DOCOSANOL (BEHENYL ALCOHOL)

Docosanol (Behenyl Alcohol) is a long-chain fatty alcohol with the chemical formula C22H46O. 
Docosanol (Behenyl Alcohol) is a white, waxy solid that is insoluble in water but soluble in organic solvents
Docosanol (Behenyl Alcohol) is a saturated fatty alcohol containing 22 carbon atoms, used traditionally as an emollient, emulsifier, and thickener in cosmetics.

CAS Number: 1599-67-3
Molecular Formula: C22H44
Molecular Weight: 308.58
EINECS Number: 216-490-6

Synonyms: Docosanol (Behenyl Alcohol), Docosanol, docosan-1-ol, Behenyl alcohol, 661-19-8, Behenic alcohol, Abreva, n-Docosanol, Docosyl alcohol, Lidavol, Tadenan, Stenol 1822, Lidakol, Lanette 22, Stenol 1822A, Docosanol [USAN], Nacol 22-97, IK 2, 30303-65-2, NAA 422, IK.2, NSC 8407, HSDB 5739, NSC-8407, EINECS 211-546-6, UNII-9G1OE216XY, Docosanol (Abreva), Docosanol (USAN), BRN 1770470, 9G1OE216XY, CCRIS 8943, DTXSID4027286, CHEBI:31000, AI3-36489, MFCD00002939, DTXCID907286, NSC8407, EC 211-546-6, 4-01-00-01906 (Beilstein Handbook Reference), NCGC00159370-02, DOCOSANOL (II), DOCOSANOL [II], DOCOSANOL (MART.), DOCOSANOL [MART.], Docosanol (VAN), C22H46O, Erazaban, Herepair, Healip, Cachalot BE-22, Abreva (TN), Loxiol VPG 1451, n-Docosan-1-ol, Docosanol-(1), Docosanol (Behenyl Alcohol), 98%, Cold Sore Fever Blister, DOCOSANOL [HSDB], DOCOSANOL [VANDF], N-DOCOSANOL [MI], DOCOSANOL [WHO-DD], SCHEMBL51925, DOCOSANOL [ORANGE BOOK], CHEMBL1200453, Cold Sore Fever Blister Treatment, HMS2093P22, Pharmakon1600-01505729, HY-B0222, Tox21_111611, LMFA05000008, NSC759235, s1637, AKOS015902887, CCG-213539, DB00632, NSC-759235, Behenyl alcohol, AI3-36489, Behenic alcohol, Docosanol (Behenyl Alcohol), Docosyl alcohol, IK-2, Tadenan, NCGC00159370-03, NCGC00159370-04, NCGC00159370-05, Docosanol (Behenyl Alcohol), purum, >=97.0% (GC), AC-19852, CAS-661-19-8, DA-69546, SBI-0206938.P001, D0964, NS00009524, D03884, D70615, AB01563123_01, AB01563123_02, EN300-6495479, SR-05000001915, Q3033497, SR-05000001915-1, BRD-K50050533-001-02-1, BRD-K50050533-001-03-9, BRD-K50050533-001-04-7, A3D72D45-625E-49B5-B0FC-394010B3485D, InChI=1/C22H46O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23/h23H,2-22H2, 1H, 1-Docosene, containes C20, C24 homologs;1-Docosene, tech-95, contains C20, C24 hoMologs;docos-1-ene;adenine monoribo-nucleotide;adenine ribonucleotide;1-Docosene,~99%;ALCOHOL C22;1-DOCOSENE

An alkene that is Docosanol (Behenyl Alcohol) with an unsaturation at position 1. 
Docosanol (Behenyl Alcohol) is thought to work by interfering with and stabilizing the host cell's surface phospholipids, preventing the fusion of the herpes virus's viral envelope with the human host cell. 
This disrupted ability of the virus to fuse with the host cell membrane prevents entry and subsequent replication.

In July 2000, docosanol was approved for medical use in the United States as an antiviral agent for reducing the duration of cold sores.
Docosanol (Behenyl Alcohol) is an over-the-counter medication (OTC). 
It is sold under the brand name Abreva among others.

Docosanol (Behenyl Alcohol) is a straight-chain saturated fatty alcohol with a long aliphatic chain, which gives it its waxy texture.
Docosanol (Behenyl Alcohol) is a saturated 22-carbon aliphatic alcohol with antiviral activity.
Docosanol (Behenyl Alcohol) has a distinct mechanism of action and inhibits fusion between the plasma membrane and the herpes simplex virus envelope, thereby preventing viral entry into cells and subsequent viral activity and replication.

Docosanol (Behenyl Alcohol) is used topically in the treatment of recurrent herpes simplex labialis episodes and relieves associated pain and may help
heal sores faster.
Docosanol (Behenyl Alcohol) inhibits replication of certain viruses (herpes simplex virus and respiratory syncytial virus) within primary target cells in vitro.
Docosanol (Behenyl Alcohol) has been isolated.

Docosanol (Behenyl Alcohol), also known as behenyl alcohol, is a saturated fatty alcohol containing 22 carbon atoms, used traditionally as an emollient, emulsifier, and thickener in cosmetics, and nutritional supplement (as an individual entity and also as a constituent of policosanol).
More recently, docosanol has been approved by the Food and Drug Administration (FDA) as a pharmaceutical antiviral agent for reducing the duration of cold sores caused by the herpes simplex virus in the OTC medication Abreva.
In Europe, Docosanol (Behenyl Alcohol) is available as Erazaban.

This topical has not been yet tested if it is safe to be used by pregnant women.
Docosanol (Behenyl Alcohol) is not established whether the active ingredient in the medicine passes into the breast milk.
Docosanol (Behenyl Alcohol) has not been specifically approved for treatment of children under 12 but is not expected to produce different side effects or problems than it does in adults. 

This topical is only intended for external, oral-facial use and not for genital herpes or shingles.
Cosmetic products are recommended to be avoided while using Docosanol (Behenyl Alcohol) because no interaction studies have been done.
Docosanol (Behenyl Alcohol) is thought to act by inhibiting the fusion of the human host cell with the viral envelope of the herpes virus, thus preventing its replication.

This mechanism has not been demonstrated empirically.
Docosanol (Behenyl Alcohol) is a drug used for topical treatment for recurrent herpes simplex labialis episodes (episodes of cold sores or fever blisters).
A saturated 22-carbon aliphatic alcohol, Docosanol (Behenyl Alcohol) exhibits antiviral activity against many lipid enveloped viruses including herpes
simplex virus (HSV).

Docosanol is a drug used for topical treatment for recurrent herpes simplex labialis episodes (episodes of cold sores or fever blisters). 
A saturated 22-carbon aliphatic alcohol, docosanol exhibits antiviral activity against many lipid enveloped viruses including herpes simplex virus (HSV). 
Docosanol (Behenyl Alcohol) inhibits fusion between the plasma membrane and the herpes simplex virus (HSV) envelope, thereby preventing viral entry into cells and subsequent viral replication.

Docosanol (Behenyl Alcohol) is a natural, vegetable source long chain fatty alcohol used to regulate viscosity in formulations.
Docosanol (Behenyl Alcohol) functions as a thickener and stabilizer and may be used as a co-emulsifier.
Docosanol (Behenyl Alcohol) may be used in anhydrous formulations such as ointments, body butters and scrubs.

Docosanol (Behenyl Alcohol) is produced from vegetable sources and is derived from non-genetically modified plants.
Production is by chemical reaction typical of the industrial process of fatty alcohol production.
Docosanol (Behenyl Alcohol) is a saturated fatty alcohol of vegetable origin, used to regulate viscosity in formulations.

Docosanol (Behenyl Alcohol) acts as a thickener and stabilizer and can be used as a co-emulsifier.
Docosanol (Behenyl Alcohol) can be used in water-in-oil emulsions, oil-in-water emulsions and anhydrous formulations such as ointments, body butters and peelings.
Docosanol (Behenyl Alcohol) produces elegant emulsions and gives the skin a soft, velvety feel.

Docosanol (Behenyl Alcohol) has one characteristic of making a layer over water to minimize evaporation.
This is particularly useful in hot weather.
Same way Docosanol (Behenyl Alcohol) does not let moisture evaporate from skin or hair’s surface, thus act as emollient.

Docosanol (Behenyl Alcohol) is similar to other members of the behenic group a good emulsion stabilizer.
Docosanol (Behenyl Alcohol) is used as viscosity increasing agent.
Docosanol (Behenyl Alcohol) is used in formulations such as ointments, scrubs, and body butter.

Docosanol (Behenyl Alcohol) is a colorless, waxy solid.
Docosanol (Behenyl Alcohol)’s usually found naturally from vegetables, in their long-chain fatty acid mixture.
Docosanol (Behenyl Alcohol) is a plant-based emulsifier and thickening agent.

Docosanol (Behenyl Alcohol) is considered a fatty alcohol which is by far the best type of alcohol for skin care and cosmetics.
This is because Docosanol (Behenyl Alcohol) acts as both an emulsifier and emollient, but more on that below.
As an emulsifier, behenyl alcohol, holds the water and oils together in cosmetics.

Docosanol (Behenyl Alcohol) is typically made from the fats in vegetable oils.
However, the greatest thing about fatty alcohols is they aren't drying or irritating on your skin, as some other alcohols might be.
Instead, because of the "fatty" part of the molecule, they also act as an emollient.

This means that they protect your skin and keep the moisture in your skin.
Docosanol (Behenyl Alcohol) is actually a really common ingredient, and unfortunately can be made synthetically as well.
Docosanol (Behenyl Alcohol) is important to look out for natural behenyl alcohol in your products, but all in all, this is one of the best fatty alcohols and is healthy for your skin.

Docosanol (Behenyl Alcohol) is used to thicken and stabilize formulations.
Docosanol (Behenyl Alcohol) can also serve as a co-emulsifier in some formulations.
Docosanol (Behenyl Alcohol) can be used in water-in-oil emulsions, oil-in-water emulsions, and anhydrous formulations cream, lotion, ointment, body butter, salt scrubs.

One of the most common side effects that has been reported from Docosanol (Behenyl Alcohol) is headache. 
Headaches caused by the medication tend to be mild and can occur in any region of the head.
In clinical trials, headache occurred in 10.4% of people treated with Docosanol (Behenyl Alcohol) cream and 10.7% of people treated with placebo.

The most serious side effects, although rare, are allergic reactions. 
Some of the patients experienced the symptoms of allergic reactions, including difficulty breathing, confusion, angioedema (facial swelling), fainting, dizziness, hives or chest pain.
Other side effects may include: acne, burning, dryness, itching, rash, redness, acute diarrhea, soreness, swelling.

Melting point: 65-72 °C(lit.)
Boiling point: 180 °C0.22 mm Hg(lit.)
Density: 0.7830 (estimate)
refractive index: 1.4568 (estimate)
Flash point: 38 °C
storage temp.: 2-8°C
solubility: Chloroform, Ethyl Acetate (Slightly)
form: Solid
color: White to Off-White
Stability: Light Sensitive

Docosanol (Behenyl Alcohol) is a long-chain alkene and one of the lipophilic components of the aerial parts of the plant Origanum vulgare.
Docosanol (Behenyl Alcohol) is a binder and an emulsion stabilizer.
Docosanol (Behenyl Alcohol) is also used to increase a formulation’s viscosity.

Docosanol (Behenyl Alcohol) may be derived either synthetically or from plants.
Docosanol (Behenyl Alcohol) inhibits fusion between the plasma membrane and the herpes simplex virus (HSV) envelope, thereby preventing viral entry into cells and subsequent viral replication.
Docosanol (Behenyl Alcohol) is a natural product found in Populus tremula, Hypericum laricifolium, and other organisms.

Docosanol (Behenyl Alcohol) is a saturated fatty alcohol used traditionally as an emollient, emulsifier, and thickener in cosmetics, and nutritional supplement; inhibitor of lipid-enveloped viruses including herpes simplex.
Docosanol (Behenyl Alcohol) is a saturated fatty alcoholused traditionally as an emollient, emulsifier, and thickener in cosmetics, nutritional supplement.
Docosanol (Behenyl Alcohol) is used to treat "cold sores/fever blisters" .

Docosanol (Behenyl Alcohol) can speed up healing of the sores and decrease symptoms (such as tingling, pain, burning, itching).
Docosanol (Behenyl Alcohol) works by blocking the virus that causes the cold sores (herpes simplex) from entering the healthy skin cells and growing in number.
This medication does not cure herpes and does not prevent passing the infection to someone else.

Docosanol (Behenyl Alcohol) does not prevent a future occurrence.
Do not use this medication to treat canker sores (sores found commonly in the mouth), shingles, or genital herpes.
Docosanol (Behenyl Alcohol) (n-docosanol or behenyl alcohol; Abreva) is a saturated 22-carbon aliphatic alcohol that inhibits a broad range of lipidenveloped viruses including
HSV-1 and HSV-2 at millimolar concentrations in vitro.

Docosanol (Behenyl Alcohol) is not directly virucidal, and its principal anti-HSV mechanism of action in vitro apparently relates to interference with viral fusion to host cell membranes early in replication, although other inhibitory effects may be possible a nonantiviral mechanism of action resulting from anti-inflammatory effects has been described.
In a guinea pig model of cutaneous HSV, topical docosanol did not show antiviral or therapeutic benefits and was less active than topical penciclovir and acyclovir.

Docosanol (Behenyl Alcohol) 10% cream is available over the counter for treatment of recurrent herpes labialis in immunocompetent individuals.
Early treatment (five applications daily until healing up to maximum of 10 days) shortens the time to complete healing by about 0.7 day and time to resolution of symptoms by 0.5 day.
Application site reactions occur in about 2%, and its use is generally well tolerated.

Whether combined treatment with docosanol and topical nucleosides might provide greater therapeutic effects remains to be determined.
Docosanol (Behenyl Alcohol) is an aliphatic alcohol that inhibits fusion between the plasma membrane and the HSV envelope, thereby preventing viral entry into cells and viral replication.
A 10% docosanol cream is available for treating herpes labialis.

Docosanol (Behenyl Alcohol) is a saturated fatty alcohol used traditionally as an emollient, emulsifier, and thickener in cosmetics, nutritional supplement, and more recently approved as an antiviral agent for reducing the duration of cold sores caused by the herpes simplex virus.
The presumed mechanism of action in docosanol is by inhibiting the fusion of the human host cell with the viral envelope of the herpes virus, thus preventing its replication.
Docosanol (Behenyl Alcohol) is a topical cream of the treatment for recurrent episodes of oral-facial herpes simplex.

Docosanol (Behenyl Alcohol) can be used in anhydrous (products containing no water) and water based formulations.
Famously Docosanol (Behenyl Alcohol) is the main active ingredient in many cold sore and herpes products, where is used at 10%.
For this reason you will find it used in Balms and Creams, however it is also very useful in haircare products where it acts as an emollient increasing the moisture content in the hair.

Docosanol (Behenyl Alcohol) has an excellent property of removing stickiness from products such as beeswax, whilst at the same time in can greasy products feel less greasy and improve the way they spread and absorb on the skin.
Docosanol (Behenyl Alcohol) will be found Behenyl alcohol in many solid deodorant sticks, where the Behenyl alcohol takes the stickiness away from the product, whilst emulsifying the ingredients, including oils and providing antimicrobial properties.
Docosanol (Behenyl Alcohol) is a saturated fatty alcohol used traditionally as an emollient, emulsifier, and thickener in cosmetics, and nutritional supplement.

Docosanol (Behenyl Alcohol)s thickening property allows products to achieve a more desirable, spreadable texture.
Thus, manufacturers will add behenyl alcohol to formulations to create a thick, smooth, and creamy product.

Docosanol (Behenyl Alcohol) is used as an emollient in cosmetic formulations because of its ability to soften and soothe the skin. After topical application, behenyl alcohol forms a protective layer on the skin that helps to prevent moisture loss.
Docosanol (Behenyl Alcohol) is a large fatty straight-chain alcohol.

Uses Of Docosanol (Behenyl Alcohol):
Docosanol (Behenyl Alcohol) is a long-chain alkene and one of the lipophilic components of the aerial parts of the plant Origanum vulgare. 
Docosanol (Behenyl Alcohol) is used in creams, lotions, and other personal care products to provide moisturizing properties and improve the texture of formulations.
Helps to stabilize and thicken emulsions, contributing to a desirable consistency in lotions and creams.

Docosanol (Behenyl Alcohol) acts as a barrier to prevent moisture loss, enhancing skin hydration.
Antiviral used in the treatment of herpes simplex labialis.
Provides moisturizing properties, helping to soften and smooth the skin. 

Docosanol (Behenyl Alcohol) is commonly found in lotions, creams, and balms.
Docosanol (Behenyl Alcohol) is used to enhance the viscosity and stability of emulsions, improving the texture of products like lotions and creams.
Acts as a barrier to prevent moisture loss from the skin, contributing to overall hydration.

Helps stabilize formulations, ensuring consistency and performance over time.
As an active ingredient in topical treatments (e.g., Abreva), docosanol inhibits the replication of the herpes simplex virus, reducing the duration and severity of cold sore symptoms.
Docosanol (Behenyl Alcohol) is used in formulations for its soothing and protective properties.

Occasionally utilized as a food additive or ingredient in certain formulations, particularly in coatings or texture enhancement.
Docosanol (Behenyl Alcohol) is used in the production of surfactants for cleaning products, detergents, and emulsifiers.
Employed in industrial lubricants due to its fatty alcohol properties, helping to reduce friction and wear.

Can be found in some agricultural formulations for its emulsifying and stabilizing properties.
Docosanol (Behenyl Alcohol) is used in the manufacture of plastic materials to enhance flexibility.
Docosanol (Behenyl Alcohol)’s fatty acid structure allows it to penetrate the skin barrier, providing deep hydration. 

Docosanol (Behenyl Alcohol) is especially effective in creams and lotions aimed at dry skin conditions.
In hair care products, it helps improve the texture and manageability of hair, providing a smooth and soft feel.
Docosanol (Behenyl Alcohol) is used in foundations and lipsticks to enhance spreadability and create a luxurious texture. 

Docosanol (Behenyl Alcohol) can also help in providing a glossy finish.
Docosanol (Behenyl Alcohol) is particularly noted for its use in treating cold sores caused by the herpes simplex virus. 
It has been shown to reduce healing time and severity when applied at the first signs of an outbreak.

Incorporated into creams and ointments designed for conditions such as eczema and psoriasis to alleviate dryness and irritation.
Docosanol (Behenyl Alcohol)s protective properties make it suitable for inclusion in formulations aimed at promoting wound healing and skin barrier restoration.
Although not as common, Docosanol (Behenyl Alcohol) can be used as an emulsifier in food products to help blend ingredients that typically do not mix, such as oil and water.

Docosanol (Behenyl Alcohol) can be used to modify the mouthfeel and texture of certain food products, contributing to a smoother and creamier consistency.
As a component in surfactants, Docosanol (Behenyl Alcohol) can improve the wetting properties of cleaning products, making them more effective in breaking down and removing dirt and grease.
Docosanol (Behenyl Alcohol) is used in formulations for paints and coatings, where it helps stabilize emulsions, preventing separation and ensuring a uniform application.

In mechanical and industrial settings, Docosanol (Behenyl Alcohol) can serve as a lubricant to reduce friction in machinery and improve the longevity of equipment.
Docosanol (Behenyl Alcohol) may be included in agricultural products as an emulsifier to enhance the efficacy of pesticide applications, improving the dispersion and adherence of active ingredients to plant surfaces.
Docosanol (Behenyl Alcohol) has been studied for its potential role in cellular biology and membrane studies due to its lipid-like properties, making it useful in experimental setups involving cell membranes.

Docosanol (Behenyl Alcohol) is generally recognized as safe (GRAS) for use in food and personal care products, with low irritation potential.
Its multifunctional properties allow it to serve in various capacities across different formulations, making it a valuable ingredient for manufacturers.

Safety Profile Of Docosanol (Behenyl Alcohol):
In some individuals, particularly those with sensitive skin, Docosanol (Behenyl Alcohol) can cause mild skin irritation or allergic reactions. 
This may manifest as redness, itching, or a rash upon contact.
If Docosanol (Behenyl Alcohol) comes into contact with the eyes, it may cause irritation. 

Symptoms could include redness, tearing, and discomfort. 
Docosanol (Behenyl Alcohol) is advised to avoid direct contact with the eyes.

While Docosanol (Behenyl Alcohol) is not typically aerosolized, inhalation of any fine powders or mists containing docosanol could potentially lead to respiratory irritation.
Proper handling procedures should be followed in industrial settings to minimize exposure.