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Description
EDTA 4Na 40% refers to a solution of Disodium Ethylenediaminetetraacetate (EDTA 4Na) in water, where the concentration of EDTA 4Na is 40% by weight.
EDTA is a versatile chelating agent used to bind and remove metal ions from various environments.
Cas Number
6381-92-6
Synonyms
EDTA disodium salt,Disodium ethylenediaminetetraacetate,Ethylenediaminetetraacetic acid disodium salt,EDTA disodium,EDTA 4Na,Sodium ethylenediaminetetraacetate
EDTA 4Na is a synthetic compound derived from ethylenediaminetetraacetic acid (EDTA), a polyamino carboxylic acid.
It is widely recognized for its ability to chelate (bind) metal ions, making it invaluable in industries ranging from pharmaceuticals to agriculture.
The 40% concentration refers to an aqueous solution containing 40% EDTA 4Na by weight, which is commonly used for its ease of handling and consistent performance.
Chemical Properties
Chemical Structure:
EDTA 4Na has four sodium ions associated with the EDTA molecule, making it highly water-soluble.
The molecule consists of a central ethylenediamine backbone with four carboxylate groups (-COO⁻) attached.
Physical Properties:
Appearance: In its solid form, it is a white crystalline powder. In a 40% solution, it appears as a clear, colorless liquid.
Solubility: Highly soluble in water, with limited solubility in organic solvents.
pH: The 40% solution is alkaline, typically with a pH of 11–12, due to the presence of sodium ions.
Chelating Capacity:
EDTA 4Na forms stable, water-soluble complexes with metal ions such as Ca²⁺, Mg²⁺, Fe²⁺/Fe³⁺, Cu²⁺, and Zn²⁺.
The stability constants of these complexes vary depending on the metal ion, with higher constants indicating stronger binding.
Thermal Stability:
Stable under normal temperatures but may decompose at high temperatures (above 150°C), releasing carbon dioxide and nitrogen oxides.
Mechanism of Action
Chelation Process:
EDTA 4Na acts as a hexadentate ligand, meaning it can form six bonds with a single metal ion.
The two nitrogen atoms and four oxygen atoms from the carboxylate groups coordinate with the metal ion, forming a stable ring-like structure.
Applications of Chelation:
Sequestration: Prevents metal ions from participating in chemical reactions, such as oxidation or precipitation.
Detoxification: Binds toxic metal ions (e.g., lead, mercury) and facilitates their removal from biological systems.
Stabilization: Protects formulations from metal-catalyzed degradation.
Applications
Industrial Cleaning:
Water Softening: EDTA 4Na is added to detergents to bind calcium and magnesium ions, preventing the formation of insoluble salts (scale).
Boiler and Cooling Systems: Prevents scale buildup, improving efficiency and longevity of equipment.
Metal Cleaning: Removes metal oxides and rust from surfaces.
Pharmaceuticals:
Anticoagulant: Used in blood collection tubes to chelate calcium ions, preventing blood clotting.
Stabilizer: Prevents metal-catalyzed degradation of active pharmaceutical ingredients (APIs).
Heavy Metal Poisoning Treatment: Administered as a chelating agent to remove toxic metals like lead and mercury.
Cosmetics:
Preservative: Enhances the shelf life of products by chelating metal ions that promote microbial growth.
Stabilizer: Prevents discoloration and rancidity in oils and emulsions.
Hair Care: Improves the performance of shampoos and conditioners by softening water.
Food Industry:
Preservative: Extends the shelf life of canned foods, dressings, and beverages by preventing oxidation.
Color Retention: Maintains the color of fruits and vegetables by chelating metal ions that cause browning.
Flavor Protection: Prevents off-flavors caused by metal-catalyzed reactions.
Agriculture:
Micronutrient Delivery: Used in fertilizers to provide essential metals (e.g., iron, zinc) in a bioavailable form.
Soil Remediation: Helps remove heavy metals from contaminated soils.
Laboratory and Research:
Buffer Component: Used in molecular biology to maintain metal-free conditions in experiments.
Cell Culture: Prevents metal-induced toxicity in cell culture media.
Analytical Chemistry: Used as a titrant in complexometric titrations to determine metal ion concentrations.
SAFETY INFORMATION ABOUT EDTA 4Na 40%
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:
If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.
In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.
If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.
Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas
Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.
Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.
Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.
Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.
Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials
Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.
Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.
If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.
Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.
