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DESCRIPTION:
Frescolat MGA is colorless liquid used as an active cooling agent.
Frescolat MGA creates a strong, long-lasting sensation of freshness and cooling.
Benefits include signal for efficacy, non-irritating, optimal for alkalin formulations, low odor, clear liquid and suitable for oral care (FEMA 3807).
CAS No.: 63187-91-7
INCI: Menthone Glycerin Acetal.
Purity: >97%
MW: 228.33
Frescolat MGA is a patented, menthol-free cooling agent.
Frescolat MGA is a natural extract.
Frescolat MGA provides relief solution for the skin.
Frescolat MGA gives immediate, strong and long-lasting cooling effect.
Frescolat MGA is used in oral care applications.
Frescolat MGA is China compliant.
Combination of the patented Frescolat MGA technology with the well-known L-menthol freshness
Frescolat MGA is Cost efficient, strong cooling sensation
Frescolat MGA has Efficacy marker for cleanliness in rinse-off products
Frescolat MGA is Colorless liquid, low minty scent, less fragrance used
Frescolat MGA is Soluble in alcohol and glycol
Frescolat MGA is Stable at pH>6.5, ideal for bar soap
Frescolat MGA is Food grade - suitable for oral care
Frescolat MGA is China compliant
SPECIFICATIONS OF FRESCOLAT MGA:
MW228.33
Purity>97%
Molecular formulaC13H24O3.
FormColorless Liquid
CAS No.63187-91-7
SourceSynthetic
PubChem CID162184
Chemical name(9-methyl-6-propan-2-yl-1,4-dioxaspiro[4.5]decan-3-yl)methanol.
Biological activity
TargetTRPM8 channel
Effective concentration0.1-10 µM.
ActivityFrescolat MGA is a TRPM8 channel activator and cooling agent. It activates mouse TRPM8 channels with EC50 of 4.8 µM1.
References
Behrendt, H.J. et al. (2004) Br. J. Pharmacol. 141, 737.
Solubility and storage
Shipping and storage:
Shipped at room temperature.
Product as supplied can be stored intact at room temperature for several weeks.
For longer periods, it should be stored at -20°C.
Store in a cool and dry place.
SolubilityUp to 200 mM in DMSO.
Centrifuge all products before use (10000 x g 5 min).
Storage of solutionsUp to three months at -20°C.
SAFETY INFORMATION ABOUT FRESCOLAT MGA
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:
If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.
In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.
If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.
Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas
Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.
Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.
Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.
Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.
Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials
Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.
Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.
If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.
Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.
