ETHYL NICOTINATE

Ethyl nicotinate is a member of pyridines and an aromatic carboxylic acid.
Ethyl nicotinate, also known as nicotine acid ethyl ester or mucotherm, is a member of the class of compounds known as pyridinecarboxylic acids. 
Ethyl nicotinate acids are compounds containing a pyridine ring bearing a carboxylic acid group. 

CAS Number: 614-18-6
Molecular Formula: C8H9NO2
Molecular Weight: 151.16
EINECS Number: 210-370-7

Ethyl nicotinate is soluble (in water) and a strong basic compound (based on its pKa). 
Ethyl nicotinate can be found in sweet orange, which makes ethyl nicotinate a potential biomarker for the consumption of this food product. 
Ethyl nicotinate exists in all eukaryotes, ranging from yeast to humans.

Ethyl Nicotinate is an active substance from the group of rubefacients that stimulates blood circulation. 
Ethyl nicotinate is used for topical treatment of muscle, joint and ligament pain. 
Ethyl Nicotinate can be used in creams, baths and emulsions, in veterinary as well as in human medicines.

Ethyl nicotinate, also known as mucotherm, belongs to the class of organic compounds known as pyridinecarboxylic acids. 
Ethyl nicotinate is a strong basic compound (based on its pKa). 
Outside of the human body, Ethyl nicotinate has been detected, but not quantified in, sweet oranges. 

This could make ethyl nicotinate a potential biomarker for the consumption of these foods. 
These are Ethyl nicotinates containing a pyridine ring bearing a carboxylic acid group.
Ethyl nicotinate is used for skin-conditioning cosmetics. 

Ethyl nicotinate is principally used in medicine as a local vasodilator at a concentration of 1 to 2 % in creams, ointments and pomades. 
Ethyl nicotinate is utilized for the treatment sprains, wrenches, muscular pains and tendonitis.
Ethyl nicotinate is an organic compound that is derived from nicotinic acid, which is a form of niacin (vitamin B3). 

Ethyl nicotinate is an ester, specifically the ethyl ester of nicotinic acid. 
The chemical formula for ethyl nicotinate is C9H9NO2.
Ethyl nicotinate is known for its characteristic odor, which may be described as sweet and somewhat fruity.

Ethyl nicotinate is typically synthesized through the esterification reaction between nicotinic acid (niacin) and ethanol (ethyl alcohol). 
This reaction is often catalyzed by an acid.
Ethyl nicotinate has been used in the pharmaceutical and cosmetic industries. 

Ethyl nicotinate is known for its potential vasodilatory (blood vessel widening) effects and has been explored for applications related to skin care and circulation.
Ethyl nicotinate has been investigated for its ability to enhance blood flow. 
This property is sometimes utilized in cosmetic formulations or topical products designed to improve skin circulation.

Ethyl nicotinate is used in certain topical formulations, such as creams or ointments, where its vasodilatory effects may be desired for improving skin appearance and health.
In the pharmaceutical industry, ethyl nicotinate has been explored for its potential role in vasodilation and its impact on blood circulation. 
Ethyl nicotinate may be considered in formulations for conditions related to poor blood flow.

While not as common as other esters in flavor and fragrance applications, Ethyl nicotinate may contribute to the overall scent of certain products.
Ethyl nicotinate can cause skin irritation, and its use in cosmetic or topical products should be carefully controlled to avoid adverse reactions.
Ethyl nicotinate is related to niacin, also known as vitamin B3. Niacin is an essential nutrient for the human body and is involved in various physiological processes, including energy metabolism.

The vasodilatory effects of ethyl nicotinate, which widen blood vessels, have led to its exploration in formulations designed to improve blood circulation. 
This can be relevant in the context of skincare and certain health conditions.
Some studies suggest that nicotinic acid and its derivatives, including ethyl nicotinate, may have anti-inflammatory properties. 

This property may be relevant in skincare formulations for conditions related to inflammation.
Ethyl nicotinate is used in cosmetic formulations, particularly in products designed to improve skin tone and appearance. 
Ethyl nicotinate is ability to enhance blood flow may contribute to a healthy complexion.

Research studies have explored the potential therapeutic applications of ethyl nicotinate, especially in the context of cardiovascular health and blood circulation disorders.
In addition to its physiological effects, ethyl nicotinate may contribute to the sensory profile of certain products, providing a characteristic scent or taste.
Ethyl nicotinate has been investigated for its potential to improve microcirculation in the skin. 

This can be relevant in skincare formulations targeting conditions such as cellulite.
When used topically, ethyl nicotinate can be absorbed through the skin. 
This property is considered in the formulation of products to ensure controlled and effective delivery.

Due to its effects on blood flow and potential anti-inflammatory properties, ethyl nicotinate may be considered in formulations designed for certain dermatological conditions.
The stability of ethyl nicotinate in formulations, especially regarding its vasodilatory effects, is an important consideration in product development.
The vasodilatory effects of ethyl nicotinate may induce a warming or tingling sensation on the skin, which is sometimes perceived in certain cosmetic or skincare products.

Ethyl nicotinate is a nicotinic acid derivative that has a high affinity for magnesium. 
Ethyl nicotinate is used as an ingredient in skin care products to improve the appearance of aging skin. 
Ethyl nicotinate binds to the magnesium ion, which acts as an electron donor, and forms an electrochemical complex. 

This complex can catalyze the oxidation of hydrochloric acid to form picolinic acid and hydrogen chloride gas, which are thought to be responsible for its exfoliating properties. 
The coordination geometry of ethyl nicotinate depends on the counterion it binds with, with either octahedral or square pyramidal geometries possible. 
The nitrogen atoms are primarily bound to carbon atoms in ethyl nicotinate, with two lone pairs of electrons pointing away from the molecule in opposite directions.

Ethyl nicotinate is an organic compound with a fruity, sweet aroma and flavor. 
Ethyl nicotinate is commonly used as a food additive to impart flavor in various food products such as baked goods, candies, and chewing gum. 
Ethyl nicotinate also finds applications in the cosmetic industry as a fragrance ingredient. 

Ethyl nicotinate should be stored in a cool, dry place away from sources of heat or ignition and kept tightly sealed to prevent moisture absorption. 
Ethyl nicotinate is not considered hazardous under normal handling conditions but may cause skin irritation upon prolonged exposure.

Melting point: 8-10 °C (lit.)
Boiling point: 223-224 °C (lit.)
Density: 1.107 g/mL at 25 °C (lit.)
vapor pressure: 4.2-5.5Pa at 20-25℃
refractive index: n20/D 1.504(lit.)
Flash point: 93 °C
storage temp.: Store below +30°C.
solubility: 50g/l
form: neat
pka: pK1:3.35(+1) (25°C)
Specific Gravity: 1.107
color: light yellow
Water Solubility: miscible
LogP: 1.32

Ethyl nicotinate is sometimes included in anti-aging skincare formulations due to its potential to improve blood circulation and contribute to a more youthful appearance.
Some studies suggest that nicotinic acid derivatives, including ethyl nicotinate, may have properties that could support wound healing. 
Research in this area is ongoing.

Ethyl nicotinate's important to note that ethyl nicotinate can have sensitizing effects on the skin. 
Formulators need to carefully consider the concentration used in products to minimize the risk of irritation.
Ethyl nicotinate is listed in cosmetic ingredients databases, and its use is subject to regulations and guidelines set by regulatory authorities in different regions.

Some research studies on the application of ethyl nicotinate can be found in journals related to experimental dermatology and skincare science.
Products containing ethyl nicotinate should provide clear labeling to inform consumers about its presence and potential effects. 
This is in accordance with regulatory requirements for cosmetic and skincare products.

In vitro studies have been conducted to explore the effects of ethyl nicotinate on various skin-related parameters, contributing to the understanding of its potential benefits.
Ethyl nicotinate is often used in studies assessing microcirculation in the skin, examining its impact on blood flow and perfusion.
Ethyl nicotinate may be used in combination with other ingredients in skincare formulations to enhance overall product efficacy.

Pharmacological actions associated with ethyl nicotinate include its role as a vasodilator and its potential impact on cellular processes related to inflammation.
Clinical studies are conducted to evaluate the safety and efficacy of skincare products containing ethyl nicotinate, providing valuable insights into its practical applications.
Studies may investigate the penetration of ethyl nicotinate into the skin, considering factors such as molecular size and formulation characteristics.

Instruments and devices measuring skin microcirculation are often used in studies involving ethyl nicotinate to quantify its effects objectively.
The vasodilatory effect of ethyl nicotinate is related to its role in releasing prostaglandins, which are lipid compounds with various physiological effects, including blood vessel dilation.
Ethyl nicotinate is known to interact with certain receptors in the skin, contributing to its vasodilatory effects. 

These receptors are involved in the regulation of blood flow.
Studies have explored the potential use of Ethyl nicotinate acid derivatives, including ethyl nicotinate, in addressing peripheral arterial disease (PAD) by improving blood circulation in the extremities.
The biological effects of ethyl nicotinate are multifaceted and may include improved oxygenation of tissues, enhanced nutrient delivery, and potential anti-inflammatory actions.

Due to its potential to improve microcirculation and blood flow, ethyl nicotinate has been investigated for use in anti-cellulite formulations, where improved circulation is considered beneficial.
Some studies suggest that nicotinic acid derivatives, including ethyl nicotinate, may have photoprotective properties, potentially contributing to protection against UV-induced damage.
The vasodilatory action of ethyl nicotinate can lead to temporary skin redness and a warming sensation, which is often perceived when applied topically.

Formulators need to address challenges related to the potential irritation caused by ethyl nicotinate, ensuring that formulations are well-tolerated by the skin.
Ongoing research and development in the skincare industry may result in new patents and formulation innovations that leverage the properties of ethyl nicotinate.
Products containing ethyl nicotinate may be available over-the-counter, especially in skincare formulations targeting circulation improvement and related benefits.

Safety assessments for products containing ethyl nicotinate typically include patch testing and other measures to ensure that potential skin sensitization and irritation risks are minimized.
Clinical studies involving ethyl nicotinate may assess endpoints such as skin blood flow, skin temperature, and the subjective experience of participants to evaluate its effects.
In vivo studies, involving live organisms or tissues, are conducted to better understand the physiological effects of ethyl nicotinate on skin microcirculation.

Ethyl nicotinate is bio converted to nicotinamide which is further converted to nicotinamide adenine dinucleotide (NAD+) and the hydride equivalent (NADH) which are coenzymes necessary for tissue metabolism, lipid metabolism, and glycogenolysis. 
Ethyl nicotinate (but not nicotinamide) in gram doses reduces LDL-C, Apo B, Lp(a), TG, and TC, and increases HDL-C. 
The increase in HDL-C is associated with an increase in apolipoprotein A-I (Apo A-I) and a shift in the distribution of HDL subfractions. 

These shifts include an increase in the HDL2:HDL3 ratio, and an elevation in lipoprotein A-I (Lp A-I, an HDL-C particle containing only Apo A-I). 
The mechanism by which niacin alters lipid profiles is not completely understood and may involve several actions, including partial inhibition of release of free fatty acids from adipose tissue, and increased lipoprotein lipase activity (which may increase the rate of chylomicron triglyceride removal from plasma). 

Ethyl nicotinate decreases the rate of hepatic synthesis of VLDL-C and LDL-C, and does not appear to affect fecal excretion of fats, sterols, or bile acids. 
As an adjunct to diet, the efficacy of Ethyl nicotinate and lovastatin in improving lipid profiles (either individually, or in combination with each other, or Ethyl nicotinate in combination with other statins) for the treatment of dyslipidemia has been well documented.

Uses Of Ethyl nicotinate:
Ethyl nicotinate is used for skin-conditioning cosmetics. 
Ethyl nicotinate is principally used in medicine as a local vasodilator at a concentration of 1 to 2 % in creams, ointments and pomades. 
Ethyl nicotinate is utilized for the treatment sprains, wrenches, muscular pains and tendonitis.

Ethyl nicotinate is frequently employed in formulations aiming to enhance skin microcirculation. 
This may contribute to improved oxygenation and nutrient delivery to the skin.
Ethyl nicotinate is often used in combination with other active ingredients in skincare formulations to create products with comprehensive benefits for skin health.

In some formulations, ethyl nicotinate is applied to localized areas where vasodilation is desired, such as areas prone to poor circulation.
Ongoing research explores the potential anti-inflammatory effects of nicotinic acid derivatives like ethyl nicotinate. 
This could have implications for skincare products addressing inflammatory skin conditions.

Clinical studies may focus on evaluating the actual impact of ethyl nicotinate on blood flow, using objective measures to assess its efficacy.
In hair care products, ethyl nicotinate may be included for its potential to stimulate blood flow to the hair follicles, promoting a healthy scalp environment.
Some skincare products formulated with ethyl nicotinate may be marketed for use in cold weather, as the vasodilatory effects could help maintain skin warmth.

Ethyl nicotinate is sometimes included in massage oils due to its warming sensation and potential benefits in promoting localized blood circulation.
Clinical studies evaluating the efficacy of skincare products containing ethyl nicotinate may use endpoints such as skin hydration, elasticity, and overall skin appearance.
Research suggests that the vasodilatory effects of nicotinic acid derivatives may contribute to scar tissue healing. 

This could have implications for skincare products designed to address scars.
Studies may explore the effects of ethyl nicotinate in individuals with skin conditions such as rosacea and eczema, where vascular and inflammatory aspects are often considered.
Dermatologists may incorporate ethyl nicotinate-containing products into clinical practices for specific skincare treatments.

Ethyl nicotinate may be part of innovations in dermocosmetic formulations, where the intersection of skincare and pharmaceutical science is explored.
Skincare products containing ethyl nicotinate are marketed to consumers for the purpose of enhancing the overall appearance and health of the skin.
Collaborative research initiatives between cosmetic companies and academic institutions may focus on the development and optimization of products containing ethyl nicotinate.

Ethyl nicotinate is a nicotinic acid derivative used for skin-conditioning cosmetics.
Ethyl nicotinate is principally used in medicine as a local vasodilator at a concentration of 1 to 2 % in creams, ointments and pomades.
Ethyl nicotinate is used in skincare formulations, such as creams, lotions, and serums, due to its vasodilatory properties. 

Ethyl nicotinate is believed to improve blood circulation in the skin, contributing to a healthy and vibrant complexion.
Due to its potential to enhance blood flow and oxygenation of tissues, ethyl nicotinate is included in some anti-aging skincare products. 
Improved circulation is associated with skin rejuvenation.

The vasodilatory effects of ethyl nicotinate may be utilized in certain topical analgesic formulations. 
Ethyl nicotinate is believed to help alleviate discomfort or pain by increasing blood flow to the affected area.
Ethyl nicotinate is explored in formulations designed to address cellulite. 

Ethyl nicotinate is ability to enhance microcirculation is considered beneficial for reducing the appearance of cellulite.
In some formulations, ethyl nicotinate may be included in hair care products to potentially support blood circulation in the scalp, which is believed to be beneficial for hair health.
Due to its potential anti-inflammatory properties and impact on blood flow, ethyl nicotinate is investigated for its role in formulations designed to support wound healing.

Some studies suggest that nicotinic acid derivatives, including ethyl nicotinate, may offer photoprotective effects. 
This property could be relevant in formulations designed to protect the skin from UV-induced damage.
Research studies have explored the potential use of nicotinic acid derivatives, including ethyl nicotinate, in addressing peripheral arterial disease (PAD) by improving blood circulation in the extremities.

Ethyl nicotinate is often included in formulations targeting microcirculation improvement, addressing conditions where increased blood flow is desired for overall skin health.
Studies continue to investigate the potential benefits of ethyl nicotinate in various dermatological conditions, such as inflammatory skin disorders and conditions associated with impaired blood flow.
Ethyl nicotinate is often explored in the realm of cosmetic dermatology, where formulations are developed to address aesthetic concerns and improve overall skin health.

Scientific studies may specifically investigate the impact of ethyl nicotinate on cutaneous (skin) blood flow, shedding light on its potential mechanisms of action.
In vitro models, utilizing artificial skin constructs or skin cells in a controlled environment, may be used to study the effects of ethyl nicotinate on skin perfusion.
Ethyl nicotinate might be considered in cosmetic procedures where temporary vasodilation and improved blood flow are desired, contributing to a refreshed and revitalized appearance.

Ongoing research may explore innovative delivery systems for ethyl nicotinate, ensuring its controlled release and efficacy in specific skin areas.
Ethyl nicotinate may find applications in dermatological treatments targeting specific skin conditions or concerns, especially those related to circulation and microcirculation.
Companies and researchers may file patent applications related to novel formulations, methods of use, or combinations involving ethyl nicotinate in skincare and cosmetic products.

Studies may investigate the impact of ethyl nicotinate on skin oxygenation, evaluating its potential role in enhancing the delivery of oxygen to skin tissues.
Ethyl nicotinate-containing products may be used in professional spa treatments, where the temporary effects of vasodilation contribute to a relaxing and rejuvenating experience.
Cosmetic and skincare companies may collaborate with medical professionals, including dermatologists and plastic surgeons, to develop products and procedures incorporating ethyl nicotinate.

Ethyl nicotinate can be incorporated into various dermatological formulations, including gels, creams, and serums, tailored for specific skincare goals.
Research may explore the potential of ethyl nicotinate in addressing underlying skin conditions, such as impaired microcirculation associated with certain dermatoses.
Investigations into the long-term effects of ethyl nicotinate on skin health and aging may contribute to a better understanding of its role in skincare formulations.

Studies may assess the dermal penetration of ethyl nicotinate, examining its ability to reach target skin layers and exert its physiological effects.
Research and product development may focus on formulations containing ethyl nicotinate that are suitable for individuals with sensitive or reactive skin.

Safety Profile Of Ethyl nicotinate:
Ethyl nicotinate has the potential to cause skin irritation, especially when used at high concentrations. 
Individuals with sensitive or reactive skin may be more prone to experiencing irritation. 
Ethyl nicotinate is crucial to follow recommended usage guidelines and conduct patch testing before widespread application.

The vasodilatory effects of ethyl nicotinate may lead to temporary skin redness and a warming sensation. 
While this is often intentional in certain formulations, individuals with sensitive skin may find these effects uncomfortable.
Contact with eyes can lead to irritation. 

Ethyl nicotinate's essential to avoid direct contact with the eyes and rinse thoroughly if accidental exposure occurs.
Inhalation of ethyl nicotinate vapors or aerosols should be avoided. 
Proper ventilation is necessary when working with products containing Ethyl nicotinate.

There is a potential for skin sensitization, where repeated exposure to ethyl nicotinate may lead to an allergic reaction in some individuals. 
Patch testing is recommended to identify potential sensitivities.
Individuals with pre-existing skin conditions or compromised skin barriers may be more susceptible to adverse reactions. 

Consulting with a dermatologist before using products containing ethyl nicotinate is advisable, especially for those with skin concerns.
The safety of using ethyl nicotinate during pregnancy or while nursing is not well-established. 
Pregnant or nursing individuals should consult with a healthcare professional before using products containing this compound.

Formulators should consider the overall concentration of ethyl nicotinate in a product, ensuring it is within safe limits. 
Combining Ethyl nicotinate with other potentially irritating ingredients should also be carefully evaluated.

Synonyms Of Ethyl nicotinate:
Ethyl nicotinate
614-18-6
ethyl pyridine-3-carboxylate
Ethyl nicotinoate
Ethylnicotinate
Nicotinic acid ethyl ester
3-Pyridinecarboxylic acid, ethyl ester
Ignicut
Nicotinic acid, ethyl ester
Ethyl 3-pyridinecarboxylate
Mucotherm
Nicaethan
Nikethan
Nikithan
Ignocut
3-Carbethoxypyridine
3-(Ethoxycarbonyl)pyridine
Ba 2673
3-Pyridinecarboxylic Acid Ethyl Ester
NSC 8872
Nicotinic acid-ethyl ester
NIJ3H353YH
123574-71-0
DTXSID9046526
NSC-8872
3-Picolinic acid ethyl ester
NCGC00166056-01
.beta.-Pyridinecarboxylic acid ethyl ester
ETHYL NICOTINATE-2,4,5,6-D4
DTXCID7026526
CAS-614-18-6
Nicotinic acid,ethyl ester
UNII-NIJ3H353YH
Mucotherm (TN)
EINECS 210-370-7
MFCD00006389
beta-Pyridinecarboxylic acid ethyl ester
3-ethoxycarbonylpyridine
AI3-02579
Ethyl nicotinate, 99%
Nicotine acid ethyl ester
ethyl 3-pyridine carboxylate
SCHEMBL24853
ETHYL NICOTINATE [INCI]
CHEMBL2251611
ETHYL NICOTINATE [MART.]
NSC8872
CHEBI:192166
ETHYL NICOTINATE [WHO-DD]
BCP30661
Tox21_112299
Ethyl nicotinate, analytical standard
AKOS000119658
pyridine-3-carboxylic acid ethyl ester
Tox21_112299_1
AB00748
CS-W014344
FS-3453
NCGC00166056-02
AC-22480
3-PYRIDINECARBOXYLIC ACID,ETHYL ESTER
AM20061373
FT-0645165
FT-0652424
FT-0668338
N0085
EN300-20116
D08274
A805121
A833209
Q-100710
Q16948611
F0001-1619
Z104476924
InChI=1/C8H9NO2/c1-2-11-8(10)7-4-3-5-9-6-7/h3-6H,2H2,1H
2,4-dimethoxy-N-[(E)-2-(1,3,3-trimethylindol-1-ium-2-yl)vinyl]aniline; hydrogen sulfate;Ethyl nicotinate
Nicotinic acid ethyl ester pound>>3-carboethoxypyridine pound>>Ethyl 3-pyridinecarboxylate pound>>3-Picolinic acid ethyl ester