GAMMA-AMINOPROPYLTRIMETHOXYSILANE

Gamma-aminopropyltrimethoxysilane is a high-reactivity aminosilane engineered for the deposition of cationic Self-Assembled Monolayers (SAMs) on inorganic substrates.
Gamma-aminopropyltrimethoxysilane improves bonding in glass fiber–reinforced composites by promoting strong interfacial interaction between glass surfaces and resin matrices.
Gamma-aminopropyltrimethoxysilane is widely used to improve adhesion between inorganic substrates (such as glass, silica, and metals) and organic polymers (such as epoxy, polyurethane, and acrylic systems).

CAS Number: 13822-56-5
EC Number: 237-511-5
Molecular Formula: C6H17NO3Si
Molecular Weight: 179.29 g/mol

Synonyms: 13822-56-5, 3-Aminopropyltrimethoxysilane, (3-Aminopropyl)trimethoxysilane, 3-(Trimethoxysilyl)propylamine, 3-(Trimethoxysilyl)-1-propanamine, 1-Propanamine, 3-(trimethoxysilyl)-, Aminopropyltrimethoxysilane, Silane SC 3900, Propylamine, 3-(trimethoxysilyl)-, KBE 903, SC 3900, 7MRY0C9SB6, TMSPA cpd, GENIOSIL GF 96, NSC-83845, 3-(aminopropyl)trimethoxysilane, RefChem:915703, APS-3, 237-511-5, 3-(Trimethoxysilyl)propan-1-amine, 3-trimethoxysilylpropan-1-amine, N-(Trimethoxysilylpropyl)amine, C6H17NO3Si, MFCD00008206, gamma-Aminopropyltrimethoxysilane, NSC 83845, 3-aminopropyl trimethoxysilane, 3-aminopropyl-trimethoxysilane, (.gamma.-Aminopropyl)trimethoxysilane, S00825, 54115-51-4, (gamma-Aminopropyl)trimethoxysilane, UNII-7MRY0C9SB6, (3-aminopropyl) trimethoxysilane, Dynasylan AMMO, EINECS 237-511-5, Union Carbide A-1110, aminopropyl trimethoxysilane, EC 237-511-5, SCHEMBL15124, 3- aminopropyltrimethoxysilane, SCHEMBL282868, 3-(amino)propyltrimethoxysilane, orb2939859, SCHEMBL4428466, SCHEMBL9717483, 3-(trimethoxysilyl) propylamine, DTXSID0038833, trimethoxy-(3-aminopropyl)silane, (3-(trimethoxysilyl)propyl)amine, (CH3O)3Si(CH2)3NH2, H2NCH2CH2CH2Si(OCH3)3, NH2CH2CH2CH2Si(OCH3)3, .gamma.-Aminopropyltrimethoxysilane, gamma-aminopropyl trimethoxy silane, NSC83845, .gamma.-Aminopropyl trimethoxysilane, AC-072, (3-Aminopropyl)trimethoxysilane, 97%, AKOS006220963, FA62894, HY-W036410, AS-14910, BP-30249, DB-028362, KH-540 AMMO 3-Aminopropyltrimethoxysilane, CS-0090503, NS00052983, T1255, E77189, EN300-206605, Q27268580, F8880-6557, (3-Aminopropyl)triethoxysilane, (γ-Aminopropyl)triethoxysilane, 1-Propanamine, 3- (triethoxysilyl)-, 1-Propanamine, 3-(triethoxysilyl)-, 213-048-4, 3-(Triethoxysilyl)-1-propanamin, 3-(Triethoxysilyl)-1-propanamine, 3-(Triéthoxysilyl)-1-propanamine, 3-(triethoxysilyl)propan-1-amine, 3-(Triethoxysilyl)propylamine, 3-aminopropyl triethoxysilane, 3-aminopropyl(triethoxy)silane, 3-aminopropyl-triethoxysilane, 3-aminopropyltriethoxy silane, 3-Aminopropyltriethoxysilane, 3-Triethoxysilylpropylamine, 919-30-2, Aminopropyltriethoxysilane, APTES, APTS, L8S6UBW552, Propylamine, 3- (triethoxysilyl)-, Silane, (γ-aminopropyl)triethoxy-, γ-Aminopropyltriethoxy silane, γ-aminopropyltriethoxysilane, (3-Aminopropyl)triethoxysilane; 3-Triethoxysilylpropylamine; APTES; APTS, (3-Triethoxysilylpropylamine), (3-​aminopropyl)​triethoxysilane, 22-25% in water, 29159-37-3, 3-(Triethoxysilyl)-propylamine, 3-(Triethoxysilyl)propan-1-amin, 3-amino propyl triethoxysilane, 3-amino-propyltriethoxysilane, 3-aminopropyl triethoxy silane, 3-aminopropyl(triethoxyl)silane, 3-aminopropyltriethoxy-silane, 3-Aminopropyltriethoxysilan, 3-Aminopropyltriethoxysilane, 98%, contained in 50 ml Swagelok� cylinder for CVD/ALD, 3-triethoxysilyl-1-propanamine, 3-triethoxysilylpropan-1-amine, 3-​aminopropyltriethoxy​silane, 4-04-00-04273, 98%, 98%, contained in high-temp 50 ml Swagelok cylinder (96-1071) for CVD/ALD, amino-propyl-triethoxy-silane, aminopropyl triethoxysilane, aminopropyl-triethoxysilane, Aminopropylsilsesquioxane oligomer, aminopropyltriethoxy silane, Aminopropyltriethoxysilane(KH550), Propylamine, 3-(triethoxysilyl)-, Propylamine, 3-(triethoxysilyl)- (8CI), Silane, (3-aminopropyl)triethoxy-, silane, 3-aminopropyltriethoxy-, Silane, γ-aminopropyltriethoxy-, Triethoxy(3-aminopropyl)silane, Triethoxyaminopropylsilane, Uc-A 1100, Z3-SI-O2&O2&O2, γ-aminopropyl triethoxysilane

Gamma-aminopropyltrimethoxysilane is an organofunctional silane coupling agent containing a primary amine group and three hydrolyzable methoxy groups attached to silicon.
Gamma-aminopropyltrimethoxysilane is widely used to improve adhesion between inorganic substrates (such as glass, silica, and metals) and organic polymers (such as epoxy, polyurethane, and acrylic systems).
The molecule can hydrolyze in the presence of moisture to form silanol groups, which then condense with hydroxyl groups on mineral surfaces, forming strong siloxane bonds.

Gamma-aminopropyltrimethoxysilane is an aminosilane frequently used in the process of silanization, the functionalization of surfaces with alkoxysilane molecules.
Gamma-aminopropyltrimethoxysilane can also be used for covalent attaching of organic films to metal oxides such as silica and titania.

Gamma-aminopropyltrimethoxysilane is a high-reactivity aminosilane engineered for the deposition of cationic Self-Assembled Monolayers (SAMs) on inorganic substrates.
Gamma-aminopropyltrimethoxysilane's trimethoxy structure ensures faster hydrolysis and denser surface grafting compared to ethoxy-silanes, providing a terminal primary amine (-NH2) handle for the covalent attachment of biomolecules, polymers, and fluorophores.

Beyond biotechnology, Gamma-aminopropyltrimethoxysilane is a pivotal interfacial modifier in nanoelectronics, where it passivates dielectric surfaces to enhance charge-carrier mobility in organic field-effect transistors (OFETs) and enables the precise alignment of carbon nanotubes and graphene.
Refined to a 97% high-purity specification, this grade is engineered to provide excellent consistency for applications requiring precise and reliable surface functionalization.

Uses of Gamma-Aminopropyltrimethoxysilane:
Gamma-aminopropyltrimethoxysilane is used as a silane coupling agent to enhance adhesion between inorganic substrates and organic polymers.
Gamma-aminopropyltrimethoxysilane improves bonding in glass fiber–reinforced composites by promoting strong interfacial interaction between glass surfaces and resin matrices.
Gamma-aminopropyltrimethoxysilane is widely applied in epoxy systems, where the primary amine group reacts with epoxy groups to improve crosslink density and mechanical performance.

Gamma-aminopropyltrimethoxysilane is used in adhesives, sealants, and coatings to increase adhesion to glass, metals, ceramics, and mineral fillers.
In polyurethane and acrylic systems, Gamma-aminopropyltrimethoxysilane enhances substrate bonding and moisture resistance.
Gamma-aminopropyltrimethoxysilane is also used for surface modification of silica, alumina, talc, and nanoparticles to improve dispersion and compatibility in polymer formulations.

In primers and surface treatments, Gamma-aminopropyltrimethoxysilane functions as an adhesion promoter for glass, concrete, and metal surfaces.
Additionally, Gamma-aminopropyltrimethoxysilane is applied in corrosion-resistant coatings and hybrid organic–inorganic materials to improve durability and long-term performance.

Gamma-aminopropyltrimethoxysilane is an amino-functional silane that may be used over a broad range of applications to give an improvement in the bond between a substrate, filler or reinforcement and resins that react with the amino group.
Gamma-aminopropyltrimethoxysilane is especially recommended to thermoplastic resins and thermosetting resins such as epoxy, PBT, polyurethane etc.

Gamma-aminopropyltrimethoxysilane can improve reinforced plastic's physical properties and electric properties as flexural strength, compression strength and shear strength.
Gamma-aminopropyltrimethoxysilane also can improve the dispersion and wet ability of filler in the high molecular materials.

Gamma-aminopropyltrimethoxysilane is an excellent promoter of adhesion and sealant (such as polyurethane, epoxy, and phenol).
In the glass wool and FRP products, Gamma-aminopropyltrimethoxysilane can be added into phenol resins to improve the wet resistance and mechanical performance. Applications:

Gamma-aminopropyltrimethoxysilane is superior adhesion promoter in RTV silicones and other hybrid sealants.
Gamma-aminopropyltrimethoxysilane has excellent adhesion promoter for difficult substrates such as ABC, PVC ad Poly Shyrene.
Gamma-aminopropyltrimethoxysilane is useful component in primer systems for hybrid and polyurethane sealants.

As a versatile molecular bridge, Gamma-aminopropyltrimethoxysilane is essential for engineering intelligent interfaces and stimuli-responsive systems that enable precise interactions at the intersection of nanotechnology, biology, and electronics.

Stimuli-Responsive Nanocarriers:
Functionalizes mesoporous silica pores to create pH-sensitive "gatekeepers" that trigger drug release specifically within acidic tumor microenvironments.

Gene & Nucleic Acid Delivery:
Modulates the surface zeta potential of nanoparticles to facilitate high-efficiency electrostatic loading and endosomal escape of siRNA, mRNA, and pDNA.

Precision Bioconjugation:
Gamma-aminopropyltrimethoxysilane acts as a molecular bridge for anchoring targeting ligands (e.g., Folate, RGD peptides) or PEG chains to gold and iron oxide nanoparticles for enhanced circulation and cell-specific uptake.

Advanced Biosensing:
Gamma-aminopropyltrimethoxysilane utilized in LSPR-based diagnostics to immobilize antibodies onto gold nanostructures, enabling real-time detection of clinical biomarkers such as C-reactive protein (CRP).

Neuro-Targeting:
Recent findings highlight Gamma-aminopropyltrimethoxysilane's role in tuning nanoparticle surface charge to improve Blood-Brain Barrier (BBB) permeability via adsorptive-mediated transcytosis

Use Wth Cell Cultures:
Gamma-aminopropyltrimethoxysilane-functionalized surfaces have been shown to be nontoxic to embryonic rat cardiomyocytes in vitro.
Further experimentation is needed to evaluate toxicity to other cell types in extended culture.

Use with PDMS:
Gamma-aminopropyltrimethoxysilane can be used to covalently bond thermoplastics to poly(dimethylsiloxane) (PDMS).
Thermoplastics are treated with oxygen plasma to functionalize surface molecules, and subsequently coated with an aqueous 1% by volume Gamma-aminopropyltrimethoxysilane solution.

PDMS is treated with oxygen plasma and placed in contact with the functionalized thermoplastic surface.
A stable, covalent bond forms within 2 minutes.

Industry Uses:
Adhesion/cohesion promoter
Sealant (barrier)
Intermediates
Adhesives and sealant chemicals
Plating agents and surface treating agents
Processing aids, not otherwise listed
Paint additives and coating additives not described by other categories

Consumer Uses:
Monomers
Sealant (barrier)

Benefits of Gamma-Aminopropyltrimethoxysilane:
Gamma-aminopropyltrimethoxysilane significantly improves adhesion between inorganic substrates and organic polymer systems by forming strong siloxane bonds with mineral surfaces and covalent interactions with reactive polymer groups.
Gamma-aminopropyltrimethoxysilane enhances interfacial bonding in glass fiber–reinforced composites, leading to improved mechanical strength, impact resistance, and long-term durability.

The primary amine functionality increases reactivity with epoxy and other reactive resins, promoting better crosslinking and improved chemical resistance.
Gamma-aminopropyltrimethoxysilane improves moisture resistance and reduces interfacial degradation, which enhances the longevity of coatings and adhesives under humid conditions.

Gamma-aminopropyltrimethoxysilane also improves filler dispersion in polymer matrices, resulting in more uniform mechanical properties and enhanced processing performance.
In corrosion protection systems, Gamma-aminopropyltrimethoxysilane strengthens substrate adhesion and reduces underfilm corrosion.

Stability and Reactivity of Gamma-Aminopropyltrimethoxysilane:

Chemical Stability:
Gamma-aminopropyltrimethoxysilane is stable under dry, controlled storage conditions.
Gamma-aminopropyltrimethoxysilane is moisture-sensitive and gradually hydrolyzes in the presence of water.

Reactivity:
The methoxy groups hydrolyze with water to form silanol groups.
These silanol groups can further condense to form siloxane bonds.

The primary amine group reacts with epoxy and other electrophilic functional groups.
Gamma-aminopropyltrimethoxysilane may react with strong oxidizing agents and strong acids.

Conditions to Avoid:
Exposure to moisture.
High humidity.

Excessive heat.
Open flames.
Contact with incompatible chemicals.

Incompatible Materials:
Strong oxidizing agents.
Strong acids.

Acid chlorides.
Water during storage.

Hazardous Decomposition Products:
Thermal decomposition or combustion may produce carbon oxides (CO, CO₂).
Nitrogen oxides (NOx) may form.

Silicon oxides may be generated.
Irritating organic vapors can be released.

Hazardous Polymerization:
Does not occur under normal conditions.

Handling and Storage of Gamma-Aminopropyltrimethoxysilane:

Handling:
Handle in well-ventilated areas.
Avoid inhalation of vapors.

Avoid contact with skin and eyes.
Use appropriate personal protective equipment.
Prevent moisture contamination during transfer.

Storage:
Store in tightly sealed containers in a cool, dry, and well-ventilated area.
Protect from humidity and water exposure.
Keep away from heat sources and incompatible materials.

First Aid Measures of Gamma-Aminopropyltrimethoxysilane:

Inhalation:
Move the affected person to fresh air.
Keep at rest.
Seek medical attention if symptoms persist.

Skin Contact:
Wash thoroughly with soap and water.
Remove contaminated clothing.
Seek medical advice if irritation develops.

Eye Contact:
Rinse cautiously with plenty of water for several minutes.
Remove contact lenses if present and easy to do.

Continue rinsing.
Obtain medical attention.

Ingestion:
Rinse mouth with water.
Do not induce vomiting.
Seek medical attention immediately.

Firefighting Measures of Gamma-Aminopropyltrimethoxysilane:

Suitable Extinguishing Media:
Alcohol-resistant foam.
Dry chemical powder.

Carbon dioxide (CO₂).
Water spray.

Specific Hazards:
Combustion may generate toxic fumes including carbon oxides.
Nitrogen oxides may be released.
Silicon-containing vapors may form.

Protective Equipment for Firefighters:
Wear self-contained breathing apparatus.
Wear full protective clothing.

Special Firefighting Procedures:
Cool exposed containers with water spray to prevent pressure build-up.

Accidental Release Measures of Gamma-Aminopropyltrimethoxysilane:

Personal Precautions:
Ensure adequate ventilation.
Avoid contact with skin and eyes.

Eliminate ignition sources.
Wear appropriate protective equipment.

Environmental Precautions:
Prevent entry into drains, surface water, and soil.

Methods for Containment and Cleaning:
Absorb with inert material such as sand or vermiculite.
Collect in suitable containers for disposal according to local regulations.

Exposure Controls / Personal Protection of Gamma-Aminopropyltrimethoxysilane:

Engineering Controls:
Provide adequate ventilation or local exhaust ventilation to control vapor exposure.

Respiratory Protection:
Use an appropriate organic vapor respirator if ventilation is insufficient.

Hand Protection:
Wear chemical-resistant gloves such as nitrile or butyl rubber.

Eye Protection:
Wear safety goggles or face shield.

Skin and Body Protection:
Wear suitable protective clothing to minimize skin exposure.

Identifiers of Gamma-Aminopropyltrimethoxysilane:
CAS Number: 13822-56-5
EC Number: 237-511-5
Molecular Formula: C6H17NO3Si
Molecular Weight: 179.29 g/mol
Functional Groups: Primary amine (-NH2), trimethoxysilane (-Si(OCH3)3)
Chemical Class: Organofunctional silane coupling agent
Appearance: Colorless to pale yellow liquid

Linear Formula: H2N(CH2)3Si(OCH3)3
CAS Number: 13822-56-5
Molecular Weight: 179.29
UNSPSC Code: 12352103
NACRES: NA.23
PubChem Substance ID: 24856993
EC Number: 237-511-5
Beilstein/REAXYS Number: 2038118
MDL number: MFCD00008206

CAS No: 13822-56-5
Chemical Name: 3-Aminopropyltrimethoxysilane
CBNumber: CB7457872
Molecular Formula: C6H17NO3Si
Molecular Weight: 179.29
MDL Number: MFCD00008206

Molecular formula: C9H23NO3Si
Average mass: 221.373
Monoisotopic mass: 221.144720
ChemSpider ID: 12933

Properties of Gamma-Aminopropyltrimethoxysilane:
Appearance: Colorless to pale yellow liquid
Odor: Amine-like odor
Physical State: Liquid at room temperature
Molecular Formula: C6H17NO3Si
Molecular Weight: 179.29 g/mol
Density (20°C): Approximately 1.01–1.03 g/cm³
Boiling Point: ~217–220°C
Flash Point: ~95–105°C (closed cup)
Refractive Index (20°C): ~1.420–1.425
Viscosity (25°C): Low viscosity
Vapor Pressure (20°C): Low
Solubility in Water: Hydrolyzes in water
Solubility in Organic Solvents: Soluble in alcohols and many organic solvents
pH (aqueous solution): Alkaline due to amine group

Melting point: <-60°C
Boiling point: 91-92 °C15 mm Hg(lit.)
Density: 1.027 g/mL at 25 °C(lit.)
vapor pressure: 0-12790Pa at 20-25℃
refractive index: n20/D 1.424(lit.)
Flash point: 182 °F
storage temp.: Store below +30°C.
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Liquid
pka: 10.61±0.10(Predicted)
color: Clear colorless
Specific Gravity: 1.027
PH: >9 (20g/l, H2O, 20℃)
Odor: Ammoniacal odor
Viscosity: 1.77mm2/s
Water Solubility: reacts
Sensitive: Moisture Sensitive

InChI key: SJECZPVISLOESU-UHFFFAOYSA-N
InChI: 1S/C6H17NO3Si/c1-8-11(9-2,10-3)6-4-5-7/h4-7H2,1-3H3
SMILES string: CO[Si](CCCN)(OC)OC
assay: 97%
form: liquid
Quality Level: 200
refractive index: n20/D 1.424 (lit.)
bp: 91-92 °C/15 mmHg (lit.)
density: 1.027 g/mL at 25 °C (lit.)

Molecular Weight: 249.45 g/mol
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 9
Exact Mass: 249.12164666 Da
Monoisotopic Mass: 249.12164666 Da
Topological Polar Surface Area: 53.7 Ų
Heavy Atom Count: 15
Complexity: 118
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes