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E1206 Neutral methacrylate copolymer is commonly applied in sustained-release tablets, pellets, granules, and capsules where controlled diffusion of active ingredients is required.
E1206 Neutral methacrylate copolymer is also used for moisture protection and stabilization of sensitive pharmaceutical compounds.
E1206 Neutral methacrylate copolymer is used as a glazing agent and coating agent in dietary supplements.
CAS Number: 9010-88-2
EC Number: Polymer exempt / not specifically assigned
Molecular Formula: Variable copolymer formula
Molecular Weight: Variable polymeric molecular weight
SYNONYMS:
Neutral Methacrylate Copolymer, Neutral Acrylic Copolymer, Methacrylate Copolymer Type B, Poly(ethyl acrylate-co-methyl methacrylate), Acrylic Resin Copolymer, Neutral Polymethacrylate, Eudragit NE, Eudragit RL, Eudragit RS, Acrylic Film-Forming Copolymer, Ethyl acrylate methyl methacrylate polymer, Ethyl acrylate methyl methacrylate polymer, Ethyl acrylate polymer with methyl methacrylate, NMC, Methyl methacrylate ethyl acrylate polymer, Methyl methacrylate polymer with ethyl acrylate
E1206 Neutral Methacrylate Copolymer is a synthetic neutral polymer mainly composed of methacrylic acid ester monomers such as ethyl acrylate and methyl methacrylate.
E1206 Neutral methacrylate copolymer is widely used in pharmaceutical coatings, food supplement coatings, cosmetic formulations, and industrial film technologies because of its excellent film-forming properties, chemical stability, transparency, flexibility, and controlled permeability.
Unlike basic or anionic methacrylate copolymers, E1206 Neutral methacrylate copolymer does not contain strongly ionizable functional groups.
This gives them relatively pH-independent behavior and allows the formation of stable, water-insoluble films with controlled permeability characteristics.
E1206 Neutral methacrylate copolymer is especially important in sustained-release pharmaceutical systems, protective coatings, and moisture-barrier applications.
E1206 Neutral methacrylate copolymer also shows good compatibility with pigments, titanium dioxide, opacifiers, and colorants.
This allows the production of customized pharmaceutical appearances and identification systems.
From a materials science perspective, E1206 Neutral methacrylate copolymer possesses a balance between hydrophobicity and flexibility.
Hydrophobic methacrylate segments contribute to moisture resistance, while E1206 Neutral methacrylate copolymer chain architecture provides elasticity and film toughness.
The thermal properties of E1206 Neutral methacrylate copolymer are also important.
Glass transition temperature influences film flexibility, hardness, and release behavior.
Lower glass transition temperatures generally produce softer and more flexible films.
In industrial coatings, E1206 Neutral methacrylate copolymer is valued for weather resistance, UV stability, and long-term durability.
Their resistance to environmental degradation contributes to their use in specialty protective coatings and high-performance materials.
E1206 Neutral methacrylate copolymer is generally considered biologically inert because of their high molecular weight and insoluble nature.
Systemic absorption after oral administration is minimal, and the material usually passes through the gastrointestinal tract without significant metabolism.
Research continues into advanced applications including nanoparticle coatings, colon-targeted delivery systems, bioadhesive formulations, and smart controlled-release technologies using methacrylate polymer combinations.
Because these materials are copolymeric systems produced with varying monomer ratios and polymerization conditions, physical properties such as viscosity, permeability, flexibility, and molecular weight can differ significantly between commercial grades.
E1206 Neutral methacrylate copolymer is a synthetic glazing and sustained-release coating agent used in solid food supplements.
E1206 Neutral methacrylate copolymer is a group of polymeric compounds used as food additives.
E1206 Neutral methacrylate copolymer is a fully synthetic polymer.
E1206 Neutral methacrylate copolymer is a milky white mixture with a slight, specific odor, produced by mixing and processing various chemical substances.
Therefore, you will not find E1206 Neutral methacrylate copolymer in ordinary foods such as bread, soft drinks, or candy, but exclusively in tablets and capsules.
E1206 Neutral methacrylate copolymer ensures that the active ingredients in the supplement are released into your body more slowly.
Because E1206 Neutral methacrylate copolymer is a relatively new food additive, little research has been conducted on it.
E1206 Neutral methacrylate copolymer is a semi-digestible plastic, currently only approved as a coating for dietary supplements.
E1206 Neutral methacrylate copolymer Neutral methacrylate copolymer and E 1207 are synthesized by emulsion polymerization of various acrylates.
The finished polymers contain a diverse mixture of "residual substances," which are permitted in quantities up to 0.1 grams per kilogram.
USES and APPLICATIONS of E1206 NEUTRAL METHACRYLATE COPOLYMER:
E1206 Neutral Methacrylate Copolymer is extensively used in pharmaceutical coating technologies.
E1206 Neutral methacrylate copolymer is commonly applied in sustained-release tablets, pellets, granules, and capsules where controlled diffusion of active ingredients is required.
E1206 Neutral methacrylate copolymer is also used for moisture protection and stabilization of sensitive pharmaceutical compounds.
E1206 Neutral methacrylate copolymer is used as a glazing agent and coating agent in dietary supplements.
Because the coatings are flexible and durable, E1206 Neutral methacrylate copolymer improves mechanical resistance during manufacturing and packaging.
In nutraceutical and food supplement industries, E1206 Neutral methacrylate copolymer may be used in protective coatings for vitamins, probiotics, minerals, and dietary supplements.
The cosmetic industry utilizes E1206 Neutral methacrylate copolymer in nail coatings, hair styling products, film-forming formulations, and long-lasting cosmetic products because of their gloss and durability.
Industrial applications of E1206 Neutral methacrylate copolymer include specialty coatings, resins, inks, adhesives, membrane technologies, and controlled permeability films.
E1206 Neutral methacrylate copolymer is also widely used in microencapsulation systems where active ingredients require gradual release or environmental protection.
The basic form of E1206 Neutral methacrylate copolymer is used as a glazing agent in solid food supplements and in solid foods for special medical purposes (FSMPs).
E1206 Neutral methacrylate copolymer is used as a glazing agent in solid food supplements and solid FSMPs.
The anionic form of E1206 Neutral methacrylate copolymer is used as a glazing agent in solid food supplements and solid FSMPs.
Sodium lauryl sulfate, a non-authorised ingredient, was found to be present in some samples
E1206 Neutral methacrylate copolymer is a synthetic food additive belonging to the 'Other' category under European regulations.
E1206 Neutral methacrylate copolymer is a polymer formed by the copolymerization of methacrylic acid esters, mainly methyl methacrylate and butyl methacrylate, in proportions that yield a neutral copolymer (without ionizable groups).
Industrially, E1206 Neutral methacrylate copolymer is obtained by emulsion or suspension polymerization using radical initiators and surfactants, followed by drying and milling processes to obtain a fine powder.
E1206 Neutral methacrylate copolymer's physicochemical properties include: appearance as a white or slightly yellowish powder, insoluble in water but soluble in organic solvents, high molecular weight, and a glass transition temperature around 50-70 °C.
E1206 Neutral methacrylate copolymer forms flexible and transparent films, making it useful as a coating agent in foods.
E1206 Neutral methacrylate copolymer's main function is as a film former (glazing agent) and stabilizer, protecting foods from moisture and improving their appearance.
Historically, E1206 Neutral methacrylate copolymer was approved in the European Union as a food additive in 2014, following evaluation by the European Food Safety Authority (EFSA).
EFSA, in E1206 Neutral methacrylate copolymer's 2010 opinion, established that there are no safety concerns at the proposed use levels, and no numerical Acceptable Daily Intake (ADI) was assigned, as the estimated exposure is low and does not pose a health risk.
The World Health Organization (WHO) has also evaluated E1206 Neutral methacrylate copolymer through the Joint FAO/WHO Expert Committee on Food Additives (JECFA), which concluded that there are no safety issues.
Regarding labeling, it must appear in the ingredient list as 'E1206 Neutral methacrylate copolymer' or with its E number E1206.
The overall safety assessment is positive: E1206 Neutral methacrylate copolymer is considered a safe additive for consumers under authorized conditions of use.
No significant adverse effects have been reported in toxicological studies, and E1206 Neutral methacrylate copolymer's use is permitted in a variety of food products, mainly dietary supplements and coated foods.
E1206 Neutral methacrylate copolymer is a fully polymerised copolymer used in the pharmaceutical industry to permit pH-independent delayed release of active ingredients from oral dosage forms.
This function has potential use with solid food supplements.
E1206 Neutral methacrylate copolymer is intended to be used as a sustained-release glazing agent.
Sustained-release formulations allow the continuous dissolution of a nutrient over a defined time.
E1206 Neutral methacrylate copolymer is approved to use as food additive(E1206) in EU.
E1206 Neutral methacrylate copolymer is considered one of the most versatile functional polymers used in controlled-release pharmaceutical technology.
E1206 Neutral methacrylate copolymer's importance comes from its ability to create semi-permeable films that do not dissolve rapidly in gastrointestinal fluids but instead allow slow penetration of water and gradual diffusion of active ingredients.
This property makes E1206 Neutral methacrylate copolymer especially useful in sustained-release and prolonged-release dosage forms.
Unlike enteric methacrylate polymers that dissolve only at certain intestinal pH levels, E1206 Neutral methacrylate copolymers remain structurally stable over a wide pH range.
This allows drug release to occur mainly through diffusion mechanisms rather than complete polymer dissolution.
Because of this, the release profile can often be controlled more precisely and consistently.
E1206 Neutral methacrylate copolymer is frequently used in matrix systems and reservoir coating systems for oral drug delivery.
In matrix tablets, the active ingredient is dispersed throughout the polymer network, while in coated reservoir systems E1206 Neutral methacrylate copolymer forms an outer membrane controlling the penetration of fluids and release of the drug core.
One particularly valuable feature is the tunable permeability of the polymer films.
Manufacturers can adjust the permeability by changing the ratio of monomers, coating thickness, plasticizer concentration, and pore-forming agents.
This allows highly customized release kinetics for different active pharmaceutical ingredients.
E1206 Neutral methacrylate copolymer is also widely used because of their excellent flexibility.
The films resist cracking during tablet compression, coating, packaging, and transportation.
Mechanical durability is very important in large-scale pharmaceutical manufacturing where dosage forms undergo continuous handling.
Another important property is optical clarity.
E1206 Neutral methacrylate copolymer forms highly transparent and glossy films that improve product appearance and facilitate visual inspection of coated products.
This characteristic is also beneficial in cosmetic and specialty coating applications.
In pharmaceutical processing, aqueous dispersions of E1206 Neutral methacrylate copolymers are often preferred because they reduce the need for large amounts of organic solvents.
Water-based coating systems are considered safer, more environmentally friendly, and easier to manage in industrial production environments.
E1206 Neutral methacrylate copolymer also demonstrates relatively low tackiness during coating operations, reducing sticking problems during fluidized bed and pan coating processes.
This improves manufacturing efficiency and coating uniformity.
E1206 Neutral methacrylate copolymer is highly compatible with plasticizers such as triethyl citrate, polyethylene glycol, and dibutyl sebacate.
Plasticizers improve film flexibility, elasticity, and processability while reducing brittleness.
In addition to pharmaceuticals, E1206 Neutral methacrylate copolymer is used in nutraceutical coatings for vitamins, probiotics, omega-3 oils, enzymes, and herbal extracts.
E1206 Neutral methacrylate copolymer protects sensitive compounds from oxidation, humidity, light, and premature degradation.
E1206 Neutral methacrylate copolymer also has importance in microencapsulation technologies.
Fine particles coated with E1206 Neutral methacrylate copolymers can achieve controlled release, odor masking, taste masking, and stabilization of volatile compounds.
Certain grades containing low levels of quaternary ammonium groups exhibit enhanced permeability while remaining insoluble.
These modified grades are especially useful for diffusion-controlled release systems where slow water penetration is required.
CHARACTERISTICS of E1206 NEUTRAL METHACRYLATE COPOLYMER:
E1206 Neutral methacrylate copolymer is characterized by its pH-independent behavior, flexibility, and controlled permeability.
Unlike ionic methacrylate polymers, E1206 Neutral methacrylate copolymer does not dissolve rapidly under acidic or alkaline conditions.
E1206 Neutral methacrylate copolymer is an insoluble films capable of allowing slow diffusion of water and active substances.
E1206 Neutral methacrylate copolymer creates smooth, transparent, flexible coatings with strong adhesion and good mechanical resistance.
E1206 Neutral methacrylate copolymer helps protect sensitive ingredients from environmental moisture, oxygen, and mechanical damage.
E1206 Neutral methacrylate copolymer's neutral chemical structure provides excellent compatibility with many pharmaceutical excipients, pigments, plasticizers, and active compounds.
E1206 Neutral methacrylate copolymer can also be tailored for different permeability and release rates by adjusting monomer ratios and film thickness.
E1206 Neutral methacrylate copolymer is highly valued in sustained-release technologies because they allow gradual diffusion of active ingredients while maintaining coating integrity.
BENEFITS of E1206 NEUTRAL METHACRYLATE COPOLYMER:
One major benefit of E1206 Neutral methacrylate copolymer is its ability to form stable, flexible, and transparent films with controlled permeability.
This makes E1206 Neutral methacrylate copolymer highly suitable for sustained-release and protective coating systems.
Another important advantage is E1206 Neutral methacrylate copolymer's low pH sensitivity, allowing relatively consistent performance across different environmental conditions.
E1206 Neutral methacrylate copolymer also provides excellent mechanical strength, moisture resistance, and surface gloss.
E1206 Neutral methacrylate copolymer improves product appearance, stability, and durability.
E1206 Neutral methacrylate copolymer's compatibility with many formulation ingredients allows highly customizable pharmaceutical and industrial applications.
E1206 Neutral methacrylate copolymer can also help extend shelf life by protecting sensitive active compounds from humidity, oxygen exposure, and mechanical stress.
ADDITIONAL TECHNICAL INFORMATION of E1206 NEUTRAL METHACRYLATE COPOLYMER:
E1206 Neutral methacrylate copolymer is produced through free-radical polymerization of methacrylate ester monomers.
The exact composition varies depending on the intended application and desired permeability characteristics.
Commercial methacrylate systems such as Eudragit NE, RL, and RS grades are widely used in pharmaceutical modified-release technologies.
Some grades contain small amounts of quaternary ammonium groups that modify permeability without causing complete solubility.
E1206 Neutral methacrylate copolymer’s hydrophobic backbone contributes to water resistance, while controlled porosity allows diffusion-based release mechanisms.
Film properties of E1206 Neutral methacrylate copolymer such as elasticity, permeability, hardness, and gloss can be adjusted through formulation design, plasticizers, and processing conditions.
Because E1206 Neutral methacrylate copolymer is a copolymeric system, exact molecular formulas and molecular weights are variable and depend on manufacturing conditions and monomer ratios.
PHYSICAL and CHEMICAL PROPERTIES of E1206 NEUTRAL METHACRYLATE COPOLYMER:
Common Name: Neutral Methacrylate Copolymer
E Number: E1206
CAS Number: 9010-88-2
EC Number: Polymer exempt / not specifically assigned
Chemical Type: Synthetic neutral copolymer
Main Components: Ethyl acrylate, methyl methacrylate and related methacrylate esters
Molecular Formula: Variable copolymer formula
Molecular Weight: Variable polymeric molecular weight
Appearance: White powder, granules, or dispersion
Physical State: Powder, pellets, granules, or aqueous dispersion
Color: White to slightly translucent
Odor: Slight characteristic odor or nearly odorless
Taste: Neutral or slightly characteristic
Polymer Type: Neutral copolymer
Solubility in Water: Insoluble
Solubility in Organic Solvents: Soluble in alcohols, acetone, esters
Water Permeability: Controlled permeability
Moisture Resistance: Good
Density: Approximately 1.05–1.20 g/cm³
Glass Transition Temperature: Approximately 10–70 °C depending on grade
Thermal Stability: Good
Film Forming Ability: Excellent
Flexibility: High flexibility
Transparency: Forms clear transparent films
Adhesion Properties: Good adhesion
Mechanical Strength: Good film toughness
Chemical Stability: Stable under normal conditions
pH Sensitivity: Minimal or low
Surface Characteristics: Smooth and glossy
Hygroscopicity: Low
Viscosity: Variable depending on molecular weight
Barrier Properties: Good oxygen and moisture barrier
Weather Resistance: Good environmental stability
Decomposition Temperature: Typically above 200 °C
FIRST AID MEASURES of E1206 NEUTRAL METHACRYLATE COPOLYMER:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available
ACCIDENTAL RELEASE MEASURES of E1206 NEUTRAL METHACRYLATE COPOLYMER:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.
FIRE FIGHTING MEASURES of E1206 NEUTRAL METHACRYLATE COPOLYMER:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.
EXPOSURE CONTROLS/PERSONAL PROTECTION of E1206 NEUTRAL METHACRYLATE COPOLYMER:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.
HANDLING and STORAGE of E1206 NEUTRAL METHACRYLATE COPOLYMER:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.
STABILITY and REACTIVITY of E1206 NEUTRAL METHACRYLATE COPOLYMER:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available
