CAS Number = 80-39-7
EC Number = 232-465-2
UNII Number = 992S798SJB
N-ETHYL-P-TOLUENESULFONAMIDE = N-Ethyl-4-methylbenzenesulfonamide = Santicizer 3 = N-Ethyl-p-tolylsulfonamide
IUPAC Name = N-ethyl-4-methylbenzenesulfonamide
Properties of Ethyl Tosylamide:
Property Name Property Value
Molecular Weight 199.27
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 3
Exact Mass 199.06669983
Monoisotopic Mass 199.06669983
Topological Polar Surface Area 54.6 Å²
Heavy Atom Count 13
Formal Charge 0
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes
Origin (s): Synthetic
INCI name: ETHYL TOSYLAMIDE
N ° EINECS / ELINCS: 201-275-1 / 214-073-3
Physical Properties of Ethyl Tosylamide:
Appearance: off-white platelets (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 311.00 °C. @ 760.00 mm Hg (est)
Flash Point: 287.00 °F. TCC ( 141.90 °C. ) (est)
logP (o/w): 1.960 (est)
Soluble in: water, 1106 mg/L @ 25 °C (est)
Density: 1.153 g/cm3
Boiling Point: 317.2ºCat 760 mmHg
Melting Point: 344-350 °C(lit.)
Flash Point: 145.7ºC
Refractive Index: 1.526
Vapor Pressure: 0.00039mmHg at 25°C
Ethyl Tosylamide increases the durability of nail polish products and helps in increasing adhesion of the polish to the nail surface.
Ethyl Tosylamide is a sulfur-based antibiotic and is banned in Europe for use in cosmetics since it can cause mild to severe allergic reactions.
Ethyl Tosylamide is also known to be a major hormonal disrupter that affects the endocrine function.
Ethyl Tosylamide's a film-forming plasticizer.
N-ETHYL-P-TOLUENESULFONAMIDE helps make nail polish flexible and durable, and also helps improve how well the polish sticks to the nail.
Ethyl tosylamide serves as a plasticizer and film-former in nail polish, and is formed from toluene and ethanesulfonamide.
Ethyl Tosylamide: A highly viscous, amber liquid used primarily as plasticizer and film former in coatings like nail polish.
It also acts as a secondary film former and is a mixture of isomers of toluene bound to ethanesulfonamide.
Ethyl Tosylamide is a synthetic substance, exactly a mixture of isomers of aromatic amides (toluene and ethanesulfonamide).
Ethyl Tosylamide is in the form of a viscous yellowish liquid, insoluble in water.
N-ETHYL-P-TOLUENESULFONAMIDE acts as a film-forming agent, emulsifier and softener.
Ethyl Tosylamide is often part of nail polishes, supports the durability and flexibility of the film and the adhesion of the varnish to the nail.
N-ETHYL-P-TOLUENESULFONAMIDE is an irritant to the skin, eyes, and respiratory system.
Ethyl Tosylamide is a substance that serves primarily as an emollient in nail polishes.
It consists of toluene and ethane sulfonamide.
Ethyl Tosylamide is a mixture of isomers of aromatic amides (toluene and ethanesulfonamide).
N-ETHYL-P-TOLUENESULFONAMIDE is a highly viscous amber, water-insoluble liquid.
N-ETHYL-P-TOLUENESULFONAMIDE is mainly used as a plasticizer and film-forming substance in nail varnishes.
It helps to improve the flexibility of the created film.
N-ETHYL-P-TOLUENESULFONAMIDE supports the durability and stability of synthetic polymers, increases their durability, adhesion of the varnish to the nail.
N-ETHYL-P-TOLUENESULFONAMIDE prevents the paint from wearing quickly due to normal influences that can damage it mechanically.
Ethyl Tosylamide also serves as a plasticizer.
Ethyl Tosylamide is classified as a sulfoamide (subgroup of antibiotics) and is therefore being discussed for use in the cosmetics industry due to the possible cause of antibiotic resistance.
Substance information of Ethyl Tosylamide:
"Ethyl" usually denotes ethanol (ethanol, ethyl alcohol) as an alcoholic component or, in general, a hydrocarbon radical with 2 carbon atoms.
"Tosyl ..." refers to p-toluenesulfonic acid as a component of this ingredient.
Amides are generally reaction products of carboxylic acids (mostly fatty acids) or other acids with nitrogen compounds (ammonia or alkyl and alkanolamines, amino acids, etc.)
Examples: "Steraramides" are amides of stearic acid, "Cocamides" are amides of coconut fatty acids.
General characteristics of Ethyl Tosylamide:
Ethyl Tosylamide is a mixture of isomers of aromatic amides.
Ethyl Tosylamide is a highly viscous amber, water-insoluble liquid.
Ethyl Tosylamide is mainly used as a plasticizer and film-forming substance in nail varnishes supports the durability and stability of synthetic polymers, increases their durability, adhesion of the varnish to the nail prevents rapid wear of the paint due to normal influences that can mechanically damage it.
Ethyl Tosylamide also serves as a softener.
Use of Ethyl Tosylamide:
Action in cosmetics
A substance used as a plasticizer in nail polishes
it allows you to create a varnish coating and prevents the varnish from dripping too quickly.
GHS Hazard Statements
H315 (98.39%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (98.39%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (96.77%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure
Respiratory tract irritation]
Precautionary Statement Codes
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501
ECHA C&L Notifications Summary
Aggregated GHS information provided by 80 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Reported as not meeting GHS hazard criteria by 18 of 80 companies.
Of the 6 notification(s) provided by 62 of 80 companies with hazard statement code(s).
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Reactivity Profile of Ethyl Tosylamide
Organic amides/imides react with azo and diazo compounds to generate toxic gases.
Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents.
Amides are very weak bases (weaker than water).
Imides are less basic yet and in fact react with strong bases to form salts.
That is, they can react as acids.
Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile.
The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Nonfire Spill Response of Ethyl Tosylamide:
SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container.
Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material.
Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal.
Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution.
Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing.
Do not contaminate water, foodstuffs, feed or seed by storage or disposal.
Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning.
Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill.
Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
STORAGE PRECAUTIONS: You should store this material under ambient temperatures.
Handling and storage
Precautions for safe handling
Avoid contact with skin and eyes.
Avoid formation of dust and aerosols.
Avoid exposure - obtain special instructions before use.
Provide appropriate exhaust ventilation at places where dust is formed.
Conditions for safe storage, including any incompatibilities
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
Synonyms of Ethyl Tosylamide:
n-Ethyl-o (or p)-toluenesulfonamide
N-ethyl(4-methyl phenyl) sulfonamide
p-Toluenesulfonamide, N-ethyl- (8CI)
UNII-X3491OQT7S component OHPZPBNDOVQJMH-UHFFFAOYSA-N