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CAS: 577-11-7
MF: C20H37O7S.Na
MW: 444.56
EINECS: 209-406-4
Description
Docusate sodium is a type of medicine called a laxative.
Docusate sodium helps to soften your poo and makes your bowel movements easier if you have problems pooing (constipation).
It is helpful when you have difficulty going to the toilet because of dry poos or piles (haemorrhoids) or if you have a tear in the lining of your intestine near your anus (anal fissure).
Docusate Sodium comes in capsule form and is used to treat constipation and reduce pain or rectal damage cause by straining during bowel movements.
Docusate sodium works by increasing the amount of water in stool, making it softer and easier to pass.
Common side effects of Docusate Sodium may include dizziness, weakness, gas, bloating and sweating.
Docusate sodium comes as capsules and as a liquid that you swallow.
Docusate sodium also comes as an enema.
Docusate sodium is a tube of liquid medicine which you squeeze into your anus (bottom).
Docusate sodium is available on prescription or to buy from pharmacies.
Docusate sodium is a laxative used to for the research of constipation, for constipation due to the use of opiates it maybe used with a stimulant laxative, can be taken by mouth or rectally.
Docusate sodium Chemical Properties
Melting point: 173-179 °C(lit.)
Boiling point: 82.7°C
Density: 1.1
Vapor pressure: 0Pa at 25℃
Storage temp.: Inert atmosphere,Room Temperature
Solubility: methanol: 0.1 M at 20 °C, clear, colorless
Form: Waxy Solid
Specific Gravity: 1.005_PERCENT VOLATILE: 40
Color: White
Water Solubility: 1.5 g/100 mL (25 ºC)
λmax: λ: 260 nm Amax: 0.1
λ: 280 nm Amax: 0.05
Sensitive: Hygroscopic
Merck: 14,3401
BRN: 4117588
Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey: APSBXTVYXVQYAB-UHFFFAOYSA-M
LogP: 1.998 at 20℃
CAS DataBase Reference: 577-11-7(CAS DataBase Reference)
EPA Substance Registry System: Bis(2-ethylhexyl) Docusate sodium (577-11-7)
Docusate sodium is a white or almost white, waxlike, bitter tasting, plastic solid with a characteristic octanol-like odor.
Docusate sodium is hygroscopic and usually available in the form of pellets, flakes, or rolls of tissuethin material.
Uses
Docusate sodium is a mild surfactant used as a cleans ing agent.
Docusate sodium is a wetting and emulsifying agent that is slowly soluble in water, having a solubility of 1 g in 70 ml of water.
Docusate sodium functions as a wetting agent in fumaric acid-containing powdered fruit drinks to help the acid dissolve in water.
Docusate sodium is used as a stabilizing agent on gums at not more than 0.5% by weight of the gum.
Docusate sodium is used as a flavor potentiator in canned milk where it improves and maintains the flavor of the sterilized milk during storage.
Docusate sodium also functions as a processing aid in the manufacture of unrefined sugar.
Docusate sodium is also termed sodium dioctylsulfosuccinate.
Docusate sodium, used for the treatment of constipation, acting as a laxative or stool softener.
Also used in the synthesis of electrospun fibres for tailored and controlled antibiotic drug release.
Wetting and solubilizing agent.
Docusate sodium is used as a surfactant, wetting agent and in the preparation of reverse micelles.
Docusate sodium is utilized in electrophoresis detection of natural and synthetic estrogens.
Docusate sodium also finds use in the drug, cosmetics, food industry and as a laxative to treat constipation.
Further, Docusate sodium is used as a food additive, emulsifier and dispersant.
Docusate sodium plays an important role as an excipient in the production of tablets and suspensions.
Pharmaceutical Applications
Docusate sodium and docusate salts are widely used as anionic surfactants in pharmaceutical formulations.
Docusate sodium is mainly used in capsule and direct-compression tablet formulations to assist in wetting and dissolution.
Solubility in organics
Docusate sodium is the dioctyl ester of sodium sulfosuccinate (bis-2-ethyl-hexyl sodium sulfosuccinate).
Docusate sodium dissolves slowly in water; at 25°C to the extent of 1.5 gm/100cc; at 70°C, 5.5 gm/100cc.
Docusate sodium dissolves in oils, hydrocarbons, fats and waxs by heating above 75°C and remains in solution when cooled to room temperature.
At room temperature, Docusate sodium is readily soluble in most organic solvents, both polar and non-polar.
soluble in carbon tetrachloride, petroleum ether, naphtha, xylene, dibutyl phthalate, liquid petroleum, acetone, alcohol, vegetable oils.
Synonyms
Docusate sodium
577-11-7
Dioctyl sodium sulfosuccinate
Dioctyl sulfosuccinate sodium salt
Aerosol OT
Constonate
Dioctylal
Diotilan
Disonate
Molatoc
Regutol
Doxol
Nevax
Velmol
Docusate (Sodium)
Doxinate
Colace
Dialose
Molcer
Soliwax
Waxsol
Docusate sodium salt
Diox
Manoxol OT
Adekacol EC 8600
Bis(2-ethylhexyl) sulfosuccinate sodium salt
Dioctyl sulfosuccinate sodium
Comfolax
Coprola
Dulcivac
Eurowet
Jamylene
Empimin op70
Sanmorin ot 70n
Airrol ct-1
Mackanate dos-70
Nikkol otp-75
Triton gr-pg 70
Gemtex pa-70
Rapisol a 30
Bis(2-ethylhexyl) sodium sulfosuccinate
Nissan rapisol a 30
Dioctyl ester of sodium sulfosuccinic acid
Ins no.480
Monawet mo 65-150
sodium 1,4-bis[(2-ethylhexyl)oxy]-1,4-dioxobutane-2-sulfonate
Ins-480
Butanedioic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt
F05Q2T2JA0
Sodium 1,4-bis(2-ethylhexyl) sulfosuccinate
Diethylhexyl Sodium Sulfosuccinate
sodium docusate
NSC-760404
AOT
Diomedicone
Clestol
Complemix
Defilin
Dioctlyn
Diosuccin
Dulsivac
Laxinate
Mervamine
Molofac
Requtol
Sobital
Coprol
Diovac
Konlax
Kosate
Obston
Softil
Revac
E 480
E-480
Modane Soft
DSSTox_CID_2959
Alcopol O
Alphasol OT
Manoxal OT
Sulfimel DOS
Aerosol AOT
Aerosol GPG
Wetaid SR
DSSTox_RID_76808
Aerosol OT-A
DSSTox_GSID_22959
Laxinate 100
Sanmorin OT 70
Triton GR 7
Triton GR-5
Aerosol OT 70PG
Aerosol OT 75
Celanol DOS 65
Celanol DOS 75
DESS
Humifen WT 27G
Monawet MD 70E
Solusol-75%
Nikkol OTP 70
Aerosol A 501
Alkasurf SS-O 75
Solusol-100%
Nekal WT-27
Berol 478
Coloxyl
Dioctyl
Docolace
Docuprene
Geriplex
Silace
Unilax
Bloat treatment
Docusato sodico
Sodium bis(2-ethylhexyl) sulfosuccinate
Dioctyl sodium sulfosuccinate (JAN)
Docusate sodique
Dialose Plus
Natrii dioctylsulfosuccinas
Tex-Wet 1001
Senokot S
Correctol Caplets
Correctol Tablets
Senokap DSS
Docusatum natricum
D-S-S
Doc Q Lace
CAS-577-11-7
Sodium dioctyl sulphosuccinate
Feen-a-Mint Pills
DIOCTYL SODIUM SULFOSUCCINATE [JAN]
Correctol Extra Gentle Tablets
Docusate sodique [INN-French]
Docusato sodico [INN-Spanish]
Docusatum natricum [INN-Latin]
HSDB 3065
2-Ethylhexyl sulfosuccinate sodium
NCGC00164140-03
EINECS 209-406-4
SV 102
Bis(2-ethylhexyl)sodium sulfosuccinate
Dioctyl ester of sodium sulfosuccinate
Di-(2-ethylhexyl) sodium sulfosuccinate
Sodium di-(2-ethylhexyl) sulfosuccinate
Dioctyl sodium sulphosuccinat
UNII-F05Q2T2JA0
Prenexa
Purgasol
Vinacol
Bis(2-ethylhexyl) S-sodium sulfosuccinate
AI3-00239
Docusate Sod
Sodium 1,4-bis(2-ethylhexyl)sulfosuccinate
1,4-Bis(2-ethylhexyl) sodium sulfosuccinate
Sodium sulfodi-(2-ethylhexyl)-sulfosuccinate
Senexon-S
Folca[s care pme
Folcal DHA
Senna-S
Di(2-ethylhexyl)sulfosuccinic acid, sodium salt
Bis(ethylhexyl) ester of sodium sulfosuccinic acid
Bis-2-ethylhexylester sulfojantaranu sodneho [Czech]
Colace (TN)
MFCD00012455
Sodium di(2-ethylhexyl)sulfosuccinate
Sulfosuccinic acid, bis(2-ethylhexyl)ester sodium salt
Docusate sodium [USAN:USP:INN:BAN]
Sol sodowej sulfobursztynianu dwu-2-etyloheksylowego [Polish]
Docusate sodium (USP)
Docusate sodium solution
Bis-2-ethylhexylester sulfojantaranu sodneho
CHEMAX DOSS/75E
Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt
NCGC00183136-01
EC 209-406-4
SCHEMBL4113
DOCUSATE SODIUM [II]
DOCUSATE SODIUM [MI]
MLS004773938
DOCUSATE SODIUM [INN]
1,4-Bis(2-ethylhexyl)sulfobutanedioate, sodium salt
Sol sodowej sulfobursztynianu dwu-2-etyloheksylowego
DOCUSATE SODIUM [HSDB]
DOCUSATE SODIUM [USAN]
CHEBI:4674
Sulfosuccinic acid bis(2-ethylhexyl) ester sodium salt
DOCUSATE SODIUM [VANDF]
CHEMBL1905872
DOCUSATE SODIUM [MART.]
DTXSID8022959
Correctol Stool Softener Laxative
DOCUSATE SODIUM [USP-RS]
DOCUSATE SODIUM [WHO-DD]
Sulfosuccinic acid, di-(2-ethylhexyl) ester, sodium salt
HMS3264P07
HMS3885B10
sodium;1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonate
BCP31325
HY-B1268
4-(4-Bromophenoxymethyl)benzoicacid
Aerosol™ OT, Solid Anhydrous
Sodium dioctyl sulfosuccinate (INN)
Tox21_112087
Tox21_113469
Tox21_201342
Tox21_300496
s4588
DIOCTYL DISODIUM SULFOSUCCINATE
AKOS015901806
DOCUSATE SODIUM [USP IMPURITY]
CCG-213234
CS-4813
DOCUSATE SODIUM [USP MONOGRAPH]
NSC 760404
Sodium Di(2-ethylhexyl) Sulfosuccinate
Docusate sodium salt, BioXtra, >=99%
DOCUSATE SODIUM SOLUTION [VANDF]
Dioctyl sulfosuccinate sodium salt, 96%
NCGC00164140-01
NCGC00254414-01
NCGC00258894-01
AS-13347
E480
SMR001595510
Aerosol™ OT Solution, 10% (w/w)
DIOCTYL SODIUM SULFOSUCCINATE [FCC]
Dioctyl Sodium Sulfosuccinate with Ethanol
Bis(2-ethylhexyl) sulfosuccinatesodium salt
Dioctyl sulfosuccinate sodium salt, >=97%
AEC DIETHYLHEXYL SODIUM SULFOSUCCINATE
FT-0689234
D00305
Docusate sodium salt, p.a., 99.0-100.5%
E77584
DIETHYLHEXYL SODIUM SULFOSUCCINATE [INCI]
Docusate sodium salt, purum, >=96.0% (TLC)
Docusate sodium salt, BioUltra, >=99.0% (TLC)
Docusate sodium, meets USP testing specifications
Dioctyl Sodium Sulfosuccinate with Diethylene Glycol
Dioctyl Sodium Sulfosuccinate with Propylene Glycol
Q2815334
W-105447
F8880-5559
Docusate sodium, British Pharmacopoeia (BP) Reference Standard
Docusate sodium, European Pharmacopoeia (EP) Reference Standard
sodium 1,4-bis(2-ethylhexyloxy)-1,4-dioxobutane-2-sulfonate
Docusate sodium, United States Pharmacopeia (USP) Reference Standard
Dioctyl Sodium Sulfosuccinate with Diethylene Glycol and Glycol Ethers
1,4-bis(2-ethylhexyl)sodiumsulfosuccinate pound>>Dioctyl sulfosuccinate sodium salt
Butanedioic acid, 2-sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt (1:1)
