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E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is a synthetic polymer obtained by copolymerization of N-vinylpyrrolidone (PVP) and vinyl acetate (VA), both petrochemical monomers.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is a water-soluble, semi-synthetic copolymer preferred in tablet film coatings, dispersions, and adhesives.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is a copolymer formed by the combination of polyvinylpyrrolidone (PVP) and vinyl acetate monomers.
CAS Number: 25086-89-9.
EC Number: 607-540-1.
Molecular Formula: (C6H9NO)n · (C4H6O2)m.
Synonyms: polyvinylpyrrolidone-vinyl acetate copolymer, Aceticacid,ethenylester,polymerwith1-ethenyl-2-pyrrolidinone, aceticacidethenylester,polymerwith1-ethenyl-2-pyrrolidinone, aceticacidethenylestercopolymerwith1-ethenyl-2-pyrrolidinone, aceticacidvinylester,polymerwith1-vinyl-2-pyrrolidinone, gantrons860, i535, i635, i735, kolima10, kolima35, kolima75, kollidonva64, luviskolva28i, luviskolva37e, luviskolva37i, luviskolva55e, luviskolva55i, luviskolva64, luviskolva73e, polectron845, pvp/vacopolymer, pvp/va-s630, pvp-va, PVP-VAcopolymer, pvp-va-e735, 1-Vinylpyrrolidone-2(NVP), N-vinyl-y-pyrrolidone, POLY(1-VINYLPYRROLIDONE-CO-VINYL ACETATE ), POWDER, POLY(1-VINYLPYRROLIDONE-CO-VINYL ACETATE ), 50 WT. % SOLUTION IN 2-PROPANOL, Copolymer3:7,50%inethanol, POLYVINYLPYRROLIDONE-VINYL ACETATE (COPOLYMER 3: 7) 50% IN ETOH, poly(1-vinylpyrrolidone - vinyl acetate), poly(1-vinylpyrrolidone-co-vinyl acetate) solution, PVP-A Copolymer Series, POLYVINYLPYRROLIDONE-VINYLACETATECOPOLYMER, Vinylpyrrolidon-Vinylacetat-Copolymer, copovidone, pvp/va copolymer, Vinyl acetate/N-Vinyl-2-pyrrolidinone copolymer, Poly(1-vinylpyrrolidone-co-Vinyl Acetate) (Copolymer, 7:3) (50% in Ethanol), Poly(1-vinylpyrrolidone-co-Vinyl Acetate) (Copolymer, 3:7) (50% in Ethanol), Vinyl ketopyrrolidine/vinyl acetate copolymer, Vinyl acetate-Vinylpirrolidone copolymer, 1-Vinyl-2-pyrrolidone-vinyl acetate copolymer, 2-Pyrrolidinone, 1-ethenyl-, polymer with ethenyl acetate, Ethenyl acetate, polymer with 1-ethenyl-2-pyrrolidinone, (CopolyMer, 7:3) (50% in Ethanol), Poly(1-vinylpyrrolidone-co-Vinyl Acetate) , PVP/VA (Copovidone) --VA64/VA73, copolyresinvinylketopyrrolidine/vinylacetate, copolyvidon, e335, e535, gaf-s630, ganexe535, gantronpvp, gantrons630, s630, Vinylacetate-N-vinylpyrrolidinone, Vinylpyrrolidone Vinyl Acetate Copolymer Va-64, Ethenyl Ester, Polymer With 1-Ethenyl-2-Pyrrolidinone, Acetic Acid Ethenyl Ester, Polymer With, Vinylpyrrolidone Vinyl Acetate Copolymer, Vinylpyrrolidone Vinyl Acetate, Ethenyl Acetate, Polymer With 1-Ethenyl-2-Pyrrolidinone, ACETIC ACID, ETHENYL ESTER, POLYMER WITH 1-ETHENYL-2-PYRROLIDINONE, Ethenyl acetate, Vinylpyrrolidone-Vinyl Acetate Copolymer Va-64, Vinyl Pyrrolidone Copolymer, Co Povidone EP VA64, Luviskol Va 73 E, Ethanol, Pvp/Va E-735, 1-Ethenyl-2-Pyrrolidinone, Acetic Acid,, Pvp/Va Copolymer, Vinylpyrrolidone-Vinyl Acetate Copolymer, Vinylpyrrolidone Vinyl Acetate Copolymer 64E, Vinylpyrrolidone/Vinyl Acetate, Polymer with 1-ethenyl-2-pyrrolidinone
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is a fully polymerised cationic copolymer with taste-masking and moisture protection properties.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is used as a pharmaceutical excipient and has potential use as a glazing/coating agent to solid food supplements.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is a chemical compound, a copolymer or copolymers that can be random or linear and are produced synthetically through the "radical polymerization" process, where the double bonds present in the monomer unit are converted into saturated ones.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is the product of the conventional radical copolymerization of N-vinyl-2-pyrrolidone and vinyl acetate in a propan-2-ol solution with initiators.
The ratios of vinyl acetate and vinylpyrrolidone can vary between 30/70 and 70/30.
Polymers with 30%, 50%, 60%, and 70% vinylpyrrolidone content are produced in isopropanol and ethanol.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymers with 60% and 70% vinylpyrrolidone content are either 50% aqueous solutions or solids.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is a synthetic polymer obtained by copolymerization of N-vinylpyrrolidone (PVP) and vinyl acetate (VA), both petrochemical monomers.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer's manufacture isentirely industrial, with precise control of molecular weight and copolymer proportions to adjust solubility, adhesion, and film formation.
The process uses no raw materials or byproducts of animal origin at any stage.
The resulting material is chemically defined, stable, and inert, and there is no animal-derived method for obtaining this copolymer.
Due to its origin and processing, E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is suitable for vegans.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is presented as a white powder to cream or as a solution, depending on the grade.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer resins are linear, random copolymers produced by the free-radical polymerization of the monomers in ratios varying from 70/30 to 30/70 vinyl acetate to vinylpyrrolidone.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymers are available as white powders or clear solutions in ethanol, isopropanol and water.
Polymers in the four ranges of vinylpyrrolidone content (30, 50, 60 and 70 percent), are produced in ethanol or isopropanol.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymers with 60 and 70 percent vinylpyrrolidone content are available as solids or as 50 percent aqueous solutions.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is a water-soluble, semi-synthetic copolymer preferred in tablet film coatings, dispersions, and adhesives.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer possesses good film-forming and binding properties.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is a copolymer formed by the combination of polyvinylpyrrolidone (PVP) and vinyl acetate monomers.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is a versatile polymer that finds applications in various industries.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is a food additive belonging to the category of 'others'.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is a synthetic polymer formed by the copolymerization of N-vinylpyrrolidone and vinyl acetate.
Industrially, E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is obtained by solution or emulsion polymerization using radical initiators such as peroxides.
The final product is a white or slightly yellowish powder, soluble in water and polar organic solvents.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer's physicochemical properties include film-forming ability, adhesiveness, and stabilization of suspensions.
In the food industry, E1208 Polyvinylpyrrolidone-vinyl acetate copolymer's main function is to act as a coating agent, film former, and stabilizer.
Uses of E1208 Polyvinylpyrrolidone-Vinyl Acetate Copolymer:
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is mainly used in the food industry as a coating agent and film former.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is found in food supplements, especially tablets and capsules, to improve their appearance and facilitate swallowing.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is also used in confectionery products, such as chewing gum and candies, to provide a shiny and protective layer.
In the Spanish market, E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is common in brands of vitamin supplements and in some industrial bakery products.
The authorized limits under Regulation EC 1333/2008 vary by food category; for example, in food supplements up to 100 mg/kg is allowed.
The FDA classifies E1208 Polyvinylpyrrolidone-vinyl acetate copolymer as GRAS (Generally Recognized as Safe) for certain uses, while in Japan its use is permitted in processed foods.
Comparatively, European regulations are more restrictive regarding maximum amounts.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is used as a dispersing agent, colour stabiliser, Flavours and fragrances, pharmaceuticals.
The cross-linked form of PVP is used as a disintegrant in pharmaceutical tablets.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is used in artificial sweeteners in low joule foods and chewing gum and used as a clarifying agent in white wine and some beers and vinegar and also in personal care products like shampoo, toothpaste, paint and adhesives.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer can be used as a starting material to prepare a quasi-solid polymer electrolyte (QSPE) for dye-sensitized solar cells.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer can be used to preparepolymer blend membranes for pervaporation separation of ethanol and2-ethylhexanol mixtures.
Technological agent used as a binder, film former and stabilizer in food, supplements and pharmaceuticals (coatings, cohesion improvement); also widely used in cosmetics (hair lacquers and gels) due to E1208 Polyvinylpyrrolidone-vinyl acetate copolymer's film-forming capacity; applications in accordance with current regulations.
Advantages of E1208 Polyvinylpyrrolidone-Vinyl Acetate Copolymer:
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer has good film-forming ability and dissolves easily in water, allowing fast and uniform dispersion in formulations.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer offers a versatile application area and is especially effective in tablet coating and adhesive applications.
Film-Forming Properties:
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer has excellent film-forming properties, making it useful in various applications where the formation of thin, flexible films is desired.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer can form transparent or translucent films on surfaces.
Adhesive and Binder:
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is commonly used as an adhesive and binder in various products.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer can improve the adhesion of different materials, such as fibers, surfaces, or particles, and provide cohesive strength to the final product.
Hair Care Products:
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is widely used in hair care products, including hair sprays, gels, mousses, and styling products.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer provides hold,flexibility, and humidity resistance to hairstyles.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer can also enhance the overall manageability and appearance of the hair.
Pharmaceutical Applications:
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is utilized in pharmaceutical formulations as a binder, film former, and stabilizer.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer helps in tablet formulation by improving tablet integrity, disintegration, and controlled release properties.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer can also be used in oral suspensions and topical formulations.
Cosmetics and Personal Care Products:
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is found in various cosmetics and personal care products.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is used in makeup products, such as foundations and mascaras, to improve adhesion, wearability, and water resistance.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is also used in creams, lotions, and sunscreens to enhance texture,stability, and film-forming properties.
Industrial Applications:
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer has industrial applications as well.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is used in adhesives, coatings, inks, and paints to provide adhesion, film formation, and flexibility.
The specific properties and applications of E1208 Polyvinylpyrrolidone-vinyl acetate copolymer may vary depending on the ratio of PVP to vinyl acetate, molecular weight, and other formulation factors.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer can be customized for different requirements and performance characteristics in various industries.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer improves the strength and adhesion of the coating film and increases its application rate.
E1208 Polyvinylpyrrolidone-vinyl acetate copolymers are thermoplastic resins with molecular weights ranging from 20M to 50M.
Glass conversion temperature from 55°C to 109°C, with the increase of VP content, suction water performance increases.
Pharmaceutical grade E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is a kind of high performance film forming adhesive.
High solubility in water and a variety of organic solvents, high adhesion, at the same time has the ability of complexation.
Although its unique properties can be used in the formulation of pharmaceutical preparations and afterbirth materials, E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is currently mainly used as a tablet binder.
In general, the weight average molecular weight of the copolymer of n-vinylpyrrolidone and vinyl acetate is between 45,000 and 70,000 (K value is about 28 to 36).
On account of vinyl acetate is easy to self-polymerize in water-based system, in order to make the product colorless and transparent and improve the degree of polymerization to obtain high molecular weight copolymerization products, E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is necessary to control the reaction temperature, the concentration of initiator and chain transfer simultaneously inhibited the autoaggregation of vinyl acetate.
History of E1208 Polyvinylpyrrolidone-Vinyl Acetate Copolymer:
Historically, E1208 Polyvinylpyrrolidone-vinyl acetate copolymer was approved in the European Union after evaluations by EFSA and WHO.
EFSA established that it is not necessary to set an Acceptable Daily Intake (ADI) due to E1208 Polyvinylpyrrolidone-vinyl acetate copolymer's low absorption and toxicity.
WHO, through JECFA, also considered E1208 Polyvinylpyrrolidone-vinyl acetate copolymer safe.
Stability and Reactivity of E1208 Polyvinylpyrrolidone-Vinyl Acetate Copolymer:
Chemical stability:
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is stable under normal conditions of use, handling, and storage.
Reactivity:
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer is not expected to react dangerously under recommended conditions.
Possibility of hazardous reactions:
Hazardous polymerization or dangerous reactions are not expected during normal processing and storage.
Conditions to avoid:
Excessive heat, open flames, sparks, direct sunlight, moisture, dust formation, and unsuitable storage conditions should be avoided.
Incompatible materials:
Strong oxidizing agents, strong acids, strong bases, and highly reactive chemicals should be avoided.
Hazardous decomposition products:
Thermal decomposition or combustion may produce carbon monoxide, carbon dioxide, nitrogen oxides, and irritating fumes.
Handling and Storage of E1208 Polyvinylpyrrolidone-Vinyl Acetate Copolymer:
Handling:
E1208 Polyvinylpyrrolidone-vinyl acetate copolymer should be handled according to good industrial hygiene and safety practices.
Safe handling:
Avoid breathing dust and avoid contact with eyes, skin, and clothing.
Hygiene measures:
Wash hands thoroughly after handling and do not eat, drink, or smoke in working areas.
Storage:
Store in tightly closed containers in a cool, dry, and well-ventilated area.
Storage conditions:
Keep away from heat, moisture, direct sunlight, ignition sources, and incompatible materials.
Container requirements:
Keep containers sealed when not in use to prevent contamination and moisture absorption.
First Aid Measures of E1208 Polyvinylpyrrolidone-Vinyl Acetate Copolymer:
General advice:
Remove contaminated clothing and seek medical attention if symptoms persist.
Inhalation:
Move the person to fresh air and keep them comfortable for breathing.
Skin contact:
Wash the affected area with plenty of water and mild soap.
Eye contact:
Rinse cautiously with water for several minutes and remove contact lenses if present and easy to do.
Ingestion:
Rinse mouth with water and seek medical advice if discomfort occurs.
Firefighting Measures of E1208 Polyvinylpyrrolidone-Vinyl Acetate Copolymer:
Suitable extinguishing media:
Use water spray, dry chemical powder, carbon dioxide, or foam.
Unsuitable extinguishing media:
Do not use a strong direct water jet if E1208 Polyvinylpyrrolidone-vinyl acetate copolymer may spread dust or burning material.
Specific hazards:
Fire may produce carbon oxides, nitrogen oxides, and irritating decomposition fumes.
Protective equipment for firefighters:
Firefighters should wear self-contained breathing apparatus and full protective clothing.
Firefighting advice:
Cool exposed containers with water spray and avoid inhaling combustion products.
Accidental Release Measures of E1208 Polyvinylpyrrolidone-Vinyl Acetate Copolymer:
Personal precautions:
Avoid dust formation and avoid breathing airborne particles.
Protective equipment:
Wear safety goggles, protective gloves, and suitable protective clothing.
Emergency procedures:
Keep unnecessary personnel away and ensure adequate ventilation.
Environmental precautions:
Prevent the material from entering drains, waterways, or soil.
Methods for cleaning up:
Collect the spilled material carefully by sweeping or vacuuming without creating dust.
Disposal method:
Place collected material in a suitable labeled container and dispose of according to local regulations.
Exposure Controls / Personal Protective of E1208 Polyvinylpyrrolidone-Vinyl Acetate Copolymer:
Engineering controls:
Use adequate ventilation or local exhaust ventilation where dust may be generated.
Respiratory protection:
Use a suitable dust mask or respirator if ventilation is insufficient or dust exposure is possible.
Eye protection:
Wear safety goggles or safety glasses with side shields.
Hand protection:
Wear protective gloves suitable for chemical handling.
Skin protection:
Wear protective work clothing to prevent repeated or prolonged contact.
Hygiene controls:
Wash hands after handling and remove contaminated clothing before reuse.
Environmental exposure controls:
Avoid uncontrolled release into the environment.
Identifiers of E1208 Polyvinylpyrrolidone-Vinyl Acetate Copolymer:
Chemical Name: Vinyl Pyrrolidone/Vinyl Acetate Copolymer
CAS Number: 25086-89-9.
EC Number: 607-540-1.
Molecular Formula: (C6H9NO)n · (C4H6O2)m.
SMILES string: N1(CCCC1=O)C=C.O(C(=O)C)C=C
InChI: 1S/C6H9NO.C4H6O2/c1-2-7-5-3-4-6(7)8;1-3-6-4(2)5/h2H,1,3-5H2;3H,1H2,2H3
InChI key: FYUWIEKAVLOHSE-UHFFFAOYSA-N
Properties of E1208 Polyvinylpyrrolidone-Vinyl Acetate Copolymer:
Appearance White to light cream colored powder
Solubility Soluble in water
pH (1% solution) 4.0 – 6.5
Average Molecular Weight 45,000 – 70,000 Daltons
Molecular Weight: 45,000 – 70,000 Da
pH: 4.0 – 6.5
Appearance: White / cream colored powder
form: powder
Quality Segment: 200
mol wt: average Mw ~50,000 (GPC vs. poly(ethylene oxide))
transition temp: Tg 64 °C
density: 1.27 g/mL at 25 °C (lit.)
Specifications of E1208 Polyvinylpyrrolidone-Vinyl Acetate Copolymer:
Appearance: White powder
Nitrogen content: 7,0–8,0 %
pH: 3,0–7,0
Vinyl acetate: 42,0 %
Free vinyl acetate: 5 mg/kg
Total ash: 0,1 %
Free N-vinylpyrrolidone: 5 mg/kg
Hydrazine: 0,8 mg/kg
Peroxide: 400 mg/kg
Propane-2-ol: 150 mg/kg
As: 3 mg/kg
Pb: 2 mg/kg
Hg: 1 mg/kg
Cd: 1 mg/kg
