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EDTA Tetrasodium, known as Tetrasodium EDTA or Ethylenediaminetetraacetic Acid Tetrasodium Salt in Turkish, is a strong chelating agent with high solubility in water, in which the four carboxylic acid protons of EDTA are neutralized by sodium ions. CAS No 64-02-8 is used for the anhydrate form, and the basic chemical formula is C₁₀H₁₂N₂Na₄O₈.
The main technical function of EDTA Tetrasodium is to bind polyvalent metal ions such as calcium, magnesium, iron, copper, manganese and zinc in coordination complexes. Thus, free metal ions can be limited from causing hardness, color change, precipitation, oxidation, loss of surfactant performance or other undesirable reactions in the formulation.
EDTA Tetrasodium is used as a chelating agent in cosmetics and personal care products, especially in shampoo, liquid soap, shower gel, facial cleansing product, conditioner and different water-based formulations. In European cosmetic ingredient sources, the name INCI is defined as TETRASODIUM EDTA and its main function is to support product stability by complexing metal ions.
EDTA Tetrasodium is also an important auxiliary raw material in the cleaning and detergent industry. By binding calcium and magnesium ions in hard water, it can support the performance of surfactant systems, reduce the formation of mineral residues, and help control metal ions in alkaline cleaners.
EDTA Tetrasodium's high water solubility makes it particularly practical in liquid formulations. A water solubility of about 500 g/L at 20 °C has been reported for the anhydrate tetrasodium EDTA in GESTIS data; commercial liquid products, on the other hand, can also be sold as ready-made solutions containing about 38–40% active ingredients.
EDTA Tetrasodium is more alkaline than EDTA's disodium salt. For example, in Nouryon's Dissolvine 100-S tetrasodium EDTA solution, which contains approximately 38% actives, the pH of 1% w/v aqueous dilution is given as 11.0–11.8. For this reason, it can be used especially in alkaline or near-neutral cleaning and personal care systems.
EDTA Tetrasodium should not be considered as an antimicrobial preservative alone. Its binding of metal ions may support the performance of some preservative systems and reduce metal-catalyzed degradation; however, the appropriate preservative system for microbiological preservation of the formulation should be designed separately.
An important technical distinction of EDTA Tetrasodium is between the anhydrate and hydrated forms. The anhydrate tetrasodium EDTA CAS 64-02-8 has a molecular weight of approximately 380.17 g/mol, while tetrasodium EDTA tetrahydrate CAS 13235-36-4 has a molecular weight of approximately 452.23 g/mol.
For this reason, no two products provide the same active EDTA equivalent in the same gram amount. It is important that a formulation or purchase specification clearly states the anhydrate, tetrahydrate, or commercial aqueous solution rather than just writing "Tetrasodium EDTA".
When purchasing EDTA Tetrasodium, assay, chelating capacity, hydrate form, pH, color, NTA content, heavy metal and trace metal impurities, physical form, and current COA information should be evaluated together according to the target application.
WHAT IS EDTA TETRASODIUM?
EDTA Tetrasodium is the tetrasodium salt of Ethylenediaminetetraacetic Acid, i.e. EDTA. EDTA has four carboxylic acid groups in its molecule. In tetrasodium form, these four acidic protons have been replaced by sodium ions. Thus, the highly negatively charged ethylenediaminetetraacetate ion and four sodium counter-ions are formed. The molecular formula of the anhydrate tetrasodium EDTA is C₁₀H₁₂N₂Na₄O₈. Its molecular weight is approximately 380.17 g/mol, CAS No is 64-02-8, EC/EINECS No is 200-573-9, PubChem CID is 6144.
In the tetrahydrate form, the same chelating ion exists with four crystalline water molecules.
Tetrasodium EDTA tetrahydrate formula is C₁₀H₂₀N₂Na₄O₁₂, Molecular weight is about 452.23 g/mol, CAS No is 13235-36-4.
The basic type of EDTA chelating that the anhydrate and tetrahydrate forms provide in solution is the same.
However, the active substance equivalent of the commercial product is different on the basis of weight.
100 g of anhydrate product and 100 g of tetrahydrate product do not provide the same mole number of EDTA. This difference is important in formulation calculation.
Tetrasodium EDTA is in the strong chelating agent class.
Chelation refers to the simultaneous retention of a single metal ion by multiple donor atoms of a ligand.
EDTA has the ideal molecular geometry for this function. The molecule has two amine nitrogen and four carboxylate oxygen donor regions. Thus, it can form stable complex surrounding a metal ion from multiple points.
For this reason, EDTA is defined as a "hexadentate ligand".
Because the metal ion is held at more than one coordination point, the complex formed is generally more stable than simple single-bonded ligand complexes.
The metal binding strength of EDTA varies with the metal type and pH.
The tetrasodium form dissolves more easily, especially at higher pH, and can provide quick access to the chelating ion form.
For this reason, it is the common technical choice in cleaning, detergent, pulp & paper, textile, metal treatment and personal care formulations.
EDTA Tetrasodium is commercially available in solid powder/granule or aqueous solution form.
For example, Nouryon Dissolvine 100-S is a clear liquid tetrasodium EDTA solution with a minimum chelating assay of approximately 38.2%.
Powder grades may show anhydrate or hydrated structure.
Therefore, liquid and powder grades should not be used directly interchangeably with the same percentage.
EDTA Tetrasodium can bind calcium and magnesium ions, which make up water hardness.
It can also form strong complexes with transition metals such as iron and copper.
This property is particularly important in oxidation-sensitive formulations.
Even if iron or copper is present at trace levels, peroxide can accelerate the oxidation of oils, perfumes, dyes, and some actives.
EDTA can help formulation stability by reducing the free catalytic form of these metal ions. However, EDTA is not an antioxidant.
It does not work like a direct free radical trapping antioxidant.
It is the chelator that helps in reducing the metal-catalyzed oxidation pathway.
COMMON PRODUCT AND CHEMICAL NAMES
EDTA Tetrasodium
Tetrasodium EDTA
Tetrasodium EDTA
Tetrasodium Ethylenediaminetetraacetate
Tetrasodium Ethylenediaminetetraacetic Acid Salt
Ethylenediaminetetraacetic Acid Tetrasodium Salt
Tetrasodium Edetate
Edetate Tetrasodium
Edetate Sodium
Sodium Edetate
EDTA-Na₄
Na₄EDTA
Sodium EDTA
EDTA Sodium Salt
Tetrasodium Ethylene Diamine Tetraacetate
Tetrasodium Ethylenediamine Tetraacetate
Trilon B
Dissolvine EDTA Tetrasodium Grades
Versene Tetrasodium EDTA Grades
C₁₀H₁₂N₂Na₄O₈
CAS 64-02-8
EC 200-573-9
Tetrasodium EDTA Tetrahydrate
EDTA Tetrasodium Tetrahydrate
CAS 13235-36-4
Not all of these names refer to the same commercial grade.
Tetrasodium EDTA is the general chemical name.
Names such as Dissolvine, Trilon, and Versene are trade names that can be seen in EDTA product families from different manufacturers.
The specific grade of a trademark can be powder, tetrahydrate, or about 40% aqueous solution.
Therefore, the trade name, active concentration and hydrate form should be checked together.
"Disodium EDTA" and "Tetrasodium EDTA" are not the same product.
Disodium EDTA is the less neutralized, usually lower pH EDTA salt.
Tetrasodium EDTA, on the other hand, contains four sodium ions and shows a more alkaline character in aqueous solution.
Calcium Disodium EDTA is also a different chemical product.
E385, especially known as a food additive, is Calcium Disodium EDTA; it is not the same substance as Tetrasodium EDTA.
CAS NO, EC / EINECS NO AND CHEMICAL IDENTIFICATION
Product Name: EDTA Tetrasodium
INCI name: TETRASODIUM EDTA
Generic chemical name: Tetrasodium Ethylenediaminetetraacetate
Turkish name: Ethylenediaminetetraacetic Acid Tetrasodium Salt
Chemical class: Aminopolycarboxylate chelating agent
CAS No, anhydrate: 64-02-8
EC/EINECS No: 200-573-9
PubChem CID: 6144
Molecular formula, anhydrate: C₁₀H₁₂N₂Na₄O₈
Molecular weight, anhydrate: 380.17 g/mol
CAS No, tetrahydrate: 13235-36-4
Molecular formula, tetrahydrate: C₁₀H₂₀N₂Na₄O₁₂
Molecular weight, tetrahydrate: 452.23 g/mol
Physical form: White solid powder/granule or commercial aqueous solution
Solubility in water, reference for anhydrate: About 500 g/L, 20 °C
Ionic character: Sodium salt of anionic chelating ligand
1% solution pH: Depends on commercial grade; range of approximately 10.5–12 can be seen
1% w/v pH for Nouryon Dissolvine 100-S: 11.0–11.8
Main function: Chelating / sequestering agent
The hydrate form is particularly important in the credentials of EDTA Tetrasodium.
64-02-8 is generally associated with the anhydrate tetrasodium ethylenediaminetetraacetate.
13235-36-4 is the defined tetrahydrate form.
Some commercial products are sold as "hydrate" and the exact amount of crystal water can vary by grade.
For this reason, manufacturer TDS/COA information should be used in the calculation of molecular weight.
CHEMICAL STRUCTURE AND MOLECULAR PROPERTIES OF EDTA TETRASODIUM
In the basic skeleton of the EDTA molecule is the ethylene group that connects two nitrogen atoms.
Each nitrogen carries two acetate arms.
In the free EDTA form, these arms are -CH₂-COOH.
In tetrasodium form, four carboxylic acid groups -COO⁻ convert into Na⁺.
The simplified structure can be illustrated as follows: (NaOOC-CH₂)₂N-CH₂-CH₂-N(CH₂-COONa)₂ molecule carries a total of six potential donor atoms to bind metal.
There are two nitrogen donor sites. There are four carboxylate oxygen coordination centers.
Therefore, EDTA can keep the metal ion in a molecular lattice.
When a divalent or trivalent metal ion binds to EDTA, a 1:1 molar complex is mostly formed.
For example, one mole of EDTA can bind one mole of calcium ions.
The same general stoichiometry applies to magnesium, copper, zinc and many other metals.
However, complex stability constant is different for each metal.
This difference determines the selective chelation behavior.
The theoretical approximate sequestering values given by Nouryon for the commercial tetrasodium EDTA solution practically illustrate this difference.
For Calcium, approximately 40 mg metal/g active product equivalent is indicated.
About 65 mg/g for copper.
For ferric iron, about 60 mg/g.
For magnesium, about 25 mg/g.
For manganese, about 60 mg/g.
About 70 mg/g for zinc.
These values are the technical reference values of the specific product and are not the universal assay specification for all grades.
Also, the chelation pH range varies with the metal.
Calcium complexation in the Nouryon Dissolvine 100-S data is strong in the pH range of 5–14.
Copper can bind in the pH range of about 2–14.
The effective range for ferric iron is given as pH 1–10.
Magnesium may require a more alkaline pH.
This is because the protonation state of EDTA varies with pH.
At low pH, some of the carboxylate and nitrogen regions of the ligand are protonated.
This protonation can reduce the electron-donor capacity that can be used for metal bonding.
As the pH rises, EDTA becomes more deprotonated.
Tetrasodium EDTA therefore shows strong chelation performance in high pH formulations.
The main properties of EDTA Tetrasodium at the molecular level are:
Moving six coordination centers
Being a hexadentate ligand
Forming 1:1 complexes with metal ions
Calcium bind
Connect Magnesium
Iron binding
Copper Binding
Zinc bind
Binding to manganese
Helping to reduce metal-catalyzed oxidation
Checking water hardness
Helping to reduce mineral precipitation
Supporting formulation stability
PHYSICAL AND CHEMICAL PROPERTIES OF EDTA TETRASODIUM
EDTA Tetrasodium is a white alkaline chelating agent in solid form with high solubility in water.
Commercial products can be found as powder, crystalline hydrate or concentrated liquid solution.
General technical specifications:
Physical appearance, solid: White powder or crystalline solid
Chemical name: Tetrasodium Ethylenediaminetetraacetate
PEARL: TETRASODIUM EDTA
CAS No: 64-02-8
EC No: 200-573-9
Molecular formula: C₁₀H₁₂N₂Na₄O₈
Molecular weight: 380.17 g/mol, anhydrate
Tetrahydrate CAS No: 13235-36-4
Tetrahydrate molecular weight: 452.23 g/mol
Water solubility: Approx. 500 g/L, 20 °C, anhydrate reference value
Behavior in solution: High solubility
pH character: Alkaline
1% solution pH: Around 11 depending on grade
Commercial liquid grade example: Clear liquid
Nouryon Dissolvine 100-S assay: ≥ 38.2%, based on Fe-sequestering capacity
Nouryon Dissolvine 100-S density: Approx. 1280 kg/m³
Nouryon Dissolvine 100-S color: 150≤ APHA
Nouryon Dissolvine 100-S NTA-Na₃: ≤ 0.1%
Nouryon Dissolvine 100-S 1% w/v pH: 11.0–11.8
Nouryon Dissolvine 100-S crystallization point: ≤ -15 °C
Nouryon Dissolvine 100-S water miscibility: In all proportions
These commercial liquid grade values are not universal physical properties of pure anhydrate Tetrasodium EDTA.
It is the specification of the ready-made aqueous solution.
When purchasing Powder EDTA Tetrasodium, assay, moisture and molecular-weight basis should be evaluated separately.
The same assay percentage of tetrahydrate grade may not mean the same active EDTA content as anhydrate grade.
Therefore, formulation conversion should be done on the basis of active chelating equivalent.
HOW DOES EDTA TETRASODIUM WORK AT THE MOLECULAR LEVEL?
At the core of EDTA Tetrasodium's working mechanism is metal chelation.
When introduced into water or formulation, tetrasodium is simply soluble.
Sodium ions are separated in solution.
The negatively charged regions of the EDTA ligand can coordinate with metal ions.
For example, if the calcium ion is free in the formulation, it approaches the EDTA ligand.
Carboxylate oxygen atoms and nitrogen donor atoms are arranged around the metal ion.
Stable EDTA-calcium complex is formed.
The metal ion can no longer react with the same ease as surfactant, soap, pigment or other formulation ingredients.
This mechanism is important in cleaning systems.
Calcium and magnesium can form anionic surfactant or insoluble salts with soap.
This may reduce cleaning power and foam performance.
When EDTA binds the metal ion, this unwanted precipitation can be reduced.
Iron and copper control is particularly important in cosmetic formulations.
These metals can catalyze oxidative reactions even at very low concentrations.
The oil phase can be oxidized.
Perfume can vary.
The color may be distorted.
Some actives can be broken down.
EDTA indirectly supports the oxidative stability of the formulation by reducing free metal ion activity.
EDTA can also be considered as a preservative booster.
Divalent metal ions play a role in the external structure of some microorganisms for stability.
Combined with metal sequestration preservative system, it can promote antimicrobial performance.
However, this effect does not mean that EDTA alone is a broad-spectrum preservative.
The final formulation requires a microbial challenge test.
In metal treatment applications, EDTA can retain metal ions on the surface or in solution in a soluble complex.
In textile and pulp & paper systems, undesirable reactions of iron, manganese and hardness ions can be controlled in this way.
The main functions of EDTA Tetrasodium at the formulation level are:
Binding water hardness
Complexing calcium
Complexing Magnesium
Reducing iron catalysis
Reducing copper catalysis
Reducing metal-induced discoloration
Reducing mineral precipitation
Helping to reduce soap scum formation
Supporting surfactant performance
Helping to protect peroxide systems from metal catalysis
Supporting the preservative system
Helping to maintain formulation clarity
Keeping metal ions complex in solution
IN WHICH SECTORS IS EDTA TETRASODIUM USED?
EDTA Tetrasodium is a general-purpose chelating agent used for metal ion control in numerous industries.
Main areas of use:
Cosmetic products
Shampoos
Hair conditioners
Hair masks
Shower gels
Liquid soaps
Facial cleansing products
Body wash products
Deodorant formulations
Creams and lotions
Cleaning products
Detergents
Liquid laundry detergents
Dish cleaners
Alkaline industrial cleaners
Hard surface cleaners
Institutional cleaning
Soap production
Disinfectant formulations
Metal treatment
Electroplating auxiliary processes
Textile processes
Bleaching systems
Pulp & paper
Paper bleaching
Polymer processing
Oil industry
Industrial water treatment
Scale-control auxiliary systems
Chemical processes
Laboratory chelation applications
Nouryon directly recommends tetrasodium EDTA for cleaning, detergents & soaps, disinfectants, personal care, metal treatment, oil industry, polymer processing, pulp & paper and textile industry.
The main reason for this wide application area is that the same metal-sequestration mechanism provides value in many different processes.
COSMETIC, SHAMPOO AND PERSONAL CARE APPLICATIONS OF EDTA TETRASODIUM
EDTA Tetrasodium is mainly used as a chelating agent in personal care formulations.
In European cosmetic sources, the main function of TETRASODIUM EDTA is defined as binding metal ions.
Here are the possible functions of EDTA Tetrasodium in cosmetic applications:
Binding calcium in hard water
Connecting Magnesium
Connecting Iron
Connecting Copper
Supporting shampoo clarity
Reducing metal-induced discoloration
Supporting perfume stability
Helping to reduce metal-catalyzed oxidation of oils
Supporting Preservative Performance
Helping to reduce mineral buildup
Helping to maintain surfactant performance
Supporting the shelf life of the formulation
In shampoo formulation, hard-water ions can affect surfactant behavior.
By binding these ions, EDTA Tetrasodium can help the product perform more consistently across different water qualities.
Controlling metal ions on the hair surface or in the production water is especially important in clarifying and cleansing systems.
However, it should not be assumed that EDTA will completely remove all mineral deposits from the hair strand in a single use.
Performance depends on pH, level of use and contact time.
Traces of iron or copper in creams and lotions can increase the rate of lipid oxidation.
The addition of chelator can help reduce the formation of discoloration and rancid odour by binding these metal ions.
The alkaline character of EDTA Tetrasodium can raise the formulation pH.
For this reason, Disodium EDTA may be more suitable for formulation in serum, conditioner or acidic cleanser system with low pH target.
The tetrasodium form can be particularly practical in more alkaline cleanser and soap systems.
However, the formulator should not choose only by looking at the type of salt.
Solubility, pH and target metal ions should be evaluated together.
USE OF EDTA TETRASODIUM IN CLEANING, DETERGENT AND INDUSTRIAL PROCESSES
The cleaning industry is one of the most important uses of EDTA Tetrasodium.
Hard water can have a negative effect on cleaning chemistry due to the calcium and magnesium it contains.
It can produce calcium insoluble calcium soap in soap systems.
This condition can be seen as gray-white mineral residue or soap scum.
EDTA can reduce this mechanism by complexing Tetrasodium calcium.
It can serve as a builder/sequestrant auxiliary in detergent systems.
It can support the surfactant to remain active.
It can reduce the formation of mineral residue on the surface.
Alkaline cleaners can keep metal ions in solution.
Iron and copper control is also important in bleaching systems.
These metals can accelerate hydrogen peroxide decomposition.
EDTA can contribute to peroxide stability by limiting metal catalysis.
However, the exact suitability of EDTA in the peroxide formulation should be verified against pH and process conditions.
Metal ion control in textile bleaching can help reduce the risk of fabric damage and uneven bleaching.
In pulp & paper processes, transition metal ions can affect peroxide bleaching efficiency.
EDTA or other chelators can be used to bind these ions.
In metal treatment processes, EDTA can keep metal ions in a soluble complex form.
This advantage also requires attention in environmental wastewater management.
EDTA-bound metals may not be easily removed by precipitation.
For this reason, although strong chelation is advantageous in terms of process performance, it should be evaluated separately in terms of wastewater treatment.
IS EDTA TETRASODIUM USED IN FOOD, COSMETICS AND PHARMACEUTICAL APPLICATIONS?
EDTA Tetrasodium is common chelating agent in cosmetic and personal care formulations.
The INCI name is TETRASODIUM EDTA.
Cosmetic function is mainly defined as chelating.
However, cosmetic suitability should be verified with the cosmetic documentation and impurity profile of the exact commercial grade.
There is significant name confusion in food applications.
E385, known as a food additive, is not Tetrasodium EDTA.
E385 Calcium Disodium EDTA.
Therefore, the phrase "EDTA is used as E385 in food" cannot be used directly for Tetrasodium EDTA.
The general industrial or cosmetic grade of Tetrasodium EDTA should not be assumed to be a food raw material.
If food application is considered, the legislation of the target country and the exact permitted EDTA salt should be checked.
In the pharmaceutical field, "edetate" or EDTA salts can be found in different applications.
However, Edetate Disodium, Calcium Disodium Edetate and Tetrasodium EDTA are different chemical salts.
The presence of an EDTA derivative in a pharmacopoeia or drug preparation does not mean that the technical grade of Tetrasodium EDTA is suitable for pharmaceutical use.
In pharmaceutical practice, exact pure identity, pharmacopeial status, purity, GMP and preparation requirements should be further verified.
INDUSTRIAL APPLICATIONS OF EDTA TETRASODIUM
EDTA Tetrasodium has extensive use in industry in water-based and alkaline formulations where free metal ions must be controlled.
The following functions may be prominent in industrial EDTA Tetrasodium applications:
Water hardness control
Calcium sequestration
Magnesium sequestration
Iron sequestration
Copper sequestration
Manganese sequestration
Zinc complexation
Cleaning performance enhancement
Detergent formulation
Soap scum control
Metal precipitation control
Peroxide stabilization support
Textile processing
Pulp bleaching
Paper production
Metal treatment
Electroplating bath control
Polymer processing
Oilfield formulation
Personal care stabilization
Disinfectant formulation support
EDTA Tetrasodium dosage may not be determined solely on total water hardness.
Target metal concentration should be calculated.
Theoretically, EDTA-metal complexes are mostly formed with a 1:1 molar ratio.
Therefore, stoichiometric EDTA requirement can be calculated based on known metal concentration.
Excess chelator can be used in real formulation.
This can be due to the presence of multiple types of metals at the same time, unknown contamination, or process safety margin.
However, excessive use of EDTA does not always provide advantages.
The cost increases.
Wastewater metal mobility may be affected.
The formulation of ionic strength may vary.
Therefore, the optimum sequestering level should be determined by laboratory testing.
If commercial liquid EDTA grade of around 40% is used, active concentration should be taken into account.
For example, 10 kg of approximately 40% active solution does not provide 10 kg of pure EDTA.
It provides approximately 4 kg of active tetrasodium EDTA equivalent.
This conversion must be done when changing powder grade to liquid grade.
The following issues should be evaluated in the use of EDTA Tetrasodium in industrial systems:
Anhydrous or hydrate form
Active assay
Chelating value
Fe-sequestering capacity
Calcium sequestration
pH
Density
Colour / APHA
NTA content
Moisture
Water insolubles
Iron contamination
Heavy metals
Product form
Powder or liquid
Solubility
Crystallization temperature
Water hardness
Target metal ion concentration
Final formulation pH
Wastewater treatment impact
TDS
SDS
COA
REACH documentation
WHAT PROBLEMS CAN EDTA TETRASODIUM HELP SOLVE?
EDTA Tetrasodium can help solve technical problems, especially those related to water hardness, mineral precipitation, metal-catalyzed oxidation, and formulation stability.
Reduced cleaning performance due to hard water
Calcium and magnesium can be bound by EDTA, helping the surfactant system to be less affected by hard water.
Mineral precipitation in liquid soap
Tetrasodium EDTA can reduce the formation of insoluble soap salt by complexing hardness ions.
Clouding of shampoo
Turbidity caused by metal ion or mineral precipitation can be reduced with EDTA.
However, not every turbidity problem is caused by metal.
Color change of cosmetic product over time
Iron and copper catalyzed oxidation can be limited by metal chelation.
Oxidative odor in oil-containing cream
EDTA can indirectly support the antioxidant system by binding metal catalysts.
Weak preservative system
Chelator may support preservative efficacy in some formulations.
However, it cannot be used as a substitute for preservatives.
White mineral residue on detergent surface
Calcium and magnesium sequestration can help reduce the risk of mineral residue.
Rapid degradation of the peroxide system
Complexation of trace iron and copper ions can reduce the decomposition rate.
Metal precipitation in a metal treatment bath
EDTA can keep metal ions in a soluble complex state.
Difficulty in removing metal in wastewater
In this case, adding more EDTA is not the solution.
On the contrary, strong EDTA complexes can complicate conventional precipitation treatment.
Therefore, the wastewater treatment plan should be taken into account in the selection of chelators.
Insufficient EDTA solubility in low pH formulation
Although tetrasodium EDTA provides high solubility, it can raise the formulation pH.
Disodium EDTA or other chelator may be more appropriate.
THINGS TO CONSIDER WHEN USING EDTA TETRASODIUM
Hydrate form, active assay, formulation pH and metal-binding requirement are the basic technical parameters in the use of EDTA Tetrasodium.
The following issues should be considered when using EDTA Tetrasodium:
The CAS number must be verified.
The anhydrate or tetrahydrate form must be determined.
Molecular weight basis should be checked.
Assay should be checked.
The liquid or powder form must be verified.
Active chelator concentration should be calculated.
pH must be taken into account.
It should be noted that the tetrasodium form is alkaline.
The target metal type must be determined.
Metal concentration should be calculated.
Water hardness should be measured.
Chelating capacity should be checked.
Iron contamination should be evaluated.
NTA impurity should be checked if necessary.
Color/APHA should be checked.
Product solubility should be considered.
It should not be used instead of preservatives.
Wastewater impact should be evaluated.
It should not be assumed that it is E385 directly for food.
It should not be mixed with pharmaceutical EDTA salts.
TDS should be examined.
SDS should be examined.
The COA should be checked.
REACH/CLP information must be verified.
Although solid EDTA Tetrasodium has a high water solubility, dust exposure can occur during powder handling.
Powder inhalation and eye contact should be avoided.
Classifications related to severe eye injury and oral acute toxicity can be found in the European harmonized classification for tetrasodium EDTA.
For this reason, the risks of cosmetic final-use concentration and concentrated raw-material handling should be distinguished from each other.
INITIAL FORMULATION APPROACHES FOR EDTA TETRASODIUM
The following examples are laboratory initial approaches prepared to show how EDTA Tetrasodium can be evaluated in formulation development studies.
These are not verified commercial prescriptions.
The actual level should be optimized for water hardness, metal contamination, grade active content and target application.
EXAMPLE 1: EDTA TETRASODIUM SHAMPOO / LIQUID CLEANER CHELATOR SCAN
Purpose: To evaluate the effect of using low levels of EDTA Tetrasodium on clarity, hard water resistance and formulation stability.
Starting components:
Deionized water: 75.60%
Surfactant system – Sodium Laureth Sulfate (SLES, 70% active commercial solution): 12.00%
Surfactant system – Cocamidopropyl Betaine (CAPB, 30% active commercial solution): 8.00%
EDTA Tetrasodium (anhydrate based): 0.10%
Humectant – Glycerin: 2.00%
Preservative system – commercial blend of Phenoxyethanol / Ethylhexylglycerin: 0.80%
Perfume: 0.20%
pH regulator – 20% citric acid aqueous solution: 0.30%
Viscosity regulator – Sodium Chloride: 1.00%
Total: 100.00% (by weight; laboratory starting prescription)
Chelator screening: EDTA 0.00% / 0.05% / 0.10% / 0.20%; water 75.70% / 75.65% / 75.60% / 75.50% respectively.
Note: Initial rates. pH, stability should be verified; active equivalent should be calculated for liquid EDTA.
Application approach:
EDTA Tetrasodium is completely dissolved in the water phase.
Control formulation is prepared without EDTA.
The same formulation is prepared at different chelator levels.
The final pH is set to the same target in all samples.
Samples prepared with deionized water are compared.
A standardized hard water challenge is applied in a separate test.
Clarity is monitored.
Color change is followed.
Viscosity is measured.
Foam performance is compared.
Accelerated stability is applied.
If preservative efficacy is required, it is verified by challenge testing.
EXAMPLE 2: EDTA TETRASODIUM ALKALINE CLEANER HARD-WATER SCREENING
Objective: To determine the effect of EDTA level on calcium/magnesium-induced performance loss and surface residue.
Starting components:
Deionized water: 89.50%
Alkaline builder – Sodium Carbonate: 3.00%
Alkaline builder – Sodium Metasilicate Pentahydrate: 1.00%
Surfactant system – C9–11 Alcohol Ethoxylate (suitable commercial nonionic grade): 2.00%
Hydrotrope – Sodium Xylene Sulfonate (40% active commercial solution): 3.00%
EDTA Tetrasodium (anhydrate based): 0.50%
Other sequestering agent – Sodium Gluconate: 1.00%
Total: 100.00% (by weight; laboratory starting prescription)
EDTA scanning: 0.00% / 0.25% / 0.50% / 1.00%; water 90.00% / 89.75% / 89.50% / 89.00% respectively.
Alternative chelator comparison: If Sodium Gluconate is removed, water is increased by 1.00%. In GLDA/MGDA substitution, the active equivalent is recalculated.
Note: For laboratory screening; pH, corrosiveness, surface, and packaging compatibility must be verified.
Application approach:
Test water containing known hardness is prepared.
The concentration of calcium and magnesium is recorded.
Control formulation is prepared without a chelator.
Samples containing EDTA are prepared with the same active basis.
The final pH is equalized.
Cleaning performance is compared on standard substrate.
Soap scum/mineral deposition is observed.
Foam profile is evaluated.
Storage stability is tested.
The minimum effective chelator level is determined.
EXAMPLE 3: EDTA TETRASODIUM METAL-CATALYZED OXIDATION STABILITY SCAN
Objective: To compare the effect of chelator use on color, odor or active stability in the presence of trace iron or copper.
Starting components:
Model water-based formulation – Deionized water: 94.10%
Model water-based formulation – Glycerin: 4.00%
Solvent / solubilizer – Polysorbate 20: 0.50%
Oxidation-sensitive ingredient – Oxidation-sensitive perfume composition: 0.20%
EDTA Tetrasodium (anhydrate based): 0.10%
Buffer component – Sodium Citrate: 0.20%
Preservative system – commercial blend of Phenoxyethanol / Ethylhexylglycerin: 0.80%
Iron/copper challenge – 1000 mg/L standardized stock solution based on Fe or Cu metal: 0.10% (only one metal stock is used in each experiment)
Antioxidant: 0.00% (not added in the first series; if additional experiments with antioxidants are performed, the percentage is deducted from the water rate)
Total: 100.00% (by weight; laboratory starting prescription)
EDTA scanning: 0.00% / 0.05% / 0.10% / 0.20%; water 94.20% / 94.15% / 94.10% / 94.00% respectively.
Metal control: In the metal-free control sample, 0.10% water is used instead of stock. A metal target of approximately 1 mg/kg should be analytically validated.
Note: These are laboratory initial rates; product stability and preservative efficacy should be verified.
Application approach:
Control sample is prepared.
Control containing metal challenge is prepared.
Metal challenge + EDTA samples are prepared.
The final pH is kept the same.
Samples are stored at accelerated temperature.
Color is measured.
The change of smell is recorded.
If the active ingredient assay is required, it is measured analytically.
The lowest effective chelator level is determined.
ALTERNATIVES AND COMPARISON OF EDTA TETRASODIUM
When selecting an alternative to EDTA Tetrasodium, the label "chelating agent" alone should be considered.
pH range, biodegradability, metal selectivity, regulatory requirement and formulation compatibility should be evaluated together.
EDTA TETRASODIUM AND DISODIUM EDTA
Disodium EDTA is the partially neutralized salt of EDTA containing two sodium.
Tetrasodium EDTA contains four sodium.
Therefore the aqueous pH of the two products is markedly different.
Disodium EDTA can generally be preferred in more acidic/near-neutral formulations.
Tetrasodium EDTA shows a more alkaline character.
The active EDTA equivalent of the two products should be calculated according to molecular weight and hydrate status.
It should not be substituted directly by the same percentage.
EDTA TETRASODIUM AND EDTA ACID
EDTA Acid is the free form of ethylenediaminetetraacetic acid.
CAS No is 60-00-4.
Its solubility in water is much lower than tetrasodium salt.
Tetrasodium EDTA is more practical in formulations that require high water solubility.
EDTA Acid can be evaluated in systems where in-situ neutralization can be performed with alkali during the process.
Molecular weight and neutralization requirement are different on the basis of the same weight.
EDTA TETRASODIUM AND CALCIUM DISODIUM EDTA
Calcium Disodium EDTA is different EDTA salt that contains calcium.
It is not the same as Tetrasodium EDTA.
Calcium Disodium EDTA food additive is known as E385.
E385 should not be used for tetrasodium EDTA.
The metal-binding behavior and regulatory status of the two products are different.
It should not be considered directly equivalent.
EDTA TETRASODIUM AND GLDA
GLDA is a family of biodegradable chelating agents based on Glutamic Acid Diacetate.
Similar to EDTA, it can be used for hardness and transition-metal control.
GLDA can be preferred according to environmental profile and biodegradability targets.
EDTA is the classic reference chelator with its extensive metal-binding experience and strong complex stability.
The metal binding constant and optimum pH range of the two products are not the same.
Dosage should be redetermined by laboratory tests.
EDTA TETRASODIUM AND MGDA
MGDA is an aminopolycarboxylate chelator based on Methylglycine Diacetate.
It is one of the modern EDTA alternatives in the cleaning sector, especially for hardness control.
The complex behavior of MGDA and EDTA for calcium, iron and other metals is different.
MGDA can be preferred in detergent systems with biodegradability targets.
However, one-to-one weight substitution is not recommended.
EDTA TETRASODIUM AND SODIUM CITRATE
Sodium Citrate can have metal binding and buffer functions.
However, its chelating strength is lower than EDTA for many metals.
The citric acid/citrate system can provide the advantage of easier biodegradability.
In light hardness-control systems, citrate may be sufficient.
EDTA may be more effective in formulations where strong trace-metal control is required.
The two products are not directly equivalent.
QUALITY CONTROL AND PURCHASING CRITERIA FOR EDTA TETRASODIUM
When purchasing EDTA Tetrasodium, the physical and chemical form of the product should be clarified first.
Anhydrous powder, tetrahydrate powder and approximately 40% liquid solution are not the same product specification.
Recommended information to review before purchasing:
Full product name
Manufacturer
Tetrasodium EDTA ID
CAS No
EC No
Anhydrous or hydrate form
Whether it is tetrahydrate or not
Active assay
EDTA equivalent
Chelating value
Fe-sequestering capacity
Calcium-sequestering capacity
Moisture
Water content
pH
Colour / APHA
Density, liquid products
Crystallization point, liquid products
Water insolubles
NTA content
Iron content
Heavy metals
Chloride
Sulfate
Bulk density, powder products
Particle size
Solubility
Packaging
Shelf life
Storage conditions
Country of origin
TDS
SDS
COA
REACH information
Cosmetic documentation, if required
In liquid commercial grades such as Nouryon Dissolvine 100-S, active assay ≥38.2% can be defined over Fe-sequestering capacity.
The NTA-Na₃ level can be limited to specifications such as ≤0.1%.
These are the specifications of the specific commercial product.
It should not be generalized directly to other grades of EDTA Tetrasodium.
Molecular-weight basis is especially important in powder grade intake.
The molecular weight of the tetrahydrate product is 452.23 g/mol, while the anhydrous basis is 380.17 g/mol.
Price comparison should be made not only on kg of product but also on active EDTA mole equivalent.
STORAGE AND HANDLING OF EDTA TETRASODIUM
Storage: Solid EDTA Tetrasodium should be stored in dry, clean, and tightly sealed packaging.
Humidity: Hydrated or hygroscopic grades can be affected by atmospheric humidity. The powder product should not be kept in open packaging for a long time.
Dust control: Airborne dust formation should be limited in fine powder transfer.
Tetrahydrate: Excessively dry or hot storage in grade containing defined crystal water may affect hydrate condition; producer conditions should be monitored.
Liquid grade: Commercial approximately 40% solutions may show crystallization at low temperature. Exact crystallization temperature should be checked via TDS.
Crystallization point ≤ for Nouryon Dissolvine 100-S is given as -15 °C.
Packaging: Container compatible with alkaline aqueous chelator should be used.
Contamination: Contamination from the metal surface or other chemicals can alter the quality.
FIFO: Batch management should be applied especially in cosmetic and high-purity grades.
Transport: Exact transport classification must be verified from the current SDS.
The transportation conditions of powder and liquid grades may not be the same.
EDTA TETRASODIUM SAFETY INFORMATION
EDTA Tetrasodium is an alkaline aminopolycarboxylate salt with high water solubility.
The concentrated raw material has a different safety profile than the final cosmetic product usage level.
There are harmonized or registered classifications for Tetrasodium EDTA in European sources associated with severe eye damage and harmful oral exposure.
Solid product dust should be prevented from coming into contact with the eyes.
Unnecessary inhalation of dust should be limited.
Appropriate eye protection and chemical gloves should be used.
The high pH of liquid concentrated grade can increase the risk of eye and skin irritation.
For safe use, the current SDS of the exact commercial product should be taken as basis.
EDTA is also a chelator to consider from an environmental point of view.
It can affect the mobility of some heavy metals in wastewater because it forms strong metal complexes.
Therefore, in high-volume industrial uses, not only human exposure but also wastewater treatment impact should be evaluated.
WHAT TO CONSIDER WHEN BUYING EDTA TETRASODIUM?
The first question when buying EDTA Tetrasodium is what physical form and active concentration the product should be in.
"EDTA Tetrasodium" alone is not the definition of adequate purchase.
It should be stated whether powder or liquid is desired.
The difference between anhydrous or tetrahydrate should be clarified.
The following information should be clarified before purchasing:
Use sector
Cosmetics
Personal care
Detergent
Industrial cleaning
Textile
Paper
Metal treatment
Water treatment
Oilfield
Need for powder or liquid
Anhydrous or hydrate form
Minimum assay
Chelating value
Target pH
NTA limit
Color limit
Iron limit
Heavy metal limits
Solubility
Density, for liquid grade
Crystallization point, for liquid grade
If Cosmetic INCI documentation is required
REACH documentation
Manufacturer
Origin
Packaging
Estimated order quantity
The need for TDS
The need for SDS
The need for COA
If the existing chelator is to be substituted, current TDS and formulation information
The price of EDTA Tetrasodium should not be compared only per kilogram.
40% liquid product and 99% powder do not carry the same active amount.
Tetrahydrate and anhydrous form do not have the same active EDTA equivalent.
The actual formulation cost should be calculated based on the active chelating equivalent and required dosage.
EDTA TETRASODIUM SUPPLY FROM ATAMAN KIMYA
EDTA Tetrasodium; It is a powerful chelating agent used for the control of metal ions in cosmetics, personal care, detergents, cleaning, textiles, paper, metal processing, polymers and different industrial formulations.
Companies that want to get information about EDTA Tetrasodium supply from Ataman Kimya can request information about product suitability, current supply conditions, packaging options and price offer by sharing their usage areas and target technical criteria.
The current stock status, manufacturer, origin, anhydrate/hydrate form, powder or liquid physical form, assay value, packaging and technical specifications of the product should be confirmed from Ataman Kimya before ordering.
Sharing the following information in the request for quotation facilitates the evaluation of the right EDTA Tetrasodium product:
Use sector
Final formulation
Need for powder or liquid
Preference for anhydrous or tetrahydrate
Target active assay
Chelating capacity requirement
Final formulation pH
Target metal ions
Water hardness information
If an NTA limit is required
Color/APHA limit
Cosmetic documentation requirement
REACH document
Estimated order quantity
Type of packaging requested
Requested technical documents
TDS or COA information of the current EDTA product, if applicable
FREQUENTLY ASKED QUESTIONS ABOUT EDTA TETRASODIUM
What is EDTA Tetrasodium?
It is a high-solubility strong chelating agent in which four carboxylic acid groups of EDTA are neutralized by sodium.
What is the Turkish name of EDTA Tetrasodium?
It is called Tetrasodium EDTA or Ethylenediaminetetraacetic Acid Tetrasodium Salt.
What is the INCI name of EDTA Tetrasodium?
TETRASODIUM EDTA.
What is the CAS number of EDTA Tetrasodium?
For the anhydrate form, the CAS No is 64-02-8.
What is the EC number of EDTA Tetrasodium?
EC/EINECS No is 200-573-9.
What is the molecular formula of EDTA Tetrasodium?
For the anhydrate form, it is C₁₀H₁₂N₂Na₄O₈.
What is the molecular weight of EDTA Tetrasodium?
For the anhydrate form, it is about 380.17 g/mol.
What is EDTA Tetrasodium tetrahydrate?
It is the hydrate form of tetrasodium EDTA that contains four crystalline waters.
What is the CAS number of EDTA Tetrasodium tetrahydrate?
CAS No is 13235-36-4.
What is the molecular weight of EDTA Tetrasodium tetrahydrate?
It is approximately 452.23 g/mol.
Is anhydrate and tetrahydrate the same?
They provide the same EDTA chelating ion but differ in water content and molecular weight. Their active amounts are not the same on a gram basis.
What does EDTA Tetrasodium do?
It binds calcium, magnesium, iron, copper, zinc and other polyvalent metal ions.
Is EDTA a Tetrasodium chelator?
One of the most important properties of EDTA is that it is a very strong chelating ligand.
Why does EDTA bind metals well?
It can coordinate from multiple points to metal ions via two nitrogen and four carboxylate oxygen.
Does EDTA Tetrasodium reduce water hardness?
It can bind calcium and magnesium ions, reducing the effect of hard water on the formulation.
Is EDTA Tetrasodium soluble in water?
A water solubility of 500 g/L at approximately 20 °C has been reported for the anhydrate product.
What is the pH of EDTA Tetrasodium?
Its aqueous solution is alkaline. In the commercial tetrasodium EDTA solution sample, the pH of a 1% w/v dilution is 11.0–11.8.
Is EDTA Tetrasodium used in cosmetics?
It can be used as a chelating agent in shampoos, cleansers, creams and different personal-care products.
What does EDTA Tetrasodium do in shampoo?
It can bind hard water and trace metal ions, promoting clarity, surfactant performance, and formulation stability.
Does EDTA Tetrasodium bind minerals in hair?
It can chelate metal and hardness ions, but the final hair performance depends on the formulation, pH, concentration, and contact time.
Is EDTA Tetrasodium a preservative?
Its main function is chelating. It can support the preservative system, but should not be considered as a preservative alone.
Is EDTA Tetrasodium an antioxidant?
It is not directly antioxidant. It can help reduce metal-catalyzed oxidation by binding pro-oxidant metals such as iron and copper.
Is EDTA Tetrasodium used in detergent?
It can be used for hardness control and mineral sequestration.
Is EDTA Tetrasodium used in soap?
It can help reduce calcium and magnesium-induced insoluble soap deposits.
Is EDTA Tetrasodium used in textiles?
It can be used for the control of metal ions and to support bleaching processes.
Is EDTA Tetrasodium used in the paper industry?
It can be used for transition-metal control in pulp & paper systems.
Does EDTA help Tetrasodium hydrogen peroxide stability?
It can help by binding metals that catalyze peroxide decomposition, such as iron and copper.
Is EDTA Tetrasodium food grade?
General Tetrasodium EDTA should not be assumed to be a food additive. E385, known in food, is Calcium Disodium EDTA.
Is EDTA Tetrasodium E385?
E385 Calcium Disodium EDTA.
Is EDTA Tetrasodium the same as Disodium EDTA?
Sodium numbers, molecular weight and pH behavior in aqueous solution are different.
Is Tetrasodium EDTA or Disodium EDTA more alkaline?
Tetrasodium EDTA shows a more alkaline character.
Is EDTA Acid the same as EDTA Tetrasodium?
EDTA Acid is the free acid form and shows lower solubility in water than tetrasodium salt.
Is EDTA the same as Tetrasodium GLDA?
GLDA is different chemical chelator and its biodegradability profile is different.
Is EDTA Tetrasodium the same as MGDA?
MGDA is a different chelating agent based on Methylglycine Diacetate.
Is EDTA the same as Tetrasodium Sodium Citrate?
Both can interact with metal ions, but EDTA can provide much stronger chelation overall.
Is EDTA Tetrasodium powder or liquid?
Both commercial forms can be found.
How many percent can Liquid EDTA Tetrasodium be?
Commercial solutions containing approximately 38–40% actives are common. Exact grade should be verified from TDS.
What is the commercial liquid density of EDTA Tetrasodium?
For Nouryon Dissolvine 100-S, a value of approximately 1280 kg/m³ is given.
Why does EDTA Tetrasodium help preserve the color of the formulation?
Metal ions such as iron and copper can accelerate oxidation and discoloration reactions; EDTA chelates them.
What is the EDTA Tetrasodium usage rate?
There is no single universal ratio. For cosmetic formulations, low levels may be sufficient, while in industrial cleaning applications, higher levels may be required depending on the metal load.
How to determine the amount of EDTA Tetrasodium use?
Stoichiometric and application tests should be used together according to target metal concentration, water hardness, active assay and formulation pH.
Should EDTA Tetrasodium be considered for the environment?
Strong and permanent metal complexes can have an impact on wastewater treatment and metal mobility.
Is EDTA Tetrasodium safe?
Concentrated raw material should not be evaluated in the same way as low usage levels in final formulations. SDS instructions should be followed for concentrated powder or solution.
Can EDTA Tetrasodium be dangerous to the eye?
The concentrated substance may carry a risk of serious eye damage. Appropriate eye protection should be used.
What properties are important when buying EDTA Tetrasodium?
Anhydrous/hydrate form, assay, chelating value, pH, NTA, color, physical form and COA values are important.
What documents should be required for EDTA Tetrasodium?
TDS, SDS, and COA are essential documents. Depending on the cosmetic and industrial application, INCI, REACH, and additional regulatory documentation may be required.
How should EDTA Tetrasodium be stored?
Powder grade should be stored in dry and closed conditions; liquid grade should be stored at the manufacturer's recommended temperatures and in compatible containers.
EDTA TETRASODIUM – TECHNICAL SUMMARY
EDTA Tetrasodium is the tetrasodium salt of Ethylenediaminetetraacetic Acid that is completely neutralized with sodium. For the anhydrate product, it has CAS No 64-02-8, EC No 200-573-9, molecular formula C₁₀H₁₂N₂Na₄O₈, and molecular weight of approximately 380.17 g/mol.
The tetrahydrate form is identified by CAS No 13235-36-4, has the formula C₁₀H₂₀N₂Na₄O₁₂, and has a molecular weight of approximately 452.23 g/mol. Therefore, the anhydrate and tetrahydrate product should not be used directly interchangeably on a gram by gram basis.
EDTA Tetrasodium is a powerful aminopolycarboxylate chelating agent. With two nitrogen and four carboxylate oxygen donor atoms, it can bind metal ions at multiple points.
It can form stable complexes with metals such as calcium, magnesium, iron, copper, zinc, and manganese, helping to reduce hard-water effects, mineral precipitation, and metal-catalysed degradation.
In GESTIS data, a water solubility of 500 g/L at approximately 20 °C was reported for the anhydrate Tetrasodium EDTA. High solubility is a significant advantage in liquid formulations.
Tetrasodium EDTA solution shows alkaline character. Nouryon's Dissolvine 100-S commercial liquid grade has a dilution pH of 1% w/v 11.0–11.8.
Dissolvine 100-S has an assay of approximately 38.2% ≥, density of 1280 kg/m³, APHA color of ≤ and ≤0.1% NTA-Na₃ specification. These values refer to the specific commercial liquid grade and should not be generalized to all Tetrasodium EDTA products.
In the cosmetics industry, TETRASODIUM EDTA is used as a chelating ingredient that binds metal ions. It can help promote formulation clarity, color stability, oxidation resistance, and preservative performance.
In cleaning and detergent applications, it can support surfactant performance with calcium and magnesium sequestration and help reduce mineral/soap residue formation.
It can also be used for metal-ion control in the fields of textile, pulp & paper, metal treatment, oil industry and polymer processing.
Tetrasodium EDTA should not be considered to be food additive E385. E385 is Calcium Disodium EDTA and different chemical salt.
When purchasing EDTA Tetrasodium, anhydrate or hydrate form, powder/liquid physical form, active assay, chelating capacity, pH, color, NTA limit, impurity profile and COA results should be checked.
It is recommended that companies planning to supply EDTA Tetrasodium from Ataman Kimya confirm the current product and offer conditions by sharing their usage sector, powder or liquid needs, hydrate form, active concentration, target metal ions, formulation pH, packaging quantity and technical document needs.
