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Duodecylic Acid is a saturated fatty acid with a 12-carbon atom chain, thus having many properties of medium-chain fatty acids.
Duodecylic Acid is a bright white, powdery solid with a faint odor of bay oil or soap.
The salts and esters of Duodecylic Acid are known as laurates.
CAS Number: 143-07-7
EC Number: 205-582-1
IUPAC Name: Dodecanoic acid
Chemical Formula: C12H24O2
Other names: Emery651,Dodecanoic Acid(C12:0),Lauric acid 98%,yeuguisuan,Laurosteaic acid,Lauric acid 98-101 % (acidimetric),lauric acid, pure,LAURIC ACID, 99.5+%,lauric acid,DODECANOIC ACID,143-07-7,n-Dodecanoic acid,Dodecylic acid,Laurostearic acid,Vulvic acid,Dodecoic acid,Duodecylic acid,1-Undecanecarboxylic acid,Aliphat No. 4,Ninol AA62 Extra,Wecoline 1295,Hydrofol acid 1255,Hydrofol acid 1295,Duodecyclic acid,Hystrene 9512,Univol U-314,Lauric acid, pure,Dodecylcarboxylate,Lauric acid (natural),Laurinsaeure,Undecane-1-carboxylic acid,ABL,NSC-5026,FEMA No. 2614,laurate,C-1297,Philacid 1200,CCRIS 669,C12:0,Emery 651,Lunac L 70,CHEBI:30805,HSDB 6814,EINECS 205-582-1,MFCD00002736,UNII-1160N9NU9U,BRN 1099477,n-Dodecanoate,Kortacid 1299,Dodecanoic Acid Anion,DTXSID5021590,Prifrac 2920,AI3-00112,Lunac L 98,Univol U 314,Prifac 2920,1160N9NU9U,DAO,DTXCID801590,CH3-[CH2]10-COOH,NSC5026,EC 205-582-1,dodecylate,laurostearate,vulvate,4-02-00-01082 (Beilstein Handbook Reference),DODECANOIC ACID (LAURIC ACID),1-undecanecarboxylate,LAURIC ACID (USP-RS),LAURIC ACID [USP-RS],CH3-(CH2)10-COOH,205-582-1,8000-62-2,CAS-143-07-7,SMR001253907,laurinsaure,dodecanic acid,Nuvail,lauric-acid,Acide Laurique,3uil,Lauric acid (NF),DODECANOICACID,fatty acid 12:0,Lauric Acid, Reagent,Nissan NAA 122,Emery 650,Dodecanoic acid, 98%,Dodecanoic acid, 99%,Lauric acid (Standard),Dodecanoic (Lauric) acid,LAURIC ACID [MI],bmse000509,LAURIC ACID [FCC],LAURIC ACID [FHFI],SCHEMBL5895,NCIOpen2_009480,MLS002177807,MLS002415737,WLN: QV11,Dodecanoic acid (lauric acid),LAURIC ACID [WHO-DD],Dodecanoic acid, >=99.5%,Edenor C 1298-100,DODECANOIC ACID [HSDB],CHEMBL108766,GTPL5534,HY-Y0366R,NAA 122,NAA 312,HMS2268C14,HMS3649N06,HY-Y0366,STR08039,Dodecanoic acid, analytical standard,Lauric acid, >=98%,FCC,FG,Tox21_202149,Tox21_303010,BDBM50180948,LMFA01010012,s4726,STL281860,AKOS000277433,CCG-266587,DB03017,FA 12:0,FD16220,HYDROFOL ACID 1255 OR 1295,NCGC00090919-01,NCGC00090919-02,NCGC00090919-03,NCGC00256486-01,NCGC00259698-01,AC-16451,BP-27913,DA-64879,Dodecanoic acid, >=99% (GC/titration),LAU,Dodecanoic acid, purum, >=96.0% (GC),Lauric acid, natural, >=98%, FCC, FG,CS-0015078,L0011,NS00008441,EN300-19951,C02679,D10714,LAURIC ACID (CONSTITUENT OF SAW PALMETTO),Q422627
Duodecylic Acid is a medium-length long-chain fatty acid, or lipid, that makes up about half of the fatty acids within coconut oil.
Duodecylic Acid’s a powerful substance that is sometimes extracted from the coconut for use in developing monolaurin.
Duodecylic Acid is an antimicrobial agent that is able to fight bacteria, viruses, yeasts, and other pathogens.
Because you can’t ingest lauric acid alone (it’s irritating and not found alone in nature), you’re most likely to get Duodecylic Acid in the form of coconut oil or from fresh coconuts.
Duodecylic Acid is being studied at a breakneck pace, much of the research doesn’t pinpoint what in the oil is responsible for its reported benefits.
Because Duodecylic Acid contains much more than just lauric acid, it would be a stretch to credit it with all of the coconut oil benefits.
Still, a 2015 analysis suggests that many of the benefits tied to Duodecylic Acid are directly linked to lauric acid.
Among the benefits, they suggest Duodecylic Acid could aid weight loss and even protect against Alzheimer’s disease.
Duodecylic Acid's effects on blood cholesterol levels still need to be clarified.
This research suggests that the benefits of v are due to how the body uses it.
The majority of Duodecylic Acid is sent directly to the liver, where it’s converted to energy rather than stored as fat.
When compared with other saturated fats, Duodecylic Acid contributes the least to fat storage.
Duodecylic Acid, also known as dodecanoic acid, is a saturated fatty acid with a 12-carbon atom chain, thus falling into the medium chain fatty acids, is a white crystalline carboxylic acid with a faint odor of bay oil or soap.
Duodecylic Acid has been found at high levels in coconut oil.
Duodecylic Acid induces the activation of NF-κB and the expression of COX-2, inducible nitric oxide synthase (iNOS), and IL-1α in RAW 264.7 cells when used at a concentration of 25 μM.
Duodecylic Acid is a straight-chain, twelve-carbon medium-chain saturated fatty acid with strong bactericidal properties; the main fatty acid in coconut oil and palm kernel oil.
Duodecylic Acid has a role as a plant metabolite, an antibacterial agent and an algal metabolite.
Duodecylic Acid is a straight-chain saturated fatty acid and a medium-chain fatty acid.
Duodecylic Acid is a conjugate acid of a dodecanoate.
Duodecylic Acid derives from a hydride of a dodecane.
A white crystalline carboxylic acid, used as a plasticizer and for making detergents and soaps.
Duodecylic Acid's glycerides occur naturally in coconut and palm oils.
Duodecylic Acid is a medium-chain fatty acid with the chemical formula C₁₂H₂₄O₂.
Duodecylic Acid is a saturated fat that is naturally found in various plant oils and animal fats, most notably in coconut oil and palm kernel oil.
Duodecylic Acid is known for its antimicrobial and antiviral properties, making it useful in several applications.
As part of the fatty acid class of surfactants, Duodecylic Acid is both a versatile and effective ingredient in formulations that require cleansing, foaming, and emulsification
Duodecylic Acid is a saturated medium-chain fatty acid with the molecular formula C12H24O2.
Duodecylic Acid is naturally found in various vegetable oils and animal fats, particularly abundant in coconut oil and palm kernel oil.
Duodecylic Acid is a saturated fatty acid commonly utilized in cosmetics for its versatile properties.
With the chemical formula C12H24O2, Duodecylic Acid appears as a white, powdery solid.
Due to its emollient and cleansing characteristics, Duodecylic Acid serves as an ingredient in various skincare and haircare products.
Duodecylic Acid's ability to create a rich lather and its affinity for both water and oil make it valuable in formulations like soaps, shampoos, and cleansers.
Additionally, its potential antimicrobial properties have led to its use in certain skincare products targeting acne-prone or problematic skin, offering a holistic approach to cosmetic care.
Colorless needle-like crystals.
Soluble in methanol, slightly soluble in acetone and petroleum ether.
Duodecylic Acid occurs as a white crystalline powder with a slight odor of bay oil or a fatty odor.
Duodecylic Acid is a common constituent of most diets; large doses may produce gastrointestinal upset.
Like many other fatty acids, Duodecylic Acid is inexpensive, has a long shelf-life, and is non-toxic and safe to handle.
Duodecylic Acid is mainly used for the production of soaps and cosmetics.
For these purposes, Duodecylic Acid is neutralized with sodium hydroxide to give sodium laurate, which is a soap.
Most commonly, sodium Duodecylic Acid is obtained by saponification of various oils, such as coconut oil.
These precursors give mixtures of sodium laurate and other soaps.
Uses
Duodecylic Acid Used for the preparation of alkyd resins, as well as wetting agents, detergents and pesticides
Used for peeling vegetables and fruits with a maximum amount of 3.0g/kg.
Used as defoamer; GB 2760-86 provides for the spices allowed to use; used for the preparation of other food grade additives.
Duodecylic Acid is widely used in the surfactant industry and can be, according to the classification of surfactants, divided into cationic, anionic, non-ionic and amphoteric type.
The surfactants types of Duodecylic Acid are listed in the attached table of this item.
Some surfactants of the derivatives of Duodecylic Acid and dodecanol are also antiseptics, such as dodecyl dimethyl benzyl ammonium chloride (geramine), dodecyl dimethyl benzyl ammonium bromide (bromo-geramine) and dodecyl dimethyl (2-phenoxyethyl) ammonium bromide (domiphen bromide).
The dodecyldimethyllammonium-2,4,5-trichlorophenolate in these derivatives can be used as citrus preservative.
Duodecylic Acid also has many applications in plastic additives, food additives, spices and pharmaceutical industries.
Duodecylic Acid is used in Butter flavors and in certain Citrus flavor types, mainly in Lemon.
The concentration used may vasy from 2 to 40 ppm, calculated upon the finished consumer product.
Given its foaming properties, the derivatives of Duodecylic Acid are widely used as a base in the manufacture of soaps, detergents, and lauryl alcohol.
Duodecylic Acid is a common constituent of vegetable fats, especially coconut oil and laurel oil.
Duodecylic Acid may have a synergistic effect in a formula to help fight against mircoorganisms.
Duodecylic Acid is a mild irritant but not a sensitizer, and some sources cite it as comedogenic.
Duodecylic Acid is a fatty acid obtained from coconut oil and other veg- etable fats.
Duodecylic Acid is practically insoluble in water but is soluble in alco- hol, chloroform, and ether.
Duodecylic Acid functions as a lubricant, binder, and defoaming agent.
Like many other fatty acids, Duodecylic Acid is inexpensive, has a long shelf-life, is nontoxic, and is safe to handle.
Duodecylic Acid is used mainly for the production of soaps and cosmetics.
For these purposes, Duodecylic Acid is reacted with sodium hydroxide to give sodium laurate, which is a soap.
Most commonly, Duodecylic Acid is obtained by saponification of various oils, such as coconut oil.
These precursors give mixtures of sodium laurate and other soaps.
Duodecylic Acid is a precursor to dilauroyl peroxide, a commercial initiator of polymerizations.
Duodecylic Acid finds multifaceted uses in cosmetics and personal care.
Its emollient properties make it a valuable ingredient for moisturizing and softening the skin, enhancing the sensory experience of products like lotions and creams.
Moreover, its cleansing abilities contribute to creating rich lather in soaps, shampoos, and cleansers, effectively removing dirt and impurities.
Duodecylic Acid's compatibility with both water and oil aids in thorough cleansing.
This dual nature makes Duodecylic Acid a versatile addition, offering a balanced approach to skincare and personal hygiene, ultimately elevating the effectiveness and appeal of cosmetic formulations.
Soap and Detergent Production:
Saponification: Duodecylic Acid is commonly used in soap-making due to its ability to produce a hard bar of soap with a rich lather.
Duodecylic Acid reacts with alkalis, such as sodium hydroxide, to form soap.
Cleansing Agents: In detergents, Duodecylic Acid is used for its cleansing and foaming properties, making Duodecylic Acid a key ingredient in personal care products like body washes, shampoos, and facial cleansers.
Cosmetics and Skin Care:
Moisturizers and Emollients: Duodecylic Acid is often used in skincare products as an emollient that helps to soften and smooth the skin.
Antimicrobial Agent: Due to its antimicrobial properties, Duodecylic Acid is also included in formulations to help protect the skin from bacterial infections and reduce acne.
Industrial Uses:
Plastics and Lubricants: In industrial applications, Duodecylic Acid is used in the production of plastics, rubber, and lubricants.
Duodecylic Acid is a raw material for esters and surfactants.
Biodiesel Production: Duodecylic Acid is sometimes used as a feedstock in the production of biodiesel due to its chemical properties.
Pharmaceutical Applications
pharmaceutical applications Duodecylic Acid has also been examined for use as an enhancer for topical penetration and transdermal absorption, rectal absorption, buccal delivery,(14) and intestinal absorption.
Duodecylic Acid is also useful for stabilizing oil-in-water emulsions.
Duodecylic Acid has also been evaluated for use in aerosol formulations.
Production methods
Industrial production methods can be grouped into two categories:
derived from the saponification or high temperature and pressure decomposition of natural vegetable oils and fats;
separated from the synthetic fatty acid.
Japan mainly uses coconut oil and palm kernel oil as the raw materials for the preparation of Duodecylic Acid.
The natural vegetable oils used to produce Duodecylic Acid include coconut oil, litsea cubeba kernel oil, palm kernel oil and mountain pepper seed oil.
Other plants oil, such as palm kernel oil, tea tree seed oil and camphor tree seed oil, can also service industry to produce dodecanoic acid.
The residual C12 distillate from the extraction of Duodecylic Acid, containing a large number of dodecenoic acid, can be hydrogenated at atmospheric pressure, without catalyst, to convert into dodecanoic acid with a yield of more than 86%.
Derived from the separation and purification of coconut oil and other vegetable oil.
Duodecylic Acid naturally exists in coconut oil, litsea cubeba kernel oil, palm kernel oil and pepper kernel oil in the form of glyceride.
Duodecylic Acid can be derived from the hydrolysis of natural oils and fats in industry.
The coconut oil, water and catalyst are added into the autoclave and hydrolyzed to glycerol and fatty acid at 250 ℃ under the pressure of 5MPa.
The content of Duodecylic Acid is 45%~80%, and can be further distilled to obtain dodecanoic acid.
Production Methods
Duodecylic Acid is a fatty carboxylic acid isolated from vegetable and animal fats or oils.
For example, coconut oil and palm kernel oil both contain high proportions of Duodecylic Acid.
Isolation from natural fats and oils involves hydrolysis, separation of the fatty acids, hydrogenation to convert unsaturated fatty acids to saturated acids, and finally distillation of the specific fatty acid of interest.
Production and reactions
Duodecylic Acid is mainly isolated from natural sources.
Duodecylic Acid's reactions are representative of those of similar long chain, saturated fatty acids.
Duodecylic Acid can be converted to the symmetrical fatty ketone called laurone (O=C(C11H23)2).
Duodecylic Acid transesterifies with vinyl acetate.
Treatment with sulfur trioxide gives the α-sulfonic acid.
Reactivity Profile
Duodecylic Acid is a carboxylic acid.
Carboxylic acids donate hydrogen ions if a base is present to accept them.
They react in this way with all bases, both organic (for example, the amines) and inorganic.
Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat.
Neutralization between an acid and a base produces water plus a salt.
Duodecylic Acid's in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt.
Such reactions occur in principle for solid Duodecylic Acid's as well, but are slow if the solid acid remains dry.
Even "insoluble" Duodecylic Acid may absorb enough water from the air and dissolve sufficiently in Duodecylic Acid to corrode or dissolve iron, steel, and aluminum parts and containers.
Duodecylic Acid, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide.
The reaction is slower for dry, solid Duodecylic Acid.
Insoluble Duodecylic Acid react with solutions of cyanides to cause the release of gaseous hydrogen cyanide.
Flammable and/or toxic gases and heat are generated by the reaction of Duodecylic Acid with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides.
Duodecylic Acid, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat.
Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat.
Like other organic compounds, Duodecylic Acid can be oxidized by strong oxidizing agents and reduced by strong reducing agents.
These reactions generate heat.
A wide variety of products is possible.
Like other acids, Duodecylic Acid may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions.
Duodecylic Acid can react with oxidizing materials.
