PRODUCTS

GLYCEROL FORMAL

CAS NO.: 4740-78-7
EC/LIST NO.: 911-694-8

Glycerol formal (GF) is a light glycerol acetal that is composed of ~60% 5-hydroxy-1,3-dioxane and ~40% 4-hydroxymethyl-1,3-dioxolane.
Glycerol formal can be prepared by reacting glycerol and formaldehyde in the presence of acid catalyst.
The potential of GF as an injection solvent for use in toxicity testing has been reported.

The fine chemical GLYCEROL FORMAL is an almost odorless compound which is a combination of 5-hydroxy-1,3-dioxane and 4-hydroxymethyl-1,3- dioxolane in 60 : 40 ratio.
Glycerol formal is liquid at room temperature and is considered as a bio-genic solvent in green chemistry.
Owing to its affinity towards polar and non polar substances it completely dissolves in water, this property qualifies it for several applications. Lets get into the details of its applications; major industries include

Pharma
Cosmetics
Printing Inks
Colors & varnishes
Adhesives
Cleaning agent
Pesticides

One of the oldest know uses of glycerol formal is in the field of pharmaceuticals and veterinary medicine as carriers or enhancers for active ingredients.
The alcoholic hydroxyl functionality present in glycerol formal allows participation in reactions.

Incorporation of glycerol formal in polyacrylates, polyesters & polyurethanes is achieved by condensation reactions which in turn have numerous applications.

In addition to Glycerol formal being a solvent it also possesses lacquer forming characteristics that hamper film formation & drying.

The pharmaceutical industry is the largest consumer of glycerol formal as injectables for cattle and swine.

In casting, Glycerol formal is used as binder solvent to produce foundry core.

Taking advantage of its miscibility in water it is used in formulation of water based inks.

In the manufacture of glycerol formal acrylates.

In the paint industry it is used as Coalescence improver for water dispersion of acrylic and PVA paints.

As far as fine chemical manufacturing is concerned it cannot be ranked in line with other manufacturing process as they need utmost precision in arriving at the desired product.
Sticking to standards we at Pure Chemicals Co. deliver a broad spectrum of fine chemicals for research and pharma industry.

Glycerol Formal (mixture of 1,3-Dioxan-5-ol and 4-Hydroxymethyldioxolane), also known as glycerine, is a polyol compound and is central to all lipids known as triglycerides.
Ungraded products supplied by TCI America are generally suitable for common industrial uses or for research purposes but typically are not suitable for human consumption or therapeutic use.

Glycerol formal may be used in the multi-step synthesis of 9-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl]guanine (2′-nor-2′-deoxyguanosine), an analog of acyclovir.
Glycerol formal may be used in the preparation of 4-substituted dioxolanes.

Glycerol Formal Stabilized is a slightly viscous, clear colorless liquid having very little odor.
Glycerol formal is recommended for special pharmaceutical applications, including emulsifiers for parenteral formulations.

Glycerol Formal is used in special pharmaceutical applications, including emulsifiers for parenteral formulations, specialty solvent, specialty embalming preparations and chemical reactants.
Specifications comply with the European Pharmacopoeia.

Glycerol Formal is the mixture of 5-hydroxy-1,3-dioxane and 4-hydroxymethyl-1,3- dioxolane (60:40) which are cyclic ether compounds having 2 oxygen atoms in the ring structure and substituted by alcohol group.
Glycerol Formal is a low odour and low toxic solvent for a wide variety of applications in pharmaceutical and cosmetics industry including anti-parasite veterinary injectibles, intramuscular injections, sulphadiazine and trimethoprin preparations.
Glycerol formal is used as a slowly evaporating solvent in insecticide delivery systems.
Glycerol formal is used in formulation of water-based inks.

Glycerol formal is used to to solubilize water-insoluble compounds for subsequent aqueous dilution.
Glycerol formal has been used as a chemical and dye emulsifier and as a cosolvent for drug delivery.
Glycerol formal was used as a vehicle for antibiotic delivery in rats.
Glycerol formal may be used in the multi-step synthesis of 9-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl]guanine (2′-nor-2′-deoxyguanosine), an analog of acyclovir.
Glycerol formal may be used in the preparation of 4-substituted dioxolanes.

Chemical Name or Material : Glycerol formal
CAS : 4740-78-7,5464-28-8
pH : 4.0 to 6.5 (10% soln.)
Boiling Point : 193.0°C to 195.0°C
Assay Percent Range : 99% min. Sum of alpha-and beta-isomers (GC)
Molecular Formula : C4H8O3
Packaging : Glass bottle
Refractive Index : 1.4500 to 1.4520
Solubility Information : (50% in water) Clear
Molecular Weight (g/mol) : 104.11
Physical Form : Liquid
Viscosity : 16 mPa.s (20°C)
Name Note : 99+%
Density : 1.2100g/mL
Color : Undesignated
Flash Point : 97°C
Infrared Spectrum : Authentic
MDL Number : MFCD00003218
Merck Index : 14, 4485
Quantity : 500mL
Specific Gravity : 1.21
Formula Weight :104.11
Percent Purity : 99+%
Water : 0.5% max. (K.F.)

IUPAC NAME :

1,3-dioxan-5-ol

SYNONYMS:

α,α'-Glycerol formal
?,α'glycerol formal
1,3-Dioxan-5-ol
1,3-Dioxan-5-ol
1,3-Dioxan-5-ol
1,3-Formalglycerol
225-248-9 [EINECS]
4740-78-7 [RN]
5-m-Dioxanol
a,a'-Formaldehyde Glycerol