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Glyceryl Behenate is a mixture of glyceryl esters of behenic acid made from glycerin and behenic acid (a saturated C22 fatty acid).
The mixture contains predominantly glyceryl dibehenate.
Glyceryl Behenate is a fatty acid ester resulting from the formal condensation of the hydroxy group at position-1 of glycerol with the carboxy group of docosanoic acid.
CAS: 77538-19-3
MF: C25H50O4
MW: 414.66
EINECS: 278-717-5
Synonyms
Docosanoic acid, ester with 1,2,3-propanetriol;1,2,3-Propanetriol docosanoate;Glyceryl behenate;Glyceryl behenate;30233-64-8;Behenin;2,3-Dihydroxypropyl docosanoate;Glyceryl monobehenate;77538-19-3;6916-74-1;Docosanoic acid, 2,3-dihydroxypropyl ester;1,2,3-Propanetriol docosanoate;Docosanoic acid, monoester with 1,2,3-propanetriol;Docosanoic acid, ester with 1,2,3-propanetriol;A626UU0W2A;Glyceryl tribehenate; Glyceryl tridocosanoate; Lipovol GTB;Behenic monoglyceride;glycerine monobehenate;1-O-Docosanoylglycerol;UNII-A626UU0W2A;glycerol behenate;1-Monodocosanoin;MG 22:0;1-behenoylglycerol;1-docosanoylglycerol;EINECS 250-097-0;EINECS 278-717-5;1-Monobehenoylglycerol;Docosanoic acid, monoester with glycerol;1-acylglycerol 22:0;Docosanoic acid,2,3-dihydroxypropyl ester;EC 278-717-5;SCHEMBL3805;glycerol-behenic acid monoester;CHEBI:142497;DTXSID701015809;MAG 22:0;DA-55622;DB-217988;DB-254894;docosanoic acid 2',3'-dihydroxypropyl ester;NS00013665;Q27273676
Glyceryl Behenate has a role as a plant metabolite and an antineoplastic agent.
Glyceryl Behenate is a 1-monoglyceride and a fatty acid ester.
Glyceryl Behenate is functionally related to a glycerol and a docosanoic acid.
Glyceryl Behenate is a glycol ester that is used as an excipient in tablet formulations.
Glyceryl Behenate facilitates the absorption of drugs by increasing their solubility in water and may also increase the bioavailability of poorly soluble drugs.
Glyceryl Behenate is used as an absorption enhancer for cefpodoxime proxetil, which is a drug used to treat bacterial infections.
Glyceryl Behenate may also have therapeutic effects on alopecia areata, a disease characterized by hair loss.
The thermodynamic data indicate that Glyceryl Behenate has low bioavailability due to its insolubility in aqueous media and its lack of affinity for lipid membranes.
Glyceryl Behenate is a fat used in cosmetics, foods, and oral pharmaceutical formulations. In cosmetics, Glyceryl Behenate is mainly used as a viscosity-increasing agent in emulsions.
Glyceryl Behenate is the monoester of glycerin and behenic acid.
In cosmetic formulas, it’s used as an emollient and aids the integration of key ingredients into skin’s surface while helping to impart a smooth, soft feel.
Glyceryl Behenate can also function as an emulsifier and formulary texture enhancer.
Glyceryl behenate is a solid ester that has a melting point of approximately 70°C.
Glyceryl Behenate is commonly used as a release retardant in sustained-release dosage forms due to its good compressibility and molecular binding force properties.
In pharmaceutical formulations, Glyceryl Behenate is mainly used as a tablet and capsule lubricant and as a lipidic coating excipient.
Glyceryl Behenate has been investigated for the encapsulation of various drugs such as retinoids.
Glyceryl Behenate has also been investigated for use in the preparation of sustained release tablets as a matrix-forming agent for the controlled release of water-soluble drugs and as a lubricant in oral solid dosage formulations.
Glyceryl Behenate can also be used as a hot-melt coating agent sprayed onto a powder.
Glyceryl Behenate is used widely in cosmetics as non-comedogenic (non- pimple causing substance) ingredient.
Glyceryl Behenate does not clog the oil pores of facial skin.
Glyceryl Behenate is also used widely as ingredient for preparation of lipidic nano-particles such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC).
Chemically, Glyceryl Behenate is a mixture of various esters of behenic acid and glycerol (glycerides).
The mixture predominantly contains the diester glyceryl dibehenate.
Glyceryl Behenate is a monoester of glycin with behenic acid (C22).
Glyceryl Behenate is a high-molecular-weight solid ester that melts at about 70°C, and its properties are similar to those of Behenyl Behenate.
Glyceryl Behenate is an off-white to yellow coarse powder insoluble in water, ethanol, and propylene glycol.
Glyceryl Behenate is miscible in warm mineral and natural oils.
When added to the oil phase of an emulsion, Glyceryl Behenate enhances richness, body, and viscosity and, probably most importantly, tends to stabilize the emulsion.
Glyceryl Behenate adds emolliency to any formulation and can be a melting point modifier.
Glyceryl Behenate is formulator-friendly, possessing good solubility in warm oils, silicones, and esters.
Additionally, Glyceryl Behenate, having a long hydrophobic tail on one end of the molecule and hydroxyl groups at the other end, can function as an ethylene oxide-free, low HLB emulsifier.
Glyceryl Behenate's properties enable its use in lipsticks, decorative cosmetics, creams, and lotions.
Glyceryl Behenate is a safe ingredient that is non-irritating to skin and eyes.
Depending on the application, its use levels range from 2 to 10%.
Glyceryl Behenate Chemical Properties
Melting point: 83-84o C
Storage temp.: Refrigerator, under inert atmosphere
Solubility: Chloroform (Slightly)
Form: Solid
Color: White to Off-White
LogP: 9.354 (est)
CAS DataBase Reference: 77538-19-3(CAS DataBase Reference)
Uses
Glyceryl Behenate is derived from the glycerides of coconut fatty acids.
Glyceryl Behenate acts as an emollient, lubricant, and/or emulsifier in a cosmetic preparation.
Glyceryl Behenate is used as a carrier in lipid-based colloidal drug delivery system.
