Quick Search
Glucosamine sulfate 2KCl is a salt form of glucosamine used as a dietary supplement and over-the-counter medication for the treatment of mild to moderate osteoarthritis (OA).
Glucosamine sulfate 2KCl is a pharmaceutical and dietary supplement form of glucosamine that is chemically stabilized with sulfate and potassium chloride (2KCl) to improve its stability and solubility.
Glucosamine sulfate 2KCl is commonly derived from natural sources such as shellfish exoskeletons or produced synthetically for medical use.
CAS Number: 1296149-08-0
Molecular Formula: C6H15ClKNO9S
Molecular Weight: 351.79
EINECS Number: 420-960-8
Synonyms: Glucosamine sulfate potassium chloride, glucosamine sulfate (as potassium chloride), glucosamine sulfate potassium salt, glucosamine sulfate KCl, glucosamine sulfate potassium chloride salt, 2-amino-2-deoxy-D-glucose sulfate potassium chloride, Glucosamine sulfate potassium chloride (USP), glucosamine sulfate potassium chloride (EP monograph), glucosamine sulfate potassium chloride (WHO-DD), glucosamine sulfate potassium chloride (USP impurity), GLUCOSAMINE SULFATE POTASSIUM CHLORIDE;GLUCOSAMINE SULFATE POTASSIUM CHLORIDEium salt;Isatin Impurity 15 (4-Bromoisatin);Glucosamine sulfate potassium chloride (1:x:x)
Glucosamine sulfate 2KCl makes it an important compound in joint health supplements.
Glucosamine sulfate 2KCl consists of glucosamine (an amino sugar) combined with sulfate ions and two potassium chloride units that help maintain the salt form and improve product stability during storage.
The sulfate group is considered important because it is associated with cartilage and connective tissue metabolism.
Glucosamine sulfate 2KCl makes it relevant in joint-support chemistry.
In solution, glucosamine sulfate 2KCl dissociates into glucosamine molecules, sulfate ions, potassium ions, and chloride ions, which are absorbed and metabolized in the body through normal biochemical pathways.
Its biological role is mainly linked to supporting glycosaminoglycan and proteoglycan synthesis.
Glucosamine sulfate 2KCl makes it important in connective tissue biochemistry.
Glucosamine sulfate 2KCl is best described as a stabilized salt form of glucosamine used primarily as a nutritional supplement for joint cartilage support and osteoarthritis-related symptoms.
Its main function is supportive rather than curative.
This makes it widely used in nutraceutical applications.
Glucosamine sulfate 2KCl is often discussed in the context of cartilage homeostasis, where it is thought to support the balance between cartilage breakdown and repair by influencing chondrocyte activity in joint tissue.
Chondrocytes are the cells responsible for maintaining cartilage structure and function.
Glucosamine sulfate 2KCl makes it important in joint biology.
Its sulfate component is considered biologically relevant because sulfate groups are required for the synthesis of glycosaminoglycans such as chondroitin sulfate and keratan sulfate, which are key structural components of cartilage matrix.
Glucosamine sulfate 2KCl links the compound indirectly to connective tissue structure maintenance.
This makes it important in extracellular matrix chemistry.
Glucosamine sulfate 2KCl is frequently evaluated in relation to inflammatory signaling pathways, particularly its possible influence on cytokines such as interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-α), which are involved in cartilage degradation in osteoarthritis.
Some studies suggest it may indirectly modulate these pathways, but results are not fully consistent.
Glucosamine sulfate 2KCl makes it relevant in inflammation-related joint research.
Its role in joint biology is also linked to synovial fluid composition, where glucosamine may contribute to the synthesis of hyaluronic acid, a key molecule responsible for lubrication and shock absorption in joints.
Improved synovial function is associated with better joint mobility.
Glucosamine sulfate 2KCl makes it important in joint lubrication chemistry.
At the cellular level, glucosamine can affect chondrocyte metabolism by serving as a precursor for glycosaminoglycan synthesis, which supports extracellular matrix maintenance and cartilage structural integrity.
This biochemical pathway is central to cartilage health.
Glucosamine sulfate 2KCl makes it important in connective tissue metabolism.
Glucosamine sulfate 2KCl is often studied in the context of long-term degenerative joint disease progression, where its effects are evaluated not only on pain reduction but also on structural changes in cartilage over time.
However, clinical evidence for structural modification remains debated.
Glucosamine sulfate 2KCl makes it important in long-term osteoarthritis research.
Pharmacologically, glucosamine sulfate 2KCl is considered to have slow onset of action and mild systemic effects, which distinguishes it from fast-acting anti-inflammatory drugs like NSAIDs.
Its effects, if present, typically require continuous use over weeks.
Glucosamine sulfate 2KCl makes it relevant in chronic therapy approaches.
Glucosamine sulfate 2KCls stability as a salt form also allows consistent dosing in industrial production, reducing variability compared to less stable glucosamine sulfate forms that may degrade or absorb moisture more easily.
This improves manufacturing reliability and shelf-life performance.
Glucosamine sulfate 2KCl makes it important in pharmaceutical formulation control.
storage temp.: 2–8 °C
major application: pharmaceutical (small molecule)
InChI: InChI=1/C6H13NO5.ClH.K.H2O4S/c7-3(1-8)5(11)6(12)4(10)2-9;;;1-5(2,3)4/h1,3-6,9-12H,2,7H2;1H;;(H2,1,2,3,4)/q;;+1;/p-1/t3-,4+,5+,6+;;;/s3
InChIKey: UOUQWMJTBOYJTE-SAFQYCKMNA-M
SMILES: Cl[K].C@@H(C@@HC=O)C@HC@HCO.S(O)(O)(=O)=O |&1:2,4,8,10,r|
FDA UNII: 15VQ11I66N
UNSPSC Code: 41116107
NACRES: NA.24
Glucosamine sulfate 2KCl is believed to contribute to the biosynthesis of glycosaminoglycans, which are long-chain molecules essential for maintaining the structure and elasticity of cartilage tissue in joints.
These molecules help retain water and provide cushioning in joint spaces.
Glucosamine sulfate 2KCl makes it important in joint physiology.
Glucosamine sulfate 2KCl is commonly studied for its potential role in reducing symptoms of osteoarthritis, such as joint stiffness and pain, although clinical results vary depending on dosage, formulation, and patient condition.
Its effectiveness is still debated in medical literature.
This makes it a nutritionally supported but variable-response supplement.
The potassium chloride component in the compound serves mainly as a counterion that stabilizes the crystalline structure and improves handling, storage stability, and manufacturing consistency of the supplement.
It does not play a primary therapeutic role.
Glucosamine sulfate 2KCl makes it important in pharmaceutical formulation.
Glucosamine itself is a naturally occurring amino monosaccharide that plays a role in the formation of structural components in cartilage, tendons, ligaments, and synovial fluid.
It is part of normal connective tissue metabolism.
Glucosamine sulfate 2KCl makes it biologically relevant in musculoskeletal health.
After ingestion, glucosamine is absorbed in the gastrointestinal tract and distributed through the bloodstream, where it may be incorporated into cartilage-related biochemical pathways or metabolized by the liver.
Its bioavailability can vary between individuals and formulations.
Glucosamine sulfate 2KCl makes it important in pharmacokinetics.
Because it is a salt form, glucosamine sulfate 2KCl is often preferred over other forms in supplements due to its higher stability and consistent sulfate delivery compared with less stable glucosamine sulfate formulations.
Glucosamine sulfate 2KCl improves shelf life and product reliability.
This makes it widely used in commercial supplement production.
Glucosamine sulfate 2KCl is a stimulant for proteoglycan synthesis.
Proteoglycans are essential components for the formation and maintenance of healthy cartilage.
Glucosamine sulfate 2KCl repairs joints by building cartilage (the soft connective tissue surrounding joints).
Glucosamine sulfate 2KCl possesses anti-inflammatory properties that alleviate pain and inflammation (swelling).
In pharmacological terms, glucosamine sulfate 2KCl is often classified as a symptomatic slow-acting drug for osteoarthritis (SYSADOA), meaning it may take weeks to months to show potential effects rather than acting immediately like painkillers.
Glucosamine sulfate 2KCl delayed action is typical for structural supplements.
This makes it relevant in long-term joint therapy strategies.
Its absorption in the human body involves transport through the intestinal wall via glucose-related transport mechanisms, followed by partial metabolism in the liver before distribution to connective tissues.
However, the extent of direct cartilage incorporation is still scientifically debated.
Glucosamine sulfate 2KCl makes it important in pharmacokinetic research.
Different commercial formulations can vary in bioavailability depending on particle size, salt form, manufacturing process, and combination with other compounds such as chondroitin or MSM.
These differences can influence observed effectiveness in studies.
Glucosamine sulfate 2KCl makes formulation quality important in supplement performance.
Because it is a salt form, glucosamine sulfate 2KCl also improves chemical stability compared to glucosamine sulfate alone, reducing degradation and allowing more consistent dosing in pharmaceutical and supplement products.
This improves shelf life and manufacturing reliability.
Glucosamine sulfate 2KCl makes it important in product formulation science.
Uses:
Glucosamine sulfate 2KCl Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Glucosamine sulfate 2KCl is used as a dietary supplement for joint health, particularly in individuals experiencing osteoarthritis or age-related cartilage degeneration.
Glucosamine sulfate 2KCl is taken orally in capsule, tablet, or powder form.
This makes it common in nutraceutical products.
Glucosamine sulfate 2KCl is used in formulations aimed at supporting cartilage maintenance, joint flexibility, and mobility by providing biochemical precursors for connective tissue components.
These effects are generally supportive rather than regenerative.
This makes it important in joint-support supplementation.
It is often included in combination supplements with chondroitin sulfate, MSM (methylsulfonylmethane), or collagen to enhance overall joint health support formulations.
These combinations are designed to target multiple aspects of joint structure.
Glucosamine sulfate 2KCl makes it useful in multi-ingredient nutraceuticals.
In pharmaceutical and clinical nutrition contexts, it is used as a symptom-relief adjunct for mild to moderate osteoarthritis management under medical supervision in some countries.
Its use varies depending on regional regulatory frameworks.
This makes it relevant in medical nutrition therapy.
Glucosamine sulfate 2KCl is also used in sports nutrition products aimed at supporting joint comfort and recovery in physically active individuals exposed to repetitive joint stress.
This is especially relevant for athletes and active populations.
Glucosamine sulfate 2KCl makes it useful in performance nutrition.
In research applications, it is studied for its role in cartilage metabolism, inflammation pathways, and connective tissue biochemistry.
These studies help evaluate its therapeutic potential and limitations.
Glucosamine sulfate 2KCl makes it important in biomedical research.
Glucosamine sulfate 2KCl is widely used in nutritional supplements designed to support joint comfort, flexibility, and mobility, especially in aging populations or individuals with osteoarthritis symptoms.
It is one of the most commonly used joint-support ingredients worldwide.
Glucosamine sulfate 2KCl makes it central in nutraceutical markets.
Glucosamine sulfate 2KCl is used in combination therapies with chondroitin sulfate, MSM, collagen, or hyaluronic acid to target multiple components of joint structure and synovial fluid function.
These combinations aim to provide broader joint support effects.
Glucosamine sulfate 2KCl makes it important in multi-ingredient joint formulations.
In clinical nutrition, it is sometimes used as a supportive supplement in osteoarthritis management protocols to help reduce stiffness and improve joint function over time under medical guidance.
Its use varies depending on clinical practice and region.
Glucosamine sulfate 2KCl makes it relevant in medical supplement strategies.
In sports nutrition, it is used to support joint resilience in athletes and physically active individuals exposed to repetitive stress, impact, or long-term joint load.
It is often included in recovery-focused supplement stacks.
Glucosamine sulfate 2KCl makes it useful in performance and recovery nutrition.
Glucosamine sulfate 2KCl is used to study cartilage metabolism, inflammation pathways, and the biochemical mechanisms involved in osteoarthritis progression and joint degeneration.
These studies help evaluate its true biological effects.
Glucosamine sulfate 2KCl makes it important in biomedical research.
In pharmaceutical product development, it is used to formulate standardized dosages of glucosamine-based therapies with controlled purity, stability, and delivery characteristics.
This ensures consistent product quality and regulatory compliance.
Glucosamine sulfate 2KCl makes it important in pharmaceutical manufacturing.
Glucosamine sulfate 2KCl is primarily used in dietary supplements aimed at supporting joint health, cartilage maintenance, and mobility in individuals experiencing age-related joint discomfort or osteoarthritis symptoms.
It is one of the most widely used joint-support ingredients globally.
This makes it central in nutraceutical applications.
Glucosamine sulfate 2KCl is used in combined joint formulations with chondroitin sulfate, MSM, collagen, and hyaluronic acid to target multiple structural and functional aspects of joint health simultaneously.
These combinations are designed for broader supportive effects.
This makes it important in multi-ingredient supplement design.
In clinical and medical nutrition settings, it is used as a supportive agent in osteoarthritis management protocols to help reduce stiffness and improve joint function over long-term use under supervision.
Its role is supportive rather than curative.
Glucosamine sulfate 2KCl makes it relevant in chronic care nutrition.
In sports and fitness nutrition, it is used to support joint resilience in athletes and active individuals exposed to repetitive mechanical stress and impact loading.
It is often included in recovery and longevity-focused supplement stacks.
Glucosamine sulfate 2KCl makes it useful in performance nutrition.
In pharmaceutical development, it is used to standardize glucosamine-based products with controlled purity, stability, and reproducible dosing for regulatory-approved formulations.
This ensures consistency across medical-grade products.
Glucosamine sulfate 2KCl makes it important in pharmaceutical manufacturing.
In biomedical research, it is used to investigate cartilage metabolism, inflammatory pathways, and the biochemical mechanisms involved in osteoarthritis progression and joint tissue degeneration.
These studies help clarify its therapeutic potential and limitations.
Glucosamine sulfate 2KCl makes it important in musculoskeletal research.
Safety Profile:
Glucosamine sulfate 2KCl is generally considered a low-risk compound when used at recommended supplemental doses, as it is widely used in dietary and pharmaceutical applications.
Most safety concerns are mild and related to individual sensitivity.
Glucosamine sulfate 2KCl makes it relatively safe in normal use.
Some individuals may experience mild gastrointestinal side effects such as nausea, bloating, heartburn, or diarrhea after oral intake of glucosamine supplements.
These effects are usually temporary and dose-dependent.
Glucosamine sulfate 2KCl makes tolerability an important consideration.
Because glucosamine is often derived from shellfish, it may pose a risk of allergic reactions in individuals with shellfish allergies, depending on the source and purification method used.
However, many synthetic versions reduce this risk.
Glucosamine sulfate 2KCl makes source verification important.
It may also interact with certain medications such as anticoagulants (e.g., warfarin), potentially affecting blood clotting parameters in some individuals.
Medical supervision is recommended when used alongside prescription drugs.
Glucosamine sulfate 2KCl makes drug interaction awareness important.
From an industrial handling perspective, it is generally non-flammable, non-volatile, and chemically stable under normal storage conditions, posing minimal physical hazard.
However, standard hygiene practices are still required.
Glucosamine sulfate 2KCl makes it low risk in manufacturing environments.
Glucosamine sulfate 2KCl is a widely used nutritional compound with a strong safety profile, where risks are mostly related to individual sensitivity, allergies, or drug interactions rather than inherent chemical toxicity.
Its use is generally considered safe within recommended dietary limits.
Glucosamine sulfate 2KCl makes it a well-established but mild-risk supplement.
