Quick Search
EMEROX 1144
CAS numbers: 123-99-9 (% 88 - 92)
1852-04-6 (%5.7 - 6)
111-20-6 (%2 - 2.3)
505-48-6 (%0.9 - 1.3)
Description: Azelaic acid is a linear C9 dicarboxylic acid derived from natural, renewable sources.
General Appearance: White flakes
Emerox 1144 - General Information
Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley.
Azelaic acid is a natural substance that is produced by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin.
Azelaic acid is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%.
Azelaic acid works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear.
Azelaic acid's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.
Mechanism Of Action: The exact mechanism of action of azelaic acid is not known.
It is thought that azelaic acid manifests its antibacterial effects by inhibiting the synthesis of cellular protein in anaerobic and aerobic bacteria, especially Staphylococcus epidermidis and Propionibacterium acnes.
In aerobic bacteria, azelaic acid reversibly inhibits several oxidoreductive enzymes including tyrosinase, mitochondrial enzymes of the respiratory chain, thioredoxin reductase, 5-alpha-reductase, and DNA polymerases.
In anaerobic bacteria, azelaic acid impedes glycolysis.
Along with these actions, azelaic acid also improves acne vulgaris by normalizing the keratin process and decreasing microcomedo formation.
Azelaic acid may be effective against both inflamed and noninflamed lesions.
Specifically, azelaic acid reduces the thickness of the stratum corneum, shrinks keratohyalin granules by reducing the amount and distribution of filaggrin (a component of keratohyalin) in epidermal layers, and lowers the number of keratohyalin granules.
Emerox 1144 Azelaic Acid enhances the properties of a product by:
-improving flexibility
-providing derivatives with lower melting points than derivatives based on even-carbon acids
-initiating reactions resulting in higher molecular weight compounds
-improving dye receptivity
-providing better solubility characteristics
Emerox 1144 is used to treat mild to moderate acne.
Emerox 1144 works in part by stopping the growth of skin bacteria that can help cause acne.
Emerox 1144 also helps to lessen acne by keeping skin pores (tiny openings on the skin's surface) clear.
Emerox 1144 may also be used to treat other conditions as determined by your doctor.
Emerox 1144 is available only with your doctor's prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems.
Although this use is not included in product labeling, Emerox 1144 is used in certain patients with the following medical condition:
-Tan discoloration of face, often in pregnant women or women taking birth control pills
Properties
• Improving flexibility
• Providing derivatives with lower melting points than derivatives based upon Even-Carbon Acids
• Initiating reactions resulting in higher molecular weight compounds
• Improving dye receptivity
• Providing better solubility characteristics
Applications
• Nylon engineering plastics and fibers
• Polyester films and adhesives
• Polyester and polyamide fibers
• Urethane elastomers and elastomeric fibers
• Polyamide hot melts
• Wire coating
• Molding resins
Pharmacology of Emerox 1144
Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley.
Azelaic acid is a natural substance that is produced by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin.
Azelaic acid is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%.
Azelaic acid works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear.
Azelaic acid's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.
Uses of Emerox 1144:
Emerox 1144v is used as a raw material for the production of plasticizer dioctyl azelate and spices, lubricants, oils, and polyamide resins.
Emerox 1144 is widely used in medicine and cosmetics.
Emerox 1144 - General Information:
Emerox 1144 is a saturated dicarboxylic acid found naturally in wheat, rye, and barley.
Emerox 1144 is a natural substance that is produced (also known as Pityrosporum ovale), a yeast that lives on normal skin.
Emerox 1144 is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%.
Emerox 1144 works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear.
Emerox 1144's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.
Emerox 1144 gel is used to treat the bumps, an area of abnormal tissue change (lesions), and swelling caused by rosacea (a skin disease that causes redness, flushing, and pimples on the face).
Emerox 1144 cream is used to treat pimples (acne).
PRODUCT PROPERTIES:
Acid value (mg KOH/g): 587 – 594
Color (%, Trans. 440/550 nm): 95/99 min.
Azelaic acid content (%): 88 min.
Monobasic acid (wt.%): 0.05 max.
Keto acid (%): 0.05 max.
Dibasic acid content (GLC, wt. %)
Less than C9: 3
C9: 89
Greater than C9: 8
Monobasic acids (wt.%): 0.04
Melting point (°C): 100 - 102
Color (%, Trans. 440/550 nm): 96/100
Boiling Point: > 260 °C (> 500 °F)
Color: white
Density: 1.03 g/cm3
Flash Point: 215.5 °C (419.9 °F)
Odor: fatty odour
Recommended Use: Industrial chemical
Solubility in Water: slightly soluble
Vapor Pressure: < 1 mmHg
Applications:
-Nylon Engineering Plastics and Fibers
-Polyester Fibers, Films and Adhesives
-Urethane Elastomers and Elastomeric Fibers
-Lubricant Basestocks
-Lithium Complex Greases
-Thermosetting Unsaturated Polyester Resins
-Epoxy Flexibilizers
-PVC Plasticizers
-Corrosion Inhibitors
Storage and Handling
It is recommended to store EMEROX 1144 at room temperature and to protect the product against the effects of heat and frost.
If stored in original sealed packaging, EMEROX® 1144 should be stable for at least 335 days from the date of manufacture.
SYNONYMS:
azelaic acid
NONANEDIOIC ACID
123-99-9
Finacea
Anchoic acid
Azelex
Lepargylic acid
Skinoren
1,7-Heptanedicarboxylic acid
1,9-Nonanedioic acid
Heptanedicarboxylic acid
n-Nonanedioic acid
Emerox 1110
Emerox 1144
acide azelaique
Finevin
Azelainic acid
acidum azelaicum
Poly(azelaic anhydride)
azelate
Polyazelaic anhydride
Skinorem
1,7-Dicarboxyheptane
Azelaic acid, technical grade
Emery's L-110
Nonanedioic acid, homopolymer
ZK 62498
ZK-62498
UNII-F2VW3D43YT
NSC 19493
Azelaic acid 99%
26776-28-3
CHEBI:48131
Water-soluble azelaic acid
F2VW3D43YT
MLS000069659
azelaate
NSC19493
MFCD00004432
NSC-19493
NCGC00014993-07
SMR000059164
Acido azelaico
Azalaic Acid
DSSTox_CID_1640
Acide azelaique [French]
Acido azelaico [Spanish]
Acidum azelaicum [Latin]
DSSTox_RID_76254
DSSTox_GSID_21640
heptane-1,7-dicarboxylic acid
Azelaic acid [USAN:INN]
Azelaic polyanhydride
Azelaic
Azelaic acid polyanhydride
CAS-123-99-9
Finacea (TN)
Azelex (TN)
SR-01000075671
EINECS 204-669-1
Azelaic acid (USAN/INN)
BRN 1101094
Azelaicacidtech
Azelainsaeure
Lepargylate
Nonandisaeure
Anchoate
azelaic-acid
n-Nonanedioate
AI3-06299
HSDB 7659
1tuf
1,9-Nonanedioate
SH-441
AGN-191861
Azelaic acid, 98%
Spectrum_000057
Water-solubleazelaicacid
Opera_ID_740
Polyazelaic Polyanhydride
1,7-Heptanedicarboxylate
Spectrum2_000995
Spectrum3_000278
Spectrum4_000401
Spectrum5_001304
C9-120-alpha-polymorph
C9-140-alpha-polymorph
C9-180-alpha-polymorph
C9-220-alpha-polymorph
C9-260-alpha-polymorph
C9-298-alpha-polymorph
Epitope ID:187039
A-9800
EC 204-669-1
Nonanedioic acid homopolymer
Lopac-246379
SCHEMBL3887
CHEMBL1238
Lopac0_000051
BSPBio_001756
KBioGR_000662
KBioSS_000437
Nonanedioic acid Azelaic acid
4-02-00-02055 (Beilstein Handbook Reference)
MLS001148615
BIDD:GT0315
DivK1c_000532
SPECTRUM1500648
SPBio_001089
GTPL7484
DTXSID8021640
HMS501K14
KBio1_000532
KBio2_000437
KBio2_003005
KBio2_005573
KBio3_001256
Azelaic acid, analytical standard
NINDS_000532
HMS1921O11
HMS2092E22
HMS2234D10
HMS3260K03
HMS3372J07
Pharmakon1600-01500648
BCP18690
HY-B0704
ZINC1531036
Tox21_110063
Tox21_201989
Tox21_303011
Tox21_500051
Azelaic acid, technical grade, 80%
CCG-40081
LMFA01170054
NSC757406
s4550
STL059432
AKOS000120052
Tox21_110063_1
Azelaic acid, technical, ~85% (GC)
Azelaic acid, Vetec(TM) reagent grade
DB00548
KS-5293
LP00051
LS41867
MCULE-4093240509
NSC-757406
SDCCGMLS-0066619.P001
SDCCGMLS-0066619.P033
SDCCGSBI-0050040.P004
IDI1_000532
MLS-0066619
NCGC00014993-01
NCGC00014993-02
NCGC00014993-03
NCGC00014993-04
NCGC00014993-05
NCGC00014993-06
NCGC00014993-08
NCGC00014993-09
NCGC00014993-10
NCGC00014993-12
NCGC00014993-15
NCGC00093565-01
NCGC00093565-02
NCGC00093565-03
NCGC00093565-04
NCGC00093565-05
NCGC00093565-06
NCGC00093565-07
NCGC00256508-01
NCGC00259538-01
NCGC00260736-01
BP-27863
MLS-0066619.P021
SBI-0050040.P003
A0561
Dicarboxylic acid C9; Nonanedioic acid; AZA
EU-0100051
FT-0626920
C08261
D03034
D70171
AB00052140_12
Q413504
SR-01000075671-1
SR-01000075671-4
SR-01000075671-6
0C50D8EC-0DB0-4F24-8EFC-2919E1F0D9BF
Z57127532
F8889-5093
UNDECANEDIOIC ACID
1852-04-6
1,9-Nonanedicarboxylic acid
1,9-Nonanedicarboxylicacid
1,11-Undecanedioic acid
Undecanedionic acid
Undecandioic acid
Hendecanedioic acid
UNII-7059GFK8NV
Nonamethylenedicarboxylic Acid
7059GFK8NV
CHEBI:73713
MFCD00004444
NSC400241
Undecandioic acid; 1,11-Undecanedioic acid
Hendecanedioate
Undecanedioate
Undecanedionate
EINECS 217-440-6
undecandisäure
NSC 400241
1,11-Undecanedioate
1,9-Nonanedicarboxylate
Undecanedioic acid, 97%
bmse000847
bmse000880
EC 217-440-6
DSSTox_CID_24862
DSSTox_RID_80539
DSSTox_GSID_44862
SCHEMBL28401
CHEMBL3183300
DTXSID0044862
ZINC1593115
Tox21_300954
LMFA01170007
s6333
AKOS015919038
CS-W014841
HY-W014125
NSC-400241
NCGC00248227-01
NCGC00254856-01
AS-14889
N008
SY051603
CAS-1852-04-6
FT-0656248
N0333
Undecanedioic acid, puriss., >=99.0% (GC)
852U046
A812932
W-109719
Q27144063
sebacic acid
DECANEDIOIC ACID
111-20-6
1,8-Octanedicarboxylic acid
1,10-Decanedioic acid
Sebacic acids
Sebacinsaure
Decanedicarboxylic acid
n-Decanedioic acid
Acide sebacique
Sebacinsaeure
USAF HC-1
Ipomic acid
Sebacinsaure [German]
Seracic acid
Decanedioic acid, homopolymer
Acide sebacique [French]
UNII-97AN39ICTC
NSC 19492
1,8-dicarboxyoctane
NSC19492
26776-29-4
97AN39ICTC
CHEBI:41865
MFCD00004440
DSSTox_CID_6867
DSSTox_RID_78231
DSSTox_GSID_26867
SebacicAcid
CAS-111-20-6
CCRIS 2290
EINECS 203-845-5
BRN 1210591
n-Decanedioate
Iponic acid
AI3-09127
disodium-sebacate
4-oxodecanedioate
1,10-Decanedioate
Sebacic acid, 94%
Sebacic acid, 99%
Dicarboxylic acid C10
1i8j
1l6s
1l6y
1,8-Octanedicarboxylate
WLN: QV8VQ
EC 203-845-5
SCHEMBL3977
NCIOpen2_008624
4-02-00-02078 (Beilstein Handbook Reference)
octane-1,8-dicarboxylic acid
CHEMBL1232164
DTXSID7026867
Sebacic acid, >=95.0% (GC)
ZINC1531045
Tox21_201778
Tox21_303263
BBL011473
LMFA01170006
NSC-19492
s5732
STL146585
AKOS000120056
CCG-266598
CS-W015503
DB07645
GS-6713
HY-W014787
MCULE-3460494679
NCGC00164361-01
NCGC00164361-02
NCGC00164361-03
NCGC00257150-01
NCGC00259327-01
BP-27864
NCI60_001628
DB-121158
FT-0696757
C08277
A894762
C10-120
C10-140
C10-180
C10-220
C10-260
C10-298
Q413454
Q-201703
Z1259273339
301CFA7E-7155-4D51-BD2F-EB921428B436
1,8-Octanedicarboxylic acid; Decanedioic acid; Octane-1,8-dicarboxylic acid
Octanedioic acid
SUBERIC ACID
505-48-6
Cork acid
1,8-Octanedioic acid
1,6-Hexanedicarboxylic acid
Hexamethylenedicarboxylic acid
Octane-1,8-dioic acid
1,6-Dicarboxyhexane
Carboxylic acids, di-, C4-11
UNII-6U7Y4M9C1H
NSC25952
MFCD00004428
6U7Y4M9C1H
CHEBI:9300
C8H14O4
68937-72-4
Korksaeure
Oktandisaeure
Suberinsaeure
Korksaure
Kork Acid
1,8-Octanedioate
EINECS 208-010-9
EINECS 273-084-1
NSC 25952
Octane-1,8-dioate
Suberic acid, 98%
Octane-1,8-dioic aid
1,6-Hexanedicarboxylate
Hexamethylenedicarboxylate
AI3-52672
DSSTox_CID_1644
bmse000378
SCHEMBL3301
DSSTox_RID_76258
DSSTox_GSID_21644
Octanedioic acid Suberic acid
BIDD:ER0503
CHEMBL1162491
DTXSID8021644
NSC53777
STR03966
ZINC1531046
Tox21_200531
AC7522
BBL009289
LMFA01170001
NSC-25952
NSC-53777
s6220
STK801855
AKOS000119018
CS-W016016
HY-W015300
MCULE-1380155289
Suberic acid, purum, >=98.0% (T)
NCGC00164012-01
NCGC00164012-02
NCGC00164012-03
NCGC00258085-01
BP-27862
CAS-505-48-6
SY004501
DB-071218
AM20100233
FT-0655538
O0023
C08278
C8-120
C8-140
C8-180
C8-220
C8-260
C8-298
S-9000
AB00376809-03
Q899074
932D754A-EE85-46C7-A95B-A93A3DC1EC61
F1905-7049
