E 180 (LITHOL RUBINE BK)

Lithol rubine BK = Calcium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate

CAS Number : 5281-04-9 
EC  Number : 226-109-5
ECHA InfoCard    : 100.023.736 
PubChem CID    : 9571018
ChemSpider    : 17215383 
E number    : E180 (colours)
Chemical formula : C18H12CaN2O6S
Molar mass     : 424.44 g/mol
Appearance     : Red powder

IUPAC name : 
Calcium (4Z)-4-[(4-methyl-2-sulfonatophenyl)hydrazono]-3-oxo-2-naphthalenecarboxylate

Other names : 
Pigment Rubine, Carmine 6B, Brilliant Carmine 6B, Permanent Rubin L6B, Litholrubine, Latolrubine, C.I. Pigment Red 57, C.I. Pigment Red 57:1, D&C Red No. 7, or C.I. 15850:1; E180

E 180 (Lithol rubine BK) is a reddish synthetic azo dye. 
E 180 (Lithol rubine BK) has the appearance of a red powder and magenta when printed. 
E 180 (Lithol rubine BK) is slightly soluble in hot water, insoluble in cold water, and insoluble in ethanol. 
When dissolved in dimethylformamide, its absorption maximum lies at about 442 nm. 

E 180 (Lithol rubine BK) is usually supplied as a calcium salt.
E 180 (Lithol rubine BK) is prepared by azo coupling with 3-hydroxy-2-naphthoic acid. 
E 180 (Lithol rubine BK) is used to dye plastics, paints, printing inks, and for textile printing. 
E 180 (Lithol rubine BK) is normally used as a standard magenta in the three and four color printing processes.

When used as a food dye, it has E number E180. 
E 180 (Lithol rubine BK) is used to color cheese rind as well as a component in some lip balms.
E 180 (Lithol rubine BK) is a naphthoic acid.

Use and Manufacturing of E 180 (Lithol rubine BK)
Industry Uses of E 180 (Lithol rubine BK)
-Pigments

Consumer Uses of E 180 (Lithol rubine BK)
-Personal care products
-Plastic and rubber products not covered elsewhere

General description of E 180 (Lithol rubine BK)
Lithol Rubine BK (E-180) is a red mono azo dye, authorized as a food additive by the European Union.
E 180 (Lithol rubine BK) belongs to the class of food dyes, which are used to give colorless foodstuffs a more characteristic appearance as well as to change the original colors to preferred artificial ones. 
E-180 is reported to be used in edible cheese rind, following the Quantum Satis (QS) principle.

This product is provided by Sigma-Aldrich as a neat standard for the precise quality control of food products. 
In the European Union, E numbers are used as codes for food color additives. 
E numbers 100-199 include not only artificial food colors derived from petroleum, but also natural additives originating from sources such as vegetables, insects, or mixtures made from natural foodstuffs.
 
Application of  E 180 (Lithol rubine BK)
E 180 (Lithol rubine BK) may be used as a chelating agent for the determination of mercury (II) in water samples by spectrophotometric method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

E 180 (Lithol rubine BK) is a food additive approved by the European Union (EU). 
E 180 (Lithol rubine BK) is used as a synthetic colouring agent in food and drink products.
The common name for E 180 (Lithol rubine BK). 
E 180 (Lithol rubine BK) may also be referred to as pigment rubine.

E 180 (Lithol rubine BK) is red coloured azo dye, which is insoluble in cold water, but becomes slightly soluble in warmer water.
Individuals with intolerance to salicylates may also find that they are intolerant to E180, due to the colouring being an azo dye. 
E 180 (Lithol rubine BK) may also worsen asthma and have a negative affect on those who suffer from rhinitis or the skin disease urticaria.

The additive E 180 (Lithol rubine BK) is banned in Australia.
Examples of food and drink products that sometimes include E 180 (Lithol rubine BK):
-cheese

E 180 (Lithol rubine BK) consists essentially of calcium 3-hydroxy-4-(4-methyl-2-sulfonatophenylazo)-2-naphthalenecarboxylate and subsidiary colouring matters together with water, calcium chloride and/or calcium sulphate as the principal uncoloured components.
E 180 (Lithol rubine BK), as a pigment rubine is a reddish coloured azo dye, used solely for colouring cheese rind.
E 180 (Lithol rubine BK) has the appearance of a red powder, slightly soluble in hot water, insoluble in cold water, and insoluble in ethanol. 
When dissolved in dimethylformamide, its absorption maximum lies at about 442 nm. 

E 180 (Lithol rubine BK) usually comes as a calcium salt.
E 180 (Lithol rubine BK) is used to dye plastics, paints, printing inks, and for textile printing. 
E 180 (Lithol rubine BK) is normally used as a standard magenta in the three and four color printing processes.
When used as a food dye, E 180 (Lithol rubine BK) has E number E180. 

E 180 (Lithol rubine BK) is used to color cheese rind as well as a component in some lip balms. 
E 180 (Lithol rubine BK) is banned in some countries.

E 180 (Lithol rubine BK) is bright bluish red brilliant in masstone, clean and strong in tints.  
E 180 (Lithol rubine BK) can be obtained in versatile shades with lighter or darker masstone, bluish or yellowish print tone and undertone in different degrees of bronze and in different strength and transparency.
E 180 (Lithol rubine BK) is a synthetic red colored azo dye which belongs to the class of organic compound fixed with aryl group that makes E 180 (Lithol rubine BK) insoluble in water and other chemical solvents. 
E 180 (Lithol rubine BK) is most commonly used in the treatment of the textiles, leather and some food items. 

E 180 (Lithol rubine BK) is a reddish synthetic azo dye. 
E 180 (Lithol rubine BK) looks like red powder and magenta when pressed . 
E 180 (Lithol rubine BK) is slightly soluble in hot water, insoluble in cold water, and insoluble in ethanol. 
When dissolved in dimethylformamide, the absorption maximum is at about 442 nm. 
E 180 (Lithol rubine BK) is usually provided as a calcium salt. 
E 180 (Lithol rubine BK) is prepared by azo coupling with 3-hydroxy-2-naphthoic acid. 

E 180 (Lithol rubine BK) is used for dyeing plastics, paints, printing inks and textile printing. 
E 180 (Lithol rubine BK) is normally used as a standard magenta in three and four color printing processes.
When used as a food coloring, it has the E number E180. 
E 180 (Lithol rubine BK) is used to color the cheese crust and also as an ingredient in some lip balms.

Substance identity

EC / List no.: 226-109-5
CAS no.: 5281-04-9
Mol. formula: C18H12CaN2O6S

Hazard classification & labelling of E 180 (Lithol rubine BK)
According to the notifications provided by companies to ECHA in REACH registrations no hazards have been classified.

About E 180 (Lithol rubine BK)
E 180 (Lithol rubine BK) is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.
E 180 (Lithol rubine BK) is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Consumer Uses of E 180 (Lithol rubine BK)
E 180 (Lithol rubine BK) is used in the following products: coating products, inks and toners and polymers.
Other release to the environment of E 180 (Lithol rubine BK) is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

Article service life of E 180 (Lithol rubine BK)
Release to the environment of E 180 (Lithol rubine BK) can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal) and of articles where the substances are not intended to be released and where the conditions of use do not promote release.
Other release to the environment of E 180 (Lithol rubine BK) is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

E 180 (Lithol rubine BK) can be found in complex articles, with no release intended: vehicles and machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines).
E 180 (Lithol rubine BK) can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones), wood (e.g. floors, furniture, toys), metal (e.g. cutlery, pots, toys, jewellery) and paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper).

Widespread uses by professional workers of E 180 (Lithol rubine BK)
E 180 (Lithol rubine BK) is used in the following products: inks and toners, coating products, finger paints, metal surface treatment products and non-metal-surface treatment products.
E 180 (Lithol rubine BK) is used in the following areas: printing and recorded media reproduction, formulation of mixtures and/or re-packaging and building & construction work.
E 180 (Lithol rubine BK) is used for the manufacture of: machinery and vehicles and fabricated metal products.
Other release to the environment of E 180 (Lithol rubine BK) is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

Formulation or re-packing of E 180 (Lithol rubine BK)
E 180 (Lithol rubine BK) is used in the following products: coating products, inks and toners, polymers and finger paints.
Release to the environment of E 180 (Lithol rubine BK) can occur from industrial use: formulation of mixtures and formulation in materials.

Uses at industrial sites of E 180 (Lithol rubine BK)
E 180 (Lithol rubine BK) is used in the following products: inks and toners, coating products, polymers, finger paints, fillers, putties, plasters, modelling clay, leather treatment products, paper chemicals and dyes and cosmetics and personal care products.
E 180 (Lithol rubine BK) is used in the following areas: formulation of mixtures and/or re-packaging, printing and recorded media reproduction and municipal supply (e.g. electricity, steam, gas, water) and sewage treatment.

E 180 (Lithol rubine BK) is used for the manufacture of: plastic products and rubber products.
Release to the environment of E 180 (Lithol rubine BK) can occur from industrial use: in the production of articles.
Other release to the environment of E 180 (Lithol rubine BK) is likely to occur from: indoor use.

Manufacture of E 180 (Lithol rubine BK)
Release to the environment of E 180 (Lithol rubine BK) can occur from industrial use: manufacturing of the substance.

Synonyms:
Calcium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate
calcium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate
2-Naphthalenecarboxylic acid, 3-hydroxy-4-[2-(4-methyl-2-sulfophenyl)diazenyl]-, calcium salt (1:1)
(4Z)-4-[(4-methyl-2-sulfonatophenyl)hydrazinylidene]-3-oxonaphthalene-2-carboxylate
2-Naphthalenecarboxylic acid, 3-hydroxy-4-[(4-methyl-2-
3-Hydroxy-4-[(4-methyl-2-sulfophenyl)azo]-2-naphthalenecarboxylic acid, calcium salt (1:1)
3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate
Bricofor Rubine 4BSP
C. I. Pigment 57:1
C. I. Pigment 57:1
C.I. Pigment Red 57:1
C.I. Pigment red 57:1
C.I. Pigment Red 57:1
C.I. PIGMNET RED 57:1
C.I.Pigment Red 57:1
calcium (4Z)-4-[(4-methyl-2-sulfonatophenyl)hydrazinylidene]-3- oxonaphthalene-2-carboxylate
calcium (4Z)-4-[(4-methyl-2-sulfonatophenyl)hydrazinylidene]-3-oxonaphthalene-2- carboxylate
Calcium (4Z)-4-[(4-methyl-2-sulfonatophenyl)hydrazinylidene]-3-oxonaphthalene-2-carboxylate
calcium (4Z)-4-[(4-methyl-2-sulfonatophenyl)hydrazinylidene]-3-oxonaphthalene-2-carboxylate
calcium (E)-3-hydroxy-4-((4-methyl-2-sulfonatophenyl)diazenyl)-2-naphthoate
Calcium 3-hydroxy-4-[(4-methyl-2-sulfonatophenyl)diazenyl]-2-naphthoate
calcium 3-hydroxy-4-[(4-methyl-2-sulfonatophenyl)diazenyl]-2-naphthoate
calcium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)
calcium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2
calcium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-
Calcium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate
calcium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate
Calcium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate
calcium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate
calcium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate; C.I. Pigment Red 57:1;D+C RED 7
Calcium 3-hydroxy-4-[(E)-2-(4-methyl-2-sulfonatophenyl)diazen-1-yl]naphthalene-2-carboxylate
calcium 3-hydroxy-4-[(E)-2-(4-methyl-2-sulfophenyl)diazen-1-yl]naphthalene-2-carboxylate
Calcium bis[2-(3-carboxy-2-hydroxynephthylazo)-5-methylbenzenesulfonate]
calcium(4Z)-4-[(4-methyl-2-sulfonatophenyl)hydrazinylidene]-3-oxonaphthalene-2-carboxylate
calcium(4z)-4-[(4-methyl-2-sulfonatophenyl)hydrazinylidene]-3-oxonaphthalene-2-carboxylate
calcium(4Z)-4-[(4-methyl-2-sulphonatophenyl)hydrazinylidene]-3-oxonaphtalene-2-carboxylate
CARMINE GB PR 57:1
D + C Red 7 (Lithol Rubine B, Ca Lake + Lithol Rubine B, Ca Salt)
D+C Red No. 7, Unipure Red LC 3079
DC Red 7
Lithol Rubin BCA
Lithol rubine Ca
Panax Carmine 157, Panax Carmine HF-S(N), Panax Carmine 570W
pigment red 54:1
Pigment Red 57
Pigment Red 57.1
PIGMENT RED 57:1
Pigment Red 57:1
pigment red 57:1
PR57:1
Rubine red pigment
C. I. Pigment Red 57:1
Registration dossier
C.I. 15850:1
C.I. Pigment Red 57:1
D + C Red 7 (Lithol Rubine B, Ca Lake + Lithol Rubine B, Ca Salt)
Neelicert D + C Red 7Lavanya IndicaLithol RubinNeelicet D + C Red 7 Ca LakeLavanya ElegansPIGMENT RED 57:1
Pigment Red 57, calcium salt (1:1)
PIGMENT RED 57:1
Pigment Red 57:1
PR 57:1
SEIKAFAST CARMINE 6B 1476T-7
Sudacolor Red 635
SYMULER Brilliant Carmine 6B
Versal Red 4BP
Versal Red F6RO
Versal Red F6RW
Versal Red F6RWB
Versalová červeň F6RO
Versalová červeň F6RW
Versalová červeň F6RWB
Pigment Red 57:1
106008-82-6
11145-41-8
116357-55-2
116711-94-5
12238-33-4
12238-35-6
12238-36-7
12238-46-9
12238-47-0
1255344-55-8
128282-14-4
1325-10-6
149003-64-5
1818339-54-6
1878210-16-2
217821-04-0
37340-13-9
39340-05-1
5281-04-9
53028-84-5
53612-29-6
57176-64-4
57917-29-0
60748-28-9
69458-81-7
Pigment red 57
5858-81-1
Lithol Rubine
D and C Red No. 6
D&C Red No. 6
LITHOLRUBINBCA
C.I. Pigment Red 57, disodium salt
UNII-481744AI4O
C.I. Pigment Red 57
Lithol rubin B
481744AI4O
C.I. 15850
Pigment Rubine B
Siloton Rubine B
Vynamon Claret Y
Irgalite Red 4B
Isol Ruby BK
Isol Ruby BKS
Segnale Red 3R
Permanent Red 4B
Plastol Rubine BC
Lithol Rubine BNA
Irgalite Rubine PB
Resamine Rubine BC
Siloton Rubine 2B
Pigment Rubine BCL
Silotermo Carmine G
Isol Bona Rubine BK
Japan Red 201
Permanent Red F 6R
D&c red no.6
Isol Bona Rubine BKS
Isol Bona Rubine KBK
Kromon Permanent Red 4B
Rubine Red RR 1253
sodium (E)-3-hydroxy-4-((4-methyl-2-sulfonatophenyl)diazenyl)-2-naphthoate
D & C Red no. 6
Cerven pigment 57 [Czech]
Cerven pigment 57
11070 Red
EINECS 227-497-9
Red 202
CCRIS 8549
Lithol Rubine B
Lithol Rubine BK
CI 15850
FD&C Red No. 6
2-Naphthalenecarboxylic acid, 3-hydroxy-4-((4-methyl-2-sulfophenyl)azo)-, disodium salt
Organic Pigment Red 57:1
SCHEMBL341437
SCHEMBL1435735
DTXSID6064038
CHEBI:172619
Disodium 3-hydroxy-4-((4-methyl-2-sulphonatophenyl)azo)-2-naphthoate
AKOS032950039
3-Hydroxy-4-((4-methyl-2-sulfophenyl)azo)-2-naphthalenecarboxylic acid, disodium salt
H11383
Q427230
Disodium 3-hydroxy-4-[(4-methyl-2-sulfonatophenyl)diazenyl]-2-naphthoate, AldrichCPR
disodium;2-[(3-carboxy-2-oxidonaphthalen-1-yl)diazenyl]-5-methylbenzenesulfonate
disodium;2-[(3-carboxy-2-oxidonaphthalen-1-yl)diazenyl]-5-methylbenzenesulonate
2-Naphthalenecarboxylic acid, 3-hydroxy-4-(2-(4-methyl-2-sulfophenyl)diazenyl)-, sodium salt (1:2)
3,4-Dihydro-3-oxo-4-[2-[2-(sodiosulfo)-4-methylphenyl]hydrazono]naphthalene-2-carboxylic acid sodium salt