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Ethylene Glycol Monophenyl Ether (Phenoxyethanol), or Phenoxyethanol in Turkish, is a glycol ether that carries the functions of aromatic ether and primary alcohol on the same molecule. It can be used as a preservative in cosmetics and personal care products, as a preservative to help control microbial spoilage in home care and industrial formulations, as an excipient or antimicrobial ingredient in pharmaceutical systems, and as a solvent in various industrial applications.
Ethylene Glycol is a single-molecule chemical defined as Monophenyl Ether (Phenoxyethanol). It has CAS No 122-99-6, EC/EINECS No 204-589-7, molecular formula C₈H₁₀O₂, and molecular weight approximately 138.16 g/mol. Its IUPAC name is 2-Phenoxyethan-1-ol.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) are not two different substances. "Ethylene Glycol Monophenyl Ether" is one of the names that describes the chemical structure; Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is the name much more commonly used in cosmetic, pharmaceutical and commercial applications. On cosmetic product labels, the name INCI is used as Ethylene Glycol Monophenyl Ether (Phenoxyethanol).
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is colorless, clear, with a slightly aromatic odor and oil-like liquid at room temperature. It exhibits physical properties such as a boiling point of about 245 °C, a density of about 1.10–1.11 g/cm³, and a water solubility of about 24–27 g/L at 20 °C. It shows good compatibility with ethanol and various organic solvents.
One of the important advantages of Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is that it combines preservative and solvent properties in the same molecule. While it has a certain solubility in the water phase, it can also show a certain level of compatibility with less polar components due to its aromatic ether structure. Therefore, it can be used in many different cosmetic and technical formulations.
Its antimicrobial activity is especially important against bacteria. It can be used alone or in combination with other preservatives and preservative promoters to strengthen yeast and mold control or overall preservative system performance.
In the European Union Cosmetics Regulation, Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is among the preservatives allowed under Annex V. It is registered with CAS No 122-99-6 and EC No 204-589-7, and the maximum allowable concentration in the finished cosmetic product is 1.0%.
The European Commission's Scientific Committee on Consumer Safety SCCS has approved Ethylene Glycol Monophenyl Ether (Phenoxyethanol) as safe for use as a preservative in cosmetic products at a maximum level of 1.0%. This assessment also includes exposure to children.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is not only used as a cosmetic preservative. Manufacturers such as BASF and Clariant position Ethylene Glycol Monophenyl Ether (Phenoxyethanol)-based products as preservatives in home care products, hard surface cleaners, laundry products, industrial and institutional cleaning formulations, and certain technical systems.
When purchasing Ethylene Glycol Monophenyl Ether (Phenoxyethanol), only the CAS number is not sufficient. Purity, color, water content, density, refractive index, phenol and other impurities, intended use, cosmetic or pharmaceutical quality requirement, and TDS, SDS, and COA documents should be evaluated together.
WHAT IS ETHYLENE GLYCOL MONOPHENYL ETHER (PHENOXYETHANOL)?
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is an organic compound that carries the aromatic ether and primary alcohol structure together.
Its chemical name is 2-Phenoxyethan-1-ol. Its common chemical name is 2-Ethylene Glycol Monophenyl Ether (Phenoxyethanol).
Ethylene Glycol Monophenyl Ether is another name for the same chemical. Its Turkish name is Phenoxyethanol. CAS No is 122-99-6. EC/EINECS No is 204-589-7. PubChem CID is 31236.
Its molecular formula is C₈H₁₀O₂. Its molecular weight is approximately 138.16 g/mol.
Simplified molecular structure: C₆H₅-O-CH₂-CH₂-OH.
The molecule has a phenyl ring on one side.
The phenyl ring is attached to the two-carbon hydroxyethyl group via ether oxygen.
At the end of the molecule is the primary alcohol group.
This structure allows Ethylene Glycol Monophenyl Ether (Phenoxyethanol) to interact with both polar and less polar environments to a certain extent.
The phenyl ring contributes to the hydrophobic character of the molecule. The ether oxygen and the terminal hydroxyl group, on the other hand, increase the polarity of the molecule.
Therefore, Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is completely insoluble in water, but it can dissolve in a significant amount. A water solubility of approximately 24–27 g/L has been reported around 20 °C. This value corresponds to a level of approximately 2.4–2.7%.
Clariant also states that Phenoxetol is easily soluble in water up to approximately 2.4%.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) has higher compatibility with ethanol and many organic solvents.
This property is used in cosmetic formulations:
Perfume components,
some preservatives,
aroma components,
and can help solubilize some organic raw materials with relatively low water solubility.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) should not be confused with Ethylene Glycol because of the name "Ethylene Glycol Monophenyl Ether".
Ethylene Glycol: It is a different chemical with CAS No 107-21-1.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is a separate glycol ether with CAS No 122-99-6.
The toxicological and physical properties of the two substances are not the same.
This distinction is particularly important in safety assessment.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is also not the same product as Ethylene Glycol Monobutyl Ether or other glycol ethers.
Glycol ether refers to a large family of chemicals.
The area of use, volatility, toxicology and legislative status of each glycol ether should be evaluated separately.
COMMON PRODUCT AND CHEMICAL NAMES
Ethylene Glycol Monophenyl Ether (Phenoxyethanol)
Phenoxyethanol
2-Ethylene Glycol Monophenyl Ether (Phenoxyethanol)
2-Phenoxyethanol
Ethylene Glycol Monophenyl Ether
Ethylene Glycol Monophenyl Ether
Ethylene Glycol Phenyl Ether
Ethylene Glycol Phenyl Ether
2-Phenoxyethan-1-ol
2-Phenoxyethane-1-ol
Phenyl Cellosolve
Phenoxyethyl Alcohol
β-Phenoxyethyl Alcohol
Phenoxyethyl Alcohol
INCI: Ethylene Glycol Monophenyl Ether (Phenoxyethanol)
CAS 122-99-6
EC/EINECS 204-589-7
CAS NO, EC / EINECS NO AND CHEMICAL IDENTIFICATION
Product Name: Ethylene Glycol Monophenyl Ether / Ethylene Glycol Monophenyl Ether (Phenoxyethanol)
English name: Phenoxyethanol / Ethylene Glycol Monophenyl Ether
INCI name: Ethylene Glycol Monophenyl Ether (Phenoxyethanol)
IUPAC name: 2-Phenoxyethan-1-ol
Chemical class: Glycol ether / aromatic ether / primary alcohol
CAS No: 122-99-6
EC/EINECS No: 204-589-7
PubChem CID: 31236
Molecular formula: C₈H₁₀O₂
Molecular weight: Approximately 138.16 g/mol
Simplified structure: C₆H₅-O-CH₂-CH₂-OH
Physical form: Liquid
Appearance: Colorless, clear, oil-like liquid
Odor: Mildly aromatic
Boiling point: About 245 °C
Flash point: Approx. 127 °C, reported value for closed container
Density: Approx. 1.10–1.11 g/cm³, around 20 °C
Water solubility: Approx. 24–27 g/L, 20 °C
Refractive index: Approx. 1,534, 20 °C
log Kow: Approx. 1.2
Viscosity: Approx. 20.5 cSt, 25 °C
For BASF Protectol PE, a content of 99.5≥% Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is reported in high-purity commercial products.
This value belongs to the specific BASF grade.
It should not be generalized that the minimum purity of all Ethylene Glycol Monophenyl Ether (Phenoxyethanol) products is 99.5%.
Accepted impurity limits in cosmetic, pharmaceutical or technical applications may vary depending on the manufacturer's grade and area of use.
CHEMICAL STRUCTURE AND MOLECULAR PROPERTIES OF ETHYLENE GLYCOL MONOPHENYL ETHER (PHENOXYETHANOL)
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) molecule has three basic structural parts.
The first is the aromatic phenyl ring.
The second is the ether group that attaches the phenyl ring to the hydroxyethyl chain.
The third is the terminal primary alcohol group.
Molecular structure: C₆H₅-O-CH₂-CH₂-OH.
The phenyl ring forms the more hydrophobic part of the molecule.
Ether oxygen and hydroxyl group contribute to hydrogen bond interactions and polarity.
This structure allows Ethylene Glycol Monophenyl Ether (Phenoxyethanol) to be a balanced molecule that is not fully hydrophilic or completely lipophilic.
The logP value calculated by PubChem is approximately 1.2.
This value supports that the molecule can interact with both the water phase and the organic surplus at a certain level.
Although the water solubility of Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is approximately 2.5%, levels such as 0.5–1.0%, which are commonly used in cosmetic formulations, generally remain below this solubility limit.
However, in the actual formulation, surfactants, oils, polymers, perfume and electrolytes can alter the phase distribution of Ethylene Glycol Monophenyl Ether (Phenoxyethanol).
Therefore, the solubility value in pure water does not alone explain the behavior in the final formulation.
In the emulsion system, Ethylene Glycol Monophenyl Ether (Phenoxyethanol) can be dispersed between water and oil phase.
The phase of the preservative is important for microbial protection.
Since most microorganisms multiply in the water phase, sufficient amounts of the preservative must be accessible in the water phase.
Very high oil phase or preservative-binding ingredients can reduce the effective concentration of free Ethylene Glycol Monophenyl Ether (Phenoxyethanol).
Therefore, just theoretically adding 1% Ethylene Glycol Monophenyl Ether (Phenoxyethanol) does not necessarily mean that the product will be adequately preserved.
Microbiological protective efficacy testing should be performed in the final formulation.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) has a high boiling point and a low evaporation rate.
This property ensures low volatility in room temperature formulations.
In PubChem data, the relative evaporation rate is given below 0.01 compared to butyl acetate.
This property can limit the easy loss of preservative in formulation during processing and storage.
The main properties of Ethylene Glycol Monophenyl Ether (Phenoxyethanol) at the molecular level are:
Aromatic ether group carry
Primary alcohol group contain
Showing moderate polarity
Have a limited but application-relevant solubility in water
Good compatibility with ethanol and many organic solvents
Showing low volatility
Have a high boiling point
Demonstrate antimicrobial activity
To be able to provide solver function
PHYSICAL AND CHEMICAL PROPERTIES OF ETHYLENE GLYCOL MONOPHENYL ETHER (PHENOXYETHANOL)
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is colorless, clear and oil-like liquid under normal ambient conditions.
General technical specifications:
Physical appearance: Colorless, clear liquid
Odor: Slightly aromatic character
Chemical Grade: Aromatic Glycol Ether
CAS No: 122-99-6
EC/EINECS No: 204-589-7
INCI: Ethylene Glycol Monophenyl Ether (Phenoxyethanol)
Molecular formula: C₈H₁₀O₂
Molecular weight: Approximately 138.16 g/mol
Boiling point: About 245 °C
Flash point: About 127 °C
Density: Approx. 1.10–1.11 g/cm³
Water solubility: Approx. 24–27 g/L, 20 °C
Refractive index: Approx. 1,534, 20 °C
Viscosity: Approx. 20.5 cSt, 25 °C
log Kow: Approx. 1.2
Evaporation rate: Low
Solubility in ethanol: Good
Solubility in ether and various organic solvents: Good
PubChem describes Ethylene Glycol Monophenyl Ether (Phenoxyethanol) as a colorless oily liquid with a characteristic slight odor.
Different sources for water solubility have values between 24 g/L and about 26.7 g/L.
This difference can be caused by conditions such as the test method and temperature.
For this reason, it would be more accurate to give a range of approximately 24–27 g/L on the technical product sheet than to generalize a single exact value to all conditions.
Values of approximately 1,104–1,109 have been reported for density.
The quality control of the purchased commercial grade should be based on the manufacturer's TDS and COA value.
HOW DOES ETHYLENE GLYCOL MONOPHENYL ETHER (PHENOXYETHANOL) WORK AT THE MOLECULAR LEVEL?
The main task of Ethylene Glycol Monophenyl Ether (Phenoxyethanol) as a preservative is to help control the proliferation of microorganisms that may enter the formulation later or be present during production.
Microorganisms can proliferate, especially in cosmetic, cleaning, and pharmaceutical formulations that contain water.
Bacteria, yeast or mold growth of the product:
smell,
color,
viscosity,
pH,
appearance
and safety
It can disrupt.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is a powerful preservative ingredient, especially in terms of bacterial control.
Clariant's Phenoxetol technical information states efficacy against both Gram-negative and Gram-positive bacteria.
Its effectiveness on yeast and mold depends on the formulation and concentration, and alone may not be sufficient in every system.
For this reason, Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is often used in combination with other preservatives or preservative supplements.
Antimicrobial activity is considered to be related to the structure and function of the microorganism cell membrane and the disruption of cellular processes.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) can act intracellularly or on the cell membrane, limiting the normal metabolism and proliferation of the microorganism.
However, the actual preservative performance does not depend solely on the concentration of Ethylene Glycol Monophenyl Ether (Phenoxyethanol).
Formulation pH
Water activity
Surfactants
Oil phase
Packaging
Production hygiene
Other preservatives
and target microorganism
together determine performance.
One of the important properties of Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is that it can function in a wider pH range than many organic acid-based preservatives.
The effectiveness of organic acid preservatives, such as benzoic acid or sorbic acid, is highly dependent on the non-ionized form of acids and may decrease at high pH.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) does not have an equally narrow low pH requirement.
Therefore, it may be easier to use in neutral or near-neutral cosmetic systems.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) can also act as a solvent.
The coexistence of aromatic ether and hydroxyl groups can aid in the dispersion of perfume or certain organic ingredients within the formulation.
This property is also important in preservative mixtures.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) can act as a carrier in the solubilization of other preservatives or in liquid formulation.
The main functions of Ethylene Glycol Monophenyl Ether (Phenoxyethanol) at the formulation level are:
Helping to control microbial spoilage
Protecting against bacteria
Supporting the total effectiveness of the protective system
Creating a combination with other preservatives
Helping to solubilize organic components
Contributing to the preservation of the shelf life of the formulation
Helping to reduce the risk of microbial contamination after production
IN WHICH SECTORS IS ETHYLENE GLYCOL MONOPHENYL ETHER (PHENOXYETHANOL) USED?
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is most commonly used in the cosmetics and personal care industry.
Main areas of use:
Skin care creams
Lotions
Serums
Cleaning products
Makeup products
Sun care products
Shampoos
Hair conditioners
Hair styling products
Shower gels
Liquid soaps
Wet wipes
Deodorant formulations
Home care products
Hand dishwashing products
Hard surface cleaners
Laundry detergents
Laundry additives
Institutional and industrial cleaners
Metalworking fluids
Industrial water-based formulations
Pharmaceutical topical products
Topical antiseptic and disinfectant formulations
Medical formulation protection
Perfumery and fragrance systems
Certain industrial formulations, such as paints and coatings
Clariant positions Phenoxetol as a preservative in hand dishwashing, hard surface cleaning, laundry additives and laundry detergents.
BASF Protectol® PE is offered as a Ethylene Glycol Monophenyl Ether (Phenoxyethanol) based product that can be used in home care, institutional and industrial formulations, metalworking fluids and different biocidal applications under appropriate regulatory conditions.
COSMETIC AND PERSONAL CARE APPLICATIONS OF ETHYLENE GLYCOL MONOPHENYL ETHER (PHENOXYETHANOL)
The cosmetics industry is the most important area of use of Ethylene Glycol Monophenyl Ether (Phenoxyethanol).
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is used in the microbiological preservation of cosmetic formulations, especially those containing water.
Since creams and lotions contain water, oil and many organic components, they can create a suitable environment for the development of microorganisms.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) helps to control bacterial contamination within the proper preservative system.
Although surfactants can create a certain level of microbial pressure in shampoos and shower gels, this alone is not a guarantee of adequate protection.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) can be used as a component of the preservative system in these formulations.
Wet wipes may require a particularly strong protective system due to their high water content and usage patterns.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is also widely used in this field.
In the European Union Cosmetics Regulation Annex V, Ethylene Glycol Monophenyl Ether (Phenoxyethanol) can be used as a preservative in all cosmetic products, and the maximum concentration in the finished product is 1.0%.
This limit is not the concentration of raw materials, but the concentration of Ethylene Glycol Monophenyl Ether (Phenoxyethanol) in the finished cosmetic product.
For example, when a preservative mixture containing 90% Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is used at 1%, the finished product contains 0.9% Ethylene Glycol Monophenyl Ether (Phenoxyethanol).
This distinction is important in commercial preservative mixtures.
SCCS considers the use of Ethylene Glycol Monophenyl Ether (Phenoxyethanol) up to 1.0% safe in cosmetic products.
However, being below the regulatory limit alone does not prove that the formulation is microbiologically adequately protected.
The actual protection level of the cosmetic product should be verified by microbiological protective efficacy testing.
Appropriate protective efficacy tests, such as ISO 11930, can be used during formulation development.
The main advantages of Ethylene Glycol Monophenyl Ether (Phenoxyethanol) in cosmetic formulation:
Wide formulation compatibility
Liquid form
Low volatility
Usable in a wide pH range
Good efficacy against bacteria
Suitability for combination with other preservatives
Solvent property
can be considered as.
HOME CARE, CLEANING AND INDUSTRIAL APPLICATIONS OF ETHYLENE GLYCOL MONOPHENYL ETHER (PHENOXYETHANOL)
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is not only used in personal care products.
Home maintenance and industrial formulations containing water can also suffer from microbial contamination during storage.
The preservative system can be important, especially in liquid products with low active ingredients and high water content.
Clariant Phenoxetol product:
Hand dishwashing products
Hard surface cleaners
Laundry additives
Laundry detergents
It positions it as a protector for the
In these products, Ethylene Glycol Monophenyl Ether (Phenoxyethanol) can help control the microbiological degradation of the formulation during the storage period in the packaging.
BASF Protectol PE is also used as a preservative in home care, institutional and industrial formulations, and metalworking fluids.
Metalworking fluids can be prone to the development of bacteria and fungi, especially in systems diluted with water.
Microbial growth:
bad smell,
pH change,
emulsion degradation,
Alteration of corrosion behavior
and reduced life of the working fluid
It can cause problems such as.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) in the appropriate protective package can contribute to the control of these problems.
However, the 1% limit applicable to cosmetic products in home care and industrial systems should not be applied directly as a universal usage limit.
The protective or biocidal legislation of each product category may be different.
The level of use should be determined according to the manufacturer's recommendation and the relevant legislation of the target country.
IS ETHYLENE GLYCOL MONOPHENYL ETHER (PHENOXYETHANOL) USED IN FOOD, COSMETIC AND PHARMACEUTICAL APPLICATIONS?
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is a common and clearly defined preservative in cosmetic products.
In the European Union, Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is listed as a preservative under the Cosmetics Regulation Annex V, reference 29.
CAS No 122-99-6 and EC No 204-589-7.
It can be used in all cosmetic products at a maximum level of 1.0% in the finished product.
This maximum legal concentration does not necessarily mean that the product should be used at 1% in each formulation.
The actual level of use should be determined according to the protective efficacy test.
BASF's personal care product information contains commercial examples for Ethylene Glycol Monophenyl Ether (Phenoxyethanol) with a usage range of approximately 0.3–1.0%.
Clariant gives recommended use levels of approximately 0.5–1.0% for Phenoxetol.
These ratios are manufacturer-specific application recommendations.
It should be considered separately from the EU's maximum 1% legislative limit.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) should not be considered as a direct food additive.
It should not be added indiscriminately to food as a flavor, preservative or process additive.
However, some Ethylene Glycol Monophenyl Ether (Phenoxyethanol) based biocidal products can be used in applications such as surface hygiene of food processing plants or disinfection of food contact areas according to manufacturer and regulatory requirements.
This does not mean that Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is a food ingredient.
Special pharmaceutical grade Ethylene Glycol Monophenyl Ether (Phenoxyethanol) can be used in pharmaceutical applications.
BASF positions Protectol® PE GMP as a pharmaceutical active ingredient in topical antiseptics and disinfectants and as an in-package preservative in topical medical formulations.
BASF states that this grade has European Pharmacopoeia compliance and CEP.
This information does not mean that all technical or cosmetic Ethylene Glycol Monophenyl Ether (Phenoxyethanol) products are pharmaceutical grade.
In pharmaceutical application:
Ph. Eur. Eligibility
GMP
MOBILE
Impurity profile
and related quality documents
It should also be verified.
INDUSTRIAL APPLICATIONS OF ETHYLENE GLYCOL MONOPHENYL ETHER (PHENOXYETHANOL)
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is a multifunctional raw material that benefits from both preservative and solvent properties in the industry.
Its main industrial functions are:
Preservation of water-based formulations
Control of bacterial spoilage
Carrier role in preservative mixtures
Dissolving organic raw materials
Supporting the shelf life of home care products
Protection of industrial cleaners
Microbial control in metalworking fluids
Preservation of pharmaceutical formulations
Contribution to the solubilization of perfume and fragrance components
The following parameters should be evaluated together in the formulation of Ethylene Glycol Monophenyl Ether (Phenoxyethanol):
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) usage level
Product pH
Water activity
Oil phase ratio
Surfactant system
Perfume quantity
Other preservatives
Protective promoters
Packaging Type
Production hygiene
Filling conditions
Microbial load
How to use
Storage temperature
Protective efficacy testing
TDS
SDS
COA
The presence of the preservative dissolved in the formulation alone is not sufficient.
The actual microbiological efficacy must be verified on the final product.
WHAT PROBLEMS CAN ETHYLENE GLYCOL MONOPHENYL ETHER (PHENOXYETHANOL) HELP SOLVE?
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) can help solve problems related to the microbiological stability of formulations, especially those containing water.
Cosmetic product produces bacteria during storage
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) can help control bacterial growth within the appropriate preservative system.
The pH of the formulation is too high for the organic acid preservative
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) can be an alternative or complement as it can be used in a wider pH range than many organic acid preservatives.
Does not dissolve completely in preservative formulation
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) can facilitate the preparation of some preservative mixtures thanks to its liquid structure and solvent properties.
Different preservatives need to be used together in cosmetic formulation
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) can be evaluated in combination with many preservatives and preservative promoters.
Adequate bacterial control, but poor yeast and mold performance
If Ethylene Glycol Monophenyl Ether (Phenoxyethanol) alone is not sufficient, a combination with an appropriate antifungal preservative or protective supplement may be considered.
Microbial protection in wet wipes is insufficient
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) can be evaluated in the appropriate protective package. The final wipe and liquid system should be tested for preservative efficacy together.
Home care product develops odor during storage
If it is caused by microbial spoilage, the appropriate Ethylene Glycol Monophenyl Ether (Phenoxyethanol) based preservative system can be evaluated.
Microbial degradation occurs in metalworking fluid
Preservative systems containing Ethylene Glycol Monophenyl Ether (Phenoxyethanol) can be used under appropriate legislation and formulation conditions.
Challenge test fails even though protector is added
In this case, only the amount of Ethylene Glycol Monophenyl Ether (Phenoxyethanol) should not be increased.
Formulation pH, water activity, packaging, production hygiene, other preservatives and phase distribution of Ethylene Glycol Monophenyl Ether (Phenoxyethanol) should be evaluated together.
Perfume or other organic matter in the product does not dissolve
The solvent effect of Ethylene Glycol Monophenyl Ether (Phenoxyethanol) may be helpful; however, the overall solubility balance of the formulation should be tested separately.
Not every microbiological problem is solved by simply adding more preservatives.
Good manufacturing practices and hygiene are not a substitute for a protective system; likewise, the preservative should not be used to compensate for poor production hygiene.
THINGS TO CONSIDER WHEN USING ETHYLENE GLYCOL MONOPHENYL ETHER (PHENOXYETHANOL)
In the use of Ethylene Glycol Monophenyl Ether (Phenoxyethanol), the target usage area of the product, legislation and microbiological activity should be evaluated together.
The following points should be checked during use:
CAS No 122-99-6 should be verified.
The name of the INCI should be Ethylene Glycol Monophenyl Ether (Phenoxyethanol).
Purity must be checked.
The color must be checked.
The amount of water should be controlled.
The density must be controlled.
The refractive index should be checked.
Phenol and related impurities should be analyzed if necessary.
The pH of the formulation should be evaluated.
Water activity should be taken into account.
Oil-water phase distribution should be evaluated.
Compatibility with other preservatives should be checked.
Compatibility with perfume and surfactants should be tested.
The total amount of Ethylene Glycol Monophenyl Ether (Phenoxyethanol) in the cosmetic product should be calculated.
The maximum limit of 1.0% should not be exceeded in EU cosmetics.
Protective efficacy testing should be performed.
Storage stability should be evaluated.
TDS should be examined.
SDS should be examined.
Batch values must be verified via COA.
Just because Ethylene Glycol Monophenyl Ether (Phenoxyethanol) has a legal limit of 1% does not mean that every cosmetic product will automatically be protected by 1%.
In some formulations, a lower level may be sufficient.
In some formulations, 1% Ethylene Glycol Monophenyl Ether (Phenoxyethanol) may not provide sufficient broad-spectrum protection even on its own.
Therefore, challenge testing on a formulation basis is critical.
INITIAL FORMULATION APPROACHES FOR ETHYLENE GLYCOL MONOPHENYL ETHER (PHENOXYETHANOL)
The following examples are initial approaches prepared to show how Ethylene Glycol Monophenyl Ether (Phenoxyethanol) can be evaluated during formulation development. These are not validated commercial recipes.
The actual preservative level should be determined according to the microbiological preservative efficacy test, target country legislation and formulation characteristics.
All the following ratios are given as a percentage (%) by weight over the total mass of the finished product. The percentages of surfactant and citric acid solutions used belong to the concentration at which the commercial raw material is delivered. The level of pure phenoxyethanol in cosmetic samples does not exceed the limit of 1.00%. The amount of water in each sample is calculated to complete the recipe to 100%.
EXAMPLE 1: COSMETIC EMULSION PRESERVATIVE SCREENING CONTAINING Ethylene Glycol Monophenyl Ether (Phenoxyethanol)
Objective: To evaluate the effect of Ethylene Glycol Monophenyl Ether (Phenoxyethanol) usage level on microbiological protection and physical stability in water-based cosmetic emulsion.
Starting ingredients and formulations by weight:
FORMULA A – PHENOXYETHANOL-FREE CONTROL
Deionized water: 81.95%
Caprylic/capric triglyceride: 8.00%
Cetearyl alcohol: 3.00%
Glyceryl stearate citrate: 2.50%
Glycerin: 4.00%
Xanthan gum: 0.20%
Disodium EDTA: 0.10%
Perfume: 0.15%
Citric acid solution (10%): 0.10%
Phenoxyethanol (pure product): 0.00%
Ethylhexylglycerin (preservative promoter): 0.00%
Total: 100.00%
FORMULA B – LOW LEVEL
Deionized water: 81.55%
Caprylic/capric triglyceride: 8.00%
Cetearyl alcohol: 3.00%
Glyceryl stearate citrate: 2.50%
Glycerin: 4.00%
Xanthan gum: 0.20%
Disodium EDTA: 0.10%
Perfume: 0.15%
Citric acid solution (10%): 0.10%
Phenoxyethanol (pure product): 0.40%
Ethylhexylglycerin (preservative promoter): 0.00%
Total: 100.00%
FORMULA C – INTERMEDIATE LEVEL
Deionized water: 81.25%
Caprylic/capric triglyceride: 8.00%
Cetearyl alcohol: 3.00%
Glyceryl stearate citrate: 2.50%
Glycerin: 4.00%
Xanthan gum: 0.20%
Disodium EDTA: 0.10%
Perfume: 0.15%
Citric acid solution (10%): 0.10%
Phenoxyethanol (pure product): 0.70%
Ethylhexylglycerin (preservative promoter): 0.00%
Total: 100.00%
FORMULA D – SUPPORTIVE SYSTEM
Deionized water: 80.95%
Caprylic/capric triglyceride: 8.00%
Cetearyl alcohol: 3.00%
Glyceryl stearate citrate: 2.50%
Glycerin: 4.00%
Xanthan gum: 0.20%
Disodium EDTA: 0.10%
Perfume: 0.15%
Citric acid solution (10%): 0.10%
Phenoxyethanol (pure product): 0.70%
Ethylhexylglycerin (preservative promoter): 0.30%
Total: 100.00%
Formula A is phenoxyethanol-free comparison sample; it should not be considered as a microbiologically safe final product. The 0.30% ethylhexylglycerin in Formula D is only for comparison of its preservative promoter effect. The citric acid solution was kept constant at 0.10% in the initial formulation; adjustment and remass rebalancing may be required in separate pilot trials to truly achieve the target pH.
Application approach:
A control sample without Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is prepared.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is tested at different levels.
Appearance, color and smell are checked.
Viscosity and pH are recorded.
Low and high temperature stability is studied.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) crystallization or phase separation is controlled.
Appropriate microbiological protective efficacy test is performed.
The system that provides the lowest adequate protection is determined.
EXAMPLE 2: Ethylene Glycol Monophenyl Ether (Phenoxyethanol) SHAMPOO / LIQUID CLEANSER SCAN
Objective: To evaluate the preservative performance and formulation compatibility of Ethylene Glycol Monophenyl Ether (Phenoxyethanol) in aqueous system containing surfactant.
Starting ingredients and formulations by weight:
FORMULA A – PHENOXYETHANOL-FREE CONTROL
Deionized water: 60.90%
Sodium laureth sulfate (28% active): 25.00%
Cocamidopropyl betaine (30% active): 10.00%
Glycerin: 2.00%
Sodium chloride: 1.50%
Disodium EDTA: 0.10%
Perfume: 0.25%
Citric acid solution (10%): 0.25%
Phenoxyethanol (pure product): 0.00%
Total: 100.00%
FORMULA B – LOW LEVEL
Deionized water: 60.50%
Sodium laureth sulfate (28% active): 25.00%
Cocamidopropyl betaine (30% active): 10.00%
Glycerin: 2.00%
Sodium chloride: 1.50%
Disodium EDTA: 0.10%
Perfume: 0.25%
Citric acid solution (10%): 0.25%
Phenoxyethanol (pure product): 0.40%
Total: 100.00%
FORMULA C – INTERMEDIATE LEVEL
Deionized water: 60.20%
Sodium laureth sulfate (28% active): 25.00%
Cocamidopropyl betaine (30% active): 10.00%
Glycerin: 2.00%
Sodium chloride: 1.50%
Disodium EDTA: 0.10%
Perfume: 0.25%
Citric acid solution (10%): 0.25%
Phenoxyethanol (pure product): 0.70%
Total: 100.00%
FORMULA D – UPPER BORDER SCAN
Deionized water: 59.90%
Sodium laureth sulfate (28% active): 25.00%
Cocamidopropyl betaine (30% active): 10.00%
Glycerin: 2.00%
Sodium chloride: 1.50%
Disodium EDTA: 0.10%
Perfume: 0.25%
Citric acid solution (10%): 0.25%
Phenoxyethanol (pure product): 1.00%
Total: 100.00%
The ratios of sodium laureth sulfate and cocamidopropyl betaine are not pure active ingredient percentages, but rather percentages of addition of commercial solutions with the specified active ingredient ratio to the finished formulation. Formula A is phenoxyethanol-free control sample. A 1.00% level is an example of screening only at the upper allowable limit; adequate preservation or safe final product performance should be verified in the laboratory. The effects of sodium chloride and citric acid amounts on viscosity and pH should be reviewed in the formulation stability test.
Application approach:
Basic shampoo or cleanser is prepared.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is added at controlled levels.
Clarity or opacity is checked.
Viscosity is measured.
pH is recorded.
Perfume and Ethylene Glycol Monophenyl Ether (Phenoxyethanol) compatibility are evaluated.
Turbidity is controlled at low temperature.
High temperature storage is done.
Microbiological protective efficacy test is applied.
The formulation that provides adequate protection within the legal limit is selected.
ALTERNATIVES AND COMPARISON OF ETHYLENE GLYCOL MONOPHENYL ETHER (PHENOXYETHANOL)
When choosing an alternative to Ethylene Glycol Monophenyl Ether (Phenoxyethanol), only protective power should not be considered. pH requirement, bacteria-yeast-mold spectrum, water solubility, odor, legislation and formulation compatibility should be evaluated together.
ETHYLENE GLYCOL MONOPHENYL ETHER (PHENOXYETHANOL) AND BENZYL ALCOHOL
Benzyl Alcohol and Ethylene Glycol Monophenyl Ether (Phenoxyethanol) are aromatic liquid preservative and solvent raw materials.
Benzyl Alcohol CAS No is 100-51-6.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) CAS No 122-99-6.
Both products can be used as part of a preservative system in cosmetic formulations.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is a preservative against bacteria that is strong and has broad formulation compatibility.
Benzyl Alcohol, on the other hand, has a distinct antimicrobial profile and fragrance character.
The regulatory positions and conditions of use of the two products in EU cosmetics legislation should be evaluated separately.
One-to-one weight substitution should not be made.
ETHYLENE GLYCOL MONOPHENYL ETHER (PHENOXYETHANOL) AND ETHYLENE GLYCOL MONOPHENYL ETHER (PHENOXYETHANOL) + ETHYLHEXYLGLYCERIN MIXTURES
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is often used commercially in combination with preservatives such as Ethylhexylglycerin.
Ethylhexylglycerin alone is not the same preservative as Ethylene Glycol Monophenyl Ether (Phenoxyethanol).
However, it can support the antimicrobial system of Ethylene Glycol Monophenyl Ether (Phenoxyethanol) by changing surface and microorganism interactions within the formulation.
Such ready-made mixtures are especially common in the cosmetics industry.
Pure Ethylene Glycol Monophenyl Ether (Phenoxyethanol) and ready-made Ethylene Glycol Monophenyl Ether (Phenoxyethanol)/Ethylhexylglycerin mixture should not be used at the same usage rate.
The actual percentage of Ethylene Glycol Monophenyl Ether (Phenoxyethanol) in the mixture should be calculated and the 1% maximum limit of Ethylene Glycol Monophenyl Ether (Phenoxyethanol) in the EU should be checked accordingly.
ETHYLENE GLYCOL MONOPHENYL ETHER (PHENOXYETHANOL) AND SODIUM BENZOATE
Sodium Benzoate is an organic acid-based preservative.
Its preservative effect is closely related to the non-ionized form of benzoic acid.
Therefore, it is more effective at low pH.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) can be used in wider pH range.
While Sodium Benzoate shows high solubility in water, the water solubility of Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is approximately 2.5%.
The two products can be used together in some formulations.
However, their protective mechanisms and optimal pH conditions differ.
ETHYLENE GLYCOL MONOPHENYL ETHER (PHENOXYETHANOL) AND POTASSIUM SORBATE
Potassium Sorbate is an organic acid-based preservative used especially in yeast and mold control.
It performs better in low pH conditions.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol), on the other hand, is particularly potent in bacterial control.
Therefore, in some formulations, the combination of different preservatives may be considered to balance the bacterial and fungal spectrum.
Compliance and legal limits should be checked separately.
ETHYLENE GLYCOL MONOPHENYL ETHER (PHENOXYETHANOL) AND PARABENS
Parabens are a family of preservatives consisting of esters of p-hydroxybenzoic acid.
Methylparaben and Propylparaben are known members of this class.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is non-paraben.
Its chemical structure and antimicrobial mechanism are different.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) can be easy to incorporate into formulation due to its liquid form.
Some parabens have lower water solubility and may require a dissolution system.
The permission and maximum concentrations of the two preservative families in EU cosmetics legislation should be evaluated separately.
QUALITY CONTROL AND PURCHASING CRITERIA FOR ETHYLENE GLYCOL MONOPHENYL ETHER (PHENOXYETHANOL)
When purchasing Ethylene Glycol Monophenyl Ether (Phenoxyethanol), it is important that the product is in the appropriate quality class for the target application.
Recommended information to review before purchasing:
Full product name
Manufacturer
INCI name
CAS No
EC No
Purity
Outlook
Color
Smell
Amount of water
Density
Refractive index
Acidity
Amount of phenol, if necessary
Other organic impurities
Boiling behavior
Pharmacopoeia compliance if pharmaceutical grade is required
Document status if CEP is required
Cosmetic regulatory compliance
REACH status
If biocidal use is targeted, the relevant legislation status
Origin
Shelf life
Storage conditions
Packaging
Batch number
TDS
SDS
COA
BASF has an active ingredient value of 99.5% ≥ for Protectol PE commercial grade.
This value is the useful commercial reference for high purity technical Ethylene Glycol Monophenyl Ether (Phenoxyethanol).
Pharmaceutical Protectol PE GMP is also positioned with European Pharmacopoeia compliance and CEP.
Therefore, there may be a difference between technical Ethylene Glycol Monophenyl Ether (Phenoxyethanol) with the same CAS number and pharmaceutical grade in terms of documentation and impurity control.
In the cosmetic formulation, only the phrase "99% Ethylene Glycol Monophenyl Ether (Phenoxyethanol)" should not be considered.
The color, odor, and impurity profile can also impact the appearance and sensory attributes of the final product.
Low odor can be an important purchasing criterion for unperfumed or low-scented products.
STORAGE AND HANDLING OF ETHYLENE GLYCOL MONOPHENYL ETHER (PHENOXYETHANOL)
Storage: Ethylene Glycol Monophenyl Ether (Phenoxyethanol) should be stored in clean, dry, and tightly sealed appropriate packaging.
Temperature: The storage temperature recommended by the manufacturer should be taken as a basis.
Cold environment: At low temperature, the physical appearance or flow behavior may change. The product must be completely homogeneous before use.
High temperature: Unnecessary high-temperature storage for a long time should be avoided.
Moisture: Unnecessary opening of the packaging should be prevented.
Light: It is suitable to be protected from direct sunlight and high heat sources for a long time.
Oxidizers: Uncontrolled contact with strong oxidizers should be avoided.
Packaging: Drums, IBCs or other suitable chemical packaging can be used according to the manufacturer.
Contamination: Cross-contamination with technical chemicals should be especially avoided in cosmetic or pharmaceutical grade products.
FIFO: Batch and shelf-life management should be implemented.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is a combustible organic liquid with low volatility with a closed cup flash point of approximately 127 °C.
This value indicates that it does not behave as a highly volatile and highly flammable solvent at room temperature.
However, high-temperature fire safety should be considered.
The transport classification must be verified from the current SDS document of the purchased commercial product.
ETHYLENE GLYCOL MONOPHENYL ETHER (PHENOXYETHANOL) SAFETY INFORMATION
In the safety assessment of Ethylene Glycol Monophenyl Ether (Phenoxyethanol), pure or highly concentrated raw materials should be distinguished from low usage levels in the cosmetic product.
In the current harmonized classification registers of the European Union, there are classifications for 2-Ethylene Glycol Monophenyl Ether (Phenoxyethanol) associated with acute oral toxicity and eye damage/irritation.
In the current records of ECHA, it is seen that the existing and proposed classifications have been updated over time.
For this reason, raw material handling should be based on the current manufacturer SDS.
Ingestion of concentrated Ethylene Glycol Monophenyl Ether (Phenoxyethanol) should be avoided.
Contact with the eyes should be avoided.
Appropriate protective eyewear should be used.
Prolonged skin contact should be limited.
If fog or aerosols are generated during the procedure, adequate ventilation should be provided.
Personal protective equipment selection should be made based on up-to-date SDS.
Cosmetic safety assessment is not the same as the hazard classification of concentrated raw material.
The SCCS has evaluated the available data and deemed Ethylene Glycol Monophenyl Ether (Phenoxyethanol) safe for use as a preservative in cosmetic products at a maximum level of 1.0%.
Therefore, the inference that "pure Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is dangerous to the eye, so it cannot be used in cosmetics" is not correct.
Conversely, the approach that "up to 1% is allowed in cosmetics, so concentrated raw materials are harmless" is also not correct.
Raw material safety and finished product safety should be considered separately.
WHAT TO CONSIDER WHEN BUYING ETHYLENE GLYCOL MONOPHENYL ETHER (PHENOXYETHANOL)?
When purchasing Ethylene Glycol Monophenyl Ether (Phenoxyethanol), the usage area should be determined first.
The quality and documentation required in cosmetic, home care, industrial or pharmaceutical application may not be the same.
The following information should be clarified before purchasing:
Use sector
Final Product
CAS No 122-99-6 verification
Requirement of INCI Ethylene Glycol Monophenyl Ether (Phenoxyethanol)
Minimum purity
Color limit
Fragrance requirement
Water limit
Density
Refractive index
If phenol limit is required
Cosmetic grade requirement
Pharmaceutical grade requirement
Ph. Eur. if eligibility is required
CEP requirement
Legislative status, if there is a biocidal application
REACH documents
Manufacturer
Origin
Packaging
Estimated order quantity
TDS
SDS
COA
If the existing Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is to be replaced, TDS and COA information of the existing product
The price of Ethylene Glycol Monophenyl Ether (Phenoxyethanol) should not be evaluated only by its kilogram cost.
High purity
Low color
Low odor
Controlled amount of phenol
Pharmacopoeia compliance
and technical document level
It can affect the actual value of the product.
Especially in cosmetic formulations, low-quality or high-odor Ethylene Glycol Monophenyl Ether (Phenoxyethanol) can negatively affect the odor profile of the final product.
In pharmaceutical application, the product with the necessary pharmacopoeia and GMP certificates should be preferred instead of the standard technical grade.
SUPPLY OF ETHYLENE GLYCOL MONOPHENYL ETHER (PHENOXYETHANOL) FROM ATAMAN KIMYA
Ethylene Glycol Monophenyl Ether, also known as Ethylene Glycol Monophenyl Ether (Phenoxyethanol); It is a preservative and solvent glycol ether used in cosmetics and personal care products, home care and cleaning products, institutional and industrial formulations, metalworking fluids and certain pharmaceutical applications in the appropriate quality class.
Companies that want to get information about the supply of Ethylene Glycol Monophenyl Ether (Phenoxyethanol) from Ataman Kimya can share their usage areas and technical needs and request information about product suitability, current supply conditions, packaging options and price offer.
The current stock status, manufacturer, origin, purity, color and odor properties, cosmetic or pharmaceutical quality status, packaging and other technical specifications of the product should be confirmed from Ataman Kimya before ordering.
Sharing the following information in the request for quotation facilitates the evaluation of the right Ethylene Glycol Monophenyl Ether (Phenoxyethanol) product:
Use sector
Final Product
Cosmetic, technical or pharmaceutical quality requirement
Minimum purity
Color limit
Fragrance requirement
Water limit
If phenol limit is required
Ph. Eur. if eligibility is required
CEP requirement
Estimated order quantity
Requested packing
Requested technical documents
TDS or COA information of the current Ethylene Glycol Monophenyl Ether (Phenoxyethanol) product, if applicable
FREQUENTLY ASKED QUESTIONS ABOUT ETHYLENE GLYCOL MONOPHENYL ETHER (PHENOXYETHANOL)
What is Ethylene Glycol Monophenyl Ether (Phenoxyethanol)?
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is glycol ether that carries the functions of aromatic ether and primary alcohol together. It is used as a preservative, especially in cosmetics and water-based formulations.
What is Ethylene Glycol Monophenyl Ether?
Ethylene Glycol Monophenyl Ether is another name for the same chemical substance as Ethylene Glycol Monophenyl Ether (Phenoxyethanol).
Is Ethylene Glycol Monophenyl Ether the same as Ethylene Glycol Monophenyl Ether (Phenoxyethanol)?
Both refer to the same chemical substance with CAS No 122-99-6.
What is the Turkish name of Ethylene Glycol Monophenyl Ether (Phenoxyethanol)?
It is phenoxyethanol.
What is the INCI name of Ethylene Glycol Monophenyl Ether (Phenoxyethanol)?
Ethylene Glycol is Monophenyl Ether (Phenoxyethanol).
What is the CAS number of Ethylene Glycol Monophenyl Ether (Phenoxyethanol)?
CAS No is 122-99-6.
What is the EC number of Ethylene Glycol Monophenyl Ether (Phenoxyethanol)?
EC / EINECS No is 204-589-7.
What is the molecular formula of Ethylene Glycol Monophenyl Ether (Phenoxyethanol)?
C₈H₁₀O₂.
What is the molecular weight of Ethylene Glycol Monophenyl Ether (Phenoxyethanol)?
It is approximately 138.16 g/mol.
What is the IUPAC name of Ethylene Glycol Monophenyl Ether (Phenoxyethanol)?
It is 2-Phenoxyethan-1-ol.
Is Ethylene Glycol Monophenyl Ether (Phenoxyethanol) a liquid?
It is a colorless, clear and oil-like liquid under normal ambient conditions.
Is Ethylene Glycol Monophenyl Ether (Phenoxyethanol) odorous?
It has a slightly aromatic scent.
What is the boiling point of Ethylene Glycol Monophenyl Ether (Phenoxyethanol)?
It is about 245 °C.
What is the flash point of Ethylene Glycol Monophenyl Ether (Phenoxyethanol)?
It is reported as approximately 127 °C in the closed cup method.
What is the density of Ethylene Glycol Monophenyl Ether (Phenoxyethanol)?
Around 20 °C it is about 1.10–1.11 g/cm³.
Is Ethylene Glycol Monophenyl Ether (Phenoxyethanol) soluble in water?
Yes, but it is limited soluble. A resolution of about 24–27 g/L has been reported around 20 °C.
Is Ethylene Glycol Monophenyl Ether (Phenoxyethanol) completely miscible with water?
It does not mix with water in all proportions.
Is Ethylene Glycol Monophenyl Ether (Phenoxyethanol) a solvent?
In addition to its protective function, it can show solvent properties for various organic compounds.
Is Ethylene Glycol Monophenyl Ether (Phenoxyethanol) a preservative?
It is a common preservative in cosmetics and various technical formulations.
Is Ethylene Glycol Monophenyl Ether (Phenoxyethanol) effective against bacteria?
It shows good antimicrobial activity, especially against bacteria.
Is Ethylene Glycol Monophenyl Ether (Phenoxyethanol) effective against yeast and mold?
It may show some level of efficacy, but in many formulations it may not provide sufficient fungal protection on its own. Therefore, combination with other preservatives may be required.
Is Ethylene Glycol Monophenyl Ether (Phenoxyethanol) used in cosmetics?
It is one of the most common cosmetic preservatives.
What is the maximum amount of Ethylene Glycol Monophenyl Ether (Phenoxyethanol) that can be used in the EU?
A maximum of 1.0% can be used in the finished cosmetic product under the European Union Cosmetics Regulation Annex V.
Is Ethylene Glycol Monophenyl Ether (Phenoxyethanol) safe at 1%?
The SCCS has evaluated the available data and deemed a maximum of 1.0% safe for use in cosmetic products.
Can Ethylene Glycol Monophenyl Ether (Phenoxyethanol) be used in children's products?
The SCCS evaluation also took into account children and concluded that a maximum of 1% use in cosmetics is safe. The entire safety assessment of the final product should be carried out separately.
Can Ethylene Glycol Monophenyl Ether (Phenoxyethanol) be used in leave-on products?
The EU lists Annex V Ethylene Glycol Monophenyl Ether (Phenoxyethanol) as a preservative at a maximum level of 1% in all cosmetic products.
Can Ethylene Glycol Monophenyl Ether (Phenoxyethanol) be used in wet wipes?
It can be widely used in the appropriate protective system.
Is Ethylene Glycol Monophenyl Ether (Phenoxyethanol) used in makeup products?
It can be used when the formulation and legislation of the product are appropriate.
Can Ethylene Glycol Monophenyl Ether (Phenoxyethanol) be used in solar products?
It can be used in accordance with cosmetic formulation requirements and a maximum limit of 1%.
Is Ethylene Glycol Monophenyl Ether (Phenoxyethanol) used in home care products?
It can be used as a preservative in hand dishwashing products, hard surface cleaners, laundry additives, and other water-based formulations.
Is Ethylene Glycol Monophenyl Ether (Phenoxyethanol) used in metalworking fluids?
Manufacturers such as BASF also position preservatives based on Ethylene Glycol Monophenyl Ether (Phenoxyethanol) in metalworking fluids.
Is Ethylene Glycol Monophenyl Ether (Phenoxyethanol) used in food?
Standard Ethylene Glycol Monophenyl Ether (Phenoxyethanol) should not be considered as a direct food additive.
Can Ethylene Glycol Monophenyl Ether (Phenoxyethanol) be used in food processing?
Certain biocidal products may be used in the surface hygiene of food processing plants under appropriate legislation. This use does not imply that Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is a food ingredient.
Is Ethylene Glycol Monophenyl Ether (Phenoxyethanol) used in pharmaceutical products?
Suitable pharmaceutical grade products can be used as a preservative in topical formulations or in certain antiseptic/disinfectant applications.
Are all Ethylene Glycol Monophenyl Ether (Phenoxyethanol) products pharmaceutical grade?
Ph. Eur., GMP, CEP and other quality documents required for pharmaceutical use must be verified separately.
Is Ethylene Glycol Monophenyl Ether (Phenoxyethanol) a paraben?
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is non-paraben.
Is Ethylene Glycol Monophenyl Ether (Phenoxyethanol) formaldehyde-releasing preservative?
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is not in the class of formaldehyde-releasing preservatives.
Is Ethylene Glycol Monophenyl Ether (Phenoxyethanol) natural?
Commercial Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is mostly produced by chemical synthesis. Some manufacturers may offer grades with increased renewable carbon content. This should not be generalized to all Ethylene Glycol Monophenyl Ether (Phenoxyethanol) products.
How is Ethylene Glycol Monophenyl Ether (Phenoxyethanol) produced?
Industrial production can generally be carried out by the reaction of phenol with ethylene oxide or the appropriate hydroxyethylation chemistry. The actual production process depends on the manufacturer's technology.
Is Ethylene Glycol Monophenyl Ether (Phenoxyethanol) the same as Phenoxyisopropanol?
They are substances with different CAS numbers and structures.
Does Ethylene Glycol Monophenyl Ether (Phenoxyethanol) have high pH dependency?
It can be used in a wider pH range compared to organic acid preservatives such as benzoate and sorbate.
Does Ethylene Glycol Monophenyl Ether (Phenoxyethanol) require challenge test?
The effectiveness of the preservative system in cosmetic formulations should be confirmed by appropriate microbiological preservative efficacy testing on the final product.
Is Ethylene Glycol Monophenyl Ether (Phenoxyethanol) a sufficient preservative on its own?
In some formulations, it may be; while in some formulations it may need to be used in combination with other preservatives to improve yeast and mold control or overall protection spectrum.
Can Ethylene Glycol Monophenyl Ether (Phenoxyethanol) be used together with Ethylhexylglycerin?
This combination is common in cosmetic preservative systems.
Can Ethylene Glycol Monophenyl Ether (Phenoxyethanol) be used together with Sodium Benzoate?
Under appropriate pH and formulation conditions, the combination can be evaluated.
Is Ethylene Glycol Monophenyl Ether (Phenoxyethanol) low volatile?
Due to its high boiling point and low evaporation rate, it exhibits relatively low volatility at room temperature.
What is the logP value of Ethylene Glycol Monophenyl Ether (Phenoxyethanol)?
It is approximately 1.2.
What is the refractive index of Ethylene Glycol Monophenyl Ether (Phenoxyethanol)?
At 20 °C, it is about 1,534.
What are the most important criteria when purchasing Ethylene Glycol Monophenyl Ether (Phenoxyethanol)?
Purity, color, odor, water content, density, refractive index, impurity profile and legislative documents related to the area of use are important.
What documents should be required for Ethylene Glycol Monophenyl Ether (Phenoxyethanol)?
TDS, SDS, and COA are essential documents. For cosmetic or pharmaceutical use, relevant legislation, pharmacopoeia, GMP, or CEP documents may also be required.
How should Ethylene Glycol Monophenyl Ether (Phenoxyethanol) be stored?
It should be stored in clean, dry, tightly closed appropriate packaging and manufacturer-recommended temperature conditions.
ETHYLENE GLYCOL MONOPHENYL ETHER (PHENOXYETHANOL) – TECHNICAL SUMMARY
Ethylene Glycol Monophenyl Ether, 2-Ethylene Glycol Monophenyl Ether (Phenoxyethanol) and Ethylene Glycol Monophenyl Ether (Phenoxyethanol) refer to the same chemical substance.
Its Turkish name is Phenoxyethanol. Its INCI name is Ethylene Glycol Monophenyl Ether (Phenoxyethanol).
It has CAS No 122-99-6, EC/EINECS No 204-589-7, molecular formula C₈H₁₀O₂, and molecular weight of approximately 138.16 g/mol. Its IUPAC name is 2-Phenoxyethan-1-ol.
The molecular structure can be represented as C₆H₅-O-CH₂-CH₂-OH.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is a glycol ether that combines the properties of an aromatic ether and a primary alcohol in the same molecule.
Under normal conditions, it is a colorless, clear and slightly aromatic liquid. Its boiling point is approximately 245 °C.
Its closed cup flash point is about 127 °C. Around 20 °C, its density is about 1.10–1.11 g/cm³.
Water solubility is about 24–27 g/L.
It shows good compatibility with ethanol and various organic solvents.
It has a refractive index of about 1.534 and a logP value of about 1.2.
The primary commercial function of Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is protection.
It exhibits particularly good efficacy against bacteria and can be used in combination with other preservatives or preservative supplements in cosmetic formulations.
At the same time, thanks to its solvent properties, it can help the dispersion of some organic components in the formulation.
In the European Union Cosmetics Regulation Annex V, Ethylene Glycol Monophenyl Ether (Phenoxyethanol) is listed as a permitted preservative under reference 29.
The maximum usage concentration for all cosmetic products is 1.0% of the finished product.
SCCS has accepted Ethylene Glycol Monophenyl Ether (Phenoxyethanol) as safe for use as a preservative in cosmetic products at a maximum level of 1% within the framework of current scientific data.
However, a regulatory limit of 1% does not automatically mean that a formulation is microbiologically adequately protected.
Appropriate preservative efficacy testing should be performed in the final formulation.
Apart from cosmetics, Ethylene Glycol Monophenyl Ether (Phenoxyethanol) can also be used as a preservative in hand dishwashing products, hard surface cleaners, laundry products, institutional and industrial cleaners, and metalworking fluids.
Pharmaceutical grade Ethylene Glycol Monophenyl Ether (Phenoxyethanol) can also be used in topical medical formulations.
BASF Protectol PE GMP is one of the commercial examples in this field with Ph. Eur. compliance and CEP.
It should not be considered as a direct food additive.
Ethylene Glycol Monophenyl Ether (Phenoxyethanol) and Ethylene Glycol are not the same substance.
The name "Ethylene Glycol Monophenyl Ether" is one of the synonyms that refers only to the phenyl ether and hydroxyethyl portion in the chemical structure of Ethylene Glycol Monophenyl Ether (Phenoxyethanol).
When purchasing Ethylene Glycol Monophenyl Ether (Phenoxyethanol), minimum purity, color, odor, water content, density, refractive index, phenol and other impurities and documents required for cosmetic, technical or pharmaceutical use should be evaluated together.
Companies planning to supply Ethylene Glycol Monophenyl Ether / Ethylene Glycol Monophenyl Ether (Phenoxyethanol) from Ataman Kimya are recommended to confirm the current product and offer conditions by sharing their usage area, minimum purity, cosmetic or pharmaceutical quality requirement, quantity, packaging and technical document needs.
