Disodium EDTA is used widely in topical, oral, and parenteral pharmaceutical formulations; it is used extensively in cosmetic and food products. Disodium EDTA and EDTA calcium disodium are used in a greater number and variety of pharmaceutical formulations than is edetic acid. Both Disodium EDTA and EDTA calcium disodium are poorly absorbed from the gastrointestinal tract and are associated with few adverse effects when used as excipients in pharmaceutical formulations.
CAS NO: 139-33-3
Sodium dihydrogen ethylenediaminetetraacetate; Edetic acid disodium salt; Disodium EDTA disodium salt; (Ethylenedinitrilo)tetraacetic acid disodium salt; Disodium EDTA; Disodium EDTA disodium salt; 139-33-3; Disodium Disodium EDTA; Ethylenediaminetetraacetic acid disodium salt; Disodium EDTA disodium; Disodium ethylenediaminetetraacetate; Disodium EDTA 2Na; Disodium ethylenediaminetetraacetic acid; Disodium dihydrogen ethylenediaminetetraacetate; 6381-92-6; ethylenediamine tetraacetic acid disodium salt; ETA Solution;Ethylenediaminetetraacetic acid disodium salt solution; Disodium EDTA 2Na Solution; SCHEMBL33501; AKOS015900960; AKOS016016390; CS-W019532; KS-0000058S; SC-65716; D3789; E0091; E0103; ethylenediamine tetra-acetic acid disodium salt; Disodium N,N'-1,2-ethanediylbis(N-(carboxymethyl)glycine); (Ethylenedinitrilo)-tetraacetic acid disodium salt; Cheladrate; Chelaplex III; Chelaton 3; Chelaton III; Chelest 200; Chelest B; Clewat N; Complexon III; DR-16133; Dinatrium ethylendiamintetraacetat [Czech]; Diso-Tate; Disodium (ethylenedinitrilo)tetraacetate; Disodium (ethylenedinitrilo)tetraacetic acid; Disodium diacid
Ethylenediaminetetra-acetic acid (abbreviated as Disodium EDTA) is used in several industrial applications attributing to its high ability to bind to most of metal cations. Disodium EDTA is produced as several salts, e.g. ethylenediaminetetra-acetic acid disodium salt (Disodium EDTAS). Disodium EDTA and its salts are used as chelating agents in cosmetic formulations. Disodium EDTAS is a preservative, sequestrant, and stabilizer in foods. Disodium EDTA is added to ascorbic acid-disodium benzoate containing soft drinks to mitigate the formation of benzene. Disodium EDTA and its salts are used as a component in the production of food-contact paper and paperboard. Disodium EDTAS is permitted in the feed and drinking water of animals and/or for the treatment of food-producing animals. In the textile industry, Disodium EDTA and its salts prevent metal ion impurities from changing colors of dyed products. In the pulp and paper industry, Disodium EDTA and its salts inhibit the ability of metal ions from catalyzing the disproportionation of hydrogen peroxide (a typical bleaching agent). Disodium edentate behaves as a weak acid, displacing carbon dioxide from carbonates and reacting with metals to form hydrogen. It is incompatible with strong oxidizing agents, strong bases, metal ions, and metal alloys.
Additives may be incompatible with the reconstituted (diluted) solution required for intravenous infusion. Consult with pharmacist, if available. When introducing additives, use aseptic technique, mix thoroughly and do not store.
As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer saftey standards, such as those described in the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern than those on List C, and with List C containing pesticides of greater concern than those on List D.
Disodium EDTA is used in synthetic rubber manufacture. Disodium EDTA is also used as a corrosion inhibitor to carbon steel in the industries. As an anticoagulant, Disodium EDTAS and tripotassium salts of Disodium EDTA are most commonly used. Disodium EDTA occurs as a white crystalline, odorless powder with a slightly acidic taste. Disodium Dihydrogen Disodium EDTA is a sequestrant and chelating agent whose complete name is disodium ethylenediamine tetraacetate. it is a nonhygroscopic powder that is colorless, odorless, and tasteless at recommended use levels. A 1% solution has a ph of 4.3–4.7. It is used to control the reaction of trace metals to include calcium and magnesium with other organic and inorganic components in food to prevent deterioration of color, texture, and development of precipitates and to prevent oxidation. Its function is comparable to that of disodium calcium Disodium EDTA. 10 mols of ethylene diamine as a 30% aqueous solution and 4 mols of solid caustic soda are placed in a steam heated kettle supplied with an agitator. 8 mols of sodium cyanide as a concentrated water solution (about 30%) are added and the solution heated to 60°C. About a 10 inch vacuum is applied to bring the liquid to incipient boiling. Formaldehyde (7.5 mols of 37% to 40% aqueous solution) is slowly added, the temperature being held at 60°C, and the solution vigorously stirred. Then, when the evolution of ammonia has substantially stopped, an additional 8 mols of sodium cyanide, followed by 8 mols of formaldehyde are added as before.
This is continued until 40 mols of cyanide and 40 mols of formaldehyde have been added. Then at the end about 2 mols more of formaldehyde are added, making 42 mols in all, to remove any last traces of cyanide. About 8 to 10 hours are required to complete the reaction. The resulting product, referred to herein as the crude reaction product, is essentially an aqueous solution of the sodium salt of ethylene diamine tetracetic acid. To 1,000 g of the crude reaction product are added 264 g of ethylene diamine tetracetic acid. The mixture is preferably heated to incipient boiling to increase the rate of reaction, and then the mixture is allowed to cool and crystallize. The crystals formed are filtered off, washed with the smallest possible amount of ice water, and dried to a constant weight, which is 452 g. A representative sample of the product so prepared showed, upon analysis, 13.26% sodium against a theoretical of 13.70% for the disodium salt. The dialkali salt has a pH of about 5.3 and behaves like a weak acid, displacing CO2 from carbonates and reacting with metals to form hydrogen. It is a white crystalline solid. Disodium EDTA is used as a chelating agent in a wide range of pharmaceutical preparations, including mouthwashes, ophthalmic preparations, and topical preparations, typically at concentrations between 0.005 and 0.1% w/v.
Disodium EDTA forms stable water-soluble complexes (chelates) with alkaline earth and heavy-metal ions. The chelated form has few of the properties of the free ion, and for this reason chelating agents are often described as ‘removing’ ions from solution, a process known as sequestering. The stability of the metal–EDTA complex is dependent on the metal ion involved and the pH. DisodiumE EDTA is also used as a water softener as it will chelate calcium and magnesium ions present in hard water. It is also used therapeutically as an anticoagulant as it will chelate calcium and prevent the coagulation of blood in vitro. Concentrations of 0.1% w/v are used in small volumes for hematological testing and 0.3% w/v in transfusions. Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. Mutation data reported. The calcium disodium salt of Disodium EDTA is used as a chelating agent in treating lead poisoning. When heated to decomposition it emits toxic fumes of NOx and NasO.
Disodium EDTA, trisodium EDTA, and edetic acid readily chelate calcium and can, in large doses, cause calcium depletion (hypocalcemia) if used over an extended period of time, or if administered too rapidly by intravenous infusion. If used in preparations for the mouth, they can also leach calcium from the teeth. However, EDTA calcium disodium does not chelate calcium.
Disodium EDTA should be used with caution in patients with renal impairment, tuberculosis, and impaired cardiac function.
Although Disodium EDTA is generally considered safe, there have been reports of Disodium EDTA toxicity in patients receiving chelation therapy. All of the industrially used methods of manufacture of Disodium EDTA and its salts involve the addition of formaldehyde and hydrogen cyanide or an alkali metal cyanide to an aqueous solution of Disodium EDTA. The salts, or EDTAs, are then formed by hydrolysis. Disodium EDTA can also be formed by heating tetrahydroxyethylethylenediamine with sodium or potassium hydroxide using a cadmium oxide catalyst.
Disodium EDTA was prepared by dissolving Disodium EDTA into a hot solution that contained two equivalents of sodium hydroxide. The solution was then allowed to crystallize. Disodium EDTA is not expected to contain pesticides, 1,4-dioxane, free ethylene oxide, monochloroacetic acid, sulfite, organic solvents, nitrosamines, or other substances. The maximum concentration of heavy metals and formaldehyde is 10 ppm and 100 ppm, respectively. Disodium EDTA is a substituted diamine. It contains 76.0% to 77.5% Disodium EDTA. When dried, the cosmetic-grade material contains not less than 99.0% of Disodium EDTA. The pharmaceutical-grade material contains not less than 99.0% and not more than 101.0% /disodium Disodium EDTA/, calculated on a dried basis.
2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid; 2-[2-[bis(carboxymethyl)amino]ethyl (carboxymethyl)amino]acetic acid; sodium; Acido Etilendiaminotetraacético Sal Disódica 2-hidrato; Dinatriumhydogenethylendiaminacetat; disodium 2-[2-[carboxylatomethyl(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetate; Disodium 2-[carboxymethyl-[2-[carboxymethyl-(2-oxido-2-oxoethyl)amino]ethyl]amino]acetate; disodium 2-[carboxymethyl-[2-[carboxymethyl-(2-oxido-2-oxoethyl)amino]ethyl]amino]acetate; disodium 2-[carboxymethyl-[2-[carboxymethyl-(2-oxido-2-oxoethyl)amino]ethyl]amino]acetate dihydrate; disodium dihydrogen 2,2',2'',2'''-(ethane-,1,2-diyldinitro)tetraacetate; Disodium dihydrogen ethylenediaminetetraacetate; disodium dihydrogen ethylenediaminetetraacetate
Dabeersen Na2 FARMACIA; DABEERSEN Na2 HQ; Dabeersen Na2 TECNICO; Dissolvine NA2; Dissolvine NA2-P; Dissolvine NA2-S; EDTA-Disodium salt (EDTA-2NA); Trilon BD; VERSENE* NA CHELATING AGENT; VERSENE* NA2 CRYSTALS CHELATING AGENT
104244-09-9; 104244-09-9; 1236140-51-4; 1236140-51-4; 139-33-3; 1892-64-4; 1892-64-4; 37341-71-2; 37341-71-2; 42615-28-1; 42615-28-1; 6381-92-6; 69772-70-9; 69772-70-9
Nasal formulations containing benzalkonium chloride and Disodium EDTA, both known to be local irritants, were shown to produce an inflammatory reaction, and microscopic examination showed an extended infiltration of the mucosa by eosinophils, and pronounced atrophy and disorganization of the epithelium, although these effects were subsequently shown to be reversible. Disodium EDTA (Sodium Disodium EDTA) is a chelating agent that is also used to stop the melting effect of collagenases and proteases on the cornea. Disodium EDTA is useful in halting melting through inhibition of matrix metalloproteinases, but is not felt to be useful for melting caused by infectious agents. As the effect of Disodium EDTA on metalloproteinases is reversible, it must be administered several times daily to be effective. EDTA salts are more stable than edetic acid (see also Edetic acid). However, Disodium EDTA dihydrate loses water of crystallization when heated to 120°C. Aqueous solutions of Disodium EDTA may be sterilized by autoclaving, and should be stored in an alkali-free container.
Disodium EDTA is hygroscopic and is unstable when exposed to moisture. It should be stored in a well-closed container in a cool, dry place. Disodium EDTA is used to hold metal ions in the laboratory. Biochemistry and molecular biology are used as a consumer against enzymes. In analytical chemistry, complexometric titration is used in water hardness masking agents analysis. It is a popular food additive used as a preservative and flavoring. Calcium disodium Disodium EDTA works as a chelating agent. This means it binds to metals and prevents them from participating in chemical reactions that could cause discoloration or flavor loss. Disodium EDTA is used to hold metal ions in the laboratory. Biochemistry and molecular biology are used as a consumer against enzymes. In analytical chemistry, complexometric titration is used in water hardness masking agents analysis. Disodium EDTA (ethylenediamine tetraacetic acid) and its salts, Calcium Disodium EDTA, Diammonium Disodium EDTA, Dipotassium Disodium EDTA, Disodium Disodium EDTA, TEA-Disodium EDTA, Tetrasodium Disodium EDTA, Tripotassium Disodium EDTA and Trisodium Disodium EDTA, and the related ingredients HDisodium EDTA (hydroxyethyl ethylenediamine triacetic acid) and its trisodium salt, Trisodium HDisodium EDTA, are crystalline powders often sold as aqueous solutions.
In cosmetics and personal care products, these ingredients are widely used and can be found in moisturizers, skin care and cleansing products, personal cleanliness products, bath soaps, shampoos and conditioners, hair dyes, hair bleaches, and many other product types. Disodium EDTA, also known as edetic acid, and its salts were developed to counteract the effects of hard water and heavy metal ions in the manufacture of textiles. These metal chelators are widely used in cosmetics and personal care products, in food, and in medicines. These ingredients form complexes with calcium, magnesium, and iron, which allows for better foaming and cleaning performance of cosmetics and personal care products. By binding with metal ions, these ingredients prevent the metals from being deposited onto the hair, scalp and skin.
The Food and Drug Administration (FDA) reviewed the safety of Disodium Disodium EDTA and Calcium Disodium Disodium EDTA and approved the use of these ingredients as food preservatives for direct addition to food. EDTA (its main salts used in EDTA and Disodium EDTA cosmetics, Tetrasodium EDTA, Trisodium EDTA) is a chelating agent that has been used since the 1930s and industrialists have full control over processing and use. Its main feature is complex heavy metals. That is, by forming a complex with them, it will neutralize them somehow, then serve them as carriers and evacuate them. Therefore, it is used quite sensibly in medicine to combat heavy metal poisoning (eg lead). Often used as a trap (calcium, limestone ) in soaps or shower gels, this allows "hard" water to be managed.
Disodium EDTA is mainly used to keep metal ions in aqueous solution.
In the textile industry, it prevents metal ion impurities from changing the color of dyed products. In the pulp and paper industry, Disodium EDTA inhibits the ability of metal ions, especially Mn2 +, to catalyze the disproportion of hydrogen peroxide used in non-chlorine bleaching. Similarly, Disodium EDTA is added to some foods as a preservative or stabilizer to prevent catalytic oxidative discoloration catalyzed by metal ions. Reduces EDTA benzene formation in soft drinks containing ascorbic acid and sodium benzoate.
EDTA (ethylenediamine tetraacetic acid) and its salts, Calcium Disodium EDTA, Diammonium EDTA, Dipotassium EDTA, Disodium EDTA, TEA-EDTA, Tetrasodium EDTA, Tripotassium EDTA and Trisodium EDTA and related components HEDTA (hydroxyethyl ethylenediamine triacetic acid) and trisodium salt, Trisodium HEDTA are crystalline powders usually sold as aqueous solutions.
These ingredients are widely used in cosmetics and personal care products and can be found in moisturizers, skin care and cleaning products, personal cleansing products, bath soaps, shampoos and conditioners, hair dyes, hair bleaches, and many other types of products.EDTA and its salts, also known as edetic acid, have been developed to resist the effects of hard water and heavy metal ions in textile production. These metal chelators are widely used in cosmetics and personal care products, food, and medicine.
Disodium EDTA forms complexes with calcium, magnesium and iron that provide better foaming and cleaning performance of cosmetics and personal care products. Disodium EDTA binds with metal ions, preventing metals from accumulating on hair, scalp and skin.
Disodium EDTA is a chelating agent that eliminates excessive mineral buildup. Disodium EDTA is sold as a water-soluble white powder that is slightly acidic. It also increases foaming and appeals to consumers who like this additional feature. EDTA (its main salts used in EDTA and Disodium EDTA cosmetics, Tetrasodium EDTA, Trisodium EDTA) is a chelating agent that has been used since the 1930s and industrialists have full control over processing and use. Its main feature is complex heavy metals. That is, by forming a complex with them, it will neutralize them somehow, then serve them as carriers and evacuate them. Therefore, it is used quite sensibly in medicine to combat heavy metal poisoning (eg lead).
Often used as a trap (calcium, limestone) in soaps or shower gels, this allows "hard" water to be managed. EDTA is most commonly used to determine the hardness (ie Calcium and Magnesium ions) in water; here the pH should be about 10 and is usually controlled by adding a buffer such as Water Hardness Buffer. For determination of hardness or Calcium using EDTA, Water Hardness Indicator (Eriochrome Black T), Eriochrome Blue Black R, Calmagite and Murexide are used. Disodium EDTA is previously registered in the USA for use as a disinfectant and component of contact lens solutions. Disodium EDTA is used as a preservative, color retention agent, antioxidant, flavoring for foods, anticoagulant for blood collection and chelating agent in personal care products. Disodium EDTA is also used in the pulp and paper industry, in laboratory titrimetric analysis of metals, and as a therapeutic chelating agent.
Disodium EDTA is used in the agriculture, chemical, pulp-cardboard, textile processing, detergent and cosmetics industries. Disodium EDTA is used as a cleaning / washing agent, disinfectant, colorant, complexing agent, stabilizer and micronutrient. Disodium EDTA is a chelating agent that binds to various metal ions and neutralizes them. The effect helps to strengthen the protective system of our products. In colorants, this helps maintain the intended color result and product stability in case of metal ion exposure during the hue production. Ethylenediaminetetraacetic acid disodium salt (EDTA 2Na) is used as detergents, liquid soap, shampoo, agricultural chemicals, fixative solution to develop colored film, water cleaner, pH modifier. While the redox reaction is specified for the polymerization of butyl benzene rubber, it is used as part of the activator to control the polymerization rate.
Disodium EDTA is an organic sodium salt, the anhydrous form of the disodium salt of ethylenediaminetetraacetic acid (EDTA). After binding with EDTA, metal ions remain in solution but exhibit reduced reactivity. EDTA is produced as several salts, mainly Disodium EDTA and calcium Disodium EDTA. Disodium EDTA is a chelating agent. It is used in viscosity control. Disodium EDTA prevents the deterioration of cosmetic products by binding metal ions with them and neutralizing them. An organic acid salt (Ethylenediaminetetraacetic Acid, disodium salt) used in aqueous solutions with other reagents and inert materials in the preparation of cleaning mixes to be applied to stone surfaces and frescoes and poultry. EDTA disodium salt is used in AB 57 poultry (I.C.R. formulation - Rome) for its ability to complex the calcium in the shells and its good solubility (better than tetrasodium salt). In addition to being a strong chelating agent of many metallic cations such as iron and copper; This feature is used for stone surfaces, wood, plaster, etc. It can be used to remove rust or copper-green stains on it.