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Ethylenediaminetetraacetic acid (EDTA), also called EDTA acid, is an aminopolycarboxylic acid with the formula [CH2N(CH2CO2H)2]2.
This white, slightly water-soluble solid is widely used to bind to iron (Fe2+/Fe3+) and calcium ions (Ca2+), forming water-soluble complexes even at neutral pH.
Ethylenediaminetetraacetic acid disodium salt is thus used to dissolve Fe- and Ca-containing scale as well as to deliver iron ions under conditions where its oxides are insoluble.
EDTA is available as several salts, notably disodium EDTA, sodium calcium edetate, and tetrasodium EDTA, but these all function similarly.
CAS: 139-33-3
MF: C10H14N2Na2O8
MW: 336.21
EINECS: 205-358-3
Product Name: Ethylenediaminetetraacetic acid disodium salt
Synonyms: SODIUM (DI) ETHYLENEDIAMINE TETRAACETATE DIHYDRATE, VERSENE NA, DIHYDRATE, VERSENE DISODIUM, WANKLYN'S EDTA, Ceftriaxone Impurity 21（EDTA Disodium）, disodium ethylenediamintetraacetate, EDTA two sodium, EDTA TITRANT 0.05M VOL SOL
Description
Ethylenediaminetetra-acetic acid (abbreviated as EDTA) is used in several industrial applications attributing to its high ability to bind to most of metal cations.
EDTA is produced as several salts, e.g. ethylenediaminetetra-acetic acid disodium salt (EDTAS).
EDTA and its salts are used as chelating agents in cosmetic formulations. EDTAS is a preservative, sequestrant, and stabilizer in foods.
EDTA is added to ascorbic acid-disodium benzoate containing soft drinks to mitigate the formation of benzene.
EDTA and its salts are used as a component in the production of food-contact paper and paperboard.
EDTAS is permitted in the feed and drinking water of animals and/or for the treatment of food-producing animals.
In the textile industry, EDTA and its salts prevent metal ion impurities from changing colors of dyed products.
In the pulp and paper industry, EDTA and its salts inhibit the ability of metal ions from catalyzing the disproportionation of hydrogen peroxide (a typical bleaching agent).
EDTAS is used in synthetic rubber manufacture.
EDTAS is also used as a corrosion inhibitor to carbon steel in the industries.
As an anticoagulant, EDTAS and tripotassium salts of EDTA are most commonly used.
Uses
EDTA is widely used in industry.
Ethylenediaminetetraacetic acid disodium salt also has applications in food preservation, medicine, cosmetics, water softening, in laboratories, and other fields.
uses
Ethylenediaminetetraacetic acid (EDTA) is an aminopolycarboxylic acid and a hexadentate ligand.
Ethylenediaminetetraacetic acid disodium salt chelates with metal ions, especially with cations to form an octahedral complex.
Ethylenediaminetetraacetic acid disodium salt (EDTA) is a blood anticoagulant and contributes to the pathogenesis of pseudothrombocytopenia.
Ethylenediaminetetraacetic acid disodium salt chelates with calcium in the blood and inhibits clotting and is routinely used in haematological tests.
Ethylenediaminetetraacetic acid disodium salt enhances the antibacterial activity of lysozyme.
EDTA used in chelation therapy chelates with calcium and favors dilation of artery, solubilisation of atheromatous plaques in atherosclerotic vascular disease.
EDTA chelation therapy may also protect from oxidative damage during blood and lipid peroxidation in liver fibrosis.
Industrial
EDTA is mainly used to sequester (bind or confine) metal ions in aqueous solution.
In the textile industry,Ethylenediaminetetraacetic acid disodium salt prevents metal ion impurities from modifying colours of dyed products.
In the pulp and paper industry, EDTA inhibits the ability of metal ions, especially Mn2+, from catalysing the disproportionation of hydrogen peroxide, which is used in chlorine-free bleaching.
Medicine
Sodium calcium edetate, an EDTA derivative, is used to bind metal ions in the practice of chelation therapy, such as for treating mercury and lead poisoning.
Ethylenediaminetetraacetic acid disodium salt is used in a similar manner to remove excess iron from the body.
This therapy is used to treat the complication of repeated blood transfusions, as would be applied to treat thalassaemia.
Dentistry
Dentists and endodontists use EDTA solutions to remove inorganic debris (smear layer) and lubricate the root canals in endodontics.
This procedure helps prepare root canals for obturation.
Furthermore, EDTA solutions with the addition of a surfactant loosen up calcifications inside a root canal and allow instrumentation (canal shaping) and facilitate apical advancement of a file in a tight or calcified root canal towards the apex.
Uses
Disodium EDTA is a preservative used in concentrations of 0.1 to 0.5 percent.
Disodium Dihydrogen EDTA is a sequestrant and chelating agent whose complete name is disodium ethylenediamine tetraacetate.
Ethylenediaminetetraacetic acid disodium salt is a nonhygroscopic powder that is colorless, odorless, and tasteless at recommended use levels.
A 1% solution has a ph of 4.3–4.7.
Ethylenediaminetetraacetic acid disodium salt is used to control the reaction of trace metals to include calcium and magnesium with other organic and inorganic components in food to prevent deterioration of color, texture, and development of precipitates and to prevent oxidation.
Its function is comparable to that of disodium calcium edta.
Chelating agent (metal); pharmaceutic aid (chelating agent).
Ethylenediaminetetraacetic acid disodium salt is widely used in textile industry. Usually applied to dissolve limescale.
Ethylenediaminetetraacetic acid disodium salt is applied in textile industry, pulp and paper industry and also in chelation therapy.
In cosmetics, Ethylenediaminetetraacetic acid disodium salt acts as a sequestering agent.
Ethylenediaminetetraacetic acid disodium salt acts as a corrosion inhibitor to carbon steel in the industries.
Ethylenediaminetetraacetic acid disodium salt also acts as a food additive.
Application
Ethylenediaminetetraacetic acid disodium salt dihydrate has been in seed germination trials of plant species and in protein extraction from Moss, Physcomitrella paten.
Ethylenediaminetetraacetic acid disodium salt has also been used in lysis and vacuole buffer for the isolation of vacuoles from Petunia petals.
Chelator of divalent cations.
Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.
Properties
Melting point: 248 °C (dec.)(lit.)
Boiling point: >100 °C
Density: 1.01 g/mL at 25 °C
Vapor pressure: 0Pa at 25℃
Refractive index: n20/D 1.363
Storage temp.: 2-8°C
Solubility: H2O: clear, colorless
Form: solution
Color: ≤5 (0.5 M)(APHA)
pH: 8.0±0.2
Odor: at 100.00%. odorless
Water Solubility: Miscible with water.
BRN: 3822669
Stability: Hygroscopic
Cosmetics Ingredients Functions: CHELATING, VISCOSITY CONTROLLING
InChI: 1S/C10H16N2O8.2Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;/q;2*+1/p-2
InChIKey: ZGTMUACCHSMWAC-UHFFFAOYSA-L
Chemical Properties
Disodium edetate occurs as a white crystalline, odorless powder with a slightly acidic taste.
Safety Profile
Poison by intraperitoneal and intravenous routes.
Moderately toxic by ingestion.
Experimental teratogenic and reproductive effects.
Mutation data reported.
The calcium disodium salt of EDTA is used as a chelating agent in treating lead poisoning.
When heated to decomposition Ethylenediaminetetraacetic acid disodium salt emits toxic fumes of NOx and NasO.
Storage
Edetate salts are more stable than edetic acid (see also Edetic acid).
However, disodium edetate dihydrate loses water of crystallization when heated to 120°C.
Aqueous solutions of disodium edetate may be sterilized by autoclaving, and should be stored in an alkali-free container.
Disodium edetate is hygroscopic and is unstable when exposed to moisture.
EDTA should be stored in a well-closed container in a cool, dry place.
Incompatibilities
Disodium edetate behaves as a weak acid, displacing carbon dioxide from carbonates and reacting with metals to form hydrogen.
EDTA is incompatible with strong oxidizing agents, strong bases, metal ions, and metal alloys.
