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CAS NUMBER: 9004-67-5
EC NUMBER: 232-674-9
MOLECULAR FORMULA: C29H54O16
MOLECULAR WEIGHT: 658.7
E461 (Methylcellulose) products are high-purity, water-soluble, non-ionic polymers designed for use as water retention aids, thickening and film-forming agents, protective colloids, suspending and emulsifying agents, binders and stabilizers.
Derived from E461 (Methylcellulose), a natural, abundant and renewable resource, HPMC products have been used for over 50 years to enhance product performance in personal care, pharmaceutical and food applications.
E461 (Methylcellulose) is available in a wide range of grades to suit all your formulation challenges.
E461 (Methylcellulose) is a bulk-forming laxative that increases the amount of water in your stools to help make them softer and easier to pass.
E461 (Methylcellulose) is used to treat constipation and to help maintain regular bowel movements.
E461 (Methylcellulose) may also be used for purposes not listed in this medication guide.
E461 (Methylcellulose) is a powder medicine that must be mixed with a full glass (8 ounces) of cold water or other liquid.
Drink all of the mixture, and then drink one more glass of water.
E461 (Methylcellulose) (or E461 (Methylcellulose)) is a chemical compound derived from cellulose.
E461 (Methylcellulose) is sold under a variety of trade names and is used as a thickener and emulsifier in various food and cosmetic products, and also as a bulk-forming laxative.
Like cellulose, E461 (Methylcellulose) is not digestible, not toxic, and not an allergen.
In 2017, E461 (Methylcellulose) was the 272nd most commonly prescribed medication in the United States, with more than one million prescriptions.
Methyl cellulose is used to treat constipation.
Effects generally occur within three days.
E461 (Methylcellulose) is taken by mouth and is recommended with sufficient water.
Side effects may include abdominal pain.
E461 (Methylcellulose) is classified as a bulk forming laxative.
E461 (Methylcellulose) works by increasing the amount of stool present which improves intestinal contractions.
E461 (Methylcellulose) is available over the counter.
E461 (Methylcellulose) is sold under the brand name Citrucel among others.
The lubricating property of methyl cellulose is of particular benefit in the treatment of dry eyes.
Solutions containing methyl cellulose or similar cellulose derivatives are used as substitute for tears or saliva if the natural production of these fluids is disturbed.
Methyl cellulose is used in the manufacture of drug capsules; its edible and nontoxic properties provide a vegetarian alternative to the use of gelatin.
Methyl cellulose is occasionally added to hair shampoos, tooth pastes and liquid soaps, to generate their characteristic thick consistency.
This is also done for foods, for example ice cream or croquette.
Methyl cellulose is also an important emulsifier, preventing the separation of two mixed liquids because it is an emulsion stabilizer.
Methyl cellulose is also used as paint rheological modifier to prevent paint sagging.
The E number of E461 (Methylcellulose) as food additive is E461.
E461 (Methylcellulose) is hydroxypropylcellulose and more soluble in water.
Methyl cellulose, as a gel, has the unique property of setting when hot and melting when cold.
Methyl cellulose is used as an ingredient in some meat analogues that are intended to replicate the texture of meat.
Methyl cellulose finds a major application as a performance additive in construction materials.
E461 (Methylcellulose) is added to mortar dry mixes to improve the mortar's properties such as workability, open and adjustment time, water retention, viscosity, adhesion to surfaces etc.
E461 (Methylcellulose) is not to be identified with food and pharmaceutical grade methyl cellulose and hydroxypropyl methyl cellulose, as it may be cross-linked with glyoxal for easy dispersion in water.
The construction materials can be cement-based or gypsum-based.
Notable examples of dry mixture mortars which utilize methyl cellulose include tile adhesives, EIFS, insulating plasters, hand-troweled and machine-sprayed plaster, stucco, self-leveling flooring, extruded cement panels, skim coats, joint & crack fillers, and tile grouts.
E461 (Methylcellulose) is about 0.2% – 0.5% of total dry powder weight for dry mixtures.
Derivatives of E461 (Methylcellulose) which improve performance characteristics include hydroxypropyl methyl cellulose (HPMC) and hydroxyethyl methyl cellulose (HEMC).
E461 (Methylcellulose)s typically improve the characteristics such as water retention, vertical surface slip resistance, open time, etc.
E461 (Methylcellulose) can be employed as a mild glue which can be washed away with water.
This may be used in the fixing of delicate pieces of art as well as in book conservation to loosen and clean off old glue from spines and bookboards.
E461 (Methylcellulose) is the main ingredient in many wallpaper pastes.
E461 (Methylcellulose) is also used as a binder in pastel crayons and also as a binder in medications.
E461 (Methylcellulose) is an FDA-approved water-soluble adhesive, has been used in various wet-adhesion applications in construction products, paints, and drug delivery for 70 years.
E461 (Methylcellulose) adheres strongly to all wet surfaces, regardless of hydrophobicity.
Methyl cellulose is also used in cell culture to study viral replication.
E461 (Methylcellulose) is dissolved in the same nutrient-containing medium in which cells are normally grown.
A single layer of cells is grown on a flat surface, then infected with a virus for a short time.
The strength of the viral sample used will determine how many cells get infected during this time.
The thick E461 (Methylcellulose) medium is then added on top of the cells in place of normal liquid medium.
As the viruses replicate in the infected cells, they are able to spread between cells whose membranes touch each other, but are trapped when they enter the methyl cellulose.
E461 (Methylcellulose)s closely neighboring an infected cell will become infected and die.
E461 (Methylcellulose) leaves small regions of dead cells called plaques in a larger background of living uninfected cells.
The number of plaques formed is determined by the strength of the original sample.
Aqueous methyl cellulose solutions have been used to slow bacterial and protozoal cell motility for closer inspection.
Changing the amount of methyl cellulose in solution permits the adjustment of the solution's viscosity.
E461 (Methylcellulose) is used in the most common approaches to quantify multiple or single lineage-committed hematopoietic progenitors, called colony-forming cells (CFCs) or colony-forming units (CFUs), in combination with culture supplements that promote their proliferation and differentiation, and allow the clonal progeny of a single progenitor cell to stay together and thus form a colony of more mature cells.
E461 (Methylcellulose) is a hydrophilic white powder in pure form and dissolves in cold (but not in hot) water, forming a clear viscous solution or gel.
E461 (Methylcellulose) is used as a buffer additive in capillary electrophoresis to control electroosmotic flow for improved separations.
E461 (Methylcellulose) does not occur naturally and is synthetically produced by heating cellulose with caustic solution (e.g. a solution of sodium hydroxide) and treating it with methyl chloride.
In the substitution reaction that follows, the hydroxyl residues (-OH functional groups) are replaced by methoxide (-OCH3 groups).
Different kinds of E461 (Methylcellulose) can be prepared depending on the number of hydroxyl groups substituted.
E461 (Methylcellulose) is a polymer consisting of numerous linked glucose molecules, each of which exposes three hydroxyl groups.
The Degree of Substitution (DS) of a given form of methyl cellulose is defined as the average number of substituted hydroxyl groups per glucose.
The theoretical maximum is thus a DS of 3.0, however more typical values are 1.3–2.6.
Different E461 (Methylcellulose) preparations can also differ in the average length of their polymer backbones.
E461 (Methylcellulose) has a lower critical solution temperature (LCST) between 40 °C and 50 °C.
At temperatures below the LCST, E461 (Methylcellulose) is readily soluble in water; above the LCST, it is not soluble, which has a paradoxical effect that heating a saturated solution of methyl cellulose will turn it solid, because methyl cellulose will precipitate out.
The temperature at which this occurs depends on DS-value, with higher DS-values giving lower solubility and lower precipitation temperatures because the polar hydroxyl groups are masked.
Preparing a solution of methyl cellulose with cold water is difficult however: as the powder comes into contact with water, a gel layer forms around it, dramatically slowing the diffusion of water into the powder; hence, the inside remains dry.
A better way is to first mix the powder with hot water, so that the methyl cellulose particles are well dispersed (and so have a much higher effective surface area) in the water, and cool down this dispersion while stirring, leading to the much more rapid dissolution of those particles.
The laxative E461 (Methylcellulose) is a synthetic modified form of cellulose.
E461 (Methylcellulose) is hydrophilic and used as a bulk-forming and stool-softening agent for treatment of constipation, for diarrhea associated with diverticulosis and irritable bowel syndrome, and in the management of patients with colostomies.
E461 (Methylcellulose) is also used in the management of obesity and is administered topically to soften hard contact lens.
Unlike ispagula and phylum, E461 (Methylcellulose) does not appear to reduce cholesterol levels.
E461 (Methylcellulose) is widely used as an emulsifier and stabilizer in the food industry.
E461 (Methylcellulose) is soluble in water (up to 55°C). This indicates slightly higher water solubility than HPC.
E461 (Methylcellulose)s aqueous solution exhibits thermal gelation properties at elevated temperatures.
A hydroalcoholic solution of MC can be prepared with polar organic solvents such as ethanol, methanol, and IPA, as long as a small amount of water (10% v/v) is added as a cosolvent.
E461 (Methylcellulose) is available in a wide range of MW grades, but almost exclusively the low MW grade with nominal viscosity of 15 cps at 2% w/v concentration is used as a tablet binder.
Although E461 (Methylcellulose) can be added as dry powder or as a solution, it generally is more effective when predissolved and added as a solution.
E461 (Methylcellulose) is a versatile binder with good plastic flow and wetting ability.
E461 (Methylcellulose) produces granulations that compress easily and tablets with moderate hardness.
Aqueous solutions of MC can be prepared in analogous fashion as described above for HPC.
E461 (Methylcellulose) is a bulk-forming laxative that increases the amount of water in your stools to help make them softer and easier to pass.
E461 (Methylcellulose) is used to treat constipation and to help maintain regular bowel movements.
E461 (Methylcellulose) may also be used for purposes not listed in this medication guide.
Methylester of cellulose. E461 (Methylcellulose) is used as an emulsifying and suspending agent in cosmetics, pharmaceutics and the chemical industry.
E461 (Methylcellulose) is used therapeutically as a bulk laxative.
Methyl cellulose is used to create semi-solid matrices, as a cell culture gel, for culture of colony forming cells such as CFU-G; CFU-GM; cells and other cells used in toxicity assays.
Low viscosity, not for plaquing assays or cloning.
Hydroxypropyl Methyl cellulose (HPMC) is non-ionic, water soluble cellulose ether which offers a variety of functional properties when dissolved in water.
E461 (Methylcellulose) can be used as thickeners, binders, surfactants, protective colloids,suspending agents and water retention agents in many construction materials.
E461 (Methylcellulose) is a laxative used to regulate bowel function.
E461 (Methylcellulose) can help manage constipation or diarrhoea.
Constipation is a common problem.
E461 (Methylcellulose) means either going to the toilet less often than usual to empty your bowels, or passing hard or painful stools.
Constipation can be caused by a number of things.
Not eating enough fibre or not drinking enough fluid can cause constipation.
Some conditions (such as pregnancy) can cause constipation, as can a lack of exercise or movement and some medicines.
When taken with a glassful of water, E461 (Methylcellulose) tablets absorb the water and swell to a soft gel consistency in your bowel.
This increases the bulk of your stools and eases constipation by encouraging your bowels to move the stools through your digestive system.
E461 (Methylcellulose) is a kind of nonionic cellulose ether prepared from cellulose, a natural macromolecule material, by a series of chemical processes.
E461 (Methylcellulose) is a white, odorless, tasteless, off-white to beige granular powder with high viscosity.
E461 (Methylcellulose) is a non-toxic white powder that can be dissolved in cold water.
E461 (Methylcellulose) has thickening, adhesion, dispersion, emulsification, film formation, suspension, adsorption, gelling, surface activity, water retention and protective colloid properties. thickener, binder, film former.
E461 (Methylcellulose), which is the most preferred in the construction chemicals industry, facilitates the making of the mortar, plays an important role in increasing work efficiency and adhesion and strength.
E461 (Methylcellulose) is widely used in construction, medicine, food, cosmetics, detergent, dyes, textile etc.
The most important feature of this chemical is that it retains water in its body.
E461 (Methylcellulose) traps a certain amount of water for a certain period of time, thus allowing the working time of the mortar to be adjusted.
By improving the consistency of the mortar, they facilitate the carding process and increase the slip resistance.
E461 (Methylcellulose) can be seen as a generic term for mixed etherification cellulose ethers.
Common to these cellulose ethers is the methoxylation. Additionally, the conversation can be achieved either with ethylene oxide or propylene oxide.
E461 (Methylcellulose) is widely used as a rheology modifier because, upon heating in aqueous solutions, MC reversibly self-assembles into ∼7–10 nm radius fibrils that percolate into a network, resulting in physical gelation.
Here, we have chemically cross-linked both MC solutions at room temperature and MC physical fibril gels at 80 °C and compared the swelling and shear modulus properties of both materials.
Thickener choices can not only impact formulation viscosity but sensorial aspects too.
Multifunctional E461 (Methylcellulose) products are nature-derived rheology modifiers that enhance the sensory experience.
E461 (Methylcellulose) is available in a wide range of grades to suit all your thickening challenges.
E461 (Methylcellulose), a natural, abundant and renewable resource, HPMC products are water-soluble, non-ionic polymers.
E461 (Methylcellulose) products are efficient thickeners and film formers that enhance foam production and foam stabilization in surfactant systems for improved foam quality that is longer lasting.
Due to its non-ionic character, E461 (Methylcellulose) is compatible with most commonly used surfactants, enabling optical clarity in formulations.
E461 (Methylcellulose) is a polysaccharide and cellulose derivative.
E461 (Methylcellulose) is present as a hydrophilic white powder with a fibrous structure, is soluble in cold water and easily digestible.
Functionally, E461 (Methylcellulose) controls the active ingredient release as a film former by embedding active ingredients or cores as a film tablet.
E461 (Methylcellulose) serves as a dry binder in the tableting process to improve compressibility, as a water-soluble binder or as a thickening and gelling agent in wet granulation.
The length and thickness of the fibres determine the functionality of the methyl cellulose.
E461 (Methylcellulose) is a bulk-forming laxative that increases the amount of water in your stools to help make them softer and easier to pass.
E461 (Methylcellulose) is used to treat constipation and to help maintain regular bowel movements.
E461 (Methylcellulose) may also be used for purposes not listed in this medication guide.
E461 (Methylcellulose) Media is a type of cell culture media used mainly for in vitro colony-forming cell (CFC) assays.
E461 (Methylcellulose) assay allows for the observation and quantification of hematopoietic progenitors based on their ability to proliferate and differentiate into colonies in semi-solid media, such as with E461 (Methylcellulose).
E461 (Methylcellulose) is derived from cellulose, is non-toxic, and forms a clear gel when dissolved in water.
Note that base E461 (Methylcellulose) media may not include the cytokines needed to activate the input cells.
Be sure to visit the manufacturer’s pages for their specific media ingredients.
E461 (Methylcellulose) is a food gum.
A derivative of cellulose, it is a non-digestible fiber and non-allergenic.
E461 (Methylcellulose) is a cellulose ether in which some of the hydroxyl groups on the cellulose back bone have been substituted with methoxy groups.
These water soluble polymers are excellent thickeners, binders, and film formers for a variety of applications including ceramic extrusion, adhesives, coatings, inks, and agrochemicals.
Solutions of E461 (Methylcellulose) will reversible gel under heat to a rigid gel structure providing a controllable boost in green strength.
E461 (Methylcellulose) ether with a methyl functional group substitution.
Methyl cellulose (MC) is a fibrous, somewhat fluffy, white powder that is used as a synthetic substitute for natural gums.
E461 (Methylcellulose) forms a highly viscous colloidal solution in cold water that reversibly gels when heated.
Methyl cellulose dries to a clear film with very little shrinkage.
E461 (Methylcellulose) has been used as a substitute for Gelatin and Glue in sizing paper and has been used as an adhesive in textile and paper conservation (Kuhn 1986).
Methyl cellulose has also been used as a poulticing material to pick up stains; as a poultice the addition of Fumed silica minimizes depth penetration while the addition of Glycerin adds flexibility.
Methyl cellulose is sometimes found as a binder in pastels and watercolor paints.
In industry, methyl cellulose is used as a lubricant, suspension aid and emulsifier.
E461 (Methylcellulose) is used in foods, leather tanning and cosmetics.
Aging studies indicate that methyl cellulose (MC) polymers have very good stability with negligible discoloration or weight loss.
E461 (Methylcellulose) ether, abbreviated MC, is a kind of long-chain substituted cellulose, in which 27% to 32% of the hydroxyl group exists in the form of methoxy.
The substitution degree affects the physical properties of methyl cellulose such as solubility.
E461 (Methylcellulose) has an average molecular weight of 10,000 to 220,000.
At room temperature, E461 (Methylcellulose) exhibits as a white powder or fibrous material, and is non-toxic, non-irritating with non-allergic effect.
E461 (Methylcellulose)s apparent relative density is 0.35 to 0.55 (with the real density being 1.26 to 1.30).
E461 (Methylcellulose) swells in water into a translucent viscous colloidal solution which is neutral to litmus, insoluble in ethanol, ether and chloroform, but soluble in glacial acetic acid.
E461 (Methylcellulose) is tolerant to the effects of acid, alkali, microorganisms, heat, and light and is also not affected by oil and grease, but will burn upon reaching ignition point.
Methyl cellulose is a product composed of cellulose glucose with all or part of three hydroxyls getting methylated.
E461 (Methylcellulose)s contain a methoxy fraction of 26% to 33% with degree of substitution being 1.7 to 2.2.
E461 (Methylcellulose) with substitution degree being 1.3 to 2.6 is soluble in water, pyridine, and acetic acid.
E461 (Methylcellulose) is widely used for architecture, such as being used as the adhesive of cement, mortar, and for mudding off the seam.
E461 (Methylcellulose) is also used for making film an adhesive in cosmetics, medicine, and food industry.
E461 (Methylcellulose) can be also used as a textile sizing agents, synthetic resin dispersing agent, paint film formers and thickeners.
E461 (Methylcellulose) is that: use pulp to produce the alkali cellulose; alkali cellulose is reacted with methyl chloride or dimethyl sulfate in an autoclave and then further refined with warm water to obtain the final product.
E461 (Methylcellulose) is widely applied in a variety of orally administrated or topical formulations; it is also widely used in cosmetics and food.
After oral administration, methyl cellulose can’t be digested or absorbed so that it is a calorie-free material.
Excessive intake of methyl cellulose may temporarily increase flatulence and even cause esophageal obstruction upon insufficient water intake.
However, methyl cellulose has a laxative effect.
E461 (Methylcellulose) is a hydrophilic colloid and is the high-viscosity cellulose derivatives.
E461 (Methylcellulose) is non-toxic and caustic, hygroscopic and can expand into a colloidal suspension in cold water.
E461 (Methylcellulose) is also insoluble in hot water, alcohol, ether, chloroform and saturated salt solution but is soluble in glacial acetic acid and the mixture of equal amount of alcohol and chloroform solution.
E461 (Methylcellulose)s solution may be agglomerated by salts, polybasic acid, phenol and tannin with adding ethanol being able to prevent this agglomeration effect.
E461 (Methylcellulose) can’t be digested, absorbed in the intestine.
E461 (Methylcellulose) can absorb moisture, mixed with water to form a large volume of hydrophilic gum, and increase the stool volume and soften it, and also stimulate the gut peristalsis to promote the defecation.
In patients with diarrhea, because the product can absorb moisture, so it reduces the intestine liquidity to take the antidiarrheal effect.
Oral administration: 1~4g/d together with taking large amounts of water as a bulk laxative for the treatment of constipation.
The product has been worked as anorectic agents for controlling appetite and inducing weight loss.
But E461 (Methylcellulose) doesn’t have a reliable effect.
Methyl cellulose can also be used as: adhesives which are suitable for choosing low or moderate viscosity grade plastic with both adding powder and solution working well.
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E461 (Methylcellulose) is used for improving drug dissolution rate or disintegration rate; the general concentration is 1% to 2%. For gels, thickening gels and creams: it is appropriate to choose high-viscosity grade.
Suspending agents and thickening agents, solutions can replace syrup; for thickening, use a concentration of up to 5%.
For Tablet coating: we can choose the high-level replacement & low viscosity product as film coating; E461 (Methylcellulose) can also be used for coating for surrounding the outer nuclear layer for isolation.
For disintegrating agents, E461 (Methylcellulose) is commonly used at a concentration of 2% to 10%.
For emulsifier, E461 (Methylcellulose) is generally recommended to use low-viscosity grade at a concentration of 1% to 5%.
For eye drops, we should use high-viscosity grade.
Methyl cellulose powder is stable and slightly hygroscopic; it should be placed in an airtight container and stored in a cool dry place.
Methyl cellulose solution is sable in diluted acid or base with pH 3 to 11 at room temperature, and is easy to be destroyed by microbes to be corrupted.
Therefore, the solution should be added into preservatives or subject to autoclaving.
After autoclaving, the change of the solution viscosity is related with pH value.
For solution of pH <4, the viscosity will decrease by more than 20% after autoclaving.
E461 (Methylcellulose) is a kind of methyl ether of cellulose.
E461 (Methylcellulose) is white or pale yellow or light gray small particles (95% through a 40 mesh sieve), filaments like or powder.
E461 (Methylcellulose) is odorless, tasteless and has hygroscopicity with an apparent density of 0.3~0.7g/mL.
When all the R in the structure is methyl, the substitution degree is equal to 3, and the methoxy content is 45.57%.
For E461 (Methylcellulose) used as the food additive, the methoxy content should be around 26%~33% which corresponds to a degree of substitution of 1.7 to 2.2.
When the substitution degree is lower than 1.3, E461 (Methylcellulose) can be dissolved in alkaline.
While E461 (Methylcellulose) with substitution degree higher than 2.6 is soluble in an organic solvent.
When the degree of substitution is less than 1.3, E461 (Methylcellulose) can be dissolved in alkali; for those with substitution degree higher than 2.6, E461 (Methylcellulose) is soluble in organic solution.
At the range between 1.3 and 2.6, it is soluble in cold water, pyridine, aniline, trimethyl formamide, benzyl alcohol and acetic acid.
Aqueous solution is stable at neutral and room temperature; but E461 (Methylcellulose) can generate gelation effect and be precipitated at high temperature.
Gelation temperature is dependent on the absolute viscosity and concentration of the solution; solution of large viscosity and high concentration has a relative low gelling temperature.
In the presence of inorganic salts, viscosity can be increased.
Due to that E461 (Methylcellulose) belongs to a non-ionic solution, the polyvalent metal is not able to precipitate E461 (Methylcellulose); Gelation will only occur when the concentration of the electrolyte and other dissolved substances exceeds a certain limit.
Aqueous solution has surfactant activity and dried to form a thin film; upon heating and cooling, it will orderly go through the reversible transition from the sol to gel.
E461 (Methylcellulose) is a gum composed of cellulose in which the meth- oxyl groups replace the hydroxyl groups.
E461 (Methylcellulose) is soluble in cold water but insoluble in hot water. solutions increase in viscosity upon heating, gel at 50–55°c, and liquefy upon cooling.
E461 (Methylcellulose) is used in baked goods for moisture retention, and in fruit pie fillings for the reduction of water absorption into the pie crust during baking.
E461 (Methylcellulose) is also used in breaded shrimp where it functions to form an oil barrier film.
As a substitute for water-soluble gums; to render paper greaseproof, in adhesives, as thickening agent in cosmetics, as protective colloid in emulsions, as binder and stabilizer in foods.
As fat replacer in the formulation of dietetic foods. Pharmaceutic aid (suspending agent).
E461 (Methylcellulose) is used as a thickener and an emulsifier in various food and cosmetic products; as a gel in advanced cookery and as a lubricant.
E461 (Methylcellulose) is also involved in the treatment of constipation.
E461 (Methylcellulose) acts as a buffer additive in capillary electrophoresis to control electoosmotic flow for improved separations.
In paper and textile industries, E461 (Methylcellulose) is used as a sizing, thereby protecting the fibers from water or oil.
E461 (Methylcellulose) is widely used in oral and topical pharmaceutical formulations;
In tablet formulations, low- or medium-viscosity grades of E461 (Methylcellulose) are used as binding agents, the E461 (Methylcellulose) being added either as a dry powder or in solution.
Highviscosity grades of E461 (Methylcellulose) may also be incorporated in tablet formulations as a disintegrant.
E461 (Methylcellulose) may be added to a tablet formulation to produce sustained-release preparations.
Tablet cores may also be spray-coated with either aqueous or organic solutions of highly substituted low-viscosity grades of E461 (Methylcellulose) to mask an unpleasant taste or to modify the release of a drug by controlling the physical nature of the granules.
E461 (Methylcellulose) coats are also used for sealing tablet cores prior to sugar coating.
Low-viscosity grades of E461 (Methylcellulose) are used to emulsify olive, peanut, and mineral oils.
They are also used as suspending or thickening agents for orally administered liquids, E461 (Methylcellulose) commonly being used in place of sugar-based syrups or other suspension bases.
E461 (Methylcellulose) delays the settling of suspensions and increases the contact time of drugs, such as antacids, in the stomach.
High-viscosity grades of E461 (Methylcellulose) are used to thicken topically applied products such as creams and gels.
In ophthalmic preparations, a 0.5–1.0% w/v solution of a highly substituted, high-viscosity grade of E461 (Methylcellulose) has been used as a vehicle for eye drops.
However, hypromellose-based formulations are now preferred for ophthalmic preparations.
E461 (Methylcellulose) is also used in injectable formulations.
Therapeutically, E461 (Methylcellulose) is used as a bulk laxative; E461 (Methylcellulose) has also been used to aid appetite control in the management of obesity, but there is little evidence supporting its efficacy.
USAGES:
E461 (Methylcellulose) is used as an additive in interior and exterior wall coating applications, tile adhesives, sheathing adhesives and plasters, thermal insulation plasters and adhesives (EIFS), repair mortars and joint fillers, exterior insulation mortar, self-leveling mortar, decorative mortar, waterproof mortars.
Thanks to its improved consistency, it provides easier spreading and sagging resistance.
E461 (Methylcellulose) can be used as thickeners; stabilizer; emulsifier; excipients; dispersant; binders; substitutes of film-forming agent hydrosol.
E461 (Methylcellulose) can also be used in mayonnaise, shortenings and some other foods.
Because of that the materials can’t digested in the body, it can maintain several times amount of water, resulting in satiety; it can be used in crackers, waffles and other food for taking effect.
For application, first 1/5 of the required amount of water for moistening the powder, together with cold water (necessary, to add ice) for mixing well.
EEC: approved for using at frozen foam products, potato chips, soft drinks, special dietary foods, baked goods filling, the top material for foaming, sauces, and sauces.
E461 (Methylcellulose) can also be used in mayonnaise, shortenings and some other foods.
Because of that the materials can’t digested in the body, it can maintain several times amount of water, resulting in satiety; it can be used in crackers, waffles and other food for taking effect.
For application, first 1/5 of the required amount of water for moistening the powder, together with cold water (necessary, to add ice) for mixing well.
EEC: approved for using at frozen foam products, potato chips, soft drinks, special dietary foods, baked goods filling, the top material for foaming, sauces, and sauces.
The product is widely used in the architecture industry such as the mixture agent for cement, plaster, and clay seams.
E461 (Methylcellulose) can also be used as adhesive film-forming agent in cosmetics, medicine, and food industry; also can be used as sizing agents for spinning, and printing and dyeing, synthetic resin dispersing agent, paint film formers and thickeners.
Methyl cellulose is a very stable material which is resistant to acid, alkalis, microorganisms, and heating.
E461 (Methylcellulose) can be excrete out from the human body without any change.
E461 (Methylcellulose) is used for synthetic resin dispersing agent, film-forming agent of painting, thickener, binder materials, textile sizing agent, and the film-forming agent in the pharmaceutical and food industries.
-efficient thickening builds viscosity to provide a rich, luxurious texture
-enhances foam production and foam stability for improved foam quality that is longer lasting
-helps to promote stability in emulsions
-nature-derived from cellulose
-excellent surfactant compatibility enabling clear formulations
APPLICATIONS:
-shampoos, including sulfate free and low surfactant style formulations
-clear and emulsion type conditioners
-styling gels
-facial cleansers
-liquid hand soaps
-hand sanitizers
-bar soaps
-bath additives
-shaving creams and gels
BENEFITS:
-E461 (Methylcellulose) modified cellulose is a unique grade of modified cellulose
-creates a thermo-reversible gel with good binding characteristics
-gels at lower temperature (40oC) than other grades of modified cellulose
-suitable for vegan applications
-stabilizes fat and water to retain moisture in finished product
-functions with a variety of vegetable based fats and oils
-facilitates formula and cost flexibility
ADVANTAGES:
-Improved adhesivestrength and flexibility, reducing the risk of splitting under expansion and contraction
-Good water retention and extended working time
-Optimized product consistency and rheology
-Improved adhesion and sliding resistance
FUNCTION:
-Thickener
-Gelling agent
-Emulsifier
-Texturizing agent
PROPERTIES:
-Quality Level: 200
-biological source: synthetic (organic)
-product line: BioReagent
-form: powder
-technique(s): cell culture | mammalian: suitable
-viscosity: 12-18 cP, 2 % in H2O(20 °C)
-solubility: water: 50 mg/mL, clear to hazy
-SMILES string: [*]OC[C@H]1O[C@@H](O[C@@H]2[C@@H](CO[*])O[C@@H](O[*])[C@H](O[*])[C@H]2O[*])[C@H](O[*])[C@@H](O[*])[C@@H]1O[*]
-Inchi Key: YLGXILFCIXHCMC-JHGZEJCSSA-N
SPECIFICATIONS:
-Appearance: white or off-white powder
-Moisture: ≤5 %
-Ash: ≤5 %
-Methoxy content: 19-24 %
-Hydroxypropyl content: 412 %
-pH value: 6-8
-Viscosity: 400-75,000 mPa.s (Brookfield RV, 2%)
CHEMICAL PROPERTIES:
E461 (Methylcellulose) occurs as a white, fibrous powder or granules.
E461 (Methylcellulose) is practically odorless and tasteless.
E461 (Methylcellulose) should be labeled to indicate its viscosity type (viscosity of a 1 in 50 solution).
SYNONYM:
Methylcellulosum
Cellulose methyl
Cellulose methylate
methylated cellulose
Cellulose methyl ether
CHEBI:53448
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