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E959 (Neohesperidine DC)

E959 (Neohesperidine DC) = 1-[4-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)propan-1-one

CAS Number : 20702-77-6 
EC  Number : 243-978-6
PubChem CID : 30231
ECHA InfoCard     : 100.039.965 
ChemSpider       : 28072 
Chemical formula : C28H36O15
Molar mass     : 612.58 g/mol

E959 (Neohesperidine DC), sometimes abbreviated to neohesperidin DC or simply NHDC, is an artificial sweetener derived from citrus.
E959 (Neohesperidine DC) is particularly effective in masking the bitter tastes of other compounds found in citrus, including limonin and naringin. 
Industrially, E959 (Neohesperidine DC) is produced by extracting neohesperidin from the bitter orange, and then hydrogenating this to make NHDC.

Discovery of E959 (Neohesperidine DC)
E959 (Neohesperidine DC) was discovered during the 1960s as part of a United States Department of Agriculture research program to find methods for minimizing the taste of bitter flavorants in citrus juices. 
Neohesperidin is one such bitter compound. 
When treated with potassium hydroxide or another strong base, and then catalytically hydrogenated, it becomes E959 (Neohesperidine DC).

Profile of E959 (Neohesperidine DC)
E959 (Neohesperidine DC) in pure form is found as a white substance not unlike powdered sugar. 
E959 (Neohesperidine DC) has an intense sweet taste because it stimulates the sweet receptor TAS1R2+TAS1R3 in humans, although this is species-dependent, as the equivalent receptor in rats does not respond to the molecule.

E959 (Neohesperidine DC) is roughly 1500-1800 times sweeter than sugar at threshold concentrations; around 340 times sweeter than sugar. 
E959 (Neohesperidine DC)s potency is naturally affected by such factors as the application in which E959 (Neohesperidine DC) is used, and the pH of the product.
Like other highly sweet glycosides, such as glycyrrhizin and those found in stevia, NHDC's sweet taste has a slower onset than sugar's and lingers in the mouth for some time.
Unlike aspartame, E959 (Neohesperidine DC) is stable to elevated temperatures and to acidic or basic conditions, and so can be used in applications that require a long shelf life. 

E959 (Neohesperidine DC) itself can stay foodsafe for up to five years when stored in optimal conditions.
The product is well known for having a strong synergistic effect when used in conjunction with other artificial sweeteners such as aspartame, saccharin, acesulfame potassium, and cyclamate, as well as sugar alcohols such as xylitol. 
E959 (Neohesperidine DC) usage boosts the effects of these sweeteners at lower concentrations than would otherwise be required; smaller amounts of other sweeteners are needed. 
This provides a cost benefit.

Approval and safety of E959 (Neohesperidine DC)
E959 (Neohesperidine DC) is approved in the European Union as sweetener (E-959) since 1994, as well as flavouring . 
E959 (Neohesperidine DC) is also listed as a Generally Recognized as Safe flavour enhancer by the Flavour and Extract Manufacturers' Association.

In November 2020, the FDA issued a no objection letter to the Generally Recognized as Safe status of Neohesperidin dihydrochalcone (NHDC). 
FDA concluded that NHDC is GRAS (based on scientific procedures) for its intended use. 
E959 (Neohesperidine DC) is intended to be used as a sweetener in various food categories at maximum levels of 10-1000 ppm.

E959 (Neohesperidine DC) is also included both in European Pharmacopoeia and United States Pharmacopoeia, for being used as excipient in drug products.
The safety of E959 (Neohesperidine DC) has been extensively tested.
Safety studies have indicated that E959 (Neohesperidine DC) is neither toxic, mutagenic nor carcinogenic.
Like other flavonoids, E959 (Neohesperidine DC) is easily metabolized by intestinal microbiota to innocuous products.

Uses of E959 (Neohesperidine DC)
In food E959 (Neohesperidine DC) is used as a flavour enhancer in concentrations of around 4-5 parts per million (ppm) and as an artificial sweetener at around 15-20 ppm.

Masking
Pharmaceutical companies are fond of the product as a means of reducing the bitterness of pharmacological drugs in tablet form, and E959 (Neohesperidine DC) has been used for livestock feed as a means of reducing feeding time. 
E959 (Neohesperidine DC) is also widely favoured for use in otherwise naturally bitter products.

Enhancer
As a flavour enhancer, E959 (Neohesperidine DC) is used in a wide range of products and is indicated by the E number E 959. 
E959 (Neohesperidine DC) is noted particularly for enhancing sensory effects (known in the industry as 'mouth feel'). 
An example of this is 'creaminess' in dairy foods such as yogurt and ice cream.

Other uses
Other products E959 (Neohesperidine DC) can be found in may include a wide variety of beverages, alcoholic and non-alcoholic, savoury foods, toothpaste, mouthwash and condiments such as ketchup and mayonnaise. 
E959 (Neohesperidine DC) is also used as excipient in drug products to mask the bitter taste of some active pharmaceutical ingredients.

E959 (Neohesperidine DC) appears as off-white crystals or powder. 
E959 (Neohesperidine DC) is insoluble in water.
Neohesperidin dihydrochalcone is a member of the dihydrochalcones that is 3,2',4',6'-tetrahydroxy-4-methoxydihydrochalcone attached to a neohesperidosyl residue at position 4' via glycosidic linkage. 
E959 (Neohesperidine DC) is found in sweet orange. 
E959 (Neohesperidine DC) has a role as an environmental contaminant, a xenobiotic, a plant metabolite and a sweetening agent. 
E959 (Neohesperidine DC) is a neohesperidoside, a disaccharide derivative and a member of dihydrochalcones.

E959 (Neohesperidine DC) is an artificial sweetener.
E959 (Neohesperidine DC) has been used in a study to assess levels of nine high-intensity sweeteners in various foods. 
E959 (Neohesperidine DC) can be used as a therapeutic agent on reactive oxygen species-related inflammatory disease.
E959 (Neohesperidine DC) is an artificial sweetener derived from citrus.

Like other highly sweet glycosides, such as glycyrrhizin and those found in stevia, E959 (Neohesperidine DC)'s sweet taste has a slower onset than sugar's and lingers in the mouth for some time. 
Unlike aspartame, E959 (Neohesperidine DC) is stable to elevated temperatures and to acidic or basic conditions, and so can be used in applications that require a long shelf life.
Industrially, E959 (Neohesperidine DC) is produced by extracting neohesperidin from the bitter orange, and then hydrogenating this to make E959 (Neohesperidine DC).

E959 (Neohesperidine DC) is an intense non-nutritive sweetener derived from neohesperidin, a naturally occurring bitter-tasting flavanone from citrus fruit. 
Although E959 (Neohesperidine DC)s relative sweetness diminishes rapidly with increasing concentration, at a sweetness level equivalent to 5% sucrose, E959 (Neohesperidine DC) is about 250 times as sweet as sucrose.
Like other highly sweet glycosides, such as glycyrrhizin, neohesperidin DC exhibits a long-lasting sweetness at high concentrations, associated with a licorice-like aftertaste and E959 (Neohesperidine DC) has an apparent synergism with citric acid (Leffingwell, 2004). 
E959 (Neohesperidine DC) has not been approved as a sweetener in the United States, although E959 (Neohesperidine DC) is considered GRAS as a flavour enhancer.

Neohesperidin dihydrochalcone, also named Neohesperidin DC, is an intensive sweetener produced from neohesperidin.
Neohesperidin DC is considered an intense and non-nutritive sweetener, with a pleasant taste and with the ability to improve the quality and sweetness profile in different food formulations.
Neohesperidin DC is a flavonoid present naturally in citrus, mainly in the bitter Seville orange (Citrus aurantium). 

Neohesperidin is found mainly in the peels of citrus fruits, but they are also found in:
-Citrus pulps
-Citrus purees
-Citrus juice

Neohesperidin DC ("NHDC" for short hereinafter) is a low-calorie sweetener derived from neohesperidin, a flavonone extracted from citrus fruit, with a sweetness of 1500 to 1800 times as that as sucrose.  
Neohesperidin DC could also be used as off-notes blocker or flavor enhancer in dietary supplements and feed additives, to reduce bitterness or other off-notes of animal feed, or improve taste profiles of certain foods and drinks. 
Neohesperidin DC could be applied to formulations of candy, chewing gum, yoghurt, beverage, dessert, ice cream, toothpaste, pharmaceutical and nutraceutical products,  in combination with other sweeteners, to obtain synergistic effects. 

Applications of Neohesperidin DC

Beverages:
Juice, milk and derivatives, water based flavoured drinks, alcoholic drinks (beer, etc.).

Desserts and related products:
Chocolate based products, dry fruits, spreads, marmalades, jams, jelly, yoghourt, sweets, chewing-gum, cider, ice-cream, fruit preserves, sauces, bakery, low calorie food.

Savory products:
Paté, sauces and condiments, seasonings, mayonnaise, soups, fish and meat preserves. 
At very low levels (1-5 ppm) it enhances the food flavour profile.

Cosmetics:
Tooth-paste, mouth-wash.

Pharmaceutical products:
Neohesperidin DC attenuates bitter taste in drug formulations.

Feedstuffs:
Improve feed taste and therefore increase daily feed intake with reduced feeding time.

NEOHESPERIDIN DC, (NHDC) has the feature of preventing bitter taste and is used as a sweetener because Neohesperidin DC has an intensely sweet structure. 
Neohesperidin DC has 1500-1800 times more sweetening properties than sugar.
Like other glycosides used as a high sweetener, Neohesperidin DC causes a slower but more persistent aftertaste release in the mouth. 
Unlike aspartame, Neohesperidin DC maintains its stability at high temperatures, acidic and basic environments, and therefore can be used comfortably in applications requiring high shelf life. 

Neohesperidin DC preserves its structure in the product for up to 5 years when stored under appropriate conditions.
Neohesperidin DC, defined by the code E959, is used as a flavor enhancer in many products. 
Neohesperidin DC is used especially in foods to increase the sensory feeling in the mouth. 
For example, Neohesperidin DC is used to create a creamy consistency in dairy products such as yogurt and ice cream.

Neohesperidine dihydrochalcone or NHDC is an artificial sweetener derived from neo hesperidin, a bitter orange and citrus fruits component. 
Neohesperidin DC is s developed in around 1960 by the United States Department of Agriculture research. 
Neohesperidin DC is around 340 times sweeter than sugar by weight. 
Neohesperidin DC is majorly used as the flavor enhancer i.e. flavonoid and is a white to pale yellow, odorless substance.

Neohesperidin DC is thermo stable and is used in wide industrial applications such as dairy products, and drinks. 
The neo hesperidin DC, when added, increases the fruitiness or flavoring characteristics of the food. 
The approvals as a flavor enhancer or a flavor modifier exist in Europe, United States, Japan, and other regions. 

Neohesperidin DC was discovered during the 1960s as part of a United States Department of Agriculture research program to find methods for minimizing the taste of bitter flavorants in citrus juices. 
Neohesperidin is one such bitter compound. 
When treated with potassium hydroxide or another strong base, and then catalytically hydrogenated, it becomes Neohesperidin DC, a compound roughly 1500-1800 times sweeter than sugar at threshold concentrations; around 340 times sweeter than sugar weight-for-weight. 
Its potency is naturally affected by such factors as the application Neohesperidin DC is used for, and the pH of the product.

Like other highly sweet glycosides, such as glycyrrhizin (from the licorice root) and those found in stevia, Neohesperidin DC's sweet taste has a slower onset than sugar's and lingers in the mouth for some time. 
Unlike aspartame, Neohesperidin DC is stable to elevated temperatures and to acidic or basic conditions, and so can be used in applications that require a long shelf life. 
Neohesperidin DC itself can stay foodsafe for up to five years when stored in optimal conditions.

Neohesperidin DC Food is an off white crystalline powder having a characteristic intense sweet taste. 
Neohesperidin DC is freely soluble in hot water, very slightly soluble in cold water and practically insoluble in ether and benzene. 
Neohesperidin DC is used as a sugar substitute or sweetener.

E959 (Neohesperidine DC) (INS 959, E 959) is a low-calorie sweetener and flavour enhancer which may be produced by hydrogenation of neohesperidine, a flavonoid occurring naturally in bitter
oranges. 
E959 (Neohesperidine DC) is 1500-1800 times sweeter than sucrose at threshold levels. 
At practical use levels, E959 (Neohesperidine DC) is about 400-600 times as sweet as sucrose.
E959 (Neohesperidine DC) is a flavonoid dihydrochalcone. 
While E959 (Neohesperidine DC) has not yet been found in nature, structurally related flavonoids and their corresponding dihydrochalcones occur naturally in many plants. 
Ingested, E959 (Neohesperidine DC) is metabolised by the intestinal flora, yielding the same or similar breakdown products as its naturally occurring analogues.

Neohesperidin dihydrochalcone (NHDC) is an intensive sweetener, derived from citrus by alkaline hydrogenation of neohesperidin.
Neohesperidin dihydrochalcone is non-caloric sweetener, it isup to 1000 times as sweet as sucrose.
Neohesperidin dihydrochalcone is found in sweet orange. 
Intensely sweet, 612 times more sweet than sucrose. 

Acceptable daily intake: 5 mg/kg (1987). 
Neohesperidin dihydrochalcone is a permitted in EU at low concs. (=10 ppm) for certain applications, e.g. low-alcohol beer. 
Generally recognised as safe (GRAS) in the USA. 
Practical use limited by slow development of taste sensation and peculiar aftertaste Neohesperidin dihydrochalcone, sometimes abbreviated to neohesperidin DC or simply NHDC, is an artificial sweetener derived from citrus. 

The European Union approved Neohesperidin dihydrochalcone's use as a sweetener in 1994. 
Neohesperidin dihydrochalcone has not been approved as a sweetener in the United States. 
Neohesperidin dihydrochalcone is sometimes said that Neohesperidin dihydrochalcone is considered a Generally Recognized as Safe flavour enhancer by the Flavour and Extract Manufacturers' Association, which is a trade group with no legal standing. 
Neohesperidin dihydrochalcone has never appeared on the FDA's GRAS listing.

Neohesperidin dihydrochalcone, sometimes abbreviated to neohesperidin DC or simply NHDC, is an artificial sweetener derived from citrus. 
It is particularly effective in masking the bitter tastes of other compounds found in citrus, including limonin and naringin. 
Industrially, it is produced by extracting neohesperidin from the bitter orange, and then hydrogenating this to make NHDC.

Benefits of Neohesperidin Dihydrochalcone
Without a doubt, this sweetener is of especially great benefit to those suffering from diabetes. 
According to experts, the food additive Е959 does not raise blood sugar levels in the body and because of this, people who are sensitive to regular sugar can eat sweets containing it without worry.
The compound is also useful for those who are trying to shed some extra pounds; it is used in the production of low-calorie/diet food products.

By consuming neohesperidin dihydrochalcone (which is currently being used with a relatively decent reputation) we can avoid other dangerous sugar substitutes such as cyclamate (E952), acesulfame K (E950), aspartame (Е951) and saccharin (E954).
For years now they have been associated with unpleasant side effects, including nausea, dizziness, loss of appetite, headache, blisters, impaired vision and many other issues.

Neohesperidin dihydrochalcone is a compound extracted from citruses and is used as a sweetener. 
Neohesperidin dihydrochalcone is known by other names, including neohesperidin DC or simply NHDC. 
The compound is also used as a food additive known as Е959. 
Neohesperidin dihydrochalcone is quickly absorbed by the human body.

On its own the substance is a white powder, odorless, with an expressed sweet taste. 
Upon consumption it leaves behind a light minty sensation. 
This food additive is many times sweeter than sucrose. 
Neohesperidin dihydrochalcone has very stable physical properties. 
Its boiling point varies between 310°F (152°C) and 310°F (154°C).

E959 (Neohesperidine DC) can be stored in the form of solutions, powders and food products. 
The compound dissolves well in hot water. 
E959 (Neohesperidine DC) has a medium solubility level in cool water. 
E959 (Neohesperidine DC) does not dissolve in lipid solvents.

Naturally, neohesperidin dihydrochalcone is found in a substance found in grapefruits. 
Even though its primary source is a natural product, NHDC is not considered a completely harmless sweetener in every country.
Neohesperidin dihydrochalcone is mostly used in the food industry as a sweetener, as well as a way to highlight a particular taste. 
Frequently, this sweetener is combined with others, among which are aspartame, sucralose and acesulfame potassium.

As a food additive, Е959 is found in a wide range of food products where crystallized sugar is absent for one reason or another. 
E959 (Neohesperidine DC) is primarily put into milk, cream, ice creams and all kinds of other dairy products. 
E959 (Neohesperidine DC) is found in different sauces, such as mayonnaise, ketchup and mustard. 
E959 (Neohesperidine DC) is used in the production of salami, sausages and others.

E959 (Neohesperidine DC) is present in gum, chewable candy, lollipops, breath mints, jelly bonbons, dried fruits, jams, jellies, purees. 
E959 (Neohesperidine DC) can be found in sandwiches, snacks, cereals, wafers, biscuits and all kinds of baked goods.
Manufacturers put neohesperidin dihydrochalcone in mousses, creams and puddings as well. 
One may also come across this sweetener in shakes, juices, nectars, sodas, liqueurs, beer, canned fish, marinades for seafood preservation, mixed pickles, chutneys, compotes and even weight loss food products.

The applications of neohesperidine dihydrochalcone do not end here. 
The compound is found in some cosmetic products as well. 
You can see it listed in toothpaste and mouthwash ingredients.
Food additive Е959 is used in the pharmaceutical industry as well - in cough syrups, vitamin complexes, lozenges and more.

The sweetness of E959 (Neohesperidine DC) is 1500-1800 times higher than sucrose and 20 times higher than saccharin. 
E959 (Neohesperidine DC) has high sweetness, good taste, non-toxic and harmless, and has a synergistic effect on other sweeteners or sweetening agents. 
E959 (Neohesperidine DC) has a refreshing taste and a lasting aftertaste. 

After use, no unpleasant feeling of saccharin or stevioside. 
More praiseworthy E959 (Neohesperidine DC) has an excellent taste-enhancing effect, and the sweetness period is a little later and longer-lasting, so E959 (Neohesperidine DC) is used together with other sweeteners as a unique additive, often used with food and beverage improvement, enhancement and overall improvement of taste, E959 (Neohesperidine DC) also has an excellent effect of keeping the pain away.


First Aid Measures of E959 (Neohesperidine DC)

EYES: 
First check the victim for contact lenses and remove if present. 
Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. 
Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. 
IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: 
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. 
Gently wash all affected skin areas thoroughly with soap and water. 
If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: 
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. 
If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. 
Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: 
DO NOT INDUCE VOMITING. 
If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. 
Be prepared to transport the victim to a hospital if advised by a physician. 
If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. 
DO NOT INDUCE VOMITING. 
IMMEDIATELY transport the victim to a hospital.


Substance identity

EC / List no.: 243-978-6
CAS no.: 20702-77-6
Mol. formula: C28H36O15

Hazard classification & labelling of E959 (Neohesperidine DC)
According to the notifications provided by companies to ECHA in REACH registrations no hazards have been classified.

About E959 (Neohesperidine DC)
E959 (Neohesperidine DC) is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 to < 10 tonnes per annum.
E959 (Neohesperidine DC) is used by consumers, by professional workers (widespread uses), in formulation or re-packing and in manufacturing.

Consumer Uses of E959 (Neohesperidine DC)
E959 (Neohesperidine DC) is used in the following products: cosmetics and personal care products.
Other release to the environment of E959 (Neohesperidine DC) is likely to occur from: indoor use as processing aid.

Article service life of E959 (Neohesperidine DC)
ECHA has no public registered data on the routes by which E959 (Neohesperidine DC) is most likely to be released to the environment. 
ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

Widespread uses by professional workers of E959 (Neohesperidine DC)
E959 (Neohesperidine DC) is used in the following products: cosmetics and personal care products.
ECHA has no public registered data on the types of manufacture using E959 (Neohesperidine DC). 
Other release to the environment of E959 (Neohesperidine DC) is likely to occur from: indoor use as processing aid.

Formulation or re-packing of E959 (Neohesperidine DC)
E959 (Neohesperidine DC) is used in the following products: cosmetics and personal care products. 
Release to the environment of E959 (Neohesperidine DC) can occur from industrial use: formulation of mixtures.

Uses at industrial sites of E959 (Neohesperidine DC)
ECHA has no public registered data indicating whether or in which chemical products the substance might be used. 
ECHA has no public registered data on the types of manufacture using E959 (Neohesperidine DC). 
ECHA has no public registered data on the routes by which E959 (Neohesperidine DC) is most likely to be released to the environment.

Manufacture of E959 (Neohesperidine DC)
Release to the environment of E959 (Neohesperidine DC) can occur from industrial use: manufacturing of the substance.


Synonyms:
neohesperidin dihydrochalcone
20702-77-6
Nhdc
Neohesperidin dc
Neohesperidin dhc
Neohesperidine dihydrochalcone
Neohesperidine
Neosperidin dihydrochalcone
NCI-C60764
UNII-3X476D83QV
Neohesperidin-dihydrochalcone
1-[4-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)propan-1-one
CHEBI:83535
3X476D83QV
1-(4-((2-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)propan-1-one
1-Propanone, 1-[4-[[2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-
1-(4-(((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)propan-1-one
1-Propanone, 1-(4-((2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)-
CCRIS 4848
EINECS 243-978-6
Neohesperidin Dihydrochalcone (Nhdc)
C28H36O15
Neosperidin-dihydrochalcone
DSSTox_CID_5706
neohesperidin dihydrochalone
DSSTox_RID_77887
DSSTox_GSID_25706
1-(4-((2-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)-
1-Propanone, 1-(4-((2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-me
3,5-Dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl) 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside
Glucopyranoside, 3,5-dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-, beta-D-
SCHEMBL909958
CHEMBL1159645
DTXSID3025706
ITVGXXMINPYUHD-CUVHLRMHSA-
HMS3884H13
HY-N0154
ZINC4175639
Tox21_200303
MFCD00017711
s2331
1-(4-((2-O-[6-Deoxy-&alpha
AKOS015895239
CCG-270237
CS-6419
NCGC00091109-01
NCGC00091109-02
NCGC00091109-04
NCGC00257857-01
3,5-dihydroxy-4-[3-(3-hydroxy-4-methoxyphenyl)propanoyl]phenyl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside
AC-34860
AS-15190
Glucopyranoside, 3,5-dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl-2-O-(6-deoxy-alpha-L-mannopyranosyl)-, beta-D-
O413
Neohesperidin dihydrochalcone, >=96%, FG
CAS-20702-77-6
N0675
Neohesperidin dihydrochalcone, >=95% (HPLC)
Neohesperidin dihydrochalcone, analytical standard
702N776
A814825
Q424595
SR-01000883756
Q-201457
SR-01000883756-1
BRD-K61032563-001-02-9
Neohesperidin dihydrochalcone, European Pharmacopoeia (EP) Reference Standard
Neohesperidin dihydrochalcone, United States Pharmacopeia (USP) Reference Standard
1-(4-((2-O-[6-Deoxy-alpha-L-mannopyranosyl]-beta-D-glucopyranosyl)oxy)-2,6-dihydroxyphenyl)-3-[3-hydroxy-4-methoxyphenyl]-1-propanone
1-(4-((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yloxy)tetrahydro-2H-pyran-2-yloxy)-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)propan-1-one
1-[4-[(2S,3R,4R,5R,6S)-4,5-dihydroxy-6-methyl-2-[(2R,3R,4S,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]oxy-tetrahydropyran-3-yl]oxy-2,6-dihydroxy-phenyl]-3-(3-hydroxy-4-methoxy-phenyl)propan-1-one
1-[4-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5
1-[4-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxy-tetrahydropyran-2-yl]oxy-2,6-dihydroxy-phenyl]-3-(3-hydroxy-4-methoxy-phenyl)propan-1-one
1-[4-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)propan-1-one
1-[4-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)propan-1-one
1-(4-{[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-2,6-dihydroxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)propan-1-one
1-[4-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)propan-1-one
1-[4-[[2-O-(6-DEOXY-α-L-MANNOPYRANOSYL)-β-D-GLUCOPYRANOSYL]OXY]-2,6-DIHYDROXYPHENYL]-3-(3-HYDROXY-4-METHOXYPHENYL)PROPAN-1-ONE
3,5-dihydroxy-4-[3-(3-hydroxy-4-methoxyphenyl)propanoyl]phenyl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside
20702-77-6

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