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CAS NO:    70445-33-9

3-[(2-Ethylhexyl)oxy]-1,2-propanediol; Octoxyglycerin; ethylhexylglycerine; 1,2-Propanediol, 3-(2-ethylhexyloxy); Ethylhexylglycerin

Ethylhexylglycerin, or octoxyglycerin, is a glyceryl ether that is commonly used as part of a preservative system in cosmetic preparations

Lexgard E; 3-[2-(EthyL;liquid,100Ml;Sensiva SC 50; OCTOXYGLYCERIN; Sensiva SC 50JP; ETHYLHEXYLGLYCERIN; Ethylhexyl Glecerine;Ethyl hexyl glycerol; Glycerol α-(2-Ethylhexyl) Ether; 3-[(2-Ethylhexyl)oxy]-1,2-propanediol; Octoxyglycerin; ethylhexylglycerine; 1,2-Propanediol, 3-(2-ethylhexyloxy); Ethylhexylglycerin; ethyl hexyl glycerin; 3-ethylnonane-1,2,3-triol; 1,2-Propanediol, 3-[(2-ethylhexyl)oxy]; 3-(2-ethylhexyloxy)propane-1,2-diol; 3-[2-(Ethylhexyl)oxyl]-1,2-propandiol; Octoxyglycerin; ethyl hexylglycerine; ethylhexylglycerine; ethyl hexylglycerin; ethylhexyl glycerin; 1,2-Propanediol, 3-(2-ethylhexyloxy); Ethylhexyl Glycerin; Octoxyglycerin; 3-(2-ETHYLHEXYL)OXY-1,2-PROPANEDIOL; 3-[2-(Ethylhexyl)oxyl]-1,2-p; octoxyglycerin; 3(2-ethylhexyloxy)propane-1,2diol; 1,2-propanediol,3-(2-ethylhexyloxy); Euxyl PE 9010; Uxyl PE9010; Phenoxyethanol (and) Ethylhexylglycerin;     ethylhexyl glecerine; 1,2-propanediol, 3-(2-ethylhexyl)oxy-; sensiva sc 50; ethylhexylglycerin; glycerol α-(2-ethylhexyl) ether;  octoxyglyceri; sensiva sc 50jp; 1,2-PROPANEDIOL, 3- ( (2-ETHYLHEXYL) OXY) -; 3- ( (2-ETHYLHEXYL) OXY) - 1,2-PROPANEDIOL; ETHYLHEXYGLYCERIN; OCTOXYGLYCERIN;  Ethylhexylglycerin; 1,2-Propanediol,3-(2-ethylhexyl)oxy-; 2-Propanediol,3-[(2-ethylhexyl)oxy]-1; 3-(2-ethylhexyloxy)propane-1,2-diol; Glycerol α-(2-ethylhexyl)ether;  3-[2-(Ethylhexyl)oxyl]-1,2-propandiol; 3-[2-(Ethylhexyl)oxyl]-1,2-propandiol, Ethyl Hexyl Glycerin, 3-(2-ethylhexoxy)propane-1,2-diol; 1,2-Propanediol,3-(2-ethylhexyl)oxy;2-propanediol,3-[(2-ethylhexyl)oxy]-1; 3-[(2-Ethylhexyl)oxy]-1,2-propanediol; Glycerol α-(2-ethylhexyl) ether; 3-[(2-Ethylhexyl)oxy]-1,2-propanediol; 1,2-Propanediol, 3-(2-ethylhexyloxy); Ethylhexyl Glycerin;Octoxyglycerin;3-(2-ETHYLHEXYL)OXY-1,2-PROPANEDIOL; 1,2-Propanediol, 3-(2-ethylhexyloxy); 2-Propanediol,3-[(2-ethylhexyl)oxy]-1; 3-(2-ethylhexyloxy)propane-1,2-diol; 3-[2-(Ethylhexyl)oxyl]-1,2-propandiol; Ethyl Hexyl Glycerin; Ethylhexyglycerin, Ethylhexyl Glycerin, Ethyhexylgycerin, 1,2-Propanediol, 3-(2-ethylhexyloxy); Octoxyglycerin. 3-[(2-Ethylhexyl)oxy]-1,2-propanediol.

Ethylhexylglycerin is an alkyl glyceryl ether. This means that the ethylhexyl group is bound to glycerin at one end by an ether linkage. Although they are also alkyl glyceryl ethers, Batyl Alcohol and Chimyl Alcohol (may also be called Cetyl Glyceryl Ether) have traditionally been used as cosmetic labeling names for these alkyl glyceryl ethers. Glyceryl Lauryl Ether and Isostearyl Glyceryl Ether are also alkyl glyceryl ethers that may be used in cosmetic products. Despite the different types of names for these ingredients, they all consist of an alkyl group bound to glycerin by an ether linkage. Ethylhexylglycerin and the other alkyl glyceryl ether ingredients may be used in bath products, body and hand products, cleansing products, deodorants, eye makeup, foundations, hair care products and suntan products.The alkyl glyceryl ether ingredients, including Ethylhexylglycerin are solids at room temperature and are generally poorly soluble in water. Ethylhexylglycerin may enhance the function of preservatives by affecting the cell walls of bacteria promoting destruction of the bacteria by the preservative.In cosmetic products, Ethylhexylglycerin has also been reported to enhance the function of some preservatives. Ethylhexylglycerin is a conditioning agent and preservative. Two studies have found it to be a skin irritant, even at low concentrations, so people with sensitive skin may experience contact dermatitis.  In addition, it is an eye irritant in animal studies.  Reactions are typically low, however.Lotions, washes, shampoo, conditioner. Ethylhexylglycerin is a relatively new chemical on the market.  Many companies use it as an alternative to parabens and claim that it's from natural sources.  Yes, it may have started out as a vegetable oil, but it's gone through several chemical processes to become what it is.  This isn't the worst ingredient in the world, but it's also not truly natural, and safety data is highly lacking for this ingredient. There are only four studies or reviews published in the National Library of Medicine.  Ethylhexylglycerin is a relatively new cosmetic ingredient that is used for its surfactant, emollient, skin-conditioning and antimicrobial properties. Since 2002, it has been occasionally reported as a contact allergen. All but one of the ethylhexylglycerin-allergic patients were female, with a median age of 43 years (range: 29-81 years), most often suffering from dermatitis on the face, and sometimes on the hands and/or axillae. As the culprit products, leave-on cosmetics were identified, including a high number of proclaimed 'hypo-allergenic' and 'preservative-free' facial creams, sun protection creams, and deodorants. Ethylhexylglycerin is a rare, but highly relevant, cosmetic sensitizer, even in those products advertised to be safe for consumers. Targeted patch testing with ethylhexylglycerin 5% pet. is very useful, and routine patch testing in a cosmetic series may be considered. Higher test concentrations might be indicated in selected cases. allergic contact dermatitis; cosmetics; deodorants; ethylhexylglycerin; octoxyglycerin; patch testing; preservative; skin conditioner; sunscreens. Ethylhexylglycerin has three jobs in our products: prevent the product from spoiling, keep the product from separating, and soften your skin. It does this by breaking the surface tension in liquids — allowing them to mix together and “soak in” better. The emollient aspect of the ingredient’s vegetable glycerin source also makes our products feel creamier and softer on skin, and its antimicrobial qualities help fight germs and bacteria. Ethylhexylglycerin is a fantastic multitasker. For one thing, it’s a much safer substitute for parabens, which are very controversial.[5,6] It also helps keep bacteria and germs off your skin and from forming inside the bottle, which in turn prevents body odor and other unfavorable scents from proliferating.[7] It also keeps our products perfectly blended and has an added bonus of making your skin feel soft and smooth. Whole Foods has deemed the ingredient acceptable in its body care quality standards.According to studies published by the American Contact Dermatitis Society and the journal Contact Dermatitis, ethylhexylglycerin is rarely an allergen. Ethylhexylglycerin is a type of alkyl glyceryl ether that is made via a process called etherification. One way to make it involves reacting the sodium salt of acetone glycerol with hexadecyl iodide in boiling glycol dimethyl ether, yielding the acetone compound of α-hexadecyl glycerol. Hydrolysis of the protecting group with acetic acid results in the formation of chimyl alcohol. Alternatively, ethylhexylglycerin can be made by reducing triglycerides with lithium aluminum hydride and boron trifluoride etherate, followed by LAH hydrogenolysis. Catalytic splitting of ethylhexylglycidyl ether, followed by the addition of water, also produces the chemical. The product can then be purified by vacuum distillation. Ethylhexylglycerin is a globally approved, versatile and multi-functional additive as well as a very effective deodorant active. As an emollient and mild humectant it improves the skin feel of cosmetic formulations. It reliably inhibits the growth and multiplication of odor-causing bacteria, while at the same time not affecting the beneficial skin flora. Additionally, it can boost the efficacy of traditional preservatives and acts as an antimicrobial stabilizer in combination with other cosmetic ingredients. Ethylhexylglycerin is a representative of the 1-alkyl glycerin ethers. The selection of emollients is critical to the character of a cosmetic product. High contents of fast spreading emollients lead to light creams with a smooth skin feel. High contents of slow spreading emollients are used in rich creams with refatting properties. Medium spreading emollients close the gap between fast and slow spreading emollients, improving the refatting properties and extending the smooth skin feel of cosmetic formulations. To achieve a long lasting soft and smooth skin feel, a combination of fast, medium and slow spreading emollients is necessary. Ethylhexylglycerin is a medium spreading emollient with a spreading coefficient of about 700 mm2/10 min. The spreading properties are similar to those of dodecyl oleate, hexyldecanol or cetearyl isononanoate. Ethylhexylglycerin is able to reduce the tackiness and increase the speed of absorption of glycerin-containing emulsions significantly. In addition, Ethylhexylglycerin is shown to reduce the greasiness and soaping and improve the overall impression. Ethylhexylglycerin is a clear, colorless and nearly odorless liquid. It is stable to hydrolysis, temperature and pH. As a result of its good chemical stability, it is highly compatible with all commonly used cosmetic ingredients. Whereas glycerin esters are attacked by lipolytic enzymes, this is not the case with Ethylhexylglycerin due to its glycerin ether structure. Ethylhexylglycerin is effective in pH-ranges up to 12. Use concentration Ethylhexylglycerin can be used as skin care additive and deodorant active in a recommended use concentration of 0.3 – 1.0%. Due to its molecular structure, Ethylhexylglycerin can have an influence on stability and/or viscosity of some emulsions. It has a surfactant-like structure which can affect the hydrophilic-lipophilic-balance (HLB) of an emulsion. The HLB value relates to the hydrophilic and lipophilic properties of an emulsifier and is a first hint of the choice of an emulsifier system. Typically, water-in-oil emulsifiers have HLB values in the range of 3 – 6 while oil-in-water emulsifier are in the range of 8 – 18. Ethylhexylglycerin has a calculated HLB of approximately 7.5. This is relatively high for the use in water-in-oil emulsions and relatively low for the use in oil-in-water emulsions. Thus it can influence a given emulsifier system in the opposite direction.Ethylhexylglycerin also functions as a surfactant. Surfactants are compounds that lower the surface tension between two substances and work to mix the two substances. This action is particularly useful in skincare and cosmetic products to mix oil and water-based ingredients, allowing them to be used in moisturizers without separating and in washes without leaving residue on the skin. This is possible because while one end of the surfactant molecule is attracted to water, the other end is attracted to oil. Thus, surfactants attract the oil, dirt, and other impurities that have accumulated on your skin during the day and wash them away. Due to these properties, ethylhexylglycerin can be found in many different cleansers and body washes.Ethylhexylglycerin is used in many deodorants and deodorizing products. This is due to its antimicrobial action, it prevents the growth and multiplication of odor-causing bacteria, while at the same time not affecting the beneficial skin flora. Given that ethylhexylglycerin can be produced from either animal-based fat or vegetable oils it really depends on the product. Most sources of ethylhexylglycerin use vegetable oils as they tend to be less expensive and stay fresh for longer, however check with the company as to where they source their ethylhexylglycerin if it doesn’t specify either way. Ethylhexylglycerin has also been found to improve the feel of cosmetic formulations. Tests have shown that ethylhexylglycerin can reduce the tackiness and greasiness of a formulation, as well as increase the speed of penetration. Ethylhexylglycerin is an alkyl glyceryl ether. This means that the ethyl hexyl group is bound to glycerin at one end by an ether linkage. it has been used as a common ingredient in bath products, body and hand products, cleansing products, deodorants, eye makeup, foundations, hair care products and suntan products. The compound is synthesized by esterfication of 2-Ethylhexanol and epichlorohydrin, followed by ring opening reaction of epoxy positioned at 1st and 2nd carbon in the chemical structure. It was characterized by NMR, seven -CH2 (position 10, 11, 9, 8, 6, 4 and 2) carbons present at negative side. Tertiary carbons are present at chemical shifts 39 ppm and 70 ppm (position at 7 and 3) and primary carbons are present at chemical shifts 10 ppm and 13 ppm (position at 14 and 12). Both primary and tertiary carbons were found on the positive side of the spectrum. From FTIR studies, peak corresponding to -OH stretch is observed at 3,391 cm-1 and the -OH bending is seen at 1,111 cm-1. By Mass characterization, the m/z value of the sample was found to be 204.9 (ES-) which represents Ethylhexylglycerin. The purity and impurity profile of material was achieved by GC-FID method with >99.0%.The ethylhexylglycerin is chemically 3-[(2-Ethylhexyl) oxy]-1, 2-propanediol with the molecular formula and molecular weight as C11H24O3 and 204.3 g•mol−1, respectively. It is widely used as an ingredient in cosmetics and in deodorants and is commercially marketed under the brand name sensiva® SC50 1. It also has anti-microbial activity, therefore, is also used as a preservative. The synthesized Ethylhexyl-glycerin was subjected to identification and characterization was carried out with GC-MS, NMR and FTIR spectroscopic methods for the confirmation of the structure. Several tests that include solubility, appearance, odour, refractive index, density, water content and presence of impurities by elemental analysis were also performed.

3-[2-(ethylhexyl)oxyl]-1,2-propandiol is also named as 3-(2-Ethylhexoxy)propane-1,2-diol, Ethylhexylglycerin, or octoxyglycerin. It is a glyceryl ether. It is used as a weak preservative, as skin conditioning agent with effective wetting ability. It is used with phenoxyethanol in cosmetics to obtain better protection against microbial growth. Ethylhexylglycerin is an ingredient that is found in many skincare and cosmetic formulations. Ethylhexylglycerin is utilized in these products for its natural preservative action and its use as a skin conditioner. It is thought that ethylhexylglycerin’s preservative characteristics come from its ability to also act as a surfactant. Surfactants are ingredients that reduce the surface tension, in the case of Ethylhexylglycerin, the disruption in surface tension and potentially damages the cell membranes of bacteria, preventing their growth. Due to ethylhexylglycerin’s antimicrobial action, it also makes a great deodorizing ingredient. Ethylhexylglycerin is a conditioning agent and preservative. It is known for being used as an alternative to parabens. Parabens are linked to many diseases but are known for being the greatest preservative. Ethylhexylglycerin is used in place of them because it is much safer and just as effective. Ethylhexyglycerin is often using in topical agents that are used to treat eczema. This chemical compound is also a deodorizer.  It is one of the most common ingredients in skincare products on the market. Ethylhexylglycerin is a chemical compound that is derived from glycerin. It is known for being a deodorizer, a preservative, and a skin conditioning agent.Chemical Compound, Preservative. Ethylhexylglycerin is derived from glycerine, obtained mainly from plant-based sources such as soybean or palm. Ethylhexylglycerin was first introduced to the cosmetic market in 1992 as a skincare additive and deodorant active called Sensiva SC50. Ethylhexylglycerin is used in a wide variety of skincare, body, and cosmetic products. It can be found in bath products, body and hand products, cleansing products, deodorants, eye makeup, foundations, hair care products, and suntan products.

3-[2-(Ethylhexyl)oxyl]-1,2-propandiol is the novel raw material for deodorants application and is widely used as a cosmetic emollient. 3-[2-(Ethylhexyl)oxyl]-1,2-propandiol reliably inhibits the odor-causing bacteria, yeast and fungi on the skin. Ethylhexylglycerin is a skin conditioning agent, helping to improve the appearance of the skin but also has beneficial anti-microbial, deodorizing and preservative effects. It can cause some minor irritation to the skin and eyes. This usually occurs in high concentrations. Skincare and cosmetic products typically contain low concentrations of ethylhexylglycerin. Lotions, Washes, Shampoos, Conditioners, Topicals. While Ethylhexylglycerin is usually good for all skin types, in extreme cases it can become an irritant.Preservative, Deodorizer, Skin Conditioning Agent. Sensitive skin types should be mindful that ethylhexylglycerin has been linked to some irritation, particularly those who experience contact dermatitis. Skin conditioning ingredients work by lubricating the surface of the skin to improve the appearance of the skin. Many skin conditioning agents also have humectant properties, which means that the ingredient draws moisture to the top layers of the skin. The skin-conditioning effects of ethylhexylglycerin are due to its derivation from glycerol. Glycerol is a natural alcohol and humectant that’s been used in skincare products for centuries, says Dr. Wendy Bollinger Bollag, cell physiologist. In research published in The Journal of Investigative Dermatology, she and co-author Dr. Xiangjian Zheng demonstrated that glycerin helps skin to look and function better by helping skin cells mature properly. Glycerin is not just a humectant but also an occlusive moisturizer as well. This means that while it softens skin, it also pulls water from the environment and helps prevent transepidermal water loss (TEWL) or moisture loss from the skin.

Appearance and Odour: The state of a chemical has a big impact on its exposure route and distribution behavior in various environmental compartments. Usually, the state (solid, liquid, gas) for a chemical under normal conditions; 10 ml of the sample was taken in a 50 ml Nessler’s cylinder and was placed over white surface. It was then observed transversally in diffused light for the presence of foreign matters followed by observing odour with odour strips.Ethylhexylglycerin (octoxyglycerin) is a topical skincare ingredient and deodorizing agent, often indicated as a conditioning ointment in the treatment of eczema. As its name suggests, ethylhexylglycerin is made using glycerin. Glycerin is a simple polyol compound derived from sugar alcohol. It is both colorless and odorless, and it is one of the most common ingredients in skincare products. It is water soluble; when mixed with certain chemicals it can be a used as a preservative. It helps to keep the various natural ingredients in beauty products from spoiling. It also helps to reduce the surface tension between the various liquids and oils in beauty products.is a achromatic liquid. As corrective arrangement of no added preservatives, ethylhexylglycerin has bacteriostasis, moisturizing effect. Due to a accessory effect of ethylhexylglycerin, dosage of acceptable preservatives in cosmetics are reduced, and the antibacterial effect of multi-functional corrective additives such as glycol and blubbery acids are improved, and abhorrent odor acquired by sebum is suppressed.

Ethylhexylglycerin has limited solubility in water (approx. 0.1 %), but is highly soluble in organic solvents, such as alcohols, glycols and glycol ethers. The solubility of Ethylhexylglycerin in selected solvents is listed below. The solubility in the single solvents depends on the whole formulation and has to be tested in individual cases. Solubility is one of the most critical properties that have a significant impact on performance of a molecule. During this study, the sample was subjected with different solvents to determine its solubility.

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