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Gamma-Tocopherol is one of the naturally occurring forms of vitamin E, recognized for its antioxidant properties and presence in various plant-based oils.
Gamma-Tocopherol differs structurally from alpha-tocopherol but offers unique health benefits, particularly in neutralizing reactive nitrogen species.
Gamma-Tocopherol is commonly used in dietary supplements, skincare products, food preservation, and pharmaceutical formulations.
CAS Number: 54-28-4
EC Number: 200-201-5
Molecular Formula: C28H48O2
Molecular Weight: 416.68 g/mol
Synonyms: γ-Tocopherol, Gamma Vitamin E, (±)-Gamma-Tocopherol, 2,7,8-Trimethyl-2-[(4,8,12-trimethyltridecyl)oxy]-6-chromanol, Natural Gamma-Tocopherol, Tocopherol Gamma, Vitamin E Gamma, Mixed Tocopherols (Gamma-rich), Gamma-Tocopherol USP, Gamma-Tocopherol Antioxidant, gamma‑Tocopherol, γ‑Tocopherol, 2,7,8‑Trimethyl‑2‑(4,8,12‑trimethyltridecyl)‑3,4‑dihydro‑2H‑1‑benzopyran‑6‑ol, dl‑γ‑Tocopherol, all‑rac‑γ‑Tocopherol, (+)‑γ‑Tocopherol, D‑γ‑Tocopherol, (R,R,R)‑γ‑Tocopherol, 7,8‑Dimethyltocol, 6‑Chromanol, 2,7,8‑Trimethyl‑2‑(4,8,12‑trimethyltridecyl)‑, o‑Xylotocopherol, E308, UNII‑ECY0XG64DO, CAS 54‑28‑4, EC 200‑201‑5, PubChem 92729, ChEBI 18185, Vitamin E γ‑isoform, Vitamin E E308, Tocopherol gamma, Tocopherol‑11, Tocopherol γ, Vitamin E 2
APPLICATIONS
Gamma-Tocopherol is used in dietary supplements as a source of vitamin E, supporting immune function and antioxidant defense.
Gamma-Tocopherol is included in mixed tocopherol formulations to provide a full spectrum of vitamin E isomers.
Gamma-Tocopherol is particularly valued for its role in neutralizing reactive nitrogen species and reducing inflammation.
Gamma-Tocopherol is used in skincare products such as creams, serums, and lotions for its antioxidant and anti-aging properties.
Gamma-Tocopherol helps protect skin cells from oxidative damage caused by UV radiation and pollution.
Gamma-Tocopherol improves skin hydration, elasticity, and the appearance of fine lines.
Gamma-Tocopherol is incorporated into sunscreens and after-sun products to reduce inflammation and promote healing.
Gamma-Tocopherol enhances the stability of cosmetic emulsions by preventing lipid oxidation.
Gamma-Tocopherol is used in combination with alpha-tocopherol and other vitamins for synergistic skin benefits.
Gamma-Tocopherol is utilized in food preservation to prevent rancidity in oils, margarine, and fat-based products.
Gamma-Tocopherol extends the shelf life of processed foods by protecting unsaturated fats from oxidative degradation.
Gamma-Tocopherol is considered a natural antioxidant alternative to synthetic preservatives like BHT and BHA.
Gamma-Tocopherol is employed in pharmaceutical formulations for its anti-inflammatory and cardioprotective effects.
Gamma-Tocopherol is studied for its role in reducing risks of chronic diseases, including cancer and cardiovascular conditions.
Gamma-Tocopherol is administered in oral capsules or soft gels, often combined with other tocopherol isomers.
Gamma-Tocopherol is used in animal nutrition as a dietary supplement for improving immunity and reproductive health.
Gamma-Tocopherol supports oxidative stress reduction in livestock, poultry, and pets.
Gamma-Tocopherol is added to feed premixes to maintain feed quality and freshness.
Gamma-Tocopherol is added to bio-based lubricants and polymers to inhibit oxidative degradation.
Gamma-Tocopherol acts as a stabilizer in bioplastics, oils, and greases used in machinery.
Gamma-Tocopherol contributes to the environmental sustainability of industrial materials.
Gamma-Tocopherol is studied for its ability to modulate gene expression and enzyme activity.
Gamma-Tocopherol is evaluated in cancer prevention research, particularly for prostate and lung health.
Gamma-Tocopherol shows potential in regulating inflammatory markers and cytokine production.
Gamma-Tocopherol is used in antioxidant-rich skincare products to combat free radical damage.
Gamma-Tocopherol is included in anti-aging creams for its protective properties against environmental stressors.
Gamma-Tocopherol is applied in sunscreens to enhance protection against UV-induced oxidative stress.
Gamma-Tocopherol is used in body lotions to improve skin hydration and elasticity.
Gamma-Tocopherol is incorporated into serums to reduce the appearance of fine lines.
Gamma-Tocopherol is used in lip balms to protect against dryness and cracking.
Gamma-Tocopherol is applied in facial oils to support skin barrier function.
Gamma-Tocopherol is included in eye creams to diminish dark circles and puffiness.
Gamma-Tocopherol is used in natural deodorants for its skin-soothing and antioxidant effects.
Gamma-Tocopherol is incorporated into scalp treatments to reduce irritation and flakiness.
Gamma-Tocopherol is used in hair conditioners to protect hair from oxidative damage.
Gamma-Tocopherol is applied in hair masks to promote strength and shine.
Gamma-Tocopherol is included in nail serums to enhance nail health.
Gamma-Tocopherol is used in cuticle creams for nourishment and healing.
Gamma-Tocopherol is applied in beard oils to condition hair and soothe the skin.
Gamma-Tocopherol is used in aftershave balms to calm irritated skin.
Gamma-Tocopherol is incorporated into bath oils for skin softening and rejuvenation.
Gamma-Tocopherol is used in stretch mark creams to support skin regeneration.
Gamma-Tocopherol is added to moisturizers for enhanced antioxidant performance.
Gamma-Tocopherol is included in scar treatment gels to support skin healing.
Gamma-Tocopherol is used in baby lotions for gentle skin nourishment.
Gamma-Tocopherol is applied in eczema creams to soothe inflammation.
Gamma-Tocopherol is incorporated into psoriasis ointments for skin barrier support.
Gamma-Tocopherol is used in sunburn relief gels for its anti-inflammatory benefits.
Gamma-Tocopherol is included in wound healing salves.
Gamma-Tocopherol is used in organic cosmetics as a natural preservative.
Gamma-Tocopherol is applied in makeup formulations to protect pigments from oxidation.
Gamma-Tocopherol is used in lipstick to stabilize oils and prevent rancidity.
Gamma-Tocopherol is included in foundations for skin protection throughout the day.
Gamma-Tocopherol is added to cleansing oils for added skincare benefits.
Gamma-Tocopherol is used in facial mists to deliver antioxidant hydration.
Gamma-Tocopherol is included in shaving creams to protect and nourish sensitive skin.
Gamma-Tocopherol is used in tanning oils to minimize oxidative stress during sun exposure.
Gamma-Tocopherol is applied in facial sheet masks for skin rejuvenation.
Gamma-Tocopherol is used in oil serums targeting hyperpigmentation.
Gamma-Tocopherol is included in anti-pollution skincare lines.
Gamma-Tocopherol is used in men’s grooming products for skin conditioning.
Gamma-Tocopherol is incorporated into body butters for rich antioxidant support.
Gamma-Tocopherol is used in night creams to help skin recover overnight.
Gamma-Tocopherol is added to massage oils for skin nourishment and relaxation.
Gamma-Tocopherol is used in lash growth serums for follicle health.
Gamma-Tocopherol is included in brow oils for hair conditioning.
Gamma-Tocopherol is applied in fitness recovery lotions for muscle comfort.
Gamma-Tocopherol is used in foot creams to protect cracked and dry skin.
Gamma-Tocopherol is added to sports skincare products for environmental defense.
DESCRIPTION
Gamma-Tocopherol is a viscous, clear to amber-colored oil with a mild, characteristic odor.
Gamma-Tocopherol is primarily derived from soybean oil, corn oil, sesame oil, and other vegetable oils.
Gamma-Tocopherol is a fat-soluble vitamin E isomer with a chromanol ring and a hydrophobic phytyl tail.
Gamma-Tocopherol differs from alpha-tocopherol in the position of methyl groups on the chromanol ring, leading to unique biological activities.
Gamma-Tocopherol is more effective at trapping reactive nitrogen species such as peroxynitrite compared to alpha-tocopherol.
Gamma-Tocopherol plays a complementary role to other vitamin E forms in maintaining antioxidant balance.
Gamma-Tocopherol is stable under typical storage conditions but may degrade upon prolonged exposure to heat, light, or oxygen.
Gamma-Tocopherol is typically stabilized with carriers like vegetable oils or mixed tocopherol blends.
Gamma-Tocopherol is considered safe for consumption and topical use within recommended dosage limits.
Gamma-Tocopherol is widely recognized for its bioactivity in cardiovascular, dermatological, and neuroprotective applications.
Gamma-Tocopherol continues to be studied for its differential effects on human health compared to other tocopherols.
Gamma-Tocopherol is generally regarded as safe (GRAS) when used in food and cosmetic applications.
Gamma-Tocopherol plays a key role in cellular protection against environmental toxins.
Gamma-Tocopherol is often used in combination with other tocopherols for synergistic effects.
Gamma-Tocopherol is a viscous, oil-soluble compound with a mild yellow color.
Gamma-Tocopherol is more abundant in the diet than alpha-tocopherol in some populations.
Gamma-Tocopherol is safe for topical use and is valued for its strong antioxidant performance in cosmetic science.
PROPERTIES
Chemical Name: Gamma-Tocopherol
Molecular Formula: C28H48O2
Molecular Weight: 416.68 g/mol
Appearance: Clear to amber-colored oily liquid
Odor: Mild, characteristic
Solubility: Insoluble in water; soluble in oils and organic solvents
Boiling Point: Decomposes
Melting Point: ~-10°C
Density: ~0.95 g/cm³
Refractive Index: ~1.495–1.510
Flash Point: >150°C
Stability: Sensitive to light, heat, and air; antioxidants may be added for stabilization
LogP (octanol/water): ~9.5
Storage: Store in cool, dry, and dark conditions in tightly sealed containers
Shelf Life: Up to 2 years when properly stored
Regulatory Status: GRAS in food; approved in cosmetics (EU, FDA, JP)
FIRST AID
Inhalation:
Move to fresh air if inhaled accidentally as vapor during processing.
Seek medical attention if irritation persists.
Skin Contact:
Wash skin with soap and water.
Gamma-Tocopherol is generally non-irritating, but discontinue use if a rash develops.
Eye Contact:
Rinse immediately with water for several minutes.
Seek medical advice if irritation persists.
Ingestion:
Generally safe in dietary quantities.
Seek medical help in case of accidental ingestion of large quantities or concentrated extract.
Note to Physicians:
Treat symptomatically.
No known antidote is required for gamma-tocopherol.
HANDLING AND STORAGE
Handling:
Wear gloves and goggles when handling in bulk or concentrated form.
Avoid contact with eyes and mucous membranes.
Wash hands thoroughly after use.
Ventilation:
Use in well-ventilated areas.
Avoid aerosol formation.
Storage:
Store in airtight containers away from heat, light, and moisture.
Use amber or opaque packaging to protect from UV exposure.
Recommended storage temperature: 10–25°C
Spill Procedures:
Absorb spills with inert materials (e.g., sand or absorbent pads).
Clean surfaces thoroughly to prevent residue buildup.
Disposal:
Dispose of according to local regulations for non-hazardous waste.
Avoid release into water sources.
