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ESCALOL 567 is a synthetic, oil-soluble organic compound widely used as a chemical sunscreen agent due to its ability to absorb ultraviolet (UV) radiation, particularly in the UVB (280–320 nm) and short-wave UVA (320–340 nm) ranges.
By absorbing high-energy UV photons and converting them into harmless low-level heat, ESCALOL 567 helps prevent sunburn, premature skin aging, and DNA damage linked to skin cancer.
Beyond personal care, ESCALOL 567 is also incorporated into plastics, coatings, and textiles to protect materials from photodegradation and discoloration caused by sunlight exposure.
CAS Number: 131-57-7
EC Number: 205-031-5
Molecular Formula: C₁₄H₁₂O₃
Molar Mass: 228.25 g/mol
Synonyms: component of Presun 29, component of Presun 30, Cyasorb uv 9, Cyasorb uv 9 light absorber, cyasorbuv9, Escalol 567, Eusolex 4360, Lankromark LE296, oxybenzone, 131-57-7, 2-HYDROXY-4-METHOXYBENZOPHENONE, Benzophenone-3, 2-Benzoyl-5-methoxyphenol, Advastab 45, (2-hydroxy-4-methoxyphenyl)(phenyl)methanone, 4-Methoxy-2-hydroxybenzophenone, Oxibenzona, Oxybenzon, Anuvex, Ongrostab HMB, Oxybenzonum, Escalol 567, Chimassorb 90, Uvinul 9, Syntase 62, Uvistat 24, Cyasorb UV 9, Methanone, (2-hydroxy-4-methoxyphenyl)phenyl-, Sunscreen UV-15, Usaf cy-9, Uvinul M40, Benzophenone 3, Spectra-sorb UV 9, Eusolex 4360, Oxibenzonum, NSC-7778, Cyasorb UV 9 Light Absorber, Oxybenzonum [INN-Latin], UF 3, UV 9, (2-Hydroxy-4-methoxyphenyl)phenylmethanone, Oxibenzona [INN-Spanish], (2-hydroxy-4-methoxyphenyl)-phenylmethanone, Benzophenone, 2-hydroxy-4-methoxy-, Tinosorb b 3, 2-hydroxy-4-methoxy benzophenone, NCI-C60957, Viosorb 110, CCRIS 1078, CHEBI:34283, HSDB 4503, UNII-95OOS7VE0Y, NSC 7778, EINECS 205-031-5, 95OOS7VE0Y, Uvinul 40, BRN 1913145, DTXSID3022405, Uvinul M 40, AI3-23644, NSC7778, MFCD00008387, MOB, CHEMBL1625, Oxybenzone [USAN:USP:INN], DTXCID002405, (2-hydroxy-4-methoxy-phenyl)-phenyl-methanone, 2-hydroxy-4-methoxy-benzophenone, EC 205-031-5, NCGC00016394-07, CAS-131-57-7, SHADE UVAGUARD COMPONENT OXYBENZONE, Oxybenzonum (INN-Latin), Oxibenzona (INN-Spanish), (2-hydroxy-4-methoxyphenyl)(phenyl) methanone, OXYBENZONE (MART.), OXYBENZONE [MART.], OXYBENZONE (USP-RS), OXYBENZONE [USP-RS], Oxybenzone (USAN:USP:INN), OXYBENZONE (USP MONOGRAPH), OXYBENZONE [USP MONOGRAPH], SMR000035344, SR-01000610567, BP-3, Neo heliopan BB, Bebak Baby Sun, Oxybenzonum (Latin), Solaquin (Salt/Mix), Oxybenzone (Standard), Spectrum_001049, DuraScreen (Salt/Mix), OXYBENZONE [MI], KAHSCREEN BZ-3, OXYBENZONE [INN], Prestwick0_000887, Prestwick1_000887, Prestwick2_000887, Prestwick3_000887, Spectrum2_001008, Spectrum3_000538, Spectrum4_000463, Spectrum5_001337, SUNSCREEN UV 15, OXYBENZONE [HSDB], OXYBENZONE [USAN], OXYBENZONE [VANDF], PreSun 15 (Salt/Mix), ADUVEX 24, Epitope ID:131795, SUMISORB 110, WLN: 1OR CQ DVR, SEESORB 101, OXYBENZONE [WHO-DD], Oprea1_174131, SCHEMBL15551, BSPBio_000674, BSPBio_002155, KBioGR_000906, KBioSS_001529, MLS000039797, MLS001055487, BIDD:ER0353, DivK1c_000184, SPECTRUM1500451, 2-HYDROXY-4-METHOXYBENZOPHENONE (OXYBENZONE), SPBio_001135, SPBio_002893
ESCALOL 567 is an organic compound widely used as a chemical sunscreen agent due to its strong ability to absorb ultraviolet (UV) radiation, particularly in the UVB (280–320 nm) and short-wave UVA (320–340 nm) ranges.
Belonging to the benzophenone family, ESCALOL 567 works by absorbing harmful UV rays and converting them into less damaging heat, thereby helping to prevent sunburn, premature skin aging, and DNA damage that may lead to skin cancers.
ESCALOL 567 is an oil-soluble, pale-yellow crystalline solid with good photostability and compatibility, which makes it suitable for use in a wide variety of cosmetic and personal care formulations, such as sunscreens, moisturizers, and makeup products with SPF.
Beyond cosmetics, ESCALOL 567 has also been incorporated into plastics, coatings, and textiles to prevent photodegradation from sunlight exposure.
However, concerns have been raised regarding ESCALOL 567's potential endocrine-disrupting effects and environmental impact, particularly its contribution to coral reef bleaching, leading some regions to restrict or ban its use.
Despite these concerns, ESCALOL 567 remains a significant UV filter in many commercial sunscreen formulations worldwide due to its effectiveness and long history of regulatory approval.
ESCALOL 567 is used as an ingredient in sunscreen and other cosmetics because it absorbs UV-A ultraviolet rays.
ESCALOL 567 absorbs UVB and UVA II rays, resulting in a photochemical excitation and absorption of energy.
Upon return to ground state, the absorbed energy results in emission of longer wavelength radiation and decreased skin penetration of radiation which reduces the risk of DNA damage.
A hydroxybenzophenone that is benzophenone which is substituted at the 2- and 4-positions of one of the benzene rings by hydroxy and methoxy groups respectively.
ESCALOL 567 is an organic compound belonging to the class of aromatic ketones known as benzophenones.
ESCALOL 567 takes the form of pale-yellow crystals that are readily soluble in most organic solvents.
ESCALOL 567 is widely used in sunscreen formulations, plastics, toys, furniture finishes, and other products to limit UV degradation.
In nature, ESCALOL 567 can be found in various flowering plants (angiosperms).
ESCALOL 567 was first synthesised in Germany by chemists König and Kostanecki in 1906.
The use of ESCALOL 567 as sunscreen ingredient is currently under scrutiny by the scientific community due to controversies about the molecule's environmental impact and safety profile (see section below).
As a result, sunscreens containing ESCALOL 567 have been banned from sale in Hawaii, Palau, and Thailand.
ESCALOL 567 is produced by the Friedel-Crafts reaction of benzoyl chloride with 3-methoxyphenol.
ESCALOL 567 is a commonly used UV filter in sun tans and skin protectants.
ESCALOL 567 act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers.
ESCALOL 567 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells.
ESCALOL 567 is a solid oil soluble UVA/UVB sunscreen.
ESCALOL 567, often labeled as ESCALOL 567 in sunscreen products, is a widely used chemical compound in cosmetics and sunscreens.
ESCALOL 567's chemical formula is C14H12O3.
This organic UV filter serves as a sunblock agent, absorbing and dissipating harmful ultraviolet (UV) rays, particularly UVB and some UVA radiation.
ESCALOL 5673 helps protect the skin from sunburn and UV-induced damage, making it a common ingredient in sunscreens, lotions, and lip balms.
Despite ESCALOL 567's effectiveness in shielding against sun damage, concerns about its potential hormone-disrupting properties have led to ongoing research and the exploration of alternative UV filters in the cosmetic industry.
ESCALOL 567 (benzophenone-3) is a synthetic, oil-soluble organic compound that belongs to the benzophenone family of chemicals and is one of the most widely used chemical UV filters in modern sunscreens.
ESCALOL 567 is primarily valued for its ability to absorb ultraviolet (UV) radiation in the UVB (280–320 nm) and part of the UVA (320–340 nm) spectrum, thereby protecting human skin from acute effects such as sunburn and long-term damage including photoaging, hyperpigmentation, and skin cancer.
ESCALOL 567 functions by absorbing high-energy UV photons and converting them into low-level heat, which is then dissipated harmlessly, preventing the UV radiation from penetrating into deeper skin layers and damaging DNA.
In ESCALOL 567's pure form, ESCALOL 567 appears as a pale-yellow crystalline powder with a faint odor, and it dissolves well in oils and alcohols, making it an ideal ingredient for lotions, creams, sprays, and cosmetic products with sun protection factor (SPF).
Beyond personal care, ESCALOL 567 is also incorporated into plastics, adhesives, paints, and textiles to protect materials from photodegradation and discoloration caused by prolonged sun exposure.
Despite its effectiveness and versatility, ESCALOL 567 has attracted controversy due to safety and environmental concerns.
Scientific studies have suggested that ESCALOL 567 may act as a potential endocrine disruptor, raising concerns about hormone-related effects when absorbed through the skin, although regulatory agencies continue to review safety data.
From an ecological perspective, ESCALOL 567 has been linked to coral reef bleaching and marine ecosystem damage, leading countries such as Palau and Hawaii to ban its use in sunscreens.
Nevertheless, ESCALOL 567 remains approved by the U.S. Food and Drug Administration (FDA), the European Union, and other regulatory authorities, and continues to be a common component in sunscreens because of its high efficacy, low cost, and ability to complement other UV filters for broad-spectrum sun protection.
For these reasons, ESCALOL 567 occupies a central role in both cosmetic science and industrial applications, balancing its benefits in skin and material protection against growing calls for safer and more environmentally friendly alternatives.
Market Overview of ESCALOL 567:
The global ESCALOL 567 market was valued at approximately USD 1.25 billion in 2023, and it is projected to grow to around USD 1.9 billion by 2033, representing an estimated CAGR of about 6.2% over the period.
A slightly more conservative outlook from another source estimates the market at USD 1.2 billion in 2024, with expected growth to USD 1.8 billion by 2033, equating to a 5.3% CAGR.
Regionally, the North American market remains the largest, followed by Europe and Asia-Pacific, reflecting strong demand for sun protection products.
The market's expansion is driven by heightened consumer awareness of UV-related health risks, increasing sunscreen usage, and ESCALOL 567’s wide applicability across sunscreen, cosmetic, and industrial sectors as a UV filter.
Uses of ESCALOL 567:
ESCALOL 567 is an organic compound used in sunscreens. ESCALOL 567 is used as an ingredient in sunscreen and other cosmetics because it absorbs UVB and short-wave UVA (ultraviolet) rays.
ESCALOL 567 was one of the first compounds incorporated into sunscreen formulations to offer enhanced UVA protection because its absorption spectrum extends to less than 350 nm.
Ultraviolet light absorber and stabilizer, especially in plastics and paints.
ESCALOL 567 is an oil-soluble uV absorber and filter with absorption rates within the uVA and uVB peak ranges.
ESCALOL 567 has an approved usage level of up to 6 percent in the united States and 10 percent in the european union.
ESCALOL 567 enhances SPF and is popular among sunscreen formulators given a concern over potential safety problems associated with more traditional sunscreen chemicals.
However, some reports associate ESCALOL 567 with causing photocontact allergy.
ESCALOL 567 is considered a non-comedogenic raw material.
ESCALOL 567 is the drug name for an FDAapproved uV filter and absorber.
ESCALOL 567 is used in plastics as an ultraviolet light absorber and stabilizer.
ESCALOL 567 is used, along with other benzophenones, in sunscreens, hair sprays, and cosmetics because they help prevent potential damage from sunlight exposure.
ESCALOL 567 is also found, as a stabilizer in concentrations up to 1%, in nail polishes.
ESCALOL 567 can also be used as a photostabilizer for synthetic resins.
ESCALOL 567 can leach from food packaging, and is widely used as photo-initiators to activate a chemical that dries ink faster.
Despite ESCALOL 567's photoprotective qualities, much controversy surrounds ESCALOL 567 because of possible negative hormonal and photoallergenic effects, leading many countries to regulate use in sunscreen products.
ESCALOL 567 is used in plastics as an ultraviolet light absorber and stabilizer.
ESCALOL 567 is used, along with otherbenzophenones, in sunscreens, hair sprays, and cosmetics because they help prevent potential damage from sunlight exposure.
ESCALOL 567 is also found, in concentrations up to 1%, in nail polishes.
ESCALOL 567 can also be used as a photostabilizer for synthetic resins.
ESCALOL 567 can leach from food packaging, and are widely used as photo-initiators used to start a chemical that dries ink faster.
ESCALOL 567 is used as an ingredient in sunscreen and other cosmetics.
ESCALOL 567 is a key ingredient in sunscreens and cosmetics.
ESCALOL 567's primary role is to protect the skin from the harmful effects of UV radiation. ESCALOL 567 absorbs UVB and some UVA rays, shielding the skin from sunburn and UV-induced damage.
ESCALOL 567 is a popular choice in sunscreens due to its broad-spectrum UV protection capabilities.
Additionally, ESCALOL 567 is used in various cosmetics like lip balms and moisturizers to provide UV protection and prevent sun damage, making it an essential component in the fight against skin aging and skin cancer caused by excessive sun exposure.
Sunscreen:
ESCALOL 567 provides a broad-spectrum ultraviolet coverage which includes UVB and short-wave UVA rays.
As a photoprotective agent, ESCALOL 567 has an absorption profile spanning from 270 to 350 nm with absorption peaks at 288 and 350 nm.
Due to toxicity and environmental concerns, the percentage of sunscreen products on the market containing ESCALOL 567 in the USA dropped to 13% in 2023 from 60% in 2019.
Some brands market their sunscreens as "ESCALOL 567 free" due to the generally negative perception of benzophenones by both the consuming public and scientific researchers.
Sunscreens and Personal Care Products:
ESCALOL 567 is widely used as a UV filter in sunscreens, creams, lotions, sprays, lip balms, and cosmetic formulations.
ESCALOL 567 provides broad-spectrum protection against both UVB and part of the UVA rays, helping prevent sunburn, premature aging, and skin cancer.
ESCALOL 567 commonly combined with other UV filters (e.g., avobenzone, octocrylene, octinoxate) to improve photostability and SPF performance.
Cosmetics and Daily Care Formulations:
Incorporated into makeup products such as foundations, powders, and BB creams to protect skin from incidental sun exposure.
ESCALOL 567 is used in hair care products (shampoos, conditioners, sprays) to prevent UV-induced damage, dryness, and color fading.
Added to lipsticks and lip balms to protect sensitive lip skin from UV rays.
Industrial Applications:
ESCALOL 567 is used as a UV stabilizer in plastics, polymers, adhesives, and coatings, protecting materials from degradation, cracking, and color fading caused by sunlight.
Incorporated into textiles and fabrics to prevent fiber weakening and discoloration.
ESCALOL 567 applied in paints, varnishes, and packaging materials to extend shelf-life and preserve product quality under UV exposure.
Pharmaceutical and Medical Uses:
Occasionally employed in topical pharmaceutical formulations to protect drugs and skin from UV-induced breakdown.
Functions as a photoprotective agent in dermatological preparations.
Benefits of ESCALOL 567:
ESCALOL 567 provides broad-spectrum UV protection, effectively absorbing both UVA and UVB radiation, which helps prevent sunburn, premature skin aging, and DNA damage linked to skin cancer.
ESCALOL 567's oil-soluble nature makes it highly compatible with a wide range of cosmetic formulations, allowing for easy incorporation into creams, lotions, and sprays without altering texture or appearance.
ESCALOL 567 also enhances the photostability of other sunscreen agents, such as avobenzone, by preventing their rapid degradation under sunlight, thereby improving the overall effectiveness and longevity of sunscreen products.
Beyond personal care, ESCALOL 567 is used to protect materials from UV degradation, extending the lifespan of plastics, coatings, and textiles by preventing fading, discoloration, and loss of mechanical strength.
ESCALOL 567's versatility, high efficiency at low concentrations, and global regulatory approval in many markets make it a cost-effective and widely used UV filter.
Application and Synthesis of ESCALOL 567:
ESCALOL 567 is a light yellow or white crystalline powder, also known as sunscreen 2, BP-3, suitable for polyvinyl chloride, polyvinylidene chloride, polymethyl methacrylate, unsaturated polyester, ABS resin and cellulose resin and other plastics, the maximum absorption wavelength range of 280-340 nm, the general amount of 0.1-1.5%, good thermal stability, does not decompose at 200 ℃.
ESCALOL 567 hardly absorb visible light, it applies to light-colored transparent products.
ESCALOL 567 can also be used for paints and synthetic rubber.
For the broad-spectrum UV absorbers, with high absorption rate, non-toxic, non-teratogenic effect, light, thermal stability.
ESCALOL 567 can absorb UV-A and UV-B together, is the US FDA approved Class I sunscreen and being used with a higher frequency in the US and European countries.
ESCALOL 567 is widely used in sunscreen cream, cream, honey, lotion, oil and other sunscreen cosmetics, but also as a product from the photosensitive and discoloration of the anti-discoloration agent.
In addition, ESCALOL 567 is usually used for PVC and unsaturated polyester and many other fields, because UV-9 has good compatibility with many kinds of plastics and resins.
Structure and electronic structure:
Being a conjugated molecule, ESCALOL 567 absorbs light at lower energies than many aromatic molecules.
As in related compounds, the hydroxyl group is hydrogen bonded to the ketone.
This interaction contributes to ESCALOL 567's light-absorption properties.
At low temperatures, however, ESCALOL 567 is possible to observe both the phosphorescence and the triplet-triplet absorption spectrum.
At 175 K the triplet lifetime is 24 ns.
The short lifetime has been attributed to a fast intramolecular hydrogen transfer between the oxygen of the C=O and the OH.
Production of ESCALOL 567:
ESCALOL 567 is produced primarily through organic synthesis using Friedel–Crafts acylation reactions.
The most common method involves the acylation of resorcinol with benzoyl chloride in the presence of a Lewis acid catalyst such as aluminum chloride, yielding a benzophenone intermediate.
This is then followed by hydroxylation or methoxylation steps to introduce the hydroxy or methoxy functional groups at specific positions on the aromatic rings, giving rise to benzophenone-3 (2-hydroxy-4-methoxybenzophenone).
Industrial production often employs solvent systems like nitrobenzene or dichloromethane to facilitate the reaction and optimize yields.
Large-scale manufacturers ensure high purity and consistency of ESCALOL 567 by applying distillation, recrystallization, and chromatography techniques during purification.
Production facilities typically integrate ESCALOL 567 into bulk cosmetic and sunscreen formulations immediately after synthesis, as demand is largely driven by the personal care and cosmetics industry.
Additionally, greener synthetic routes are being investigated to reduce environmental impacts, including catalyst recycling and solvent-free or aqueous phase reactions, reflecting the market’s shift toward more sustainable manufacturing practices.
History of ESCALOL 567:
ESCALOL 567 was first developed in the 1960s as part of the benzophenone class of organic compounds designed for ultraviolet (UV) absorption.
By the 1970s, ESCALOL 567 became one of the first chemical sunscreen agents approved for use in cosmetic and pharmaceutical formulations, offering broad-spectrum protection against both UVA and UVB rays at a time when most sunscreens primarily targeted UVB.
ESCALOL 567's widespread adoption in the 1980s and 1990s marked a major shift toward more effective sun care products, especially in regions with high sun exposure such as North America, Europe, and Australia.
ESCALOL 567 gained recognition not only for personal skincare but also for its ability to protect plastics, textiles, and coatings from UV degradation.
However, since the early 2000s, ESCALOL 567 has faced growing scrutiny due to concerns about endocrine disruption, skin allergies, and environmental impact, particularly its contribution to coral reef bleaching.
This led some countries and regions, including Hawaii, Palau, and parts of the Caribbean, to ban or restrict ESCALOL 567-containing sunscreens in the late 2010s and early 2020s.
Despite these restrictions, ESCALOL 567 remains approved and widely used in many global markets, while research continues into safer, more environmentally friendly alternatives.
Handling and Storage of ESCALOL 567:
Handle in accordance with good industrial hygiene and safety practice.
Avoid direct contact with skin, eyes, and clothing.
Store in a cool, dry, well-ventilated area away from heat, sparks, and open flames.
Keep container tightly closed and protect from direct sunlight.
Recommended storage temperature: 15–25 °C.
Stability and Reactivity of ESCALOL 567:
Stable under normal conditions of use and storage.
Photolabile:
prolonged exposure to UV light may lead to degradation.
Incompatible with strong oxidizing agents, strong acids, and bases.
Decomposition products may include carbon oxides and other organic vapors.
First Aid Measures of ESCALOL 567:
Inhalation:
Move to fresh air.
If symptoms persist, seek medical attention.
Skin Contact:
Wash with soap and plenty of water.
Remove contaminated clothing.
Seek medical help if irritation develops.
Eye Contact:
Rinse cautiously with water for several minutes.
Remove contact lenses if present.
Get medical advice if irritation continues.
Ingestion:
Rinse mouth with water.
Do not induce vomiting.
Seek medical attention immediately.
Firefighting Measures of ESCALOL 567:
Suitable extinguishing media:
Foam, dry chemical powder, carbon dioxide (CO₂), or water spray.
Hazardous combustion products:
Carbon oxides, irritating fumes, toxic smoke.
Firefighters should wear self-contained breathing apparatus (SCBA) and full protective gear.
Accidental Release Measures of ESCALOL 567:
Avoid release to the environment.
Contain and collect spillage with non-combustible absorbent materials (sand, earth, diatomaceous earth, vermiculite).
Place in a suitable container for proper disposal according to local regulations.
Prevent entry into waterways, sewers, or soil.
Exposure Controls / Personal Protection of ESCALOL 567:
Engineering Controls:
Use in well-ventilated areas or under local exhaust.
Personal Protection:
Respiratory protection:
Not normally required; use approved respirator if ventilation is inadequate.
Skin protection:
Wear protective gloves and lab coat.
Eye protection:
Safety goggles recommended.
Follow standard industrial hygiene practices, including washing hands before breaks and at the end of the workday.
Identifiers of ESCALOL 567:
IUPAC Name: (2-Hydroxy-4-methoxyphenyl)(phenyl)methanone
Common Name: ESCALOL 567
CAS Number: 131-57-7
Molecular Formula: C₁₄H₁₂O₃
Molar Mass: 228.25 g/mol
InChI: InChI=1S/C14H12O3/c1-17-12-8-6-11(9-13(12)15)14(16)10-4-2-3-5-10/h2-9,15H,1H3
InChI Key: IAUJQLCUMQIWOK-UHFFFAOYSA-N
SMILES: COc1ccc(C(=O)c2ccccc2)cc1O
UNII Code (FDA): 6S6VYF977B
EC Number: 205-031-5
PubChem CID: 4637
IUPAC Name: (2-Hydroxy-4-methoxyphenyl)(phenyl)methanone
Common Name: ESCALOL 567
CAS Number: 131-57-7
Molecular Formula: C₁₄H₁₂O₃
Molar Mass: 228.25 g/mol
InChI: InChI=1S/C14H12O3/c1-17-12-8-6-11(9-13(12)15)14(16)10-4-2-3-5-10/h2-9,15H,1H3
InChI Key: IAUJQLCUMQIWOK-UHFFFAOYSA-N
SMILES: COc1ccc(C(=O)c2ccccc2)cc1O
UNII Code (FDA): 6S6VYF977B
EC Number (EINECS): 205-031-5
PubChem CID: 4637
ChemSpider ID: 4473
KEGG Compound ID: C11002
ChEBI ID: CHEBI:81915
RTECS Number: DJ3325000
US EPA DSSTox ID: DTXSID9022237
FDA Listing: Sunscreen monograph (maximum allowed concentration: 6%)
European Commission Index Number: 604-183-00-0
Japan ENCS Number: 3-7113
Properties of ESCALOL 567:
Melting point: 62-64 °C(lit.)
Boiling point: 150-160 °C5 mm Hg(lit.)
Density: 1,3 g/cm3
Vapor pressure: 0.001Pa at 25℃
Refractive index: 1.5805 (estimate)
Fp: 216°C
Storage temp.: 2-8°C
Solubility: 95% ethanol: soluble50mg/mL, clear, colorless
Form: Crystalline Powder
pka: 7.56±0.35(Predicted)
Color: White to light yellow
Odor: ylsh. cryst., rose-like odor
Water Solubility: <0.1 g/100 mL at 20 ºC
Merck: 14,6954
BRN: 1913145
InChIKey: DXGLGDHPHMLXJC-UHFFFAOYSA-N
LogP: 3.45 at 40℃
CAS DataBase Reference: 131-57-7(CAS DataBase Reference)
NIST Chemistry Reference: ESCALOL 567(131-57-7)
EPA Substance Registry System: ESCALOL 567 (131-57-7)
Appearance: White to light yellow crystalline powder
Odor: Slight aromatic odor
Taste: Practically tasteless
Molecular Formula: C₁₄H₁₂O₃
Molecular Weight: 228.25 g/mol
Melting Point: 62–65 °C
Boiling Point: 359 °C (at 760 mmHg)
Density: 1.28 g/cm³ at 25 °C
Refractive Index: 1.573
Vapor Pressure: ~1.5 × 10⁻⁶ mmHg at 25 °C (very low volatility)
Solubility:
Water Solubility: 3.7 mg/L at 25 °C (sparingly soluble)
Soluble in: Ethanol, acetone, ethyl acetate, chloroform, benzene, and most cosmetic oils
Partition Coefficient (log P): ~3.79 (lipophilic, oil-soluble)
Absorption Maxima (λmax): 288 nm and 325–327 nm
UV Range Coverage: Primarily UVB (280–320 nm) and partial UVA II (320–340 nm) absorption
Molar Absorptivity (ε): ~19,000–20,000 L·mol⁻¹·cm⁻¹
Flash Point: >160 °C (closed cup)
Autoignition Temperature: Not easily flammable
Color Index (CI): 11775 (cosmetic ingredient reference)
Crystallinity: Orthorhombic crystalline form
