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E1205 Basic methacrylate copolymer is used as a coating agent.
E1205 Basic methacrylate copolymer is also used as a glazing agent and to prevent clumping.
E1205 Basic Methacrylate Copolymer is extensively used in pharmaceutical coating systems.
CAS Number: 25086-15-1
EC Number: Polymer exempt / not specifically assigned
Molecular Formula: Variable copolymer formula
Molecular Weight: Variable polymeric molecular weight
SYNONYMS:
Basic Methacrylate Copolymer, Methacrylate Copolymer Type A, Cationic Methacrylate Copolymer, Amino Methacrylate Copolymer, Poly(butyl methacrylate-co-(2-dimethylaminoethyl methacrylate)-co-methyl methacrylate), Eudragit E, Eudragit E100, Eudragit EPO, Dimethylaminoethyl Methacrylate Copolymer
E1205 Basic methacrylate copolymer is a chemical compound produced through a controlled thermal polymerisation process involving butyl methacrylate, methyl methacrylate monomers and dimethylaminoethyl methacrylate.
An alkylmercaptan is used as a chain modifying agent.
E1205 Basic methacrylate copolymer appears in the form of a white powder.
E1205 Basic methacrylate copolymer is a synthetic, high-molecular-weight polymethacrylate used as a film-forming excipient for enteric or controlled-release coatings on tablets and capsules (e.g., Eudragit types).
E1205 Basic methacrylate copolymer is not a nutrient and is intended to protect actives from stomach acid or to target intestinal release.
E1205 Basic methacrylate copolymer is a food additive belonging to the 'Others' category according to European classification.
E1205 Basic methacrylate copolymer is a synthetic polymer derived from methacrylic acid and its esters, mainly dimethylaminoethyl methacrylate and methyl methacrylate.
E1205 Basic Methacrylate Copolymer is a synthetic cationic copolymer mainly composed of dimethylaminoethyl methacrylate, butyl methacrylate, and methyl methacrylate.
E1205 Basic methacrylate copolymer is especially important in pharmaceutical technology where it is used for taste masking, moisture protection, film coating, and modified drug release systems.
E1205 Basic methacrylate copolymer is generally insoluble in water at neutral pH but becomes soluble under acidic conditions because of the protonation of amino groups within the polymer structure.
Historically, E1205 Basic methacrylate copolymer was approved in the European Union after evaluation by the European Food Safety Authority (EFSA), which considered it safe for use in certain applications.
Regarding labeling, E1205 Basic methacrylate copolymer must appear in the ingredient list as 'Basic methacrylate copolymer' or with its number E1205.
E1205 Basic methacrylate copolymer is a functional and safe food additive, widely used in the industry to improve the quality and preservation of foods.
E1205 Basic methacrylate copolymer is considered one of the most technologically important functional coating polymers in modern pharmaceutical manufacturing.
E1205 Basic methacrylate copolymer's unique behavior comes from the presence of dimethylaminoethyl groups within the polymer chain.
These amino groups become positively charged in acidic environments, allowing the polymer to dissolve rapidly in stomach acid while remaining largely insoluble at neutral pH.
Because of this characteristic, E1205 Basic methacrylate copolymer is frequently used for gastric-soluble coating systems and immediate-release formulations.
One of the most valuable properties of E1205 Basic methacrylate copolymer is its ability to create smooth, uniform, and highly glossy coatings on tablets and pellets.
The films produced are flexible and resistant to cracking, which improves both the appearance and mechanical durability of pharmaceutical products during packaging, transportation, and storage.
E1205 Basic methacrylate copolymer is especially important in taste-masking technologies.
Many active pharmaceutical ingredients have extremely bitter or unpleasant tastes.
E1205 Basic methacrylate copolymer forms a protective barrier around drug particles, preventing rapid dissolution in the mouth while allowing fast dissolution in the acidic stomach environment.
This significantly improves patient acceptance, particularly in pediatric and geriatric medicines.
Another important feature is E1205 Basic methacrylate copolymer's low permeability to moisture under normal storage conditions.
Moisture-sensitive active ingredients can degrade over time when exposed to humidity, but E1205 Basic methacrylate copolymer coatings help improve stability and shelf life by reducing water penetration.
USES and APPLICATIONS of E1205 BASIC METHACRYLATE COPOLYMER:
E1205 Basic methacrylate copolymer is also highly adaptable in formulation engineering.
Manufacturers can modify coating thickness, solvent systems, plasticizers, and processing conditions to achieve different release characteristics and mechanical properties.
Because of this flexibility, E1205 Basic methacrylate copolymer is widely used in advanced drug delivery technologies.
In pharmaceutical processing, E1205 Basic methacrylate copolymer can be applied using fluidized bed coating systems, pan coating systems, and spray-coating equipment.
E1205 Basic methacrylate copolymer is compatible with common pharmaceutical solvents such as ethanol and isopropanol, making industrial-scale processing relatively efficient.
E1205 Basic methacrylate copolymer also has good compatibility with pigments, plasticizers, anti-tacking agents, and other excipients.
This allows the production of colored, glossy, and customized dosage forms with improved branding and patient identification.
In microencapsulation technologies, E1205 Basic methacrylate copolymer is used to coat fine particles, vitamins, probiotics, enzymes, and sensitive active compounds.
E1205 Basic methacrylate copolymer protects active ingredients from oxygen, humidity, and environmental degradation while maintaining controlled dissolution behavior.
E1205 Basic methacrylate copolymer demonstrates relatively good thermal process stability compared with some other coating materials.
E1205 Basic methacrylate copolymer can tolerate standard drying temperatures used during pharmaceutical manufacturing without major degradation, although excessive heat may eventually cause decomposition and release of irritating fumes.
Another interesting characteristic is E1205 Basic methacrylate copolymer's cationic surface behavior.
Because E1205 Basic methacrylate copolymer carries positively charged amino groups under acidic conditions, it can interact with negatively charged substances such as acidic drugs, polymers, or biological molecules.
This property is sometimes explored in advanced pharmaceutical and biomedical research.
Compared with some cellulose-based coating polymers, E1205 Basic methacrylate copolymer often provides superior gloss, smoother coating surfaces, and improved taste masking efficiency.
However, its pH-dependent solubility makes E1205 Basic methacrylate copolymer particularly specialized for gastric-soluble systems rather than enteric coatings.
Commercially, E1205 Basic methacrylate copolymer is strongly associated with Eudragit polymer technologies developed for sophisticated oral drug delivery systems.
Different grades are available with variations in molecular weight, viscosity, and processing behavior depending on the desired pharmaceutical application.
In industrial chemistry, E1205 Basic methacrylate copolymer is also valued because of their optical clarity, adhesion strength, and film toughness.
Similar polymer systems may be used in specialty coatings, inks, resins, and surface-protection technologies outside pharmaceutical applications.
From a regulatory perspective, E1205 Basic methacrylate copolymer is generally regarded as an excipient rather than an active ingredient.
E1205 Basic methacrylate copolymer’s molecular structure contains hydrophobic methacrylate regions together with amino-functional hydrophilic segments.
This balance between hydrophobicity and hydrophilicity contributes to E1205 Basic methacrylate copolymer's controlled solubility behavior, adhesion performance, and coating efficiency.
Because E1205 Basic methacrylate copolymer is a copolymer rather than a single pure molecule, its exact molecular formula and molecular weight are variable and depend on manufacturing ratios, monomer composition, and polymerization conditions.
Industrially, E1205 Basic methacrylate copolymer is obtained by emulsion or solution polymerization, controlling molecular weight and composition to achieve desired properties.
E1205 Basic methacrylate copolymer is a white or slightly yellowish powder, soluble in water and polar organic solvents, with a basic pH in solution due to tertiary amino groups.
E1205 Basic methacrylate copolymer's main function is to act as a coating agent in the food industry, forming films that protect food from moisture, oxygen, and other environmental factors, as well as improving the controlled release of flavors or nutrients.
E1205 Basic methacrylate copolymer is also used as a glazing agent and to prevent clumping.
E1205 Basic methacrylate copolymer is used as a glazing agent in solid food supplements and in solid foods for special medical purposes (FSMPs).
The neutral form is used as a glazing agent in solid food supplements and solid FSMPs.
E1205 Basic Methacrylate Copolymer is extensively used in pharmaceutical coating systems.
E1205 Basic methacrylate copolymer functions as a film former for tablets, granules, pellets, and capsules.
E1205 Basic methacrylate copolymer is especially useful for taste masking bitter drugs because it remains insoluble in saliva but dissolves rapidly in stomach acid.
In controlled-release and immediate-release drug delivery systems, E1205 Basic methacrylate copolymer helps regulate dissolution behavior depending on environmental pH conditions.
The food industry may use similar methacrylate coating systems in specialty edible coatings and protective layers for food supplements and nutraceutical products.
In cosmetics, E1205 Basic methacrylate copolymer is used in hair sprays, nail products, styling formulations, and film-forming cosmetic systems because of their adhesion and gloss properties.
Industrial applications of E1205 Basic methacrylate copolymer include specialty coatings, protective films, adhesives, ink systems, and resin formulations.
E1205 Basic methacrylate copolymer is also used in microencapsulation technologies where active ingredients require stabilization, taste masking, or moisture protection.
E1205 Basic methacrylate copolymer is widely used in pharmaceutical, food coating, cosmetic, and industrial applications because of its film-forming ability, pH-dependent solubility, adhesion properties, and controlled-release characteristics.
BENEFITS of E1205 BASIC METHACRYLATE COPOLYMER:
One major benefit of E1205 Basic methacrylate copolymer is its pH-dependent solubility.
This allows selective dissolution under acidic conditions while remaining stable at neutral pH.
E1205 Basic methacrylate copolymer provides excellent film quality, smooth coating surfaces, and strong adhesion properties.
E1205 Basic methacrylate copolymer also improves product appearance, mechanical stability, and moisture resistance.
Another important advantage is effective taste masking for bitter pharmaceutical ingredients, improving patient compliance.
E1205 Basic methacrylate copolymer offers flexibility in formulation design because different grades and molecular weights can be selected for specific release profiles and coating performances.
E1205 Basic methacrylate copolymer's compatibility with many excipients and solvents also makes it highly adaptable in pharmaceutical manufacturing processes.
E1205 Basic methacrylate copolymer is a group of polymeric compound used as food additives.
CHARACTERISTICS of E1205 BASIC METHACRYLATE COPOLYMER:
E1205 Basic methacrylate copolymer is characterized by its amino-functional cationic structure and pH-responsive behavior.
E1205 Basic methacrylate copolymer remains insoluble in neutral and alkaline environments but dissolves rapidly under acidic conditions.
This property makes E1205 Basic methacrylate copolymer highly valuable in oral pharmaceutical formulations where release behavior depends on stomach acidity.
E1205 Basic methacrylate copolymer forms smooth, glossy, flexible films with strong adhesion and good mechanical resistance.
E1205 Basic methacrylate copolymer also provides moisture protection and taste masking properties for tablets and capsules.
E1205 Basic methacrylate copolymer's cationic amino groups allow interaction with acidic compounds and improve compatibility in specialized formulations.
E1205 Basic methacrylate copolymer is chemically stable and can be processed using standard coating technologies including spray coating and solvent-based systems.
PHYSICAL and CHEMICAL PROPERTIES of E1205 BASIC METHACRYLATE COPOLYMER:
Common Name: Basic Methacrylate Copolymer
E Number: E1205
CAS Number: 25086-15-1
EC Number: Polymer exempt / not specifically assigned
Chemical Type: Synthetic cationic copolymer
Main Monomers: Dimethylaminoethyl methacrylate, butyl methacrylate, methyl methacrylate
Molecular Formula: Variable copolymer formula
Molecular Weight: Variable polymeric molecular weight
Appearance: White to slightly yellow powder or granules
Physical State: Powder, granules, or pellets
Color: White to pale yellow
Odor: Slight characteristic odor or nearly odorless
Taste: Slightly bitter or neutral
Polymer Type: Cationic copolymer
Solubility in Water: Insoluble or slightly soluble
Solubility in Acidic Media: Soluble below pH 5
Solubility in Organic Solvents: Soluble in ethanol, isopropanol, acetone
Density: Approximately 1.1–1.2 g/cm³
Glass Transition Temperature: Approximately 45–60 °C
Thermal Stability: Good under standard processing conditions
pH Sensitivity: Strong pH-dependent solubility
Film Forming Ability: Excellent
Moisture Resistance: Good
Adhesion Properties: Strong adhesion to substrates
Flexibility: Moderate to good
Chemical Stability: Stable under normal conditions
Surface Charge: Cationic
Viscosity: Depends on molecular weight and formulation
Hygroscopicity: Low to moderate
Transparency: Forms clear films
Mechanical Strength: Good film strength
Decomposition Temperature: Above approximately 200 °C
Compatibility: Compatible with many pharmaceutical excipients
FIRST AID MEASURES of E1205 BASIC METHACRYLATE COPOLYMER:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available
ACCIDENTAL RELEASE MEASURES of E1205 BASIC METHACRYLATE COPOLYMER:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.
FIRE FIGHTING MEASURES of E1205 BASIC METHACRYLATE COPOLYMER:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.
EXPOSURE CONTROLS/PERSONAL PROTECTION of E1205 BASIC METHACRYLATE COPOLYMER:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.
HANDLING and STORAGE of E1205 BASIC METHACRYLATE COPOLYMER:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.
STABILITY and REACTIVITY of E1205 BASIC METHACRYLATE COPOLYMER:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available
