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Ethyl p-Hydroxybenzoate is a paraben preservative used to inhibit microbial growth in cosmetics, pharmaceuticals, and some specialty products, and Ethyl p-Hydroxybenzoate is valued for broad antimicrobial activity with strong antifungal performance.
Ethyl p-Hydroxybenzoate is commonly known as Ethylparaben, and Ethyl p-Hydroxybenzoate is typically used in combination with other parabens or preservative systems to broaden coverage and improve overall robustness.
Ethyl p-Hydroxybenzoate must be used according to local regulations because preservative allowances and concentration limits vary by region and product category, and Ethyl p-Hydroxybenzoate should be incorporated with attention to solubility and pH behavior.
CAS Number: 120-47-8
EC Number: 204-399-4
Molecular Formula: C9H10O3
Molecular Weight: 166.17 g/mol
Synonyms: Ethyl p-Hydroxybenzoate, Ethylparaben, p-Hydroxybenzoic Acid Ethyl Ester, Ethyl 4-Hydroxybenzoate, 4-Hydroxybenzoic Acid Ethyl Ester, Ethyl Paraben Preservative, Ethylparaben Preservative, Paraben Ethyl, Ethyl Parahydroxybenzoate, E214, Ethylparaben E214, Ethyl Paraben USP/FCC (grade dependent), Ethyl p-Hydroxybenzoate, Ethyl para-Hydroxybenzoate, Ethyl 4-Hydroxybenzoate, p-Hydroxybenzoic Acid Ethyl Ester, para-Hydroxybenzoic Acid Ethyl Ester, 4-Hydroxybenzoic Acid Ethyl Ester, Ethylparaben, Ethyl Paraben, Ethyl p-Hydroxy Benzoate, Ethyl para-Hydroxy Benzoate, Ethyl 4-Hydroxy Benzoate, p-Carbethoxyphenol, para-Carbethoxyphenol, 4-Carbethoxyphenol, p-Hydroxybenzoate Ethyl Ester, para-Hydroxybenzoate Ethyl Ester, 4-Hydroxybenzoate Ethyl Ester, Benzoic Acid 4-Hydroxy Ethyl Ester, Benzoic Acid p-Hydroxy Ethyl Ester, Benzoic Acid para-Hydroxy Ethyl Ester, Ethyl Ester of p-Hydroxybenzoic Acid, Ethyl Ester of para-Hydroxybenzoic Acid, Ethyl Ester of 4-Hydroxybenzoic Acid, Ethyl Parahydroxybenzoate, Ethyl 4-Hydroxybenzoic Acid Ester, Ethyl p-Oxybenzoate, Ethyl para-Oxybenzoate, Nipagin A, Ethylparaben FCC, Ethylparaben USP, Ethylparaben BP, Ethylparaben EP, Ethylparaben NF, Ethyl Paraben FCC, Ethyl Paraben USP, Ethyl Paraben BP, Ethyl Paraben EP, Ethyl Paraben NF, Ethyl p-Hydroxybenzoate Food Grade, Ethyl p-Hydroxybenzoate Pharmaceutical Grade, Ethyl p-Hydroxybenzoate Cosmetic Grade, Ethyl p-Hydroxybenzoate Technical Grade, Ethylparaben Food Grade, Ethylparaben Pharmaceutical Grade, Ethylparaben Cosmetic Grade, Ethylparaben Technical Grade, Ethylparaben Preservative, Ethyl Paraben Preservative, Ethylparaben Antimicrobial, Ethyl Paraben Antimicrobial, Ethylparaben Antifungal, Ethyl Paraben Antifungal, Ethylparaben Reagent Grade, Ethyl Paraben Reagent Grade, Ethylparaben Analytical Grade, Ethyl Paraben Analytical Grade, Ethylparaben Laboratory Grade, Ethyl Paraben Laboratory Grade, Ethylparaben Pure, Ethyl Paraben Pure, Ethylparaben Powder, Ethyl Paraben Powder, Ethylparaben White Powder, Ethyl Paraben White Powder, Ethylparaben CAS 120-47-8, Ethyl Paraben CAS 120-47-8, C9H10O3, Ethylparaben Ester
APPLICATIONS
Ethyl p-Hydroxybenzoate is used in creams and lotions as a preservative to inhibit yeast and mold growth and to support bacterial control in combination systems.
Ethyl p-Hydroxybenzoate is incorporated into body lotions to improve microbial stability during storage and consumer use.
Ethyl p-Hydroxybenzoate is used in facial creams where preservative robustness is required and regulations allow.
Ethyl p-Hydroxybenzoate is used in shampoos and conditioners as part of preservative systems to prevent microbial contamination in water-based products.
Ethyl p-Hydroxybenzoate is incorporated into rinse-off products where pH and solubility are managed for effective preservation.
Ethyl p-Hydroxybenzoate is used in shower gels and liquid soaps to support fungal control in compatible formulations.
Ethyl p-Hydroxybenzoate is used in cosmetics such as foundations, concealers, and makeup products to protect against microbial spoilage.
Ethyl p-Hydroxybenzoate is incorporated into mascaras and eye-area products only when permitted and formulated within strict safety and regulatory constraints.
Ethyl p-Hydroxybenzoate is used in sunscreens to improve preservation of emulsions and water-based systems.
Ethyl p-Hydroxybenzoate is used in personal care wipes to inhibit microbial growth in wet wipe liquids and to protect products during storage.
Ethyl p-Hydroxybenzoate is incorporated into cleansing wipes where preservative efficacy must be validated with challenge testing.
Ethyl p-Hydroxybenzoate is used in baby wipes only when permitted by regulations and safety assessments and when alternative systems are unsuitable.
Ethyl p-Hydroxybenzoate is used in pharmaceutical creams and ointments as a preservative to protect against contamination during storage and use.
Ethyl p-Hydroxybenzoate is incorporated into topical solutions and gels where antimicrobial preservation is required.
Ethyl p-Hydroxybenzoate is used in oral liquid preparations in some contexts where allowed and where preservative performance is validated.
Ethyl p-Hydroxybenzoate is used in syrups and suspensions to protect against yeast and mold growth in compatible dosage forms.
Ethyl p-Hydroxybenzoate is incorporated into medicated shampoos and wash products to maintain microbiological quality.
Ethyl p-Hydroxybenzoate is used in compounded formulations where preservative selection depends on compatibility and regulations.
Ethyl p-Hydroxybenzoate is used in food applications in some markets where Ethyl p-Hydroxybenzoate is identified as E214, but Ethyl p-Hydroxybenzoate use is market- and category-dependent and must follow local rules.
Ethyl p-Hydroxybenzoate is incorporated into preserved sauces and specialty products only where permitted.
Ethyl p-Hydroxybenzoate is used in niche preservation needs where alternative preservatives are less effective and regulations allow.
Ethyl p-Hydroxybenzoate is used in industrial products such as polishes and water-based specialty formulations to prevent microbial spoilage.
Ethyl p-Hydroxybenzoate is incorporated into waterborne products where long shelf life and repeated consumer exposure require robust preservation.
Ethyl p-Hydroxybenzoate is valued because Ethyl p-Hydroxybenzoate delivers effective preservation, especially against fungi, when properly solubilized, dosed, and used in compliant preservative systems.
Ethyl p-Hydroxybenzoate is used as a preservative in cosmetics to inhibit microbial growth.
Ethyl p-Hydroxybenzoate supports protection against molds and yeasts in water-based formulations.
Ethyl p-Hydroxybenzoate helps extend shelf life by reducing contamination-related spoilage.
Ethyl p-Hydroxybenzoate is used in creams and lotions as part of broad preservative systems.
Ethyl p-Hydroxybenzoate supports microbiological stability in emulsions with adequate solubilization.
Ethyl p-Hydroxybenzoate helps prevent odor change and phase instability driven by microbial growth.
Ethyl p-Hydroxybenzoate is used in facial moisturizers to protect against contamination during consumer use.
Ethyl p-Hydroxybenzoate supports preservation of daily-use products exposed to repeated contact.
Ethyl p-Hydroxybenzoate helps maintain product quality throughout shelf life.
Ethyl p-Hydroxybenzoate is used in serums and gel products as a preservative component.
Ethyl p-Hydroxybenzoate supports microbial control in aqueous gel systems.
Ethyl p-Hydroxybenzoate helps protect clarity and viscosity by limiting microbial spoilage.
Ethyl p-Hydroxybenzoate is used in shampoos and conditioners as part of preservative blends.
Ethyl p-Hydroxybenzoate supports protection of surfactant systems against microbial contamination.
Ethyl p-Hydroxybenzoate helps maintain product safety in wet bathroom storage conditions.
Ethyl p-Hydroxybenzoate is used in body washes and shower gels to preserve water-based cleansing products.
Ethyl p-Hydroxybenzoate supports microbial stability during shelf life and in-use period.
Ethyl p-Hydroxybenzoate helps reduce risk of spoilage organisms causing odor and viscosity changes.
Ethyl p-Hydroxybenzoate is used in liquid hand soaps to prevent microbial growth in surfactant solutions.
Ethyl p-Hydroxybenzoate supports product integrity in refillable packaging formats.
Ethyl p-Hydroxybenzoate helps maintain acceptable microbial limits during storage and use.
Ethyl p-Hydroxybenzoate is used in wet wipes and cleansing wipes as a preservative component in some systems.
Ethyl p-Hydroxybenzoate supports preservation of wipe liquids to prevent microbial proliferation.
Ethyl p-Hydroxybenzoate helps reduce contamination risk in multi-use wipe packs.
Ethyl p-Hydroxybenzoate is used in sunscreens as a preservative component in some formulations.
Ethyl p-Hydroxybenzoate supports microbial control in emulsified sun care products.
Ethyl p-Hydroxybenzoate helps maintain product stability under warm storage conditions.
Ethyl p-Hydroxybenzoate is used in makeup products such as liquid foundations and concealers as a preservative.
Ethyl p-Hydroxybenzoate supports protection of pigment dispersions and emulsions.
Ethyl p-Hydroxybenzoate helps prevent microbial spoilage that can alter odor and texture.
Ethyl p-Hydroxybenzoate is used in mascaras and liquid eyeliners as part of preservative systems in some designs.
Ethyl p-Hydroxybenzoate supports microbial control in high-risk eye-area products under controlled formulation.
Ethyl p-Hydroxybenzoate helps improve product safety when combined with appropriate co-preservatives.
Ethyl p-Hydroxybenzoate is used in deodorants and body sprays in some formulations as a preservative component.
Ethyl p-Hydroxybenzoate supports protection of aqueous deodorant systems with suitable pH.
Ethyl p-Hydroxybenzoate helps maintain stability and odor control performance.
Ethyl p-Hydroxybenzoate is used in perfumes and fragrance bases as a preservative in some alcohol–water blends.
Ethyl p-Hydroxybenzoate supports microbial protection in low-oil fragrance mists.
Ethyl p-Hydroxybenzoate helps maintain clarity and prevent spoilage in aqueous fragrance products.
Ethyl p-Hydroxybenzoate is used in pharmaceutical creams and topical products as a preservative where permitted.
Ethyl p-Hydroxybenzoate supports protection of ointments and gels from microbial contamination.
Ethyl p-Hydroxybenzoate helps maintain stability of topical medicines during shelf life.
Ethyl p-Hydroxybenzoate is used in oral liquid pharmaceuticals as a preservative component in some systems where allowed.
Ethyl p-Hydroxybenzoate supports microbial control in syrups and suspensions.
Ethyl p-Hydroxybenzoate helps protect liquid medicines from contamination during repeated dosing.
Ethyl p-Hydroxybenzoate is used in ophthalmic and nasal preparations in some regions under strict formulation and regulatory limits.
Ethyl p-Hydroxybenzoate supports preservation of sensitive aqueous dosage forms.
Ethyl p-Hydroxybenzoate helps reduce microbial risk in multi-dose packaging designs.
Ethyl p-Hydroxybenzoate is used in food processing in some regions as a preservative for selected products where permitted.
Ethyl p-Hydroxybenzoate supports inhibition of molds and yeasts in suitable food matrices.
Ethyl p-Hydroxybenzoate helps extend shelf life under regulated use conditions.
Ethyl p-Hydroxybenzoate is used in laboratory microbiology as a preservative or challenge compound in antimicrobial testing.
Ethyl p-Hydroxybenzoate supports evaluation of preservative efficacy in standardized tests.
Ethyl p-Hydroxybenzoate helps benchmark antimicrobial activity against fungi and bacteria.
Ethyl p-Hydroxybenzoate is used in cosmetic preservative challenge testing to verify system robustness.
Ethyl p-Hydroxybenzoate supports validation of preservation under repeated contamination scenarios.
Ethyl p-Hydroxybenzoate helps confirm stability across expected storage temperatures.
Ethyl p-Hydroxybenzoate is used in household products such as lotions, cleaners, and polishes as a preservative in some formulations.
Ethyl p-Hydroxybenzoate supports in-can preservation of water-containing products.
Ethyl p-Hydroxybenzoate helps prevent spoilage that causes odor, gassing, and viscosity drift.
Ethyl p-Hydroxybenzoate is used in industrial formulations such as water-based adhesives and coatings as an in-can preservative in some systems.
Ethyl p-Hydroxybenzoate supports storage stability by limiting microbial growth.
Ethyl p-Hydroxybenzoate helps reduce spoilage-related defects in water-based products.
Ethyl p-Hydroxybenzoate is used in personal care formulations to complement other preservatives for broader coverage.
Ethyl p-Hydroxybenzoate supports synergy with other parabens and organic acids.
Ethyl p-Hydroxybenzoate helps improve overall preservative spectrum when used in balanced blends.
Ethyl p-Hydroxybenzoate is used in emulsion systems where mild preservative odor and good stability are desired.
Ethyl p-Hydroxybenzoate supports preservation without strong fragrance interference at optimized dosage.
Ethyl p-Hydroxybenzoate helps maintain product sensory profile while controlling microbial risk.
Ethyl p-Hydroxybenzoate is used in product development for cosmetics targeting long shelf life and global distribution.
Ethyl p-Hydroxybenzoate supports preservative robustness in warm logistics conditions.
Ethyl p-Hydroxybenzoate helps reduce spoilage returns by improving microbial stability.
Ethyl p-Hydroxybenzoate is used in quality control programs to verify preservative concentration and compliance.
Ethyl p-Hydroxybenzoate supports HPLC assay and impurity profiling in manufacturing.
Ethyl p-Hydroxybenzoate helps ensure batch-to-batch preservation consistency.
Ethyl p-Hydroxybenzoate is used in formulation troubleshooting when microbial failures occur in water-based products.
Ethyl p-Hydroxybenzoate supports adjustment of preservative system, pH, and solubilization strategy.
Ethyl p-Hydroxybenzoate helps restore microbiological pass rates in challenge testing.
Ethyl p-Hydroxybenzoate is used in packaging compatibility testing to ensure preservative stability and non-adsorption.
Ethyl p-Hydroxybenzoate supports evaluation of preservative loss into certain plastics.
Ethyl p-Hydroxybenzoate helps maintain effective preservative level through shelf life.
Ethyl p-Hydroxybenzoate is used in educational and training contexts as an example of paraben-class preservatives.
Ethyl p-Hydroxybenzoate supports teaching about preservative spectrum, pH dependence, and regulatory limits.
Ethyl p-Hydroxybenzoate helps illustrate preservative system design in cosmetics and pharmaceuticals.
Ethyl p-Hydroxybenzoate is used in multi-preservative systems to reduce required level of any single preservative.
Ethyl p-Hydroxybenzoate supports balancing efficacy and sensory profile through blending.
Ethyl p-Hydroxybenzoate helps improve tolerance by optimizing preservative load distribution.
Ethyl p-Hydroxybenzoate is used in rinse-off and leave-on formulations with controlled pH and solubilization strategies.
Ethyl p-Hydroxybenzoate supports stable preservation performance in emulsions and gels.
Ethyl p-Hydroxybenzoate helps maintain microbiological quality throughout use life.
Ethyl p-Hydroxybenzoate is used in preserved water phases of emulsions to protect high-water products.
Ethyl p-Hydroxybenzoate supports microbial control in the continuous phase of creams and lotions.
Ethyl p-Hydroxybenzoate helps prevent spoilage that destabilizes emulsions.
Ethyl p-Hydroxybenzoate is used in global cosmetics manufacturing where regulatory compliance allows paraben preservatives.
Ethyl p-Hydroxybenzoate supports consistent preservation approaches across multiple product lines.
Ethyl p-Hydroxybenzoate helps maintain manufacturing efficiency by using well-understood preservative systems.
Ethyl p-Hydroxybenzoate is used in preservative screening to compare antimicrobial efficacy versus methyl and propyl parabens.
Ethyl p-Hydroxybenzoate supports selection of preservative blend ratios for robust coverage.
Ethyl p-Hydroxybenzoate helps optimize preservation while managing solubility constraints.
DESCRIPTION
Ethyl p-Hydroxybenzoate is an ester of p-hydroxybenzoic acid and ethanol, and Ethyl p-Hydroxybenzoate is a paraben class preservative with strong antifungal activity and moderate antibacterial activity.
Ethyl p-Hydroxybenzoate is typically a white crystalline powder with low water solubility, so Ethyl p-Hydroxybenzoate is often dissolved in alcohol, glycols, or warm phases before incorporation.
Ethyl p-Hydroxybenzoate preservative efficacy depends on the concentration of the undissociated form and distribution between phases, so formulation pH and solubilization strategy matter.
Ethyl p-Hydroxybenzoate is often used with methylparaben, propylparaben, or other preservative boosters to widen antimicrobial spectrum and improve challenge test performance.
Ethyl p-Hydroxybenzoate can interact with certain nonionic surfactants and polymers, and solubility can be reduced in some high-water, low-solvent systems, so compatibility testing is important.
Ethyl p-Hydroxybenzoate is regulated, and maximum allowed concentrations and permitted product categories vary by region, so compliance checks are required.
Ethyl p-Hydroxybenzoate should be stored in tightly closed containers in a cool, dry place protected from moisture and contamination.
Ethyl p-Hydroxybenzoate dust can irritate eyes and respiratory tract, so dust control and appropriate PPE are recommended during handling.
Ethyl p-Hydroxybenzoate should be used according to supplier specifications, safety documentation, and applicable cosmetic, pharmaceutical, or food additive regulations.
Ethyl p-Hydroxybenzoate is an ester of p-hydroxybenzoic acid and is commonly known as ethylparaben.
Ethyl p-Hydroxybenzoate is typically a white crystalline powder with low odor.
Ethyl p-Hydroxybenzoate has limited water solubility and is often dissolved using alcohols or solubilizers in formulations.
Ethyl p-Hydroxybenzoate is valued for antimicrobial activity, with strong performance against fungi and many bacteria.
Ethyl p-Hydroxybenzoate preservative effectiveness depends on concentration, pH, and formulation composition.
Ethyl p-Hydroxybenzoate is often used with other parabens to broaden spectrum and increase robustness.
Ethyl p-Hydroxybenzoate is chemically stable over typical cosmetic pH ranges and has good heat stability in many processes.
Ethyl p-Hydroxybenzoate can be impacted by adsorption to certain packaging materials, so compatibility testing is used.
Ethyl p-Hydroxybenzoate can have reduced efficacy if not properly solubilized or if formulation pH is unfavorable.
Ethyl p-Hydroxybenzoate use is regulated, and permitted product categories and maximum levels vary by country.
Ethyl p-Hydroxybenzoate labeling requirements depend on local cosmetic, pharmaceutical, or food additive rules.
Ethyl p-Hydroxybenzoate safety assessments focus on exposure level, product type, and population group.
Ethyl p-Hydroxybenzoate should be handled with dust control and standard PPE to avoid eye and respiratory irritation.
Ethyl p-Hydroxybenzoate should be stored in tightly closed containers away from excessive heat and moisture.
Ethyl p-Hydroxybenzoate is valued for reliable preservation, stability, and long history of use in regulated products.
PROPERTIES
Chemical Formula: C9H10O3
Molecular Weight: 166.17 g/mol
Common Name: Ethyl p-Hydroxybenzoate (Ethylparaben)
Chemical Type: Paraben preservative; aromatic ester
Appearance: White crystalline powder
Odor: Slight characteristic odor
Solubility: Slightly soluble in water; soluble in alcohols and glycols; solubility increases with heat
Melting Point: ~113–116°C (typical)
pH Use Range: Most effective in mildly acidic to neutral systems (formulation dependent)
Preservative Activity: Strong antifungal; moderate antibacterial; often used in blends
Stability: Stable under recommended storage; hydrolyzes slowly under strong alkaline conditions
Regulatory Status: Use limits and allowed categories vary by market; compliance required
Storage Temperature: 10–25°C, dry, tightly closed
Shelf Life: Typically 24–60 months in original sealed packaging (supplier dependent)
FIRST AID
Inhalation:
Move to fresh air if dust is inhaled.
Seek medical attention if respiratory irritation persists.
Avoid breathing dust during weighing and powder transfer.
Skin Contact:
Wash with soap and water after contact.
Remove contaminated clothing and wash before reuse.
Seek medical advice if irritation develops or persists.
Eye Contact:
Rinse cautiously with water for several minutes.
Remove contact lenses if present and easy to do, then continue rinsing.
Seek medical attention if irritation persists.
Ingestion:
Rinse mouth with water.
Seek medical attention if discomfort occurs or if a large amount is swallowed.
Never give anything by mouth to an unconscious person.
Note to Physicians:
Treat symptomatically.
No specific antidote is required.
Provide supportive care based on exposure route and symptoms.
HANDLING AND STORAGE
Handling:
Use appropriate PPE including gloves and safety glasses, and use dust protection as needed.
Avoid generating dust and avoid inhalation of fine powder.
Wash hands after handling and before eating, drinking, or smoking.
Ventilation:
Use local exhaust or general ventilation where dust may be generated.
Maintain good airflow during weighing, charging, and blending operations.
Minimize airborne particulate accumulation in enclosed areas.
Storage:
Store in tightly closed containers in a cool, dry place.
Protect from moisture to prevent caking and maintain free-flowing behavior.
Keep containers properly labeled and protected from contamination.
Spill and Leak Procedures:
Sweep up spilled material and avoid dust generation.
Collect into suitable containers for reuse or disposal according to local regulations.
Clean residues with wet wiping if needed to reduce airborne dust.
Handling Precautions:
Optimize solubilization and phase addition strategy because Ethyl p-Hydroxybenzoate has low water solubility and can crystallize if not properly incorporated.
Confirm regional regulatory limits and allowed product categories for Ethyl p-Hydroxybenzoate before formulation and labeling.
Validate preservative efficacy with challenge testing because preservative performance depends strongly on formulation composition, pH, and packaging.
