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DISODIUM GUANYLATE

CAS NUMBER: 5550-12-9 

EC NUMBER: 226-914-1

MOLECULAR FORMULA: C10H12N5Na2O8P 

MOLECULAR WEIGHT: 407.18

IUPAC NAME: disodium;[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate


Disodium Guanylate, also known as sodium 5'-guanylate and disodium 5'-guanylate, is a natural sodium salt of the flavor enhancing nucleotide guanosine monophosphate (GMP). 
Disodium Guanylate is a food additive with the E number E627.
Disodium Guanylate is commonly used in conjunction with glutamic acid.

As Disodium Guanylate is a fairly expensive additive, it is not used independently of glutamic acid; if disodium guanylate is present in a list of ingredients but MSG does not appear to be, it is likely that glutamic acid is provided as part of another ingredient such as a processed soy protein complex. 
Disodium Guanylate is often added to foods in conjunction with disodium inosinate; the combination is known as disodium 5'-ribonucleotides.
Disodium guanylate is produced from dried seaweed

Disodium Guanylate is often added to: 
-instant noodles
-potato chips
-other snacks
-savory rice
-tinned vegetables 
-cured meats
-packaged soup

Disodium glutamate is frequently used alongside MSG in a range of foods, such as: 
-canned soups 
-potato chips
-dairy products

What Disodium Guanylate is and how it’s used?
Disodium Guanylate is a common food additive. 
In fact, Disodium Guanylate’s a kind of salt derived from guanosine monophosphate (GMP)

In biochemical terms, GMP is a nucleotide, which is a component of important molecules like DNA.
Disodium guanylate is usually made from fermented tapioca starch, though it can also be derived from yeast, mushrooms, and seaweed. 
In nature, Disodium Guanylate’s more readily found in dried mushrooms.

USES:
Disodium Guanylate is typically paired with monosodium glutamate (MSG) or other glutamates but can be used on its own — though this is fairly rare because it’s more expensive to produce.
Glutamates are proteins that naturally occur in foods like tomatoes and cheese. 
They’re also found in your brain, where they act as neurotransmitters.

While table salt (sodium chloride) can bring out foods’ flavors, compounds like glutamates can enhance how your tongue perceives salt. 
Disodium glutamate amplifies salt’s flavor intensity, so you need a bit less salt to produce the same effect.
Together, disodium guanylate and MSG enhance the flavor of food. 
In fact, humans respond to mixtures of MSG and nucleotides like GMP eight times more strongly than MSG alone.

In other words, when MSG and disodium guanylate are combined, you’re likely to perceive food as much tastier.
In one study, the sodium content in fermented sausages was replaced with potassium chloride, resulting in unappealing qualities like poor texture and flavor. 
However, after MSG and flavor-enhancing nucleotides were added, study participants rated it delicious.

Importantly, the combination of MSG and disodium guanylate adds umami to a dish. 
Umami, which is considered the fifth basic taste, is associated with the savory or meaty flavors of beef, mushrooms, yeast, and rich broths.

What foods contain Disodium Guanylate?
Disodium guanylate is added to a wide range of processed foods.
These include: 
-prepackaged cereals, 
-sauces, 
-canned soups, 
-instant noodles, 
-snack foods, 
-pasta products, 
-spice blends, 
-cured meats, 
-energy drinks,
-canned vegetables

However, this compound also occurs naturally in foods like fish and mushrooms. 
For instance, dried shiitake mushrooms pack 150 mg in every 3.5 ounces (100 grams)
Disodium Guanylate may be listed as “yeast extract” or “natural flavors” in an ingredient list.

Disodium Guanylate is added to prepackaged snacks, cereals, instant noodles, canned soups, and other processed goods
Though Disodium Guanylate also occurs naturally in foods like fish and mushrooms.

Disodium Guanylate and MSG are both used to add a meaty or savory flavor to foods. 
Disodium Guanylate is produced by fermentation, usually of tapioca starch, although it can come from other vegetable sources as well. 
Disodium Guanylate can be classified under "natural flavors" on a food label, so it isn't always easy to determine if a food contains this additive.

Sources of Disodium Guanylate:
Disodium guanylate can be used in: 
-pasta products, 
-processed vegetables, 
-dairy products, 
-processed fruits, 
-candies, 
-breakfast cereals, 
-processed meat or poultry, 
-fish products, 
-egg products, 
-condiments, 
-alcoholic beverages, 
-energy or sports drinks, 
-soups and sauces

MSG is often used in Asian food, spice mixes, meat or fish products, salad dressings, dry or canned soups and frozen foods. 
Disodium Guanylate's sometimes hidden under another name. 
Any ingredient containing the words "glutamate," "hydrolyzed," "protein," "protease," "enzymes" or "enzyme modified" is likely to contain hidden MSG, and "yeast extract," "autolyzed yeast," "soy sauce," "Ajinomoto," "calcium caseinate" and "sodium caseinate" also indicate the potential presence of MSG.

Disodium guanylate or disodium 5′-guanylate, a flavor enhancer with the European food additive number E627. 
Disodium Guanylate is a kind of nucleotide and usually added with another flavor enhancer disodium inosinate (E631) in food and the combination is known as disodium 5′-ribonucleotides (E635), which is an MSG substitute. 
Disodium Guanylate is the organic disodium salt of guanylic acid powder or granular, the manufacturing processes are similar with that of producing disodium inosinate. 

Here are two methods: 
One process starts from sugar fermentation to obtain guanosine and subsequently react with phosphoryl chloride and then neutralize with NaOH. 
Following is the reaction equation of guanosine and phosphoryl chloride.
Disodium Guanylate can also be made from yeast extract.

Disodium 5′-guanylate is a flavor enhancer that can be used in many processed foods to strengthen the umami taste or generate a savory, meaty, or broth-like taste, commonly by the combination with MSG or conjunction with disodium inosinate.
Disodium Guanylate's flavor-enhancing power is around 2 times of disodium 5′-inosinate.
The common applications include instant noodles, snack food, potato chips, sauces, tinned vegetables, cured meats and so on.

Alternative Classes:    
*Vinylogous acids 
*Enoate esters 
*Secondary alcohols 
*Lactones 
*Enediols 
*Oxacyclic compounds 
*Monocarboxylic acids and derivatives 
*Carboxylic acids containing exactly one carboxyl groups.
*Primary alcohols 
*Organic oxides 
*Hydrocarbon derivatives 
*Carbonyl compounds 
*Organic cations

Disodium guanylate, known by many names including disodium 5’-guanylate, is derived from a nucleotide, guanosine monophosphate (GMP). 
Disodium Guanylate is similar to disodium inosinate, also known as disodium 5’-inosinate, which comes from another nucleotide, inosine monophosphate (IMP). 
The two together are frequently referred to as 5’-nucleotides (read as “five prime nucleotides.”) Nucleotides are naturally occurring substances found mostly in meats although shiitake mushrooms are also high in nucleotides. 
Nucleotides are components of information-carrying molecules (such as DNA) as well as important molecules involved in many diverse aspects of human metabolism.

Flavour enhancer As it is a fairly expensive additive, it is not used independently of glutamic acid; if disodium guanylate is present in a list of ingredients but MSG does not appear to be, it is likely that glutamic acid is provided as part of another ingredient such as a processed soy protein complex. 
Disodium Guanylate is often added to foods in conjunction with disodium inosinate; the combination is known as disodium 5'-ribonucleotides.; Disodium guanylate (E627), also known as sodium 5'-guanylate and disodium 5'-guanylate, is the disodium salt of the flavor enhancer guanosine monophosphate (GMP). 
Disodium guanylate is a food additive and is commonly used in conjunction with glutamic acid.

Substituents:    
*2-furanone
*Enoate ester
*Alpha,beta-unsaturated carboxylic ester
*Vinylogous acid
*Carboxylic acid ester
*Enediol
*Lactone
*Secondary alcohol
*Monocarboxylic acid or derivatives
*Carboxylic acid derivative
*Oxacycle
*Carbonyl group
*Primary alcohol
*Organooxygen compound
*Organic oxygen compound
*Alcohol
*Organic oxide
*Hydrocarbon derivative
*Organic cation
*Aliphatic heteromonocyclic compound

Disodium guanylate, also known as sodium 5'-guanylate and disodium 5'-guanylate, is a natural sodium salt of the flavor enhancing nucleotide guanosine monophosphate (GMP). Disodium guanylate is a food additive with the E number E627. 
Disodium Guanylate is commonly used in conjunction with glutamic acid. 
As Disodium Guanylate is a fairly expensive additive, it is not used independently of glutamic acid; if disodium guanylate is present in a list of ingredients but MSG does not appear to be, it is likely that glutamic acid is provided as part of another ingredient such as a processed soy protein complex. 
Disodium Guanylate is often added to foods in conjunction with disodium inosinate; the combination is known as disodium 5'-ribonucleotides. 
Disodium guanylate is produced from dried seaweed and is often added to instant noodles, potato chips and other snacks, savory rice, tinned vegetables, cured meats, and packaged soup.

Disodium guanylate (E627), also known as sodium 5'-guanylate and disodium 5'-guanylate, is the disodium salt of the flavor enhancer guanosine monophosphate (GMP). 
Disodium guanylate is a food additive and is usually used in synergy with glutamic acid.
As Disodium Guanylate is a fairly expensive additive, it is not used independently of glutamic acid; if disodium guanylate is present in a list of ingredients but MSG does not appear to be, it is likely that glutamic acid is provided as part of another ingredient such as a processed soy protein complex. 
Disodium Guanylate is often added to foods in conjunction with disodium inosinate; the combination is known as disodium 5'-ribonucleotides.
Disodium guanylate is produced from dried fish or dried seaweed and is often added to instant noodles, potato chips and snacks, savoury rice, tinned vegetables, cured meats, packet soup.

Disodium guanylate is one of the most used food improvers that can be found in a wide variety of products. 
Disodium Guanylate is often combined with other flavor enhancers such as monosodium glutamate.
Disodium Guanylate is a widely used food additive. 
In fact, Disodium Guanylate is a type of salt derived from guanosine monophosphate (GMP).

In biochemical terms, GMP is a nucleotide that is a component of important molecules such as DNA.
Disodium guanylate usually made from fermented tapioca starch, but with yeast, mushrooms, and seaweedIt can also be derived from. 
In nature, Disodium Guanylate is more readily found in dried mushrooms. 
Disodium Guanylate is a premium line of nucleotides with the Ajinomoto touch which unlocks the taste characteristics of foods synergy with glutamates and other flavor enhancers nucleotides have.

PHYSICAL PROPERTIES:

-Molecular Weight: 407.18

-Exact Mass: 407.02188792    

-Monoisotopic Mass: 407.02188792    

-Topological Polar Surface Area: 207 Ų        

-Compound Is Canonicalized: Yes

-Physical Description: Odourless, colourless or white crystals or white crystalline powder

-Odor: Odourless

-Color: White/Colorless

-Form: White crystals

-Solubility: Soluble in water, sparingly soluble in ethanol, practically insoluble in ether

-pH: 7,0-8,5

-Boiling Point: 890.20 °C

-Flash Point: 492.20 °C

Disodium guanylate, also known as sodium 5'-guanylate and disodium 5'-guanylate, is a natural sodium salt of the flavor enhancing nucleotide guanosine monophosphate (GMP). 
Disodium guanylate is a food additive with the E number E627. 
Disodium Guanylate is commonly used in conjunction with glutamic acid. 

As Disodium Guanylate is a fairly expensive additive, it is not used independently of glutamic acid; if disodium guanylate is present in a list of ingredients but MSG does not appear to be, it is likely that glutamic acid is provided as part of another ingredient such as a processed soy protein complex. 
Disodium Guanylate is often added to foods in conjunction with disodium inosinate; the combination is known as disodium 5'-ribonucleotides. 
Disodium guanylate is produced from dried seaweed and is often added to instant noodles, potato chips.
Disodium guanylate may be safely used as a flavor enhancer in foods, at a level not in excess of that reasonably required to produce the intended effect.

Disodium inosinate is used as a flavor enhancer, in synergy with monosodium glutamate (MSG) to provide the umami taste. 
Disodium Guanylate is often added to foods in conjunction with disodium guanylate; the combination is known as disodium 5'-ribonucleotides.
Disodium 5'-guanylate is an organic sodium salt that is the disodium salt of GMP. 
Disodium Guanylate has a role as a flavouring agent. 
Disodium Guanylate contains a guanosine 5'-monophosphate(2-).

CHEMICAL PROPERTIES:

-Heavy Atom Count: 26    

-Formal Charge: 0    

-Complexity: 586    

-Isotope Atom Count: 0    

-Defined Atom Stereocenter Count: 4    

-Undefined Atom Stereocenter Count: 0    

-Defined Bond Stereocenter Count: 0    

-Undefined Bond Stereocenter Count: 0    

-Covalently-Bonded Unit Count: 3

-Hydrogen Bond Donor Count: 4    

-Hydrogen Bond Acceptor Count: 10    

-Rotatable Bond Count: 3    

SYNONYMS:

Guanosine 5'-monophosphate disodium salt
DISODIUM 5'-GUANYLATE
Disodium guanylate
5'-Guanylic acid, disodium salt
Disodium GMP
Disodium 5'-gmp
GMP disodium salt
Disodium guanosine-5'-monophosphate
5'-Gmp disodium salt
5-Guanylic acid disodium salt
5'-Guanylic acid disodium salt
Guanosine 5'-monophosphate, disodium salt
Disodium guanosine 5'-monophosphate
Guanosine 5'-phosphate disodium salt
Sodium guanylate
Sodium ((2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate
Guanosine-5'-monophosphate disodium salt
GMP sodium salt
Sodium GMP
Sodium 5'-guanylate
disodium;[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate
Guanylic acid sodium salt
Guanosine 5'-monophosphate disodium salt hydrate
Guanosine 5'-(disodium phosphate)
Guanosine 5'MP, disodium salt
Sodium guanosine 5'-monophosphate
Disodium 5'-guanylate (VAN)
CCRIS 6561
5'-Guanylic acid, sodium salt
5'-Guanylic acid, sodium salt (1:2)
disodium 5'--guanylate
GMP sodium salt hydrate
5'-GMP 2Na hydrate
GMP disodium salt hydrate
5'-guanylic acid disodium
5'-GMP 2Na
5'-GMP-Na2
Disodium 5'-guanylate hydrate
disodium 5'-O-phosphonatoguanosine
Guanosine-5'phosphate disodium salt
5'-Guanylic acid disodium salt hydrate
Guanosine-5'-monophosphate sodium salt
[(3S,2R,4R,5R)-5-(2-amino-6-oxohydropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methy l dihydrogen phosphate, sodium salt, sodium salt
Guanosine-5'-monophosphoric acid disodiumsalt
2-METHYL-3-(TRIFLUOROMETHYL)BENZOICACID
Guanosine-5'-monophosphate disodium salt (GMP)
Guanosine-5'-Monophosphate (GMP), Disodium Salt
GUANOSINE-5'-MONOPHOSPHATE, DISODIUM SALT

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