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Frescolat ML is a cooling agent that is part of the Frescolat series, which is commonly used in cosmetic and personal care products to provide a refreshing and cooling sensation on the skin.
Frescolat ML is a white, crystalline substance giving a physiological cooling sensation on the skin and mucosa.
Frescolat ML is used to create neutral cooling effects in cosmetic or oral care preparations.
CAS Number: 59259-38-0
Molecular Formula: C13H24O3
Molecular Weight: 228.33
EINECS Number: 261-678-3
Synonyms: (-)-menthyl lactate, MENTHYL LACTATE, frescolat ML, 59259-38-0, l-Menthyl lactate, [(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] 2-hydroxypropanoate, (R)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 2-hydroxypropanoate, (1R,2S,5R)-2-ISOPROPYL-5-METHYLCYCLOHEXYL 2-HYDROXYPROPANOATE, 185915-25-7, L-Menthyl lactate, >=97%, SCHEMBL320044, (-)-p-Menthan-3-yl lactate, GTPL2466, FEMA 3748, L-Menthyl lactate, >=97%, FG, AKOS015964086, AC-9866, Q2640813, (1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl 2-hydroxypropanoate, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 2-hydroxypropanoate, AldrichCPR.
Frescolat ML has a weak odor somewhat reminiscent of tobacco and chamomile.
It is almost tasteless, with a lasting gentle cooling effect.
Frescolat ML is a translucent solid used as an active cooling agent.
Frescolat ML generates an immediate & mild sensation, is suitable for leave-on and rinse off products and supports deodorant activity.
The material is prepared by esterification of menthol with lactic acid.
The active ingredient in Frescolat ML is Menthyl Lactate, which is an ester formed from menthol and lactic acid.
Frescolat ML acts as a cooling agent.
Frescolat ML can increase the viscosity of products that contain tensides.
Frescolat ML shows enhance effectiveness if rapid hydration of the skin, brought about by products like O/W emulsions and gels.
Its cooling effect reduced if high percentages of oil- or wax-based cosmetic components.
Frescolat ML provides a pleasant cooling and fresh effect without the need for employing alcohol.
Frescolat ML should be added to emulsions at a temperature of around 40°C.
It dissolves in perfume oils, cosmetic oils or glycol solvents.
Frescolat ML is used in oral care applications.
Frescolat ML has established a leading expertise in skin sensorial receptors and provides an extensive collection of refreshing and warming ingredients.
These materials can greatly enhance the sensorial perception of personal care products and also work as a marker for efficacy.
Thermoreceptors throughout the skin are activated by hot and cold temperatures as well as chemical stimuli to allow sensory reception throughout the body.
Frescolat ML has a long and successful history in the production of menthol derivatives that are able to induce cooling effects and offers a wide choice of ingredients in its Frescolat ML range.
In order to deliver pleasant warming benefits, Frescolat ML is a great ingredient to provide a feeling of warmth and relaxation for cosmetic formulations.
Frescolat ML is a translucent solid used as an active cooling agent.
It generates an immediate & mild sensation, is suitable for leave-on and rinse off products and supports deodorant activity.
Frescolat ML acts as a nature-identical, menthol-free cooling agent.
Frescolat ML is a white crystalline substance.
It provides fast & mild refreshing sensation and body-responsive freshness reactivated with water (mimicking sweat).
Frescolat ML supports deodorant activity and decreases sweat odor by acting on the axillary microbiome.
Frescolat ML is used in oral care products.
Frescolat ML provides a long-lasting cooling sensation without the intense initial cooling associated with pure menthol, making it more suitable for products intended for prolonged use or sensitive skin areas.
Unlike menthol, which can be quite strong and sometimes irritating, Frescolat ML delivers a gentler cooling effect, which is less likely to cause irritation or discomfort.
Frescolat ML can be used in a wide range of formulations, including creams, lotions, gels, shampoos, deodorants, and oral care products.
It is stable in different formulations and at various pH levels, making it a versatile ingredient for formulators.
This ingredient is used in skincare products (like after-sun creams and body lotions), hair care products (such as shampoos and conditioners), oral care products (like toothpaste and mouthwash), and even in some pharmaceutical formulations.
Melting point: 40 °C
alpha: -74 º (c=10, EtOH)
Boiling point: 310.14°C (rough estimate)
Density: -80
FEMA: 3748 | L-MENTHYL LACTATE
refractive index: -80 ° (C=5, MeOH)
Flash point: 128 °C
storage temp.: 2-8°C
solubility: DMSO (Slightly), Ethanol (Slightly)
form: Low-Melting Solid
pka: 13.01±0.20(Predicted)
color: White to Off-White
Odor Type: minty
Water Solubility: SLIGHTLY SOLUBLE
JECFA Number: 433
LogP: 3.20
Frescolat ML is a COSMOS approved colorless liquid used as an active cooling agent.
Frescolat ML will impart a pleasant, long lasting cooling effect which conveys a desired pleasant skin feel.
It is odorless and tasteless and is easy to use and easy to solubilize.
Frescolat ML is an ester of menthol and lactic acid.
The combination of these two components brings together the refreshing properties of menthol with the mildness of lactic acid.
The molecular formula of Frescolat ML is C13H24O3.
Frescolat ML appears as a white crystalline powder, which is highly stable under normal storage conditions.
Frescolat ML has a melting point around 42-46°C (107-115°F).
It is insoluble in water but soluble in alcohols and oils, which makes it suitable for oil-based and emulsion-type formulations.
Unlike pure menthol, which provides an intense cooling sensation followed by a rapid fade, Frescolat ML offers a more prolonged cooling effect that can last for several minutes to hours, depending on the formulation.
Frescolat ML is known for being less irritating compared to menthol. This makes it ideal for products intended for sensitive skin areas, such as facial creams, eye gels, or after-shave lotions.
The mild cooling sensation of Frescolat ML enhances the sensory profile of personal care products without overpowering the user’s senses, contributing to a more pleasant and refreshing experience.
In formulations where there are undesirable base odors, Frescolat ML can help mask these odors with its mild menthol scent.
Frescolat ML is effective over a wide range of pH values (typically 3-11), which allows formulators to use it in various products without worrying about pH stability issues.
Provides a refreshing feel that is especially beneficial in after-sun products or daily moisturizers meant to invigorate the skin.
Adds a cooling effect that enhances the cleansing experience, leaving the skin feeling fresh and clean.
Offers a cooling effect that can invigorate the scalp, providing a fresh, tingling sensation that users often associate with cleanliness and refreshment.
Frescolat ML’s cooling sensation can enhance the perception of freshness in oral care products, providing a clean and minty feel that lasts longer than regular menthol.
The cooling effect can help users feel refreshed and comfortable, especially in hot climates or during physical activities.
The cooling sensation can complement other active ingredients in providing relief from pain, itching, or irritation.
Can add a cooling and soothing effect, making the application process more pleasant.
The typical use levels of Frescolat ML range from 0.2% to 2%, depending on the desired cooling intensity and the product type.
Frescolat ML is compatible with most cosmetic ingredients, but formulators should still conduct compatibility tests, especially in complex formulations.
Frescolat ML is relatively stable but should be stored in a cool, dry place, away from direct sunlight and moisture, to maintain its efficacy.
Frescolat ML works by stimulating the cold-sensitive receptors in the skin, known as TRPM8 (transient receptor potential cation channel subfamily M member 8).
When applied, it activates these receptors, mimicking the cooling effect usually produced by cold temperatures.
Unlike menthol, which provides an immediate burst of cooling followed by a rapid fade, Frescolat ML releases its cooling effect more gradually.
This is due to its chemical structure, which moderates the release of menthol-like sensations, providing a prolonged cooling experience.
Frescolat ML is recognized for its safety and is generally non-irritating and non-sensitizing when used at recommended concentrations.
Frescolat ML is suitable for use on sensitive skin areas, including the face and around the eyes.
It is widely approved for use in cosmetics globally, adhering to safety regulations in major markets like the EU, USA, and Asia.
However, formulators should always check the latest regional regulations and usage guidelines.
Frescolat ML remains stable under a wide range of conditions.
Frescolat ML does not easily degrade when exposed to light and moderate heat, ensuring a consistent cooling effect in finished products over time.
Frescolat ML has good resistance to oxidation, making it suitable for use in formulations that may be exposed to air.
Frescolat ML is highly compatible with both oil-in-water and water-in-oil emulsions, allowing for flexibility in product texture and finish.
It can be effectively used in anhydrous (water-free) formulations such as balms and sticks, where its cooling effect is not diminished by the absence of water.
Given its solubility in alcohols and oils, Frescolat ML can be incorporated into clear gel formulations, providing a cooling effect without clouding the product.
The typical concentration for most applications ranges from 0.2% to 2%.
The exact amount depends on the desired cooling intensity and the specific application.
For example, a cooling foot cream might use a higher concentration than a facial moisturizer.
For formulations intended for sensitive areas such as around the eyes or on delicate skin, lower concentrations (around 0.2% to 0.5%) are recommended to prevent any potential irritation.
Uses:
Frescolat ML is used in preparation of amides for generating a trigeminal sensory effect.
Frescolat ML is a monosodium salt of L-menthol.
It is used as a food additive. It is used in the preparation of fruit extract that is used as a mouthwash and toothpaste.
The chemical structure of it consists of two molecules: one molecule of L-menthol and one molecule of lactic acid.
This chemical compound has been shown to inhibit cavity formation in rats by increasing the pH level and inhibiting the activity of cavity inhibitor molecules like histamine.
Adds a refreshing and cooling sensation, ideal for daily use products or those designed for after-sun care to soothe and cool the skin.
Frescolat ML provides a gentle cooling effect without causing irritation, making it suitable for use in facial products, including eye creams and soothing gels.
Enhances the freshness and cleanliness feel during cleansing routines, often used in face washes, toners, and makeup removers.
Offers a cooling and invigorating sensation on the scalp, promoting a feeling of cleanliness and refreshment.
Frescolat ML's especially popular in anti-dandruff shampoos or products designed to energize the scalp.
Frescolat ML is used in products formulated to soothe or revitalize the scalp, providing a cooling effect that can relieve discomfort from dryness or irritation.
Frescolat ML is often added to these products to provide a prolonged cooling and fresh sensation in the mouth, enhancing the feeling of cleanliness and minty freshness.
Offers a cooling effect that can refresh breath and provide a pleasant sensation.
Adds a cooling and soothing effect, which can be particularly beneficial in underarm products, helping to maintain a feeling of freshness throughout the day.
Frescolat ML is used in body sprays to impart a refreshing sensation on the skin, ideal for hot climates or post-exercise refreshment.
Provides a soothing and cooling effect on the skin after sun exposure, helping to alleviate discomfort from sunburn or heat.
Adds a cooling sensation to sunscreens, making them more pleasant to apply, especially in hot or sunny conditions.
Can be added to these products to offer a cooling effect during application, enhancing the comfort of wearing makeup, especially in hot conditions or for users with sensitive skin.
Provides a refreshing feel when sprayed on the face, setting makeup while cooling the skin.
Frescolat ML is used in products designed to relieve pain or discomfort, such as muscle rubs and cooling gels, providing a soothing and cooling effect.
Helps reduce the sensation of itching and provides a cooling effect on irritated skin.
Adds a cooling sensation to shaving products, helping to calm and refresh the skin after shaving.
Frescolat ML utilized in products designed for personal freshness and comfort, providing a mild cooling sensation without irritation.
Ideal for foot care products designed to refresh and soothe tired, hot, or swollen feet, often used after prolonged standing or exercise.
Frescolat ML is used in products aimed at athletes or individuals with an active lifestyle, providing a refreshing and cooling sensation during or after physical activity.
Adds a refreshing sensation to hand sanitizers, making them more pleasant to use, especially during hot weather.
Frescolat ML is used in pet care products to provide a cooling sensation that can soothe and refresh pets, especially in warm weather or for those with irritated skin.
Frescolat ML is ideal for formulations targeting sensitive skin due to its mild cooling effect that doesn’t cause irritation.
Frescolat ML can be used in hypoallergenic skincare products aimed at reducing redness, soothing irritation, or providing relief from conditions like eczema or rosacea.
Used in products designed to reduce inflammation and provide cooling relief in conditions such as contact dermatitis, insect bites, or allergic reactions.
Included in formulations to provide a cooling effect, reducing the sensation of heat or inflammation often associated with acne treatment ingredients like benzoyl peroxide or salicylic acid.
Frescolat ML can be found in products used after dermatological procedures (such as laser treatments, chemical peels, or microdermabrasion) to soothe and cool the skin, aiding in recovery and reducing discomfort.
Utilized in formulations designed to treat minor burns by providing a cooling effect that helps alleviate pain and discomfort.
Frescolat ML is used in sports creams and gels to provide a cooling effect that helps soothe muscles after intense physical activity, aiding in muscle recovery and providing a sensation of relief.
Incorporated into products designed for quick cooling and refreshment during or after physical exertion, such as cooling towels, sprays, or wipes.
Safety Profile:
While Frescolat ML is milder than pure menthol, it can still cause mild skin or eye irritation in some individuals, particularly if used in concentrations higher than recommended.
Direct contact with the eyes should be avoided, as it may cause stinging or discomfort.
If it comes into contact with the eyes, rinsing immediately with water is advised.
Although rare, some individuals may experience allergic reactions to menthyl lactate, resulting in symptoms like redness, itching, or swelling at the site of application.
Frescolat ML is always advisable for users to conduct a patch test before using a product containing Frescolat ML, especially if they have sensitive skin or a history of allergies.
In aerosol products, inhalation of Frescolat ML could cause respiratory discomfort or irritation.
Proper formulation and usage guidelines should be followed to minimize inhalation risks, especially in confined spaces.
Using Frescolat ML in higher-than-recommended concentrations or overuse can lead to an excessively strong cooling sensation, which some users may find uncomfortable or irritating.
This is particularly important in products designed for sensitive skin areas, such as the face or underarms.
