates combination and monobasic potassium phosphate augments the efficacy of methenamine mandelate and methenamine hippurate, which are dependent upon an acid medium for antibacterial activity. Dipotassium hydrogen phosphate eliminate the odor, rash, and turbidity present with ammoniacal urine associated with urinary tract infections. However, use of phosphates for urea splitting urinary tract infections may predispose to struvite stones that form in alkaline urine.
Potassium and sodium phosphates combination and Dipotassium hydrogen phosphate have been used to reduce urinary calcium concentration and help prevent precipitation of calcium deposits in the urinary tract. 
At the renal distal tubule, the secretion of hydrogen by the tubular cell in exchange for sodium in the tubular urine converts dibasic phosphate salts to monobasic phosphate salts. Therefore, large amounts of acid can be excreted without lowering the pH of the urine to a degree that would block hydrogen transport by a high concentration gradient between the tubular cell and luminal fluid. 

Dipotassium hydrogen phosphate:/ The effects of intravenous administration of potassium phosphate in the treatment of diabetic ketoacidosis were studied in nine children, ages 9 9/12 to 17 10/12 yr. During phosphate infusion (20--40 mEq/L of fluid), all children maintained normal serum concentrations of phosphorus. Transient hypocalcemia occurred in six and transient hypomagnesemia in five patients. One child developed carpopedal spasms refractory to intravenous infusion of calcium gluconate but responsive to intramuscular injection of magnesium sulfate. In three patients, serum levels of intact parathyroid hormone were low at the time of hypocalcemia, an observation that suggests transient hypoparathyroidism. This study indicates that the use of potassium phosphate as the sole source of potassium replacement might potentiate ketoacidosis-induced hypocalcemia through multiple mechanisms.
EXPERIMENTAL THERAPY Dipotassium hydrogen phosphate:/ In 35 patients with diabetic ketosis, 9 received no potassium replacement, 13 received replacement as potassium phosphate (4.7 - 28.5 mg/kg) and 13 received replacement as potassium chloride. The use of the phosphate supplement did not cause abnormalities in calcium metabolism nor did it prevent late hypophosphatemia.

Continuous infusion of macronutrients and vitamin D in a crossover design of 2 four-day periods. There were no differences between monobasic and dibasic regimens in standard calcium (35 mg/kg/day) and phosphorus (30 mg/kg/day) intakes, balance data or plasma biochemical monitoring. Using the monobasic regimen, mineral intakes were doubled without precipitation in the infusion. This led to significant retention of both calcium and phosphorus compared with standard mineral intake levels. Improvement in calcium-phosphorus balance was accompanied by more severe calciuria and metabolic compensation for increased acid load. In addition to the possibility of exceeding the infant's buffering capacity, this relative acidosis may also be evidence of enhanced bone mineralization.

To avoid potassium or phosphorus intoxication, infuse solutions containing potassium phosphates slowly. In patients with severe renal or adrenal insufficiency, administration of Potassium Phosphates Injection may cause potassium intoxication. Infusing high concentrations of phosphorus may cause hypocalcemia, and calcium levels should be monitored.
Solutions which contain potassium ions should be used with great care if at all, in patients with hyperkalemia, severe renal failure and in conditions in which potassium retention is present.
Dipotassium hydrogen phosphate is the major cation of intracellular fluid and is essential for maintenance of acid-base balance, isotonicity, and electrodynamic characteristics of the cell. Dipotassium hydrogen phosphate is an important activator in many enzymatic reactions and is essential to a number of physiologic processes including transmission of nerve impulses; contraction of cardiac, smooth, and skeletal muscles; gastric secretion; renal function; tissue synthesis; and carbohydrate metabolism. Phosphate is a major intracellular anion that participates in providing energy for metabolism of substrates and contributes to important metabolic and enzymatic reactions in almost all organs and tissues. Dipotassium hydrogen phosphate exerts a modifying influence on calcium concentrations, a buffering effect on acid-base equilibrium, and has a major role in the renal excretion of hydrogen ions.

Dipotassium hydrogen phosphate is the major cation of intracellular fluid and is essential for maintenance of acid-base balance, isotonicity, and electrodynamic characteristics of the cell. Dipotassium hydrogen phosphate is an important activator in many enzymatic reactions and is essential to a number of physiologic processes including transmission of nerve impulses; contraction of cardiac, smooth, and skeletal muscles; gastric secretion; renal function; tissue synthesis; and carbohydrate metabolism.
Phosphorus in the form of organic and inorganic phosphate has a variety of important biochemical functions in the body and is involved in many significant metabolic and enzyme reactions in almost all organs and tissues. Dipotassium hydrogen phosphate exerts a modifying influence on the steady state of calcium levels, a buffering effect on acid-base equilibrium and a primary role in the renal excretion of hydrogen ion. Dipotassium hydrogen phosphate is present in plasma and other extracellular fluid, in cell membranes and intracellular fluid, as well as in collagen and bone. Phosphorus in the extracellular fluid is primarily in inorganic form, and plasma levels may vary somewhat with age. Phosphorus, present in large amounts in erythrocytes and other tissue cells, plays a significant intracellular role in the synthesis of high energy organic phosphates.
Phosphorus, present in large amounts in erythrocytes and other tissue cells, plays a significant intracellular role in the synthesis of high-energy organic phosphates. Dipotassium hydrogen phosphate has been shown to be essential to maintain red blood cell glucose utilization, lactate production, and the concentration of both erythrocyte adenosine triphosphate (ATP) and 2,3-diphosphoglycerate (DPG), and must be deemed as important to other tissue cells.

Why Do My Crops Need Potassium?
The second critical component in our Dipotassium hydrogen phosphate eco-friendly fertilizer contains the essential plant nutrient, Potassium. This macronutrient is often difficult to manipulate and can benefit from the controlled application of a Potassium supplement to ensure your crops get the correct amount of this precious nutrient to be healthy. Plants absorb Potassium in large amounts. Therefore, the help of a Dipotassium hydrogen phosphate fertilizer can keep Potassium levels steady to keep feeding your plants the rich nutrients it needs to generate a healthy harvest.
Plants need Potassium for many reasons. Potassium makes enzyme activity possible in plants. Dipotassium hydrogen phosphate also encourages respiration, transpiration and makes your plants capable of absorbing other vital nutrients. Potassium is also a key player in the transportation of water and nutrients in the xylem of the plant. A healthy supply of Potassium is critical to the operation of the plant's transport systems. A healthy crop with a sufficient Potassium supply can also increase root growth and helps stop the growth and spread of crop diseases.
Dipotassium hydrogen phosphate is an eco-friendly fertilizer, that is 100 percent water soluble and heavy metal free. Give your crops the vital support and nutrients its deserves to produce healthy, bountiful and rich plants.

What is a Dipotassium hydrogen phosphate fertilizer?
Dipotassium hydrogen phosphate (0-52-34) is the fertilizer, which contains highest amount of major elements, among other soluble fertilizers. Its formula is KH2PO4. As it contains no nitrogen, it is appropriate for plants that require intensive use of fertilizers. Dipotassium hydrogen phosphate fertilize can be the most suitable source of potassium and phosphorus when nitrogen use is contradictory. In other times it is also the preferred type of fertilizer as it can be given together with any kind of nitrogen fertilizers (ammonium, nitrate or urea nitrogen containing fertilizers).
Where is it used?
As Dipotassium hydrogen phosphate fertilizer contains no such hazardous elements such as chlorine, sodium or heavy metals, it can be applied safely to all kinds of products. It is demonstrated that Dipotassium hydrogen phosphate fertilizer application via leaves prevents fungi growth. When mixed with pesticides it is shown that it increases the effectiveness of such pesticides.

Application method
Dipotassium hydrogen phosphate fertilizer is suitable for application via leaves. As pH value of water used via sprinkler systems can be maintained at around 4,5, thanks to Dipotassium hydrogen phosphate fertilizer absorption of all major and trace elements is facilitated. Thanks to low EC value (0,7 mS/cm) risks for burns in leaves are too low and therefore it may even be used in high concentrations. It may be mixed with any soluble fertilizer; yet should not be used together with fertilizers containing calcium (Ca).

Foliar applications of 1% solution of Dipotassium hydrogen phosphate (MKP = KH2P04) fertilizer plus Triton X-100 (0.025%), sterol inhibiting (SI) fungicides, and an alternating treatment of phosphate fertilizer and SI fungicides inhibited development of the powdery mildew fungus Sphaerotheca pannosa on fruits and leaves of nectarine trees in 3 consecutive years. The effectiveness of the alternating treatments with an appropriate systemic fungicide and 1% solution of MKP was similar to that of the commercial treatment with the systemic fungicides alone. However, application of the systemic fungicides only, omitting the phosphate treatment when they were scheduled, was significantly less effective than either the phosphate or the alternation treatments. These results indicate that the use of phosphate fertilizer has a significant role in disease control, enabling up to 50% reduction with number of fungicide treatments required for powdery mildew control. These results were confirmed in a large-scale demonstration trial conducted in a commercial orchard in 1995. This trial also revealed that a tank-mix treatment of 1% MKP solution with an SI fungicide provided the best protection against powdery mildew. Phosphate solutions were not phytotoxic to plants. Fruit harvested from MKP-treated trees by either alternation or tank-mix were similar or larger in their size distribution to those harvested from the commercial fungicide-based treatment. Fruit harvested from control, nontreated, trees were much smaller and produced ca. 23% nonmarketable fruits. The inhibitory effectiveness of Dipotassium hydrogen phosphate against powdery mildew in nectarine makes it a potential major component of an integrated pest management program.

Uses of Dipotassium hydrogen phosphate
Dipotassium hydrogen phosphate helps control the amount of calcium in the body and urine. Dipotassium hydrogen phosphate works by making the urine more acidic.It is used to prevent calcium kidney stones. It is also used to decrease the amount of ammonia in urine, thereby reducing odor and skin irritation caused by high-ammonia urine. This medication is also given to help certain antibiotics for bladder infections (e.g., methenamine) work better.

How to use Dipotassium hydrogen phosphate, Soluble
Take this medication by mouth, usually 4 times a day with meals and at bedtime or as directed by your doctor. Allow the tablet(s) to dissolve in a full glass (8 ounces or 240 milliliters) of water for 3 to 5 minutes. Do not use any liquid other than plain water. If any medication remains undissolved, crush the pieces in the water and stir well. After the medication has completely dissolved, stir and drink the mixture.
Take this medication regularly in order to get the most benefit from it. To help you remember, take it at the same times each day.
Your dosage is based on your condition and response to therapy.
Take this medication 2-3 hours before or after taking any products containing magnesium, aluminum, or calcium. Some examples include quinapril, didanosine, vitamins/minerals, and antacids. Dairy products (e.g., milk, yogurt), calcium-enriched juice, sucralfate, bismuth subsalicylate, iron, and zinc are also included. These products bind with phosphate, preventing its full absorption.

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