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Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt is a highly water-soluble aminopolycarboxylate chelating agent commonly known as tetrasodium EDTA.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt binds calcium, magnesium, iron, copper, manganese, zinc, and other polyvalent metal ions to form stable water-soluble coordination complexes.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt is used in detergents, cleaners, cosmetics, textile processing, pulp and paper production, water treatment, metal finishing, polymer processing, agricultural formulations, analytical chemistry, and specialty industrial products.
CAS Number: 64-02-8
EC Number: 200-573-9
Molecular Formula: C₁₀H₁₂N₂Na₄O₈
Molecular Weight: 380.17 g/mol
SYNONYMS
Tetrasodium EDTA, EDTA Tetrasodium Salt, Ethylenediaminetetraacetic Acid Tetrasodium Salt, Tetrasodium Ethylenediaminetetraacetate, Tetrasodium Edetate, Edetate Tetrasodium, Edetate Sodium, Sodium Edetate, Ethylenediaminetetraacetate Tetrasodium, Ethylenediaminetetraacetic Acid Sodium Salt (1:4), Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], sodium salt (1:4), Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt, Acetic Acid, 2,2',2'',2'''-(1,2-ethanediyldinitrilo)tetra-, Tetrasodium Salt, Acetic Acid, (ethylenedinitrilo)tetra-, Tetrasodium Salt, (Ethylenedinitrilo)tetraacetic Acid Tetrasodium Salt, N,N,N',N'-Ethylenediaminetetraacetic Acid Tetrasodium Salt, N,N'-Ethylenediaminediacetic Acid Tetrasodium Salt, Ethylenediamine-N,N,N',N'-tetraacetic Acid Tetrasodium Salt, Tetrasodium Ethylenediamine-N,N,N',N'-tetraacetate, Tetrasodium (Ethylenedinitrilo)tetraacetate, Tetrasodium Ethylenediaminetetraacetate Anhydrous, Anhydrous Tetrasodium EDTA, Tetrasodium EDTA Powder, Tetrasodium EDTA Crystals, Tetrasodium EDTA Solution, EDTA-Na₄, Na₄EDTA, Na4EDTA, Na₄H₀EDTA, Tetrasodium Ethylenediaminetetraacetate Chelant, Aminopolycarboxylate Chelating Agent, Aminocarboxylate Sequestering Agent, Metal-Ion Sequestrant, Calcium and Magnesium Sequestrant, Water-Softening Chelant, Metal Deactivator, Scale-Control Chelant, Detergent Chelating Agent, Cosmetic Chelating Agent, Textile Chelating Agent, Pulp and Paper Chelating Agent, Metal-Finishing Chelant, Analytical Complexometric Reagent, CAS 64-02-8, EC 200-573-9, PubChem CID 6144, EPA SRS Identifier 3798, EPA PC Code 039107, C₁₀H₁₂N₂Na₄O₈, ((NaOOCCH₂)₂NCH₂)₂, UEUXEKPTXMALOB-UHFFFAOYSA-J
APPLICATIONS
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt serves as a powerful sequestrant for calcium and magnesium ions in aqueous detergent formulations.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt reduces the interference caused by water hardness during washing and surface cleaning.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt supports surfactant efficiency by preventing insoluble calcium and magnesium soaps from forming.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt contributes to improved soil removal, rinsing, product clarity, and cleaning consistency in variable water conditions.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt functions as a chelating component in liquid laundry detergents, powdered detergents, presoaks, and institutional washing products.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt binds trace metals that can reduce surfactant and builder performance.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt helps prevent mineral deposits from accumulating on fabrics and washing equipment.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt supports more consistent cleaning across hard-water and soft-water regions.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt finds application in automatic dishwashing detergents and machine-cleaning products.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt sequesters calcium and magnesium ions that contribute to filming, spotting, and scale.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt helps keep mineral residues dispersed during the wash and rinse cycles.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt contributes to improved appearance of glass, ceramic, stainless-steel, and compatible plastic surfaces.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt serves as a performance stabilizer in hard-surface cleaners, floor cleaners, bathroom cleaners, and multipurpose cleaning concentrates.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt controls metal ions introduced by process water, raw materials, soil, and the cleaned surface.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt supports product clarity by limiting formation of insoluble inorganic precipitates.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt enables surfactants, alkaline builders, and soil-suspending agents to perform more consistently.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt functions as a scale-control component in industrial and institutional cleaning systems.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt complexes hardness ions before they can form deposits on heated or wetted equipment.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt supports cleaning of tanks, pipelines, heat-transfer surfaces, filling equipment, and process vessels.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt requires dosage control because its metal complexes may remain mobile in the wastewater stream.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt finds application as a chelating agent in soaps, liquid hand cleansers, body washes, and personal-cleansing formulations.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt reduces the effect of hardness ions on foam, clarity, viscosity, and cleansing performance.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt binds trace iron and copper that can accelerate color or fragrance deterioration.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt contributes to improved physical and oxidative stability when used at an appropriate concentration.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt serves as a stabilizing auxiliary in shampoos, conditioners, hair treatments, and styling products.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt sequesters trace metals that can interfere with surfactants, polymers, dyes, fragrances, and preservatives.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt helps limit discoloration and odor change promoted by metal-catalyzed oxidation.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt supports stable product appearance throughout validated storage conditions.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt functions as a chelating ingredient in creams, lotions, gels, deodorants, and cosmetic emulsions.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt controls trace metal contamination introduced by water, pigments, clays, botanical materials, and processing equipment.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt supports color stability and can improve the robustness of compatible preservation systems.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt does not replace an antimicrobial preservative and requires finished-product challenge testing.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt serves as a metal-ion control agent in textile scouring and preparation baths.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt complexes calcium, magnesium, iron, copper, and manganese ions that interfere with wet processing.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt helps prevent mineral precipitation, uneven wetting, and localized deposits on fibers.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt contributes to more reproducible preparation of cotton, synthetic fibers, and blended textiles.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt functions as a chelating auxiliary in bleaching baths containing peroxide-based oxidants.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt binds trace transition metals that can catalyze uncontrolled peroxide decomposition.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt supports more uniform bleaching by moderating localized radical formation.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt contributes to peroxide efficiency while process pH, temperature, and metal loading remain carefully controlled.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt finds application in textile dyeing to control metal ions that alter dye shade or fixation.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt reduces interference from hardness salts and transition-metal contamination in process water.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt promotes more uniform dye-bath behavior when compatible with the selected dye and mordant system.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt requires controlled use because excessive chelation may remove metals intentionally required by certain dyes.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt serves as a metal-control agent in pulp bleaching and paper manufacturing.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt sequesters transition metals that can decompose hydrogen peroxide or other bleaching chemicals.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt supports brightness development and reduces uncontrolled oxidant consumption.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt contributes to process consistency where metal-ion concentrations vary with wood, recycled fiber, and water sources.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt functions as a stabilizer in paper-coating, pigment-dispersion, and wet-end chemical systems.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt helps prevent metal-induced precipitation of compatible polymers, dyes, optical additives, and dispersants.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt supports control of calcium-related deposits in recirculating paper-process water.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt requires evaluation for wastewater persistence and interaction with dissolved metals.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt finds application in industrial water treatment as a sequestrant for hardness and transition-metal ions.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt maintains selected metal ions in soluble complexed form.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt helps reduce precipitation and deposition under appropriately controlled pH and concentration conditions.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt must be used with environmental controls because stable complexes can transport metals through wastewater systems.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt serves as a cleaning and descaling auxiliary in compatible boiler, heat-exchanger, and process-water systems.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt complexes dissolved calcium, magnesium, iron, and other metal ions released from deposits.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt supports removal or suspension of selected mineral residues during controlled cleaning cycles.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt requires corrosion, metallurgy, wastewater, and rinse-completeness testing before full-scale use.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt functions as a metal-cleaning auxiliary in alkaline and neutral cleaning formulations.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt complexes metal ions released from oxides, scales, soils, and process residues.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt helps keep removed contamination suspended and reduces redeposition.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt supports preparation of metal surfaces for plating, coating, bonding, or further treatment.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt finds application in electroplating and electroless-deposition baths as a complexing or bath-conditioning agent.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt modifies the concentration of free metal ions by forming soluble coordination complexes.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt can influence deposition rate, throwing power, uniformity, and bath stability.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt requires metal-specific electrochemical testing because excessive complexation may suppress or destabilize deposition.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt serves as a metal deactivator in polymerization and resin-manufacturing processes.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt binds trace iron, copper, and other metals that can initiate unwanted oxidation or radical reactions.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt supports color stability, storage stability, and reproducible reaction behavior in compatible aqueous systems.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt requires evaluation because it may also complex metal catalysts intentionally included in the process.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt functions as a stabilizing auxiliary in water-based paints, coatings, inks, and pigment dispersions.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt sequesters trace metals that can promote discoloration, viscosity drift, precipitation, or oxidative degradation.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt supports compatibility among pigments, dispersants, binders, and process water.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt must be optimized to avoid interference with metal-containing pigments, driers, or crosslinking catalysts.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt finds application in photographic processing and imaging-related chemical systems.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt controls calcium, iron, and other polyvalent ions that can interfere with solution stability.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt supports preparation of stable processing baths and selected silver-recovery operations.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt requires compatibility testing with silver compounds, oxidants, reducing agents, buffers, and photographic substrates.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt serves as a sequestrant in agricultural and pesticide formulations where such use is authorized.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt binds metal ions that can precipitate active ingredients, destabilize surfactants, or reduce solution clarity.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt supports dilution stability in hard water and can improve compatibility among formulation components.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt has regulated antimicrobial-pesticide associations and must be used only within applicable authorization conditions.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt functions as a micronutrient-complexing component in selected agricultural chemical systems.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt forms complexes with iron, manganese, zinc, copper, and other nutrient metals.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt can help maintain compatible metals in soluble form during preparation and application.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt requires agronomic and regulatory evaluation because complex stability and nutrient availability depend on soil and solution conditions.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt serves as a metal-control agent in oilfield, drilling-fluid, and petroleum-processing formulations.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt complexes calcium, magnesium, iron, and other metal ions under compatible process conditions.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt supports scale management, equipment cleaning, and stabilization of selected aqueous additives.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt requires testing under the actual salinity, pH, temperature, pressure, and metallurgy of the process.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt finds application in leather processing as a sequestrant and process-water conditioner.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt controls calcium, iron, and other metals that can contribute to uneven treatment or staining.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt supports more uniform cleaning, dyeing, finishing, and chemical penetration.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt requires compatibility assessment with tanning metals and other deliberately added process chemicals.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt functions as a laboratory reagent in complexometric titration of calcium, magnesium, zinc, copper, and other metal ions.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt reacts with many polyvalent metals in well-defined stoichiometric relationships.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt supports determination of water hardness and metal concentration when suitable indicators, buffers, and masking agents are used.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt requires standardized concentration and traceable preparation for quantitative analytical procedures.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt serves as a masking reagent in analytical chemistry.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt selectively lowers the free-ion concentration of interfering metals.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt supports spectrophotometric, electrochemical, chromatographic, and wet-chemical methods requiring controlled metal speciation.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt requires pH control because complex stability varies with protonation and metal identity.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt finds application in laboratory sample preparation and decontamination procedures.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt binds residual metal ions on compatible surfaces, glassware, membranes, and process equipment.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt supports removal of selected inorganic contaminants before sensitive analytical measurements.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt must be removed adequately when residual chelant could interfere with subsequent analysis.
DESCRIPTION
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt is the systematic registry name for tetrasodium ethylenediaminetetraacetate.
The substance is identified by CAS Number 64-02-8 and EC Number 200-573-9.
Its anhydrous molecular formula is C₁₀H₁₂N₂Na₄O₈.
Its anhydrous molecular weight is approximately 380.17 g/mol.
The structure contains two nitrogen atoms connected by an ethylene bridge.
Each nitrogen atom is attached to two acetate groups.
The fully neutralized material contains four sodium ions associated with four carboxylate groups.
The resulting molecule behaves as a multidentate aminopolycarboxylate ligand.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt can coordinate a metal through both nitrogen atoms and several carboxylate oxygen atoms.
A single chelant molecule can surround a suitable metal ion through multiple donor sites.
This multidentate binding produces complexes that are generally more stable than comparable complexes formed by simple monodentate ligands.
The phenomenon is commonly described as the chelate effect.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt binds many divalent and trivalent metal ions.
Commonly complexed ions include calcium, magnesium, iron, copper, manganese, zinc, nickel, cobalt, lead, and related metals.
The relative stability of each complex depends on metal identity, pH, temperature, concentration, competing ligands, and ionic strength.
Chelation reduces the concentration of chemically free metal ions without necessarily removing the total metal content.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt is more highly neutralized and generally more water soluble than free ethylenediaminetetraacetic acid.
The tetrasodium form produces alkaline aqueous solutions because all four carboxylic acid groups are present principally as sodium carboxylates.
Its alkaline character must be considered when the material is added to pH-sensitive formulations.
Final formulation pH should be adjusted after the chelant has been completely dissolved.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt normally appears as a colorless or white crystalline powder.
Commercial grades may also be supplied as granules, hydrated crystals, concentrated aqueous solutions, or low-dust solids.
Appearance can vary with hydration state, particle size, moisture content, and manufacturing process.
Anhydrous, dihydrate, tetrahydrate, and solution grades must not be treated as having identical active content.
The anhydrous salt has a molecular weight of approximately 380.17 g/mol.
The dihydrate contains two water molecules per formula unit and has a correspondingly higher formula weight.
The tetrahydrate contains four water molecules per formula unit and has a still higher formula weight.
Assay calculations must therefore distinguish active tetrasodium EDTA from water of hydration and formulation water.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt is highly soluble in water.
International chemical-safety data report a representative solubility of approximately 100–110 g per 100 mL of water at 20°C.
Dissolution rate depends on particle size, water temperature, agitation, ionic strength, and the order of ingredient addition.
Highly concentrated solutions may show increased viscosity and crystallization during cooling.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt has negligible practical volatility under ordinary ambient conditions.
Airborne exposure occurs primarily through dust generated by dry powder handling rather than through evaporation.
Aerosol exposure may also occur when concentrated solutions are sprayed or atomized.
Enclosed transfer and local exhaust ventilation are therefore important during powder charging and high-energy liquid processing.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt decomposes when strongly heated.
International chemical-safety information reports decomposition above approximately 200°C.
Thermal decomposition can produce nitrogen oxides and other irritating or toxic fumes.
The material should not be heated as though it possessed a normal distillable boiling point.
Finely divided Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt can form an explosive dust–air mixture.
Dust accumulation on equipment, beams, floors, ducts, and elevated surfaces can contribute to secondary-explosion hazards.
Ignition controls, conductive equipment, effective housekeeping, and dust-explosion-resistant systems may be required in large-scale powder handling.
The material is described as combustible despite its ionic and highly water-soluble character.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt reacts with strong oxidizing agents.
Strong bases are also identified as incompatible in international chemical-safety information.
Reactive incompatibility may increase heat generation, decomposition, gas formation, or loss of chelating performance.
Compatibility testing should be completed before combining concentrated material with powerful oxidants or strongly caustic process streams.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt is commonly produced through neutralization of ethylenediaminetetraacetic acid with sodium hydroxide.
Industrial routes may also generate the tetrasodium salt through hydrolysis of aminonitrile intermediates under alkaline conditions.
The final product may be concentrated as a solution or crystallized, separated, dried, milled, and classified as a solid.
Manufacturing quality control must limit unreacted intermediates, inorganic salts, color, moisture, and trace-metal contamination.
The principal technical function of Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt is sequestration rather than precipitation.
Metal ions remain present in solution but are converted into coordinated forms with lower free-ion activity.
This effect can prevent scale, discoloration, oxidation, precipitation, and catalytic decomposition.
The resulting metal complexes may remain mobile and require consideration during wastewater treatment.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt can increase the apparent solubility of some metals.
This property is useful in cleaning, metal processing, analysis, and deposit removal.
The same property can mobilize metals in soil, sediment, wastewater, or industrial effluent.
Environmental-release control is therefore an important part of responsible use.
EDTA-related chelants can persist through some conventional wastewater-treatment processes.
Stable metal complexes may travel farther through water systems than the corresponding uncomplexed metal ions.
Wastewater treatment should be evaluated using the actual chelant concentration and metal-loading profile.
Discharge decisions should not be based only on the comparatively low volatility of the material.
Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt is harmful if swallowed according to cited international GHS information.
The solid can cause mild skin irritation and serious eye irritation.
Inhalation of dispersed particles may cause coughing and sore throat.
A harmful airborne concentration can be reached quickly when fine powder is dispersed in an enclosed area.
The strongly chelating behavior of Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt can influence biological metal availability.
Concentrated exposure should therefore be prevented even when the substance is used routinely at low formulation levels.
Grade-specific toxicological and regulatory requirements vary by application and jurisdiction.
The current Safety Data Sheet should determine classification, protective equipment, transport, and emergency procedures.
Quality control commonly includes appearance, identity, active content, moisture, pH, water-insoluble matter, color, iron content, and chelating value.
Solution grades may additionally be tested for density, clarity, viscosity, crystallization behavior, and microbiological quality.
Low-metal grades are important where trace contamination could interfere with cosmetics, electronics, analytical methods, or peroxide systems.
The applicable certificate of analysis should define the accepted values for the intended commercial grade.
PROPERTIES
Chemical Name: Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt
Common Name: Tetrasodium EDTA
Alternative Common Name: Tetrasodium ethylenediaminetetraacetate
CAS Number: 64-02-8
EC Number: 200-573-9
PubChem CID: 6144
EPA SRS Identifier: 3798
EPA PC Code: 039107
Molecular Formula: C₁₀H₁₂N₂Na₄O₈
Condensed Structural Formula: ((NaOOCCH₂)₂NCH₂)₂
Molecular Weight: 380.17 g/mol
Chemical Family: Aminopolycarboxylate chelating agents
Functional Groups: Tertiary amine donor groups and sodium carboxylate groups
Substance Type: Organic sodium salt
Degree of Neutralization: Tetrasodium or fully neutralized EDTA salt
Physical State: Crystalline solid
Appearance: Colorless to white crystalline powder
Odor: Generally odorless
Water Solubility at 20°C: Approximately 100–110 g/100 mL
Water-Solubility Classification: Highly soluble
Aqueous-Solution Character: Alkaline
Volatility: Negligible under ordinary ambient conditions
Vapor-Exposure Potential: Low
Dust-Exposure Potential: Significant when fine powder is dispersed
Representative Relative Density: Approximately 0.7 in cited international safety data
Decomposition Temperature: Greater than approximately 200°C
Stable Atmospheric Boiling Point: Not applicable because decomposition occurs
Autoignition Temperature: Greater than approximately 200°C in cited international safety data
Combustibility: Combustible
Dust-Explosion Potential: Possible when fine particles are dispersed in air
Primary Function: Chelating and sequestering agent
Primary Chelated Metals: Calcium, magnesium, iron, copper, manganese, zinc, nickel, cobalt, lead, and other polyvalent metals
Primary Applications: Detergents, cleaners, cosmetics, textiles, pulp and paper, water treatment, metal finishing, coatings, polymers, agricultural formulations, oilfield chemicals, leather processing, photography, and analytical chemistry
Water-Softening Function: Sequesters calcium and magnesium ions
Oxidation-Stability Function: Sequesters iron, copper, manganese, and other oxidation-promoting metals
Scale-Control Function: Maintains selected hardness ions in soluble complexed form
Analytical Function: Complexometric titration and metal masking
Cosmetic Function: Chelating and formulation-stabilizing ingredient
Hazard Summary: Harmful if swallowed, mildly irritating to skin, and seriously irritating to eyes
Inhalation Effects: Coughing and sore throat may occur after dust exposure
Eye Effects: Redness and pain
Skin Effects: Redness and mild irritation
Chemical Stability: Stable under recommended dry storage conditions
Incompatible Materials: Strong oxidizing agents and strong bases
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides, sodium-containing residues, and irritating or toxic fumes
Environmental Behavior: Highly water soluble and capable of maintaining metals in mobile complexed form
Recommended Storage: Cool, dry, tightly closed, and well-ventilated storage
Moisture Precaution: Protect powder grades from humidity and caking
Current Data Requirement: Confirm hydration state, active content, physical form, hazard classification, transport status, and shelf life from current grade-specific documentation.
FIRST AID
Inhalation:
Move the affected person immediately to fresh air.
Keep the person at rest in a position comfortable for breathing.
Avoid further exposure to Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt dust, aerosol, smoke, or decomposition fumes.
Obtain medical attention if coughing, sore throat, breathing discomfort, headache, or other symptoms develop or persist.
Skin Contact:
Remove contaminated clothing and footwear.
Rinse the affected skin with plenty of water or use an emergency shower.
Wash the skin thoroughly with soap and water.
Obtain medical attention if redness, irritation, pain, or other symptoms persist.
Wash contaminated clothing thoroughly before reuse.
Eye Contact:
Rinse the eyes immediately with plenty of clean, gently flowing water.
Hold the eyelids open to ensure complete irrigation.
Remove contact lenses when present and easy to do, then continue rinsing.
Continue rinsing for at least 15 minutes.
Obtain prompt medical attention because serious eye irritation, redness, and pain may occur.
Ingestion:
Rinse the mouth thoroughly with water.
Do not induce vomiting unless directed by qualified medical personnel or a poison center.
Never give anything by mouth to an unconscious or convulsing person.
Obtain prompt medical attention because Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt is harmful if swallowed.
Provide the current Safety Data Sheet to medical personnel.
Note to Physicians:
No substance-specific antidote should be assumed.
Provide supportive care and treat according to the patient’s symptoms and clinical condition.
Assess the eyes, skin, respiratory tract, gastrointestinal system, fluid balance, and electrolyte status following substantial exposure.
Consider the material’s metal-chelating properties when evaluating significant ingestion.
Use current poison-center guidance and the grade-specific Safety Data Sheet as the primary medical references.
HANDLING AND STORAGE
Handling:
Handle Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt in accordance with good industrial-hygiene and chemical-safety practices.
Review the current technical specification and Safety Data Sheet before opening or processing the material.
Avoid unnecessary contact with the skin, eyes, and clothing.
Do not breathe dust, aerosol, mist, smoke, or thermal-decomposition fumes.
Use enclosed charging, weighing, transfer, dissolving, and packaging systems wherever practicable.
Avoid pouring, grinding, sweeping, or pneumatic-transfer methods that create uncontrolled dust.
Add solid material gradually to water under controlled agitation to prevent lumping, splashing, and airborne powder.
Use clean, dry, and chemically compatible equipment for sampling, weighing, dissolving, and transfer.
Wash the hands, face, and exposed skin thoroughly after handling.
Do not eat, drink, or smoke in areas where Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt is processed.
Keep containers tightly closed when the product is not being sampled or transferred.
Prevent release of concentrated material and metal-containing chelate solutions to uncontrolled wastewater systems.
Ventilation:
Provide effective general ventilation in storage and processing areas.
Use local exhaust ventilation at weighing stations, bag-emptying points, mixers, dissolving vessels, dryers, mills, and packaging equipment.
Capture dust at its source rather than allowing particles to spread through the workplace.
Use dust-collection equipment suitable for combustible particulate material where required.
Prevent recirculation of contaminated air unless it has been adequately filtered.
Provide additional ventilation when concentrated solutions are sprayed, atomized, heated, or handled in confined equipment.
Use suitable particulate respiratory protection when engineering controls cannot adequately limit exposure.
Select respiratory equipment through a documented workplace exposure and hazard assessment.
Inspect and maintain ventilation systems regularly to prevent loss of extraction efficiency and accumulation of combustible dust.
Storage:
Store Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt in tightly closed and correctly labeled containers.
Keep the material in a cool, dry, secure, and well-ventilated location.
Protect the product from moisture, excessive heat, direct sunlight, contamination, and physical damage.
Keep Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt separated from strong oxidizing agents and strong bases.
Keep dry powder away from open flames, sparks, hot surfaces, and uncontrolled ignition sources.
Prevent water, dirt, metals, oxidants, strongly alkaline residues, and process chemicals from entering opened containers.
Carefully reseal partially used containers immediately after sampling or transfer.
Use moisture-resistant packaging for powder grades.
Use first-in, first-out stock rotation within the applicable shelf life.
Inspect stored material for caking, discoloration, damaged packaging, contamination, or moisture uptake before use.
Store concentrated solutions at temperatures that prevent freezing, crystallization, or container damage.
Spill and Leak Procedures:
Restrict access to the affected area and remove unnecessary personnel.
Eliminate ignition sources when this can be done safely.
Avoid dry sweeping, compressed-air cleaning, or other methods that disperse powder.
Provide effective ventilation before beginning spill recovery.
Wear suitable chemical-resistant gloves, protective clothing, eye protection, and particulate respiratory protection.
Prevent Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-], tetrasodium salt from entering drains, sewers, soil, groundwater, or surface water.
Carefully vacuum spilled powder using equipment suitable for combustible dust.
Sweep material gently into covered containers when suitable vacuum recovery is unavailable.
Moisten powder cautiously only when this is compatible with the recovery and disposal procedure.
Contain liquid spills with sand, earth, vermiculite, or another compatible inert absorbent.
Collect recovered material and contaminated cleaning residues in tightly closed and correctly labeled containers.
Prevent metal-containing spill solutions from entering uncontrolled wastewater systems.
Dispose of recovered product and cleaning residues through an authorized waste-management route.
Handling Precautions:
Wear chemical-resistant protective gloves selected from documented compatibility and permeation data.
Use tightly fitting chemical goggles.
Wear a face shield in addition to goggles where solution splashing or heavy dust exposure is reasonably foreseeable.
Use protective clothing and closed chemical-resistant footwear.
Provide accessible eyewash and emergency-shower equipment near major handling locations.
Use a particulate-filter respirator adapted to the airborne concentration when respiratory protection is required.
Ground and bond conductive equipment where combustible-dust or electrostatic hazards have been identified.
Inspect containers, seals, valves, transfer devices, ventilation systems, and dust collectors before use.
Avoid contact with strong oxidizing agents and strongly alkaline reactive materials.
Do not subject the product to uncontrolled heating because decomposition can produce toxic nitrogen-containing fumes.
Evaluate compatibility before using the chelant with metal catalysts, metal-containing pigments, nutrients, or treatment chemicals.
Review the current technical specification, Safety Data Sheet, certificate of analysis, occupational requirements, environmental regulations, and transport rules before production, formulation, storage, cleaning, or disposal.
