DISODIUM EDTA

Application:EDTA, Disodium Salt, Dihydrate is a chelating agent for metal ions; minimizes metal ion impurities in reaction buffers
CAS Number:6381-92-6
Purity:≥99%
Molecular Weight:372.2
Molecular Formula:C10H14N2Na2O8•2H2O
synonyms :  INCI: Disodium EDTA; Isodium dihydrogen ethylenediaminetetraacetate; Edetic acid disodium salt; EDTA disodium salt; (Ethylenedinitrilo)tetraacetic acid disodium salt; Disodium Edetate; EDTA disodium salt; 139-33-3; Disodium EDTA; Ethylenediaminetetraacetic acid disodium salt; Edta disodium; Disodium ethylenediaminetetraacetate; EDTA 2Na; Disodium ethylenediaminetetraacetic acid; Disodium dihydrogen ethylenediaminetetraacetate; 6381-92-6;
ethylenediamine tetraacetic acid disodium salt; ETA Solution;Ethylenediaminetetraacetic acid disodium salt solution; EDTA 2Na Solution; SCHEMBL33501; AKOS015900960; AKOS016016390; CS-W019532; KS-0000058S; SC-65716; D3789; E0091; E0103; ethylenediamine tetra-acetic acid disodium salt; N-[2-[Bis(sodiooxycarbonylmethyl)amino]ethyl]iminobis(acetic acid); sodium 2,2'-(2-(bis(carboxymethyl)amino)ethylazanediyl)diacetate;
Disodium N,N'-1,2-ethanediylbis(N-(carboxymethyl)glycine); (Ethylenedinitrilo)-tetraacetic acid disodium salt; Cheladrate; Chelaplex III; Chelaton 3; Chelaton III; Chelest 200; Chelest B; Clewat N; Complexon III; DR-16133; Dinatrium ethylendiamintetraacetat [Czech]; Diso-Tate; Disodium (ethylenedinitrilo)tetraacetate; Disodium (ethylenedinitrilo)tetraacetic acid; Disodium diacid ethylenediaminetetraacetate; Disodium dihydrogen ethylenediaminetetraacetate; Disodium dihydrogen(ethylenedinitrilo)tetraacetate; Disodium edathamil; Disodium edetate; Disodium EDTA, anhydrous; Disodium ethylenediamine-N,N,N',N'-tetraacetate; Disodium ethylenediaminetetraacetate; Disodium ethylenediaminetetraacetic acid; Disodium salt of EDTA; Disodium sequestrene; Disodium tetracemate; Disodium versenate; Disodium versene; Dotite 2NA; E.D.T.A. disodique [French]; EDTA disodium; EDTA disodium salt; Edathamil disodium; Edetate disodium; Edetate sodium; Edetic acid disodium salt; Endrate disodium; Ethylenebis(iminodiacetic acid) disodium salt; Ethylenediaminetetraacetate, disodium salt; Ethylenediaminetetraacetic acid disodium salt; Ethylenediaminetetraacetic acid, disodium salt; F 1; F 1 (VAN); F 1 (complexon); Kiresuto B; Komplexon III; Mavacid ED 4; Metaquest B; N,N'-1,2-Ethanediylbis(N-(carboxymethyl)glycine) disodium salt; Perma Kleer 50 Crystals disodium salt; Perma Kleer Di Crystals; Selekton B 2; Sequestrene sodium 2; Sodium ethylenediaminetetraacetate; Sodium versenate; Tetracemate disodium; Titriplex III; Trilon BD; Triplex III; Veresene disodium salt; Versene NA; Versene Na2; Versonol 120; Zonon D; Ethylene diamine tetraacetic acid, disodium salt; Glycine, N,N'-1,2-ethanediylbis(N-(carboxymethyl)-, disodium salt; Glycine, N,N'-1,2-ethanediylbis(N-(carboxymethyl)-, sodium salt (1:2); Acetic acid, (ethylenedinitrilo)tetra-, disodium salt;
EDTA is used to hold metal ions in the laboratory. Biochemistry and molecular biology are used as a consumer against enzymes. In analytical chemistry, complexometric titration is used in water hardness masking agents analysis.
It is a popular food additive used as a preservative and flavoring. Calcium disodium EDTA works as a chelating agent. This means it binds to metals and prevents them from participating in chemical reactions that could cause discoloration or flavor loss.
EDTA is used to hold metal ions in the laboratory. Biochemistry and molecular biology are used as a consumer against enzymes. In analytical chemistry, complexometric titration is used in water hardness masking agents analysis.
EDTA Na2 (ethylenediaminetetracetic acid disodium) is a chelating agent, used to sequester and decrease the reactivity of metal ions that may be present in many industrial and personal care products.
Industrial applications:
EDTA Na2 is used in cleaners, detergent, fertilizers, fixer solution for development of colour film, water cleaner and pH modifier. It is also used in redox reaction for the polymerization of butyl benzene rubber, it is used as part of activator for the control of polymerization speed.
Personal Care:
EDTA Na2 is used in Cosmetics to increase effectiveness and improve stability of bar and solid soaps, bath preparations; creams, oils, hair care products and many other personal care formulations.
Connect Chemicals offer valid and effective alternatives to EDTA Na2, please see the product pages of H-Quest and GLDA, both 100% biodegradable and obtained from bio-feedstock.
Packaging & Shelf Life: bags 25 kg net,Under proper storage conditions the shelf life is 36 months 
Disodium EDTA is a preservative, sequestrant, and stabilizer ... Disodium EDTA is permitted in the feed and drinking water of animals and/or for the treatment of food-producing animals. ... Disodium EDTA is not expected to contain preservatives, antioxidants, or sequestering agents for the purposes of stabilization.
Prevent discoloration due to trace metals in antibiotics, antihistamines, and local anesthetics. They are used to stabilize solutions of ascorbic acid (vitamin C), hydrogen peroxide, formaldehyde, folic acid, and hyaluronidase and are used to increase antibacterial activity of components of ophthalmic and contact lens care solutions.
Disodium edentate is used as a chelating agent in a wide range of pharmaceutical preparations, including mouthwashes, ophthalmic preparations, and topical preparation, typically at concentrations between 0.005 and 0.1 % w/v.
Disodium edentate is also used as a water softener as it will chelate calcium and magnesium ions present in hard water.
Adhesives and sealant chemicals
Agricultural chemicals (non-pesticidal)
Corrosion inhibitors and anti-scaling agents
Ion exchange agents
Oxidizing/reducing agents
Processing aids, not otherwise listed
Processing aids, specific to petroleum production
Solids separation agents
Surface active agents
preservative
All of the industrially used methods of manufacture of EDTA and its salts involve the addition of formaldehyde and hydrogen cyanide or an alkali metal cyanide to an aqueous solution of EDTA. The salts, or edetates, are then formed by hydrolysis. EDTA can also be formed by heating tetrahydroxyethylethylenediamine with sodium or potassium hydroxide using a cadmium oxide catalyst. Disodium EDTA was prepared by dissolving EDTA into a hot solution that contained two equivalents of sodium hydroxide. The solution was then allowed to crystallize.
Disodium EDTA is not expected to contain pesticides, 1,4-dioxane, free ethylene oxide, monochloroacetic acid, sulfite, organic solvents, nitrosamines, or other substances. The maximum concentration of heavy metals and formaldehyde is 10 ppm and 100 ppm, respectively.
Disodium EDTA is a substituted diamine ... it contains 76.0% to 77.5% EDTA. When dried, the cosmetic-grade material contains not less than 99.0% of Disodium EDTA ... The pharmaceutical-grade material contains not less than 99.0% and not more than 101.0% /disodium EDTA/, calculated on a dried basis.
Production volume for non-confidential chemicals reported under the 2006 Inventory Update Rule. Chemical: Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:2). Aggregated National Production Volume: 1 to < 10 million lbs.[US EPA; Non-Confidential 2006 Inventory Update Reporting. National Chemical Information. Glycine, N,N'-1,2-ethanediylbis
All other basic organic chemical manufacturing
Mining (except oil and gas) and support activities
Miscellaneous manufacturing
Oil and gas drilling, extraction, and support activities
Pesticide, fertilizer, and other agricultural chemical manufacturing
Pharmaceutical and medicine manufacturing
Soap, cleaning compound, and toilet preparation manufacturing
Synthetic dye and pigment manufacturing
Synthetic rubber manufacturing
Aggregated GHS information provided by 412 companies from 21 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Reported as not meeting GHS hazard criteria by 92 of 412 companies. For more detailed information, please visit ECHA C&L website
Of the 19 notification(s) provided by 320 of 412 companies with hazard statement code(s):
H302 (59.06%): Harmful if swallowed [Warning Acute toxicity, oral]
H312 (36.56%): Harmful in contact with skin [Warning Acute toxicity, dermal]
H315 (43.75%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (51.56%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H332 (56.25%): Harmful if inhaled [Warning Acute toxicity, inhalation]
H335 (42.81%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
H373 (21.88%): Causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]
H412 (36.25%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Residues of the following chemical substances are exempted from the requirement of a tolerance when used in accordance with good manufacturing practice as ingredients in an antimicrobial pesticide formulation, provided that the substance is applied on a semi-permanent or permanent food-contact surface (other than being applied on food packaging) with adequate draining before contact with food. ... (b) The following chemical substances when used as ingredients in an antimicrobial pesticide formulation may be applied to: Dairy processing equipment, and food-processing equipment and utensils. Ethylenediaminetetraacetic acid (EDTA), disodium salt is included on this list. Limit: When ready for use, the end-use concentration is not to exceed 1400 ppm.
Residues of the following chemical substances are exempted from the requirement of a tolerance when used in accordance with good manufacturing practice as ingredients in an antimicrobial pesticide formulation, provided that the substance is applied on a semi-permanent or permanent food-contact surface (other than being applied on food packaging) with adequate draining before contact with food. ... (c) The following chemical substances when used as ingredients in an antimicrobial pesticide formulation may be applied to: Food-processing equipment and utensils. Ethylenediaminetetraacetic acid (EDTA), disodium salt is included on this list. Limit: When ready for use, the end-use concentration is not to exceed 1400 ppm.
Disodium edentate behaves as a weak acid, displacing carbon dioxide from carbonates and reacting with metals to form hydrogen. It is incompatible with strong oxidizing agents, strong bases, metal ions, and metal alloys.
Additives may be incompatible with the reconstituted (diluted) solution required for intravenous infusion. Consult with pharmacist, if available. When introducing additives, use aseptic technique, mix thoroughly and do not store.
As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer saftey standards, such as those described in the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern than those on List C, and with List C containing pesticides of greater concern than those on List D. Ethylenediaminetetraacetic acid, disodium salt is found on List D. Case No: 4036; Pesticide type: insecticide, fungicide, herbicide, antimicrobial; Case Status: None of the active ingredients in the case are being supported for reregistration by their registrants. All are unsupported, or some are unsupported and some are cancelled. Cases described as "unsupported" generally are being processed for cancellation.; Active ingredient (AI): Ethylenediaminetetraacetic acid, disodium salt; AI Status: The active ingredient is no longer contained in any registered products ... "cancelled."
Residues of the following chemical substances are exempted from the requirement of a tolerance when used in accordance with good manufacturing practice as ingredients in an antimicrobial pesticide formulation, provided that the substance is applied on a semi-permanent or permanent food-contact surface (other than being applied on food packaging) with adequate draining before contact with food. ... (b) The following chemical substances when used as ingredients in an antimicrobial pesticide formulation may be applied to: Dairy processing equipment, and food-processing equipment and utensils. Ethylenediaminetetraacetic acid (EDTA), disodium salt is included on this list. Limit: When ready for use, the end-use concentration is not to exceed 1400 ppm.
OTHER TOXICITY INFORMATION/ Fatal medication errors have occurred that involve confusion between edetate calcium disodium (calcium EDTA) and edetate disodium (no longer commercially available in the US). Children and adults have mistakenly received edetate disodium instead of edetate calcium disodium; at least 5 deaths have occurred as a result of inadvertent administration of edetate disodium. Although both edetate calcium disodium and edetate disodium are heavy metal antagonists, the 2 drugs were originally approved by the US Food and Drug Administration (FDA) for different uses and have different effects; edetate disodium was formerly FDA approved for use in selected patients for the emergency treatment of hypercalcemia or for the control of ventricular arrhythmias associated with cardiac glycoside toxicity. Use of edetate disodium may result in a substantial, and sometimes fatal, decrease in serum calcium concentrations. In June 2008, FDA withdrew its prior approval for edetate disodium because of safety concerns following a review of the risk-benefit profile of the drug. FDA stated that it was not considering additional action regarding edetate calcium disodium at that time; most of the fatalities following administration of an EDTA drug have involved medication errors in which edetate disodium was administered instead of edetate calcium disodium. FDA has not received reports of any fatalities resulting from the administration of edetate calcium disodium that involve a medication error.
Disodium EDTA at a concentration of 1% (w/v; 24 mM) increased the in situ drug absorption of acetazolamide from the small intestine of male Charles River rats when administered with 1% (w/v) reduced glutathione. Intestinal absorption was increased by 1.5 to 2 times; however, absorption from the stomach was not affected by treatment with EDTA and glutathione. The investigators suggested that Disodium EDTA altered the aqueous permeability of the intestinal epithelium by the chelation of magnesium and calcium ions, thereby separating the epithelial cells.
Organic compounds that coordinate metal ions into circular structures (chelate circles) are called chelating reagents. Most  chelating reagents include oxygen, nitrogen, or sulfur atoms in their molecules. Chelate structures with five or six member rings form the most stable chelate circle. In chelating reactions of typical chelating reagents, such as ethylenediamine, acetylacetone, and oxine, several molecules are coordinated with one metal ion. Ethylenediamine tetraacetic acid (EDTA), which has many coordinated atoms, forms a very stable chelate between one molecule of EDTA and metal ion. Chelating reagents are utilized for chelate titration, isolation, and separation of metal ions. They are also used to mask certain ions, solubilize metals in organic solvents, and for gas chromatography of metal ions. Metal indicators are chelating reagents that can be used to colorimetrically or fluorometrically determine metal ion concentration in solutions. Acetylacetone (AA) and its analogs are utilized for solvent extractions of metal ions from aqueous solutions. These metal complexes are used as catalysts of polymerization, dryness, and combustion. Chelating reagents, including EDTA, EDTA analogs, metal salts, and others, are available in bulk quantities from Dojindo. The following table indicates the stability constants of chelators with various metal ions and chelate reagents.
EDTA, Disodium Salt, Dihydrate is an extensively used chelator of divalent cations such as Ca2+. EDTA (Ethylenediaminetetraacetic acid) is a chelating agent, a general chemical, and a sequestrant. In molecular biology applications, it is used to minimize metal ion contaminants. Also used to facilitate enzymatic reactions that could be inhibited by heavy metal traces. Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.
EDTA is the commonly used abbreviation for (Ethylene­dinitrilo)­tetra­acetic Acid (also called Ethylene­diamine­tetra­acetic Acid or Edetic Acid). The Disodium salt of EDTA is the most commonly used form of this versatile organic complexing agent, which is used for the determination of many metal ions either by direct titration or by back-titration. Adjustment of reaction conditions, either by controlling the pH or by use of masking agents, and selection of the appropriate indicator permits a wide variety of metal ions to be determined using EDTA.

Molarity is best used in expressing EDTA concentration, because the reaction involves the complexation of one metal ion by one EDTA molecule or ion, whether the free acid form of EDTA or one of its more soluble Sodium salts is used. The general reaction involving the Disodium salt is:

EDTA2- + Mn+ → [EDTA-M]+n-2
where M = Ca, Mg, Cd, Mn, Ni, Al, Zn, Bi, Co, Cu, or other metal ion

An indicator is added that forms a colored complex with some of the metal ion being determined. When the endpoint is reached, all of the free metal ion has been complexed by the EDTA. The last addition of EDTA then removes the metal ion from its complex with the indicator, producing a color change. The relative strength of the EDTA-metal ion complex compared to that of the indicator-metal ion complex determines whether a direct titration or a back-titration is applicable.

EDTA is most commonly used to determine hardness (i.e., Calcium and Magnesium ions) in water, where the pH must be approximately 10 and is usually controlled by adding a buffer such as Water Hardness Buffer. Water Hardness Indicator (Eriochrome Black T), Eriochrome Blue Black R, Calmagite, and Murexide are used for hardness or Calcium determinations using EDTA.
Formerly registered in the US for use as a disinfectant and component of contact lens solutions; [NPIRS] Used as a preservative, color retention agent, antioxidant, flavoring agent for foods, anticoagulant for blood collection, and chelating agent in personal care products; Also used in the pulp and paper industry, in laboratory titrimetric analysis of metals, and as a therapeutic chelating agent; [Merck Index] Used in the agricultural, chemical, paper-pulp-board, textile processing, detergent, and cosmetics industries; Used as a cleaning/washing agent, disinfectant, coloring agent, complexing agent, stabilizer, and micro-nutrient; [IUCLID]
Ethylenediaminetetraacetic acid disodium salt (EDTA 2Na) is used in detergents, liquid soap, shampoo, agricultural chemicals, fixer solution for development of color film, water cleaner, pH modifier. When stating the redox reaction for the polymerization of butyl benzene rubber, it is used as part of activator for the control of polymerization speed.
Preservative and sequestrant in foods Ethylenediaminetetraacetic acid, widely abbreviated as EDTA, is a polyamino carboxylic acid and a colourless, water-soluble solid. Its conjugate base is named ethylenediaminetetraacetate. It is widely used to dissolve limescale. Its usefulness arises because of its role as a hexadentate ("six-toothed") ligand and chelating agent, i.e. its ability to "sequester" metal ions such as Ca2+ and Fe3+. After being bound by EDTA, metal ions remain in solution but exhibit diminished reactivity. EDTA is produced as several salts, notably disodium EDTA and calcium disodium EDTA. (Wikipedia) Chelating agent used in food processing Ethylenediaminetetraacetic acid, widely abbreviated as EDTA, is a polyamino carboxylic acid and a colourless, water-soluble solid. Its conjugate base is named ethylenediaminetetraacetate. It is widely used to dissolve limescale. Its usefulness arises because of its role as a hexadentate ("six-toothed") ligand and chelating agent, i.e. its ability to "sequester" metal ions such as Ca2+ and Fe3+. After being bound by EDTA, metal ions remain in solution but exhibit diminished reactivity. EDTA is produced as several salts, notably disodium EDTA and calcium disodium EDTA. (Wikipedia) Sequestrant, preservative and discolouration inhibitor for foods Ethylenediaminetetraacetic acid, widely abbreviated as EDTA, is a polyamino carboxylic acid and a colourless, water-soluble solid. Its conjugate base is named ethylenediaminetetraacetate. It is widely used to dissolve limescale. Its usefulness arises because of its role as a hexadentate ("six-toothed") ligand and chelating agent, i.e. its ability to "sequester" metal ions such as Ca2+ and Fe3+. After being bound by EDTA, metal ions remain in solution but exhibit diminished reactivity. EDTA is produced as several salts, notably disodium EDTA and calcium disodium EDTA.
EDTA (ethylenediamine tetraacetic acid) and its salts, Calcium Disodium EDTA, Diammonium EDTA, Dipotassium EDTA, Disodium EDTA, TEA-EDTA, Tetrasodium EDTA, Tripotassium EDTA and Trisodium EDTA, and the related ingredients HEDTA (hydroxyethyl ethylenediamine triacetic acid) and its trisodium salt, Trisodium HEDTA, are crystalline powders often sold as aqueous solutions.
In cosmetics and personal care products, these ingredients are widely used and can be found in moisturizers, skin care and cleansing products, personal cleanliness products, bath soaps, shampoos and conditioners, hair dyes, hair bleaches, and many other product types.
EDTA, also known as edetic acid, and its salts were developed to counteract the effects of hard water and heavy metal ions in the manufacture of textiles. These metal chelators are widely used in cosmetics and personal care products, in food, and in medicines.
These ingredients form complexes with calcium, magnesium, and iron, which allows for better foaming and cleaning performance of cosmetics and personal care products. By binding with metal ions, these ingredients prevent the metals from being deposited onto the hair, scalp and skin.
The Food and Drug Administration (FDA) reviewed the safety of Disodium EDTA and Calcium Disodium EDTA and approved the use of these ingredients as food preservatives for direct addition to food.
The safety of Disodium EDTA, Calcium Disodium EDTA, Diammonium EDTA, Dipotassium EDTA, EDTA, HEDTA, TEA-EDTA, Tetrasodium EDTA, Tripotassium EDTA and Trisodium HEDTA was assessed by the Cosmetic Ingredient Review (CIR) Expert Panel.
The CIR Expert Panel evaluated the scientific data and concluded that Disodium EDTA and related ingredients were safe as used in cosmetics and personal care products.
CIR Safety Review: EDTA and the related ingredients at the concentrations used in cosmetic and personal care products were not dermal irritants or sensitizers. Studies indicated that these ingredients were not carcinogens. Because these ingredients bind metals required for normal cell division, some studies that indicated that these compounds were weakly mutagenic. Some studies showed reproductive and developmental effects following oral exposure to large doses of metal chelators, likely an effect of the binding of metals required for normal reproduction and development.
The CIR Expert Panel reviewed data that indicated that EDTA and the related ingredients were not well absorbed through the skin. Therefore, dermal exposures to EDTA or HEDTA from the use of cosmetics and personal care products containing these ingredients would result in very little skin penetration and systemic levels well below those shown to produce adverse effects in oral studies. Because no data were available regarding the absorption of these ingredients following inhalation exposure, the CIR Panel expressed concern about EDTA in products that may be inhaled. They conducted an exposure assessment assuming 25% EDTA in a product. The calculated dose of EDTA via inhalation of an aerosolized product based on this assessment did not raise concerns about adverse effects of EDTA or its salts in cosmetics and personal care products that may be inhaled.
The CIR Expert Panel also recognized that EDTA, HEDTA and their salts are penetration enhancers. Therefore, formulators should be aware of this when combining these ingredients with those found to be safe primarily because they were not significantly absorbed.
EDTA (ethylenediamine tetraacetic acid) and its salts are substituted diamines. HEDTA (hydroxyethyl ethylenediamine triacetic acid) and Trisodium HEDTA are substituted amines. All of these ingredients function as chelating agents in cosmetics and personal care products.
Chelating agents, also called sequestrants, are ingredients that have the ability to bind with and inactivate metallic ions to prevent their adverse effects on the stability or appearance of cosmetic products.