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E1207 Anionic Methacrylate Copolymer is primarily used in pharmaceutical enteric coatings.
E1207 Anionic methacrylate copolymer is widely applied to tablets, capsules, pellets, granules, and multiparticulate drug delivery systems requiring intestinal release.
CAS Number: 25086-15-1 / varies by grade
EC Number: Polymer exempt / not specifically assigned
Molecular Formula: Variable copolymer formula
Molecular Weight: Variable polymeric molecular weight
SYNONYMS:
Anionic Methacrylate Copolymer, Methacrylic Acid Copolymer, Anionic Acrylic Copolymer, Enteric Methacrylate Copolymer, Poly(methacrylic acid-co-methyl methacrylate), Methacrylate Copolymer Type C, Acidic Methacrylate Copolymer, Eudragit L, Eudragit S, Methacrylic Acid–Methyl Methacrylate Copolymer, Acrylates copolymers, methyl acrylate, methyl methacrylate, methacrylic acid polymer, methacrylic acid polymer with methyl acrylate and methyl methacrylate, AMC
E1207 Anionic Methacrylate Copolymer is a synthetic anionic polymer mainly composed of methacrylic acid and methacrylate ester monomers such as methyl methacrylate or ethyl acrylate.
E1207 Anionic methacrylate copolymer is especially important in enteric coating technologies.
E1207 Anionic methacrylate copolymer remains insoluble in acidic stomach conditions but dissolves at higher intestinal pH levels.
Because of this behavior, E1207 Anionic methacrylate copolymer is commonly used to protect acid-sensitive drugs and to reduce gastric irritation caused by certain medications.
Commercially, E1207 Anionic methacrylate copolymer is strongly associated with pharmaceutical coating systems.
E1207 Anionic Methacrylate Copolymer is a synthetic polymer used as an enteric coating and glazing agent in solid food supplements and medical foods.
E1207 Anionic methacrylate copolymer protects sensitive nutrients from stomach acid or prevents stomach irritation from supplement ingredients.
Methacrylate copolymers are a group of polymeric compounds used as food additives.
The E numbers are E1205, E1206, and E1207, depending on whether the substance is basic, neutral, or anionic, respectively.
E1207 Anionic methacrylate copolymer, also known as anionic methacrylate copolymer, is a food additive belonging to the 'Other' category according to European classification.
E1207 Anionic methacrylate copolymer is a synthetic polymer derived from methacrylic acid and its esters, produced by emulsion or solution polymerization.
Industrially, E1207 Anionic methacrylate copolymer is obtained by copolymerization of methacrylic acid with methyl or ethyl methacrylate, followed by partial neutralization with bases such as sodium hydroxide to form an anionic salt.
E1207 Anionic methacrylate copolymer is a white or slightly yellowish powder, soluble in water, with film-forming properties and the ability to form protective coatings.
E1207 Anionic methacrylate copolymer's main function in food is as a coating (glazing) agent to protect sensitive compounds, improve stability, control the release of active ingredients, or mask flavors.
Historically, E1207 Anionic methacrylate copolymer was approved in the European Union in 2012 after evaluation by the European Food Safety Authority (EFSA).
EFSA, in its 2010 opinion, established that no numerical acceptable daily intake (ADI) is needed, as estimated exposure is low and poses no health risks.
The World Health Organization (WHO) has not set a specific ADI but considers it safe under authorized conditions of use.
Regarding food safety, E1207 Anionic methacrylate copolymer is considered a low-risk additive with no significant adverse effects in toxicological studies.
On labeling, E1207 Anionic methacrylate copolymer must appear as 'Anionic methacrylate copolymer' or with its E number.
E1207 Anionic methacrylate copolymer is a chemical compound produced in aqueous solution through a polymerization process with methyl methacrylate, methacrylic acid, and methyl acrylate.
The free radical initiators are polysorbate 80 and sodium lauryl sulfate.
The latter compound is not an authorized food additive.
Simethicone reduces foaming.
E1207 Anionic methacrylate copolymer comes in the form of a white powder soluble in water.
E1207 Anionic methacrylate copolymer is a milky white mixture with a slight, specific odor that is produced by combining and processing various chemical substances.
USES and APPLICATIONS of E1207 ANIONIC METHACRYLATE COPOLYMER:
E1207 Anionic Methacrylate Copolymer is primarily used in pharmaceutical enteric coatings.
E1207 Anionic methacrylate copolymer is widely applied to tablets, capsules, pellets, granules, and multiparticulate drug delivery systems requiring intestinal release.
E1207 Anionic methacrylate copolymer protects acid-sensitive drugs such as proton pump inhibitors, enzymes, probiotics, and certain antibiotics from degradation in stomach acid.
E1207 Anionic methacrylate copolymer is also used to delay drug release until the dosage form reaches the intestine.
This improves therapeutic targeting and reduces gastric side effects for drugs that may irritate the stomach.
In nutraceutical and food supplement products, E1207 Anionic methacrylate copolymer may protect vitamins, probiotics, omega-3 oils, and herbal extracts during gastric transit.
E1207 Anionic methacrylate copolymer is also utilized in controlled-release systems, microencapsulation technologies, and moisture-protective coatings.
Cosmetic and industrial applications of E1207 Anionic methacrylate copolymer include specialty coatings, protective films, and pH-responsive materials.
E1207 Anionic methacrylate copolymer is widely used in pharmaceutical coatings, enteric delivery systems, food supplement coatings, cosmetic formulations, and industrial film technologies because of its pH-dependent solubility, film-forming capability, chemical resistance, and controlled-release properties.
The basic form of methacrylate copolymer is used as a glazing agent in solid food supplements and in solid foods for special medical purposes (FSMPs).
The neutral form is used as a glazing agent in solid food supplements and solid FSMPs.
E1207 Anionic methacrylate copolymer is used as a glazing agent in solid food supplements and solid FSMPs. Sodium lauryl sulfate, a non-authorised ingredient, was found to be present in some samples.
E1207 Anionic methacrylate copolymer is among the most important excipient materials in delayed-release oral dosage technology.
Its ability to resist stomach acid while dissolving in intestinal fluid makes E1207 Anionic methacrylate copolymer essential in modern gastro-resistant formulations.
E1207 Anionic methacrylate copolymer acts as a protective barrier around sensitive active ingredients.
Many drugs are unstable in acidic conditions and may lose effectiveness if exposed to stomach acid.
Enteric methacrylate coatings prevent premature degradation and preserve drug potency until intestinal release occurs.
The dissolution mechanism is based on ionization of carboxylic acid groups within E1207 Anionic methacrylate copolymer structure.
At low pH, these acidic groups remain protonated and insoluble.
As pH increases in the intestine, ionization occurs, increasing polymer hydrophilicity and eventually causing dissolution.
Film thickness strongly influences drug release timing.
Thicker coatings delay dissolution longer, while thinner coatings allow faster intestinal release.
Manufacturers carefully optimize coating thickness for therapeutic performance.
E1207 Anionic methacrylate copolymer also provides protection against humidity and oxygen.
This is particularly important for probiotics, enzymes, and moisture-sensitive pharmaceuticals.
Modern pharmaceutical technology often combines E1207 Anionic methacrylate copolymer with neutral or cationic polymers to achieve highly specialized release profiles.
Multi-layer coating systems may combine immediate-release, delayed-release, and sustained-release functions within a single dosage form.
In industrial coating operations, E1207 Anionic methacrylate copolymer demonstrates excellent sprayability and process stability.
Fluidized bed systems and pan coaters commonly use methacrylate dispersions because E1207 Anionic methacrylate copolymer provides uniform coatings with good surface smoothness.
Certain advanced applications of E1207 Anionic methacrylate copolymer involve colon-targeted delivery systems.
By selecting appropriate polymer grades and coating thicknesses, drugs can be protected until reaching distal intestinal regions.
Research also explores E1207 Anionic methacrylate copolymer in nanoparticle coatings, peptide delivery systems, and biomedical encapsulation technologies.
You will not find E1207 Anionic methacrylate copolymer in common foods such as bread, soft drinks, or snacks.
E1207 Anionic methacrylate copolymer is used almost exclusively as a coating on tablets and capsules of dietary supplements.
The function of E1207 Anionic methacrylate copolymer is twofold: it protects your stomach against potentially irritating components of the supplement and it protects the active ingredients against stomach acid.
E1207 Anionic methacrylate copolymer only dissolves at a specific acidity level in the intestine, ensuring that the contents of the tablet are released exactly where they are needed.
This makes E1207 Anionic methacrylate copolymer a technical aid, not an ingredient you consciously consume.
WHAT E1207 ANIONIC METHACRYLATE COPOLYMER IS USED FOR AND WHERE
Diet
Ingredient included in the list of European food additives as E1207 Anionic methacrylate copolymer with the function of a coating agent in solid food supplements (capsules, tablets, pills and other similar forms such as pellets and powders).
Medicine
E1207 Anionic methacrylate copolymer is used in microcapsules as drug release at a very high zero-order rate
CHARACTERISTICS of E1207 ANIONIC METHACRYLATE COPOLYMER:
E1207 Anionic methacrylate copolymer is characterized by its acidic functional groups and pH-dependent dissolution behavior.
E1207 Anionic methacrylate copolymer remains intact in acidic stomach environments but dissolves when exposed to higher intestinal pH levels.
This selective solubility is essential for enteric drug delivery systems.
E1207 Anionic methacrylate copolymer forms smooth, continuous, and mechanically resistant films that protect active ingredients from gastric acid and moisture.
These coatings can also prevent irritation of the stomach lining by certain medications.
E1207 Anionic methacrylate copolymer's anionic carboxylic acid groups become ionized at higher pH values, causing the polymer to swell and dissolve.
Different grades dissolve at different intestinal pH thresholds depending on monomer composition.
E1207 Anionic methacrylate copolymer is chemically stable and compatible with many pharmaceutical excipients, pigments, plasticizers, and coating additives.
BENEFITS of E1207 ANIONIC METHACRYLATE COPOLYMER:
One major benefit of E1207 Anionic methacrylate copolymer is its enteric functionality.
E1207 Anionic methacrylate copolymer effectively protects active compounds from acidic degradation while enabling targeted intestinal release.
Another important advantage of E1207 Anionic methacrylate copolymer is reduced gastric irritation.
Drugs that may damage or irritate the stomach can be safely delivered to the intestine using enteric coatings based on this polymer.
E1207 Anionic methacrylate copolymer also provides excellent film quality, transparency, adhesion, and mechanical resistance.
Coatings remain stable during storage, transportation, and manufacturing processes.
E1207 Anionic methacrylate copolymer's customizable dissolution profile allows manufacturers to select different grades depending on the desired intestinal release pH.
E1207 Anionic methacrylate copolymer also improves product stability by reducing exposure to moisture, oxygen, and environmental stress.
PHYSICAL and CHEMICAL PROPERTIES of E1207 ANIONIC METHACRYLATE COPOLYMER:
Common Name: Anionic Methacrylate Copolymer
E Number: E1207
CAS Number: 25086-15-1 / varies by grade
EC Number: Polymer exempt / not specifically assigned
Chemical Type: Synthetic anionic copolymer
Main Monomers: Methacrylic acid, methyl methacrylate, ethyl acrylate
Molecular Formula: Variable copolymer formula
Molecular Weight: Variable polymeric molecular weight
Appearance: White powder, granules, or aqueous dispersion
Physical State: Powder, granules, pellets, or dispersion
Color: White to off-white
Odor: Slight characteristic odor or nearly odorless
Taste: Slightly acidic or neutral
Polymer Type: Anionic copolymer
Solubility in Water: Insoluble at low pH
Solubility in Alkaline Media: Soluble at intestinal pH
Solubility in Organic Solvents: Soluble in alcohols, acetone, esters
pH Sensitivity: Strong pH-dependent solubility
Density: Approximately 1.1–1.3 g/cm³
Glass Transition Temperature: Approximately 50–160 °C depending on grade
Film Forming Ability: Excellent
Transparency: Forms clear films
Flexibility: Moderate to good
Mechanical Strength: Good coating durability
Moisture Resistance: Moderate
Thermal Stability: Good
Chemical Stability: Stable under normal conditions
Surface Charge: Negative under ionized conditions
Hygroscopicity: Low to moderate
Adhesion Properties: Good
Barrier Properties: Good acid resistance
Viscosity: Variable depending on molecular weight
Decomposition Temperature: Typically above 200 °C
FIRST AID MEASURES of E1207 ANIONIC METHACRYLATE COPOLYMER:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available
ACCIDENTAL RELEASE MEASURES of E1207 ANIONIC METHACRYLATE COPOLYMER:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.
FIRE FIGHTING MEASURES of E1207 ANIONIC METHACRYLATE COPOLYMER:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.
EXPOSURE CONTROLS/PERSONAL PROTECTION of E1207 ANIONIC METHACRYLATE COPOLYMER:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.
HANDLING and STORAGE of E1207 ANIONIC METHACRYLATE COPOLYMER:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.
STABILITY and REACTIVITY of E1207 ANIONIC METHACRYLATE COPOLYMER:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available
